Codon usage bias covaries with expression breadth and the rate of synonymous evolution in humans, but this is not evidence for selection

Genetics

Volumn 159, Issue 3, 2001, Pages 1191-1199

  Urrutia, Araxi O ^a   Hurst, Laurence D ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CODON; COVARIANCE; DROSOPHILA; EVOLUTION; GENE EXPRESSION; HUMAN; MATHEMATICAL ANALYSIS; NATURAL SELECTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPECIES DIFFERENCE; TISSUE SPECIFICITY;

AMINO ACIDS; ANIMALS; CODON; HUMANS; LIKELIHOOD FUNCTIONS; MODELS, GENETIC; MODELS, STATISTICAL; NUCLEOTIDES; OBSERVER VARIATION;

MAMMALIA;

EID: 0035671698     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. The human genome: Organization and evolutionary history
2. Isochores and synonymous substitutions in mammalian genes
3. Evolution of the genome and the genetic-code - Selection at the dinucleotide level by methylation and polyribonucleotide cleavage
4. Selection on silent sites in the rodent H3 histone gene family
5. Substitution rates in Drosophila nuclear genes: Implications for translational selection
6. The covariation between TpA deficiency, CpG deficiency, and G + C content of human isochores is due to a mathematical artifact
7. The elevated GC content at exonic third sites is not evidence against neutralist models of isochore evolution
8. Expression pattern and, surprisingly, gene length shape codon usage in Caenorhabditis, Drosophila, Arabidopsis
9. Determinants of substitution rates in mammalian genes: Expression pattern affects selection intensity but not mutation rate
10. An analysis of codon usage in mammals - Selection or mutation bias
11. Codon usage in bacteria - Correlation with gene expressivity
12. Acnuc - A nucleic-acid sequence data-base and analysis system
13. The effects of guanine and cytosine variation on dinucleotide frequency and amino-acid composition in the human genome
14. Evident diversity of codon usage patterns of human genes with respect to chromosome-banding patterns and chromosome-numbers - Relation between nucleotide-sequence data and cytogenetic data
15. Studies of codon usage and tRNA genes of 18 unicellular organisms and quantification of Bacillus subtilis tRNAs: Gene expression level and species-specific diversity of codon usage based on multivariate analysis
16. What drives codon choices in human genes?
17. Non-Darwinian evolution
18. Initial sequencing and analysis of the human genome
19. Retroviral transfer and expression of a humanized, red-shifted green fluorescent protein gene into human tumor cells
20. Unbiased estimation of the rates of synonymous and nonsynonymous substitution
21. Does recombination improve selection on codon usage? Lessons from nematode and fly complete genomes
22. Codon usage bias and tRNA abundance in Drosophila
23. Evolution of codon usage bias in Drosophila
24. The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias
25. Codon usage in yeast - Cluster-analysis clearly differentiates highly and lowly expressed genes
26. DNA-sequence evolution - The sounds of silence
27. Codon usage in Caenorhabditis elegans: Delineation of translational selection and mutational biases
28. Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch
29. The effective number of codons used in a gene
30. Papillomavirus capsid protein expression level depends on the match between codon usage and tRNA availability
31. A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells