Role of locus coeruleus in attention and behavioral flexibility

Biological Psychiatry

Volumn 46, Issue 9, 1999, Pages 1309-1320

  Aston Jones, Gary ^a   Rajkowski, Janusz ^a   Cohen, Jonathan ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Attention; Locus coeruleus; Monkey; Neurophysiology; Norepinephrine; Visual discrimination

Indexed keywords

ANIMAL MODEL; ATTENTION; BEHAVIOR; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; LOCUS CERULEUS; MONKEY; NONHUMAN; PRIORITY JOURNAL; REVIEW; VISUAL DISCRIMINATION;

ANIMALS; ATTENTION; BEHAVIOR, ANIMAL; HAPLORHINI; LOCUS COERULEUS; NEURAL NETWORKS (COMPUTER); NEURONS; NOREPINEPHRINE;

EID: 0033232478     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00140-7     Document Type: Review

References (76)

1. Abercrombie E., Jacobs B. Single unit response of noradrenergic neurons in locus coeruleus of freely moving cats II. Adaptation to chronically presented stressful stimuli. J Neurosci. 7:1987;2844-2848.
2. Abercrombie E.D., Jacobs B.L. Single unit response of noradrenergic neurons in locus coeruleus of freely moving cats I. Acutely presented stressful and nonstressful stimuli. J Neurosci. 7:1987;2837-2843.
3. Aghajanian G.K., Cedarbaum J.M., Wang R.Y. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Res. 136:1977;570-577.
4. Aston-Jones G. Behavioral functions of the locus coeruleus derived from cellular attributes. Physiol Psych. 13:1985;118-126.
5. Aston-Jones G., Alexinsky T., Grant S. Activity of locus coeruleus neurons in behaving primates relationship with vigilance . Soc Neurosci Abstr. 14:1988;407.
6. Aston-Jones G., Bloom F.E. Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci. 1:1981;876-886.
7. Aston-Jones G., Bloom F.E. Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli. J Neurosci. 1:1981;887-900.
8. Aston-Jones G., Chiang C., Alexinsky T. Discharge of noradrenergic locus coeruleus neurons in behaving rats and monkeys suggests a role in vigilance. Prog Brain Res. 88:1991;501-520.
9. Aston-Jones G., Ennis M., Pieribone V.A., Nickell W.T., Shipley M.T. The brain nucleus locus coeruleus restricted afferent control of a broad efferent network . Science. 234:1986;734-737.
10. Aston-Jones G, Foote SL, Bloom FE (1984): Anatomy and physiology of locus coeruleus neurons: functional implications. In: Ziegler M, Lake CR, editors, Norepinephrine (Frontiers of Clinical Neuroscience, Vol. 2). Baltimore: Williams and Wilkins, pp 92-116.
11. Aston-Jones G., Rajkowski J., Kubiak P. Conditioned responses of monkey locus coeruleus neurons anticipate acquisition of discriminative behavior in a vigilance task. Neuroscience. 80:1997;697-715.
12. Aston-Jones G., Rajkowski J., Kubiak P., Alexinsky T. Locus coeruleus neurons in the monkey are selectively activated by attended stimuli in a vigilance task. J Neurosci. 14:1994;4467-4480.
13. Aston-Jones G., Rajkowski J., Kubiak P., Valentino R., Shipley M. Role of the locus coeruleus in emotional activation. Prog Brain Res. 107:1996;379-402.
14. Aston-Jones G., Valentino R.J., Van Bockstaele E., Meyerson A. Locus coeruleus, stress, and PTSD Neurobiological and clinical parallels . Murburg M. Catecholamine Function in Post-Traumatic Stress Disorder. 1994;17-62 American Psychiatric Press, Washington, DC.
15. Bernander O., Koch C., Usher M. The effect of synchronized inputs at the single neuron level. Neural Comput. 6:1994;622-641.
16. Berridge C.W., Foote S.L. Effects of locus coeruleus activation on electroencephalographic activity in the neocortex and hippocampus. J Neurosci. 11:1991;3135-3145.
17. Biegon A., Fieldust S. Reduced tyrosine hydroxylase immunoreactivity in locus coeruleus of suicide victims. Synapse. 10:1992;79-82.
18. Chan-Palay V. Alterations in the locus coeruleus in dementias of Alzheimer's and Parkinson's disease. Prog Brain Res. 88:1991;625-630.
19. Chan-Palay V. Depression and dementia in Parkinson's disease. Catecholamine changes in the locus ceruleus, a basis for therapy. Adv Neurol. 60:1993;438-446.
20. Chiang C., Aston-Jones G. Response of locus coeruleus neurons to footshock stimulation is mediated by neurons in the ventrolateral medulla. Neuroscience. 53:1993;705-715.
21. Christie M.J., Jelinek H.F. Dye-coupling among neurons of the rat locus coeruleus during postnatal development. Neuroscience. 56:1993;129-137.
22. Christie M.J., Williams J.T., North R.A. Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in vitro from neonatal rats. J Neurosci. 9:1989;3584-3589.
23. Dahlstrom A., Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand. 62:1964;5-55.
