메뉴 건너뛰기




Volumn 19, Issue 2, 2014, Pages 142-156

Pharmacotherapy of cognitive deficits in schizophrenia

Author keywords

Clinical trials; cognitive deficits; MATRICS; pharmacotherapy; schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ABT 126; BRADANICLINE; BUSPIRONE; CHOLINESTERASE INHIBITOR; DEXAMPHETAMINE; DIHYDREXIDINE; DIMEBON; DONEPEZIL; DOPAMINE 1 RECEPTOR STIMULATING AGENT; ENCENICLINE; FLUMAZENIL; FLUPHENAZINE; HALOPERIDOL; LORAZEPAM; MK 0777; MUSCARINIC AGENT; NEUROLEPTIC AGENT; NICOTINIC AGENT; ONDANSETRON; PLACEBO; PREGNENOLONE; RISPERIDONE; RIVASTIGMINE; SEROTONIN 1A AGONIST; SEROTONIN 3 AGONIST; TANDOSPIRONE; TROPISETRON; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANOMELINE; ATYPICAL ANTIPSYCHOTIC AGENT; GLUTAMATE RECEPTOR AGONIST; MINOCYCLINE; PRASTERONE; SEROTONIN ANTAGONIST; VALACICLOVIR; PSYCHOTROPIC AGENT; RECEPTOR;

EID: 84901725044     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1092852913000771     Document Type: Review
Times cited : (18)

References (67)
  • 2
    • 7544244277 scopus 로고    scopus 로고
    • Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS
    • DOI 10.1016/j.schres.2004.09.009, PII S0920996404003445
    • Green MF, Kern RS, Heaton RK. Longitudinal studies of cognition and functional outcome in schizophrenia: Implications for MATRICS. Schizophr Res. 2004; 72(1): 41-51. (Pubitemid 39452904)
    • (2004) Schizophrenia Research , vol.72 , Issue.1 , pp. 41-51
    • Green, M.F.1    Kern, R.S.2    Heaton, R.K.3
  • 3
    • 0029918481 scopus 로고    scopus 로고
    • What are the functional consequences of neurocognitive deficits in schizophrenia?
    • Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996; 153(3): 321-330. (Pubitemid 26074706)
    • (1996) American Journal of Psychiatry , vol.153 , Issue.3 , pp. 321-330
    • Green, M.F.1
  • 4
    • 7544237332 scopus 로고    scopus 로고
    • Measurement and Treatment Research to Improve Cognition in Schizophrenia: NIMH MATRICS initiative to support the development of agents for improving cognition in schizophrenia
    • DOI 10.1016/j.schres.2004.09.010, PII S0920996404003457
    • Marder SR, Fenton W. Measurement and treatment research to improve cognition in schizophrenia: NIMH MATRICS initiative to support the development of agents for improving cognition in schizophrenia. Schizophr Res. 2004; 72(1): 5-9. (Pubitemid 39452900)
    • (2004) Schizophrenia Research , vol.72 , Issue.1 , pp. 5-9
    • Marder, S.R.1    Fenton, W.2
  • 5
    • 33748529631 scopus 로고    scopus 로고
    • The neurobiology of cognition in schizophrenia
    • Tamminga CA. The neurobiology of cognition in schizophrenia. J Clin Psychiatry. 2006; 67(9): 9-13. (Pubitemid 44369649)
    • (2006) Journal of Clinical Psychiatry , vol.67 , Issue.SUPPL. 9 , pp. 9-13
    • Tamminga, C.A.1
  • 6
    • 33646160988 scopus 로고    scopus 로고
    • The NIMH-MATRICS project for developing cognitionenhancing agents for schizophrenia
    • Marder SR. The NIMH-MATRICS project for developing cognitionenhancing agents for schizophrenia. Dialogues Clin Neurosci. 2006; 8(1): 109-113.
