Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's Disease

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Sung, Hye Youn ^a   Choi, Eun Nam ^a   Lyu, Dahyun ^a   Mook Jung, Inhee ^b   Ahn, Jung Hyuck ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; SMALL INTERFERING RNA; SOMATOMEDIN BINDING PROTEIN 3; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME REPRESSION; GENE CONTROL; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENETIC EPIGENESIS; GENETIC TRANSFECTION; HIPPOCAMPUS; HUMAN; HUMAN CELL; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; ANIMAL; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PATHOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CASPASE 3; CELL SURVIVAL; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; MICE; MICE, TRANSGENIC; RATS;

EID: 84903544063     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099047     Document Type: Article

References (41)

1. Scheuner D, Eckman C, Jensen M, Song X, Citron M, et al. (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870. (Pubitemid 26296755)
2. Kimberly WT, Zheng JB, Guenette SY, Selkoe DJ (2001) The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem 276: 40288-40292.
3. Cao X, Sudhof TC (2001) A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293: 115-120. (Pubitemid 32625507)
4. Cai XD, Golde TE, Younkin SG (1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259: 514-516. (Pubitemid 23058708)
5. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, et al. (1992) Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360: 672-674. (Pubitemid 23007680)
6. Shin J, Yu SB, Yu UY, Jo SA, Ahn JH (2010) Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease. BMB Rep 43: 704-709.
7. Baxter RC, Dai J (1994) Purification and characterization of the acid-labile subunit of rat serum insulin-like growth factor binding protein complex. Endocrinology 134: 848-852. (Pubitemid 24057232)
8. Firth SM, McDougall F, McLachlan AJ, Baxter RC (2002) Impaired blockade of insulin-like growth factor I (IGF-I)-induced hypoglycemia by IGF binding protein-3 analog with reduced ternary complex-forming ability. Endocrinology 143: 1669-1676. (Pubitemid 34415881)
9. Yamada PM, Lee KW (2009) Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. Am J Physiol Cell Physiol 296: C954-976.
10. Jogie-Brahim S, Feldman D, Oh Y (2009) Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev 30: 417-437.
11. Martin JL, Weenink SM, Baxter RC (2003) Insulin-like growth factor-binding protein-3 potentiates epidermal growth factor action in MCF-10A mammary epithelial cells. Involvement of p44/42 and p38 mitogen-activated protein kinases. J Biol Chem 278: 2969-2976. (Pubitemid 36801203)
12. Martin JL, Lin MZ, McGowan EM, Baxter RC (2009) Potentiation of growth factor signaling by insulin-like growth factor-binding protein-3 in breast epithelial cells requires sphingosine kinase activity. J Biol Chem 284: 25542-25552.
13. Granata R, Trovato L, Lupia E, Sala G, Settanni F, et al. (2007) Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms. J Thromb Haemost 5: 835-845. (Pubitemid 46563585)
14. Butt AJ, Martin JL, Dickson KA, McDougall F, Firth SM, et al. (2004) Insulin-like growth factor binding protein-3 expression is associated with growth stimulation of T47D human breast cancer cells: the role of altered epidermal growth factor signaling. J Clin Endocrinol Metab 89: 1950-1956. (Pubitemid 38507956)
15. Leibowitz BJ, Cohick WS (2009) Endogenous IGFBP-3 is required for both growth factor-stimulated cell proliferation and cytokine-induced apoptosis in mammary epithelial cells. J Cell Physiol 220: 182-188.
16. Granata R, Trovato L, Garbarino G, Taliano M, Ponti R, et al. (2004) Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways. FASEB J 18: 1456-1458. (Pubitemid 39561613)
17. Yamashita S, Tsujino Y, Moriguchi K, Tatematsu M, Ushijima T (2006) Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2′-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci 97: 64-71. (Pubitemid 43257029)
18. Dar AA, Majid S, Nosrati M, de Semir D, Federman S, et al. (2010) Functional modulation of IGF-binding protein-3 expression in melanoma. J Invest Dermatol 130: 2071-2079.
19. Tomii K, Tsukuda K, Toyooka S, Dote H, Hanafusa T, et al. (2007) Aberrant promoter methylation of insulin-like growth factor binding protein-3 gene in human cancers. Int J Cancer 120: 566-573. (Pubitemid 44969028)
