Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): A Mg2+/Mn2+-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30842-30852

  Gao, Rui ^a   Huang, Shar Yin N ^a   Marchand, Christophe ^a   Pommier, Yves ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL CHARACTERISTICS; BIOCHEMICAL CHARACTERIZATION; CATALYTIC MECHANISMS; CATALYTIC MOTIF; DUPLEX DNA; ENDONUCLEASES; ENZYMATIC ACTIVITIES; KEY RESIDUES; PHOSPHODIESTERASE ACTIVITY; PHOSPHODIESTERASES; RECEPTOR-ASSOCIATED PROTEINS; SEQUENCE ALIGNMENTS; SINGLE-STRANDED DNA; SUBSTRATE SPECIFICITY; TOPOISOMERASE II; TOPOISOMERASES;

AMINO ACIDS; BINDING SITES; ENZYMES; ESTERS; GENES; MANGANESE; MANGANESE COMPOUNDS; QUANTUM CHEMISTRY; SIGNAL TRANSDUCTION; SUBSTRATES;

DNA;

ALANINE; ASPARAGINE; ASPARTIC ACID; CALCIUM ION; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA TOPOISOMERASE; DOUBLE STRANDED DNA; ESTERASE; GLUTAMIC ACID; HISTIDINE; MAGNESIUM ION; MANGANESE; PHOSPHODIESTERASE; SINGLE STRANDED DNA; TYROSINE; TYROSYL DNA PHOSPHODIESTERASE 1; TYROSYL DNA PHOSPHODIESTERASE 2; UNCLASSIFIED DRUG; ZINC ION;

AMINO ACID SUBSTITUTION; ARTICLE; BASE PAIRING; BINDING SITE; CATALYSIS; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA PROTEIN COMPLEX; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; METAL BINDING; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY;

AMINO ACID MOTIFS; ANTIGENS, NEOPLASM; BINDING SITES; CATIONS, DIVALENT; DNA ADDUCTS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; DNA-BINDING PROTEINS; HUMANS; MAGNESIUM; MANGANESE; MULTIENZYME COMPLEXES; NUCLEAR PROTEINS; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS;

EID: 84865732472     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.393983     Document Type: Article

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