24. Davidson J.R., et al. A diagnostic and family study of PTSD. Am J Psychiatry. 142:1985;90-93.
25. Easterbrook J.A. The effect of emotion on cue utilization and the organization of behavior. Psychiatry Rev. 66:1959;183-201.
26. Ennis M., Aston-Jones G. Evidence for self- and neighbor-mediated postactivation inhibition of locus coeruleus neurons. Brain Res. 374:1986;299-305.
27. Ennis M., Aston-Jones G. Activation of locus coeruleus from nucleus paragigantocellularis a new excitatory amino acid pathway in brain . J Neurosci. 8:1988;3644-3657.
28. Foote S.L., Aston-Jones G., Bloom F.E. Impulse activity of locus coeruleus neurons in awake rats and monkeys is a function of sensory stimulation and arousal. Proc Natl Acad Sci USA. 77:1980;3033-3037.
29. Foote S.L., Bloom F.E., Aston-Jones G. Nucleus locus ceruelus new evidence of anatomical and physiological specificity . Physiol Rev. 63:1983;844-914.
30. Foote S.L., Freedman R., Oliver A.P. Effects of putative neurotransmitters on neuronal activity in monkey auditory cortex. Brain Res. 86:1975;229-242.
31. Freedman R., Foote S.L., Bloom F.E. Histochemical characterization of a neocortical projection of the nucleus locus coeruleus in the squirrel monkey. J Comp Neurol. 164:1975;209-231.
32. German D.C., Manaye K.F., White C.L., et al. Disease-specific patterns of locus coeruleus cell loss. Ann Neurol. 32:1992;667-676.
33. Grant S.J., Aston-Jones G., Redmond D.E.J. Responses of primate locus coeruleus neurons to simple and complex sensory stimuli. Brain Res Bull. 21:1988;401-411.
34. Hobson J.A., McCarley R.W., Wyzinski P.W. Sleep cycle oscillation Reciprocal discharge by two brainstem neuronal groups . Science. 189:1975;55-58.
35. Hoffer B.J., Siggins G.R., Oliver A.P., Bloom F.E. Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons Pharmacological evidence of noradrenergic central inhibition . J Pharmacol Exp Ther. 184:1973;553-569.
36. Hoogendijk W.J., Pool C.W., Troost D., van Zwieten E., Swaab D.F. Image analyser-assisted morphometry of the locus coeruleus in Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Brain. 118:1995;131-143.
37. Ishimatsu M., Williams J.T. Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions. J Neurosci. 16:1996;5196-5204.
38. Ivanov A.Y., Aston-Jones G. Intrinsic mechanisms regulating spontaneous discharge and sub-threshold oscillations in locus coeruleus (LC) neurons in vitro. Soc Neurosci Abstr. 21:1995;633.
39. Ivanova S., Rajkowski J., Silakov V., Watanabe T., Aston-Jones G. Local chemomanipulations of locus coeruleus (LC) activity in monkeys alter cortical event-related potentials (ERPs) and task performance. Soc Neurosci Abst. 23:1997;1587.
40. Knight B. Dynamics of encoding in a population of neurons. J Gen Physiol. 59:1972;734-766.
41. Koda L.Y., Schulman J.A., Bloom F.E. Ultrastructural identification of noradrenergic terminals in the rat hippocampus unilateral destruction of the locus coeruleus with 6-hydroxydopamine . Brain Res. 145:1978;190-195.
42. Kubiak P., Rajkowski J., Aston-Jones G. Behavioral performance and sensory responsiveness of LC neurons in a vigilance task varies with tonic LC discharge rate. Soc Neurosci Abstr. 18:1992;538.
43. Morilak D.A., Fornal C.A., Jacobs B.L. Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. I. Thermoregulatory challenge. Brain Res. 422:1987;17-23.
44. Morilak D.A., Fornal C.A., Jacobs B.L. Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. II. Cardiovascular challenge. Brain Res. 422:1987;24-31.
45. Morilak D.A., Fornal C.A., Jacobs B.L. Effects of physiological manipulations on locus coeruleus neuronal activity in freely moving cats. III. Glucoregulatory challenge. Brain Res. 422:1987;32-39.
46. Morrison J., Foote S. Noradrenergic and serotonergic innervation of cortical, thalamic and tectal visual structures in old and new world monkeys. J Comp Neurol. 243:1986;117-128.
47. Morrison J.H., Foote S.L., O'Connor D., Bloom F.E. Laminar, tangenital and regional organization of the noradrenergic innervation of the monkey cortex dopamine-beta-hydroxylase immunohistochemistry . Brain Res Bull. 9:1982;309-319.
48. Olschowka J.A., Molliver M.E., Grzanna R., Rice F.L., Coyle J.T. Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. J Histochem Cytochem. 29:1981;271-280.
49. Ordway G.A., Smith K.S., Haycock J.W. Elevated tyrosine hydroxylase in the locus coeruleus of suicide victims. J Neurochem. 62:1994;680-685.
50. Ordway G.A., Widdowson P.S., Smith K.S., Halaris A. Agonist binding to alpha 2-adrenoceptors is elevated in the locus coeruleus from victims of suicide. J Neurochem. 63:1994;617-624.