    • (2006) Dialogues Clin Neurosci. , vol.8 , Issue.1 , pp. 109-113
    • Marder, S.R.1
  • 7
    • 0028172230 scopus 로고
    • 1 receptor mechanisms in the cognitive performance of young adult and aged monkeys
    • DOI 10.1007/BF02245056
    • Arnsten AF, Cai JX, Murphy BL, Goldman-Rakia PS. Dopamine D1 receptor mechanism in the cognitive performance of young adult and aged monkeys. Psychopharmacology (Berl). 1994; 116(2): 143-151. (Pubitemid 24317040)
    • (1994) Psychopharmacology , vol.116 , Issue.2 , pp. 143-151
    • Arnsten, A.F.T.1    Cai, J.X.2    Murphy, B.L.3    Goldman-Rakic, P.S.4
  • 9
    • 21844469260 scopus 로고    scopus 로고
    • Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
    • DOI 10.1016/j.schres.2004.12.019, PII S092099640500006X
    • Barch DM, Carter CS. Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers. Schizophr Res. 2005; 77(1): 43-58. (Pubitemid 40957060)
    • (2005) Schizophrenia Research , vol.77 , Issue.1 , pp. 43-58
    • Barch, D.M.1    Carter, C.S.2
  • 11
    • 34548189417 scopus 로고    scopus 로고
    • 1A partial agonist, on cognitive function in schizophrenia: A randomized, double-blind, placebo-controlled study
    • DOI 10.1016/j.schres.2007.06.008, PII S0920996407002630
    • Sumiyoshi T, Park S, Jayathilake K, et al. Effect of buspirone, a serotonin1A agonist, on cognitive function in schizophrenia: A randomized, double-blind, placebo-controlled study. Schizophr Res. 2007; 95(1-3): 158-168. (Pubitemid 47313647)
    • (2007) Schizophrenia Research , vol.95 , Issue.1-3 , pp. 158-168
    • Sumiyoshi, T.1    Park, S.2    Jayathilake, K.3    Roy, A.4    Ertugrul, A.5    Meltzer, H.Y.6
  • 15
    • 58349098103 scopus 로고    scopus 로고
    • Added ondansetron for stable schizophrenia: A double blind, placebo controlled trial
    • Akhondzadeh S, Mohammadi N, Noroozian M, et al. Added ondansetron for stable schizophrenia: A double blind, placebo controlled trial. Schizophr Res. 2009; 107(2-3): 206-212.
    • (2009) Schizophr Res. , vol.107 , Issue.2-3 , pp. 206-212
    • Akhondzadeh, S.1    Mohammadi, N.2    Noroozian, M.3
  • 16
    • 84864881933 scopus 로고    scopus 로고
    • Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission
    • Morozova MA, Beniashvili AG, Lepilkina TA, Rupchev GE. Double-blind placebo-controlled randomized efficacy and safety trial of add-on treatment of dimebon plus risperidone in schizophrenic patients during transition from acute psychotic episode to remission. Psychiatr Danub. 2012; 24(2): 159-166.
    • (2012) Psychiatr Danub. , vol.24 , Issue.2 , pp. 159-166
    • Morozova, M.A.1    Beniashvili, A.G.2    Lepilkina, T.A.3    Rupchev, G.E.4
  • 17
    • 84906534688 scopus 로고    scopus 로고
    • Add-on effects of selective antagonist of 5-HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: Pilot study
    • Morozova MA, Lepilkina TA, Rupchev G, et al. Add-on effects of selective antagonist of 5-HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study. CNS Spectr. 2013; June 17 (Epub ahead of print).
    • (2013) CNS Spectr. ; June 17 (Epub Ahead of Print).
    • Morozova, M.A.1    Lepilkina, T.A.2    Rupchev, G.3
  • 18
    • 84901977343 scopus 로고    scopus 로고
    • Efficacy study exploring the effect of Lu AE58054 as augmentation therapy in patients with schizophrenia. ClinicalTrials.gov. Identifier: NCT00810667
    • Efficacy study exploring the effect of Lu AE58054 as augmentation therapy in patients with schizophrenia. ClinicalTrials.gov. Identifier: NCT00810667.
