Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2)

Journal of Biological Chemistry

Volumn 289, Issue 26, 2014, Pages 17960-17969

  Gao, Rui ^a   Schellenberg, Matthew J ^b   Huang, Shar Yin N ^a   Abdelmalak, Monica ^a   Marchand, Christophe ^a   Nitiss, Karin C ^c   Nitiss, John L ^c   Williams, R Scott ^b   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; ESTERS; RNA; SUBSTRATES;

CATALYTIC PROFILES; COVALENT COMPLEX; DOUBLE-STRAND DNAS; HOMODIMERIC ENZYME; PROTEOLYTIC DEGRADATION; PROTEOLYTIC PROCESSING; RIBONUCLEOTIDES; TOPOISOMERASE II;

DNA;

DNA TOPOISOMERASE (ATP HYDROLYSING); PHOSPHODIESTERASE; POLYPEPTIDE; RIBONUCLEOTIDE; SINGLE STRANDED DNA; TOP2 DNA CLEAVAGE COMPLEX; TOP2 RNA CLEAVAGE COMPLEX; TYROSINE; TYROSYL DNA PHOSPHODIESTERASE 2; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN HYDROLYSIS;

CRYSTAL STRUCTURE; DNA REPAIR; DNA TOPOISOMERASE; PROTEIN DEGRADATION; RNA; TDP2;

CRYSTALLOGRAPHY, X-RAY; DNA; DNA TOPOISOMERASES, TYPE II; HUMANS; MODELS, MOLECULAR; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEOLYSIS; RNA; TRANSCRIPTION FACTORS;

EID: 84903526754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.565374     Document Type: Article

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