51. Papadopoulos G.C., Parnavelas J.G., Buijs R. Monoaminergic fibers form conventional synapses in the cerebral cortex. Neurosci Lett. 76:1987;275-279.
52. Papadopoulos G.C., Parnavelas J.G., Buijs R.M. Light and electron microscopic immunocytochemical analysis of the noradrenaline innervation of the rat visual cortex. J Neurocytol. 18:1989;1-10.
53. Parasuraman R. The psychobiology of sustained attention. Warm J.S. Sustained Attention in Human Performance. 1984;61-101 John Wiley & Sons, New York.
54. Rajkowski J., Kubiak P., Aston-Jones G. Activity of locus coeruleus neurons in behaving monkeys varies with focused attention short- and long-term changes . Soc Neurosci Abstr. 18:1992;538.
55. Rajkowski J., Kubiak P., Aston-Jones G. Correlations between locus coeruleus (LC) neural activity, pupil diameter and behavior in monkey support a role of LC in attention. Soc Neurosci Abstr. 19:1993;974.
56. Rajkowski J., Kubiak P., Aston-Jones G. Locus coeruleus activity in monkey Phasic and tonic changes are associated with altered vigilance . Brain Res Bull. 35:1994;607-616.
57. Rajkowski J., Kubiak P., Ivanova S., Aston-Jones G. LC Neurons in monkey are selectively activated by the earliest predictors of reward. Soc Neurosci Abstr. 22:1996;2063.
58. Rajkowski J., Kubiak P., Ivanova S., Aston-Jones G. State related activity and reactivity of locus coeruleus neurons in behaving monkeys. Goldstein D., Eisenhofer G., McCarty R. Catecholamines Bridging Basic Science with Clinical Medicine . Vol 42:1998;740-744 Academic Press, New York.
59. Rajkowski J, Silakov V, Ivanova S, Aston-Jones G (1997): Locus coeruleus (LC) neurons in monkey are quiescent in paradoxical sleep (PS). Soc Neurosci Abst 23:2130.
60. Rasmussen K., Morilak D.A., Jacobs B.L. Single unit activity of locus coeruleus neurons in the freely moving cat. I. During naturalistic behaviors and in response to simple and complex stimuli. Brain Res. 371:1986;324-334.
61. Segal M., Bloom F.E. The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies. Brain Res. 72:1974;79-97.
62. Segal M., Bloom F.E. The action of norepinephrine in the rat hippocampus. IV. The effects of locus coeruleus stimulation on evoked hippocampal unit activity. Brain Res. 107:1976;513-525.
63. Servan-Schreiber D., Printz H., Cohen J.D. A network model of catecholamine effects gain signal to noise ratio and behavior. Science. 249:1990;892-895.
64. Siever L.J., Davis K.L. Overview Toward a dysregulation hypothesis of depression . Am J Psychiatry. 142:1985;1017-1031.
65. Solanto M.V. Neuropsychpharmacological mechanisms of stimulant drug action in attention-deficit hyperactivity disorder a review and integration . Behav Brain Res. 94:1998;127-152.
66. Travagli R.A., Wessendorf M., Dunwiddie T.V., Williams J.T. The opioid-induced current in rat locus coeruleus electrotonic considerations . Soc Neurosci Abstr. 20:1994;1734.
67. Travalgi R.A., Dunwiddie T.V., Williams J.T. Opioid inhibition in locus coeruleus. J Neurophysiol. 74:1995;519-528.
68. Ungerstedt U. Sterotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl. 367:1971;1-48.
69. Usher M., Cohen J.D., Rajkowski J., Kubiak P., Aston-Jones G. The role of locus coeruleus in the regulation of cognitive performance. Science. 283:1999;549-554.
70. Valentino R., Page M., Curtis A. Activation of noradrenergic locus coeruleus neurons by hemodynamic stress is due to local release of corticotropin-releasing factor. Brain Res. 555:1991;25-34.
71. Valentino R.J., Foote S.L., Aston-Jones G. Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus. Brain Res. 270:1983;363-367.
72. Waterhouse B.D., Moises H.C., Woodward D.J. Noradrenergic modulation of somatosensory cortical neuronal responses to iontophoretically applied putative neurotransmitters. Exp Neurol. 69:1980;30-49.
73. Waterhouse B.D., Moises H.C., Yeh H.H., Geller H.M., Woodward D.J. Comparison of norepinephrine- and benzodiazepine-induced augmentation of Purkinje cell responses to gamma-aminobutyric acid (GABA). J Pharmacol Exp Ther. 228:1984;257-267.
74. Waterhouse B.D., Woodward D.J. Interaction of norepinephrine with cerebrocortical activity evoked by stimulation of somatosensory afferent pathways in the rat. Exp Neurol. 67:1980;11-34.
75. Widdowson P.S., Ordway G.A., Halaris A.E. Reduced neuropeptide Y concentrations in suicide brain. J Neurochem. 59:1992;73-80.
76. Zweig R.M., Cardillo J.E., Cohen M., Giere S., Hedreen J.C. The locus ceruleus and dementia in Parkinson's disease. Neurology. 43:1993;986-991.