  • 19
    • 38149062692 scopus 로고    scopus 로고
    • The effects of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls
    • Barr RS, Culhave MA, Jubelt LE, et al. The effects of transdermal nicotine on cognition in nonsmokers with schizophrenia and nonpsychiatric controls. Neuropsychopharmacology. 2008; 33(3): 480-490.
    • (2008) Neuropsychopharmacology. , vol.33 , Issue.3 , pp. 480-490
    • Barr, R.S.1    Culhave, M.A.2    Jubelt, L.E.3
  • 20
    • 84865854361 scopus 로고    scopus 로고
    • Short-term tropisetron treatment and cognitive and p50 auditory gating deficits in schizophrenia
    • Zhang XY, Liu L, Hong X, et al. Short-term tropisetron treatment and cognitive and p50 auditory gating deficits in schizophrenia. Am J Psychiatry. 2012; 169(9): 974-981.
    • (2012) Am J Psychiatry. , vol.169 , Issue.9 , pp. 974-981
    • Zhang, X.Y.1    Liu, L.2    Hong, X.3
  • 22
    • 84901977344 scopus 로고    scopus 로고
    • Methodological issues affecting signal detection in a clinical trial for cognitive impairment in schizophrenia
    • 21-23 February,; Washington D.C
    • Hufford M, Gawryl M, Dgetluck N, et al. Methodological issues affecting signal detection in a clinical trial for cognitive impairment in schizophrenia. Poster Abstracts, ISCTM 8th Annual Scientific Meeting; 21-23 February, 2012; Washington D.C.
    • (2012) Poster Abstracts, ISCTM 8th Annual Scientific Meeting
    • Hufford, M.1    Gawryl, M.2    Dgetluck, N.3
  • 23
    • 77949466440 scopus 로고    scopus 로고
    • Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists
    • Radek RJ, Kohlhaas KL, Rueter LE, Mohler EG. Treating the cognitive deficits of schizophrenia with alpha4beta2 neuronal nicotinic receptor agonists. Curr Pharm Des. 2010; 16(3): 309-322.
    • (2010) Curr Pharm Des. , vol.16 , Issue.3 , pp. 309-322
    • Radek, R.J.1    Kohlhaas, K.L.2    Rueter, L.E.3    Mohler, E.G.4
  • 24
    • 84901977345 scopus 로고    scopus 로고
    • A phase 2 study to evaluate ABT-126 for the treatment of cognitive deficits in schizophrenia. ClinicalTrials.gov. Identifier: NCT01678755
    • A phase 2 study to evaluate ABT-126 for the treatment of cognitive deficits in schizophrenia. ClinicalTrials.gov. Identifier: NCT01678755.
  • 25
    • 84878590414 scopus 로고    scopus 로고
    • A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (tc-5619) for cognitive enhancement in schizophrenia
    • Lieberman JA, Dunbar G, Segreti AC, et al. A randomized exploratory trial of an alpha-7 nicotinic receptor agonist (tc-5619) for cognitive enhancement in schizophrenia. Neuropsychopharmacology. 2013; 38(6): 968-975.
    • (2013) Neuropsychopharmacology. , vol.38 , Issue.6 , pp. 968-975
    • Lieberman, J.A.1    Dunbar, G.2    Segreti, A.C.3
  • 26
    • 48949095543 scopus 로고    scopus 로고
    • Selective muscarinic receptor agonist xanomeline as a novel treatment approach to schizophrenia
    • Shekhar A, Potter WZ, Lightfoot J, et al. Selective muscarinic receptor agonist xanomeline as a novel treatment approach to schizophrenia. Am J Psychiatry. 2008; 165(8): 1033-1039.
    • (2008) Am J Psychiatry. , vol.165 , Issue.8 , pp. 1033-1039
    • Shekhar, A.1    Potter, W.Z.2    Lightfoot, J.3
  • 27
    • 84875694713 scopus 로고    scopus 로고
    • Muscarinic M1 receptor agonists: Can they improve cognitive performance
    • Scarr E. Muscarinic M1 receptor agonists: can they improve cognitive performance? Int J Neuropsychopharmacol. 2013; 16(4): 717-720.