20. Chae SS, Yoo CB, Jo C, Yun SM, Jo SA, et al. (2010) Caspases-2 and-8 are involved in the presenilin1/ c-secretase-dependent cleavage of amyloid precursor protein after the induction of apoptosis. Journal of neuroscience research 88: 1926-1933.
21. Yun S-M, Cho S-J, Song JC, Song SY, Jo SA, et al. (2013) SUMO1 modulates Aβ generation via BACE1 accumulation. Neurobiology of aging 34: 650-662.
22. Takahashi T, Shigematsu H, Shivapurkar N, Reddy J, Zheng Y, et al. (2006) Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers. Int J Cancer 118: 924-931. (Pubitemid 43157667)
23. Borchelt DR, Wong PC, Sisodia SS, Price DL (1998) Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis. Brain Pathol 8: 735-757. (Pubitemid 28460931)
24. Duron E, Funalot B, Brunel N, Coste J, Quinquis L, et al. (2012) Insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Alzheimer's disease. J Clin Endocrinol Metab 97: 4673-4681.
25. Rensink AA, Gellekink H, Otte-Holler I, ten Donkelaar HJ, de Waal RM, et al. (2002) Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease. Acta Neuropathol 104: 525-533. (Pubitemid 36075420)
26. Niikura T, Hashimoto Y, Okamoto T, Abe Y, Yasukawa T, et al. (2001) Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. J Neurosci 21: 1902-1910. (Pubitemid 32221374)
27. Carro E, Trejo JL, Gerber A, Loetscher H, Torrado J, et al. (2006) Therapeutic actions of insulin-like growth factor I on APP/PS2 mice with severe brain amyloidosis. Neurobiol Aging 27: 1250-1257. (Pubitemid 44088577)
28. Nishijima T, Piriz J, Duflot S, Fernandez AM, Gaitan G, et al. (2010) Neuronal activity drives localized blood-brain-barrier transport of serum insulin-like growth factor-I into the CNS. Neuron 67: 834-846.
29. Mustafa A, Lannfelt L, Lilius L, Islam A, Winblad B, et al. (1999) Decreased plasma insulin-like growth factor-I level in familial Alzheimer's disease patients carrying the Swedish APP 670/671 mutation. Dement Geriatr Cogn Disord 10: 446-451. (Pubitemid 29512010)
30. Watanabe T, Miyazaki A, Katagiri T, Yamamoto H, Idei T, et al. (2005) Relationship Between Serum Insulin-Like Growth Factor-1 Levels and Alzheimer's Disease and Vascular Dementia. J Am Geriatr Soc 53: 1748-1753. (Pubitemid 43109939)
31. Tham A, Nordberg A, Grissom FE, Carlsson-Skwirut C, Viitanen M, et al. (1993) Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type. J Neural Transm Park Dis Dement Sect 5: 165-176. (Pubitemid 23227810)
32. Vardy ER, Rice PJ, Bowie PC, Holmes JD, Grant PJ, et al. (2007) Increased circulating insulin-like growth factor-1 in late-onset Alzheimer's disease. J Alzheimers Dis 12: 285-290.
33. Ikonen M, Liu B, Hashimoto Y, Ma L, Lee K-W, et al. (2003) Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proceedings of the National Academy of Sciences 100: 13042-13047. (Pubitemid 37340022)
34. Wiley A, Katsaros D, Fracchioli S, Yu H (2006) Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer. Int J Gynecol Cancer 16: 210-218.
35. Hanafusa T, Yumoto Y, Nouso K, Nakatsukasa H, Onishi T, et al. (2002) Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma. Cancer Lett 176: 149-158. (Pubitemid 34136014)
36. Kennedy BP, Bottiglieri T, Arning E, Ziegler MG, Hansen LA, et al. (2004) Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyl-transferases and cognitive function. J Neural Transm 111: 547-567. (Pubitemid 38478922)
37. West RL, Lee JM, Maroun LE (1995) Hypomethylation of the amyloid precursor protein gene in the brain of an Alzheimer's disease patient. J Mol Neurosci 6: 141-146.
38. Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S (2005) S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 28: 195-204. (Pubitemid 39656023)
39. Chang YS, Wang L, Liu D, Mao L, Hong WK, et al. (2002) Correlation between insulin-like growth factor-binding protein-3 promoter methylation and prognosis of patients with stage I non-small cell lung cancer. Clinical cancer research 8: 3669-3675. (Pubitemid 35424756)
40. Torng P-L, Lin C-W, Chan M, Yang H-W, Huang S-C, et al. (2009) Promoter methylation of IGFBP-3 and p53 expression in ovarian endometrioid carcinoma. Mol Cancer 8: 120-127.
41. Chen KL, Wang SS, Yang YY, Yuan RY, Chen RM, et al. (2009) The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem Biophys Res Commun 378: 57-61.