    • (2013) J Neuropsychopharmacol. , vol.16 , Issue.4 , pp. 717-720
    • Scarr, E.1
  • 28
    • 34447546649 scopus 로고    scopus 로고
    • A 12-week, double-blind, placebocontrolled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia
    • Lee BJ, Lee JG, Kim YH. A 12-week, double-blind, placebocontrolled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia. J Psychopharmacol. 2007; 21(4): 421-427.
    • (2007) J Psychopharmacol. , vol.21 , Issue.4 , pp. 421-427
    • Lee, B.J.1    Lee, J.G.2    Kim, Y.H.3
  • 30
    • 34547882773 scopus 로고    scopus 로고
    • No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia
    • Kohler CG, Martin EA, Kujawski E, et al. No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia. Cognit Neuropsychiatry. 2007; 12(5): 412-442.
    • (2007) Cognit Neuropsychiatry. , vol.12 , Issue.5 , pp. 412-442
    • Kohler, C.G.1    Martin, E.A.2    Kujawski, E.3
  • 31
    • 33745378627 scopus 로고    scopus 로고
    • Cognitive effects of adjunctive 24-weeks Rivastigmine treatment to antipsychotics in schizophrenia: A randomized, placebo-controlled, double-blind investigation
    • DOI 10.1016/j.schres.2006.03.037, PII S092099640600096X
    • Sharma T, Reed C, Aasen I, Kumari V. Cognitive effects of adjunctive 24-weeks rivastigmine treatment to antipsychotics in schizophrenia: A randomized, placebo-controlled, double-blind investigation. Schizophr Res. 2006; 85(1-3): 73-83. (Pubitemid 43947524)
    • (2006) Schizophrenia Research , vol.85 , Issue.1-3 , pp. 73-83
    • Sharma, T.1    Reed, C.2    Aasen, I.3    Kumari, V.4
  • 33
    • 33748751285 scopus 로고    scopus 로고
    • Galantamine Improves Cognition in Schizophrenic Patients Stabilized on Risperidone
    • DOI 10.1016/j.biopsych.2006.04.006, PII S0006322306004689
    • Schubert MH, Young KA, Hicks PB. Galantamine improves cognition in schizophrenic patients stabilized on risperidone. Biol Psychiatry. 2006; 60(6): 530-533. (Pubitemid 44402376)
    • (2006) Biological Psychiatry , vol.60 , Issue.6 , pp. 530-533
    • Schubert, M.H.1    Young, K.A.2    Hicks, P.B.3
  • 34
    • 33846986313 scopus 로고    scopus 로고
    • A 12-week, double-blind, placebo-controlled trial of galantamine adjunctive treatment to conventional antipsychotics for the cognitive impairments in chronic schizophrenia
    • Lee SW, Lee JG, Lee BJ, Kim YH. A 12-week, double-blind, placebo-controlled trial of galantamine adjunctive treatment to conventional antipsychotics for the cognitive impairments in chronic schizophrenia. Int Clin Psychopharmacol. 2007; 22(2): 63-68.
    • (2007) Clin Psychopharmacol. , vol.22 , Issue.2 , pp. 63-68
    • Lee, S.W.1    Lee, J.G.2    Lee, B.J.3    Kim, Y.H.4
  • 37
    • 84866640784 scopus 로고    scopus 로고
    • Phencyclidine/schizophrenia: One view toward the past, the other to the future
    • Domino EF, Luby ED. Phencyclidine/schizophrenia: one view toward the past, the other to the future. Schizophr Bull. 2012; 38(5): 914-919.
    • (2012) Schizophr Bull. , vol.38 , Issue.5 , pp. 914-919
    • Domino, E.F.1    Luby, E.D.2
  • 38
    • 0023225289 scopus 로고
    • Non-competitive regulation of phencyclidine/σ-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid
    • DOI 10.1016/0304-3940(87)90632-X
    • Javitt DC, Jotkowitz A, Sircar R, Zukin SR. Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-Daspartate receptor antagonist D-(-)-2-Amino-5-phosphonovaleric acid. Neurosci Lett. 1987; 78(2): 193-198. (Pubitemid 17095698)
    • (1987) Neuroscience Letters , vol.78 , Issue.2 , pp. 193-198
    • Javitt, D.C.1    Jotkowitz, A.2    Sircar, R.3    Zukin, S.R.4
  • 40
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt DC, Zukin SR. Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991; 148(10): 1301-1308.
    • (1991) Am J Psychiatry. , vol.148 , Issue.10 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 41
    • 48749112603 scopus 로고    scopus 로고
    • N-Acetyl cysteine as a glutathione precursor for schizophrenia-A double-blind, randomized, placebo-controlled trial
    • Berk M, Copolov D, Dean O, et al. N-Acetyl cysteine as a glutathione precursor for schizophrenia-A double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 2008; 64(5): 361-368.
    • (2008) Biol Psychiatry. , vol.64 , Issue.5 , pp. 361-368
    • Berk, M.1    Copolov, D.2    Dean, O.3
  • 43
    • 56049099989 scopus 로고    scopus 로고
    • Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: An exploratory study
    • Goff DC, Cather C, Gottlieb JD, et al. Once-weekly D-cycloserine effects on negative symptoms and cognition in schizophrenia: an exploratory study. Schizophr Res. 2008; 106(2-3): 320-327.
    • (2008) Schizophr Res. , vol.106 , Issue.2-3 , pp. 320-327
    • Goff, D.C.1    Cather, C.2    Gottlieb, J.D.3
  • 44
    • 77954095737 scopus 로고    scopus 로고
    • LY2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia
    • Mezler M, Geneste H, Gault L, Marek GJ. LY2140023, a prodrug of the group II metabotropic glutamate receptor agonist LY-404039 for the potential treatment of schizophrenia. Curr Opin Investig Drugs. 2010; 11(7): 833-845.
    • (2010) Curr Opin Investig Drugs. , vol.11 , Issue.7 , pp. 833-845
    • Mezler, M.1    Geneste, H.2    Gault, L.3    Marek, G.J.4
  • 45
    • 0036305484 scopus 로고    scopus 로고
    • AMPA receptor trafficking and synaptic plasticity
    • DOI 10.1146/annurev.neuro.25.112701.142758
    • Malinow R, Malenka RC. AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci. 2002; 25: 103-126. (Pubitemid 34748013)
    • (2002) Annual Review of Neuroscience , vol.25 , pp. 103-126
    • Malinow, R.1    Malenka, R.C.2
  • 46
    • 0034094628 scopus 로고    scopus 로고
    • Glutamate receptor expression in schizophrenic brain
    • DOI 10.1016/S0165-0173(99)00044-2, PII S0165017399000442
    • Meador-Woodruff JH, Healy DJ. Glutamate receptor expression in schizophrenic brain. Brain Res Rev. 2000; 31(2-3): 288-294. (Pubitemid 30136183)
    • (2000) Brain Research Reviews , vol.31 , Issue.2-3 , pp. 288-294
    • Meador-Woodruff, J.H.1    Healy, D.J.2
  • 48
    • 38149132338 scopus 로고    scopus 로고
    • A placebo-controlled add-on trial of the ampakine, CX516, for cognitive deficits in schizophrenia
    • Goff DC, Lamberti S, Leon AC, et al. A placebo-controlled add-on trial of the ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008; 33(3): 465-472.
    • (2008) Neuropsychopharmacology. , vol.33 , Issue.3 , pp. 465-472
    • Goff, D.C.1    Lamberti, S.2    Leon, A.C.3
  • 49
    • 84901977346 scopus 로고    scopus 로고
    • A study of the effect of RO4917838 on biomarker measures of cognitive dysfunction in patients with schizophrenia. ClinicalTrials.gov. Identifier: NCT01116830
    • A study of the effect of RO4917838 on biomarker measures of cognitive dysfunction in patients with schizophrenia. ClinicalTrials.gov. Identifier: NCT01116830.
  • 50
    • 77955056793 scopus 로고    scopus 로고
    • High dose D-serine in the treatment of schizophrenia
    • Kantrowitz JT, Malhotra AK, Cornblatt B, et al. High dose D-serine in the treatment of schizophrenia. Schizophr Res. 2010; 121(1-3): 125-130.
    • (2010) Schizophr Res. , vol.121 , Issue.1-3 , pp. 125-130
    • Kantrowitz, J.T.1    Malhotra, A.K.2    Cornblatt, B.3
  • 52
    • 57349167353 scopus 로고    scopus 로고
    • Subunit-selective modulation of GABA type A neurotransmission and cognition in schizophrenia
    • Lewis DA, Cho RY, Carter CS, et al. Subunit-selective modulation of GABA type A neurotransmission and cognition in schizophrenia. Am J Psychiatry. 2008; 165(12): 1585-1593.
    • (2008) Am J Psychiatry. , vol.165 , Issue.12 , pp. 1585-1593
    • Lewis, D.A.1    Cho, R.Y.2    Carter, C.S.3
  • 53
    • 79951656529 scopus 로고    scopus 로고
    • A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia
    • Buchanan RW, Keefe RS, Lieberman JA, et al. A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia. Biol Psychiatry. 2011; 69(5): 442-449.
    • (2011) Biol Psychiatry. , vol.69 , Issue.5 , pp. 442-449
    • Buchanan, R.W.1    Keefe, R.S.2    Lieberman, J.A.3
  • 55
    • 34547218379 scopus 로고    scopus 로고
    • Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: A randomized, double-blind 52-week comparison
    • DOI 10.1176/appi.ajp.164.7.1061
    • Keefe RS, Sweeney JA, Hongbin G, et al. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: A randomized double-blind 52-week comparison. Am J Psychiatry. 2007; 164(7): 1061-1071. (Pubitemid 47121395)
    • (2007) American Journal of Psychiatry , vol.164 , Issue.7 , pp. 1061-1071
    • Keefe, R.S.E.1    Sweeney, J.A.2    Gu, H.3    Hamer, R.M.4    Perkins, D.O.5    McEvoy, J.P.6    Lieberman, J.A.7
  • 57
    • 33748745743 scopus 로고    scopus 로고
    • Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: A randomized, double-blind, placebo-controlled, crossover trial
    • DOI 10.1097/01.jcp.0000237942.50270.35, PII 0000471420061000000010
    • Ritsner MS, Gibel A, Ratner Y, Tsinovoy G, Strous RD. Improvement of sustained attention and visual and movement skills, but not clinical symptoms, after dehydroepiandrosterone augmentation in schizophrenia: A randomized, double-blind, placebo-controlled, crossover trial. J Clin Psychopharmacol. 2006; 26(5): 495-499. (Pubitemid 44401470)
    • (2006) Journal of Clinical Psychopharmacology , vol.26 , Issue.5 , pp. 495-499
    • Ritsner, M.S.1    Gibel, A.2    Ratner, Y.3    Tsinovoy, G.4    Strous, R.D.5
  • 58
    • 74549188501 scopus 로고    scopus 로고
    • Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: An 8-week, doubleblind, randomized, controlled, 2-center, parallel-group trial
    • Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, doubleblind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry. 2010; 71(10): 1351-1362.
    • (2010) J Clin Psychiatry. , vol.71 , Issue.10 , pp. 1351-1362
    • Ritsner, M.S.1    Gibel, A.2    Shleifer, T.3
  • 59
    • 77649112679 scopus 로고    scopus 로고
    • A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia
    • Levkovitz Y, Medlovich S, Riskes S, et al. A double-blind, randomized study of minocycline for the treatment of negative and cognitive symptoms in early-phase schizophrenia. J Clin Psychiatry. 2010; 71(2): 138-149.
    • (2010) J Clin Psychiatry. , vol.71 , Issue.2 , pp. 138-149
    • Levkovitz, Y.1    Medlovich, S.2    Riskes, S.3
  • 60
    • 78650943515 scopus 로고    scopus 로고
    • Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone: A randomized controlled trial
    • Cho SJ, Yook K, Kim B, et al. Mirtazapine augmentation enhances cognitive and reduces negative symptoms in schizophrenia patients treated with risperidone: A randomized controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(1): 208-211.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry. , vol.35 , Issue.1 , pp. 208-211
    • Cho, S.J.1    Yook, K.2    Kim, B.3
  • 61
    • 84866345787 scopus 로고    scopus 로고
    • Predictors and mediators of add-on mirtazapine-induced cognitive enhancement in schizophrenia-A path model investigation
    • Stenberg J-H, Terevnikov V, Joffe M, et al. Predictors and mediators of add-on mirtazapine-induced cognitive enhancement in schizophrenia-A path model investigation. Neuropharmacology. 2013; 64: 248-253.
    • (2013) Neuropharmacology. , vol.64 , pp. 248-253
    • Stenberg, J.-H.1    Terevnikov, V.2    Joffe, M.3
  • 62
    • 84866345771 scopus 로고    scopus 로고
    • Modafanil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain
    • Scoriels L, Jones PB, Sahakian BJ. Modafanil effects on cognition and emotion in schizophrenia and its neurochemical modulation in the brain. Neuropharmacology. 2013; 64: 168-184.
    • (2013) Neuropharmacology. , vol.64 , pp. 168-184
    • Scoriels, L.1    Jones, P.B.2    Sahakian, B.J.3
  • 63
    • 84879324491 scopus 로고    scopus 로고
    • Antiherpes virus-specific treatment and cognition in schizophrenia: A test-of-concept randomized double-blind placebo-controlled trial
    • Prasad KM, Eack SM, Keshavan JS, et al. Antiherpes virus-specific treatment and cognition in schizophrenia: A test-of-concept randomized double-blind placebo-controlled trial. Schizophr Bull. 2013; 39(4): 857-866.
    • (2013) Schizophr Bull. , vol.39 , Issue.4 , pp. 857-866
    • Prasad, K.M.1    Eack, S.M.2    Keshavan, J.S.3
  • 64
    • 79958274304 scopus 로고    scopus 로고
    • The treatment of cognitive impairment in schizophrenia
    • Goff DC, Hill M, Barch B. The treatment of cognitive impairment in schizophrenia. Pharmacol Biochem Behav. 2011; 99(2): 245-253.
    • (2011) Pharmacol Biochem Behav. , vol.99 , Issue.2 , pp. 245-253
    • Goff, D.C.1    Hill, M.2    Barch, B.3
  • 65
    • 84862308907 scopus 로고    scopus 로고
    • Cognitive deficits in schizophrenia: An updated metanalysis of the scientific evidence
    • Fioravanti M, Bianchi V, Cinti ME. Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence. BMC Psychiatry. 2012; 12: 64.
    • (2012) BMC Psychiatry. , vol.12 , pp. 64
    • Fioravanti, M.1    Bianchi, V.2    Cinti, M.E.3
  • 66
    • 84901977337 scopus 로고    scopus 로고
    • Integrating psychopharmacology and cognitive remediation to treat cognitive dysfunction in the psychotic disorders
    • In: de Oliveira IR, Schwartz T, Stahl SM, eds. New York, NY: Routledge Books; In press
    • Medalia A, Opler MG, Opler LA. Integrating psychopharmacology and cognitive remediation to treat cognitive dysfunction in the psychotic disorders. In: de Oliveira IR, Schwartz T, Stahl SM, eds. Integrating Psychotherapy and Psychopharmacology: A Handbook for Clinicians, New York, NY: Routledge Books; In press.
    • Integrating Psychotherapy and Psychopharmacology: A Handbook for Clinicians
    • Medalia, A.1    Opler, M.G.2    Opler, L.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.