Non-spatially lateralized mechanisms in hemispatial neglect

Nature Reviews Neuroscience

Volumn 4, Issue 1, 2003, Pages 26-36

  Husain, Masud ^a   Rorden, Chris ^b  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN CORTEX; HEMISPATIAL NEGLECT; NEGLECT; NEUROANATOMY; PRIORITY JOURNAL; REVIEW; SELECTIVE ATTENTION; STROKE; SUPERIOR TEMPORAL GYRUS; WORKING MEMORY; ANIMAL; BRAIN; BRAIN MAPPING; HEMISPHERIC DOMINANCE; HUMAN; METHODOLOGY; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; PERCEPTION DISORDER; PHYSIOLOGY; PSYCHOLOGICAL ASPECT; STATISTICS;

ANIMALS; BRAIN; BRAIN MAPPING; FUNCTIONAL LATERALITY; HUMANS; NEUROPSYCHOLOGICAL TESTS; PERCEPTUAL DISORDERS;

EID: 0037270771     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn1005     Document Type: Article

References (112)

1. Bisiach, E., Perani, D., Vallar, G. & Berti, A. Unilateral neglect: personal and extra-personal. Neuropsychologia 24, 759-767 (1986).
2. Bisiach, E., Vallar, G., Perani, D., Papagno, C. & Berti, A. Unawareness of disease following lesions of the right hemisphere: anosognosia for hemiplegia and anosognosia for hemianopia. Neuropsychologia 24, 471-482 (1986).
3. Stone, S. P. et al. The assessment of visuo-spatial neglect after acute stroke. J. Neurol. Neurosurg. Psychiatry 54, 345-350 (1991).
4. Vallar, G. Extrapersonal visual unilateral spatial neglect and its neuroanatomy. Neuroimage 14, S52-58 (2001).
5. Husain, M. & Kennard, C. Visual neglect associated with frontal lobe infarction. J. Neurol. 243, 652-657 (1996).
6. Husain, M., Shapiro, K., Martin, J. & Kennard, C. Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature 385, 154-156 (1997).
7. Karnath, H. O., Ferber, S. & Himmelbach, M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature 411, 950-953 (2001).
8. Perani, D., Vallar, G., Cappa, S., Messa, C. & Fazio, F. Aphasia and neglect after subcortical stroke. A clinical/cerebral perfusion correlation study. Brain 110, 1211-1229 (1987).
9. Karnath, H. O., Himmelbach, M. & Rorden, C. The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar. Brain 125, 350-360 (2002).
10. Hillis, A. E. et al. Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion. Brain 125, 1094-1104 (2002).
11. Gainotti, G., Messerli, P & Tissot, R. Qualitative analysis of unilateral spatial neglect in relation to laterality of cerebral lesions. J. Neurol. Neurosurg. Psychiatry 35, 545-550 (1972).
12. Stone, S. P., Patel, P., Greenwood, R. J. & Halligan, P W. Measuring visual neglect in acute stroke and predicting its recovery: the visual neglect recovery index. J. Neurol. Neurosurg. Psychiatry 55, 431-436 (1992).
13. Denes, G., Semenza, C., Stoppa, E. & Lis, A. Unilateral spatial neglect and recovery from hemiplegia: a follow-up study. Brain 105, 543-552 (1982).
14. Jehkonen, M. et al. Visual neglect as a predictor of functional outcome one year after stroke. Acta Neurol. Scand. 100, 195-201 (2000).
15. Cherney, L. R., Halper, A. S., Kwasnica, C. M., Harvey, R. L. & Zhang, M. Recovery of functional status after right hemisphere stroke: relationship with unilateral neglect. Arch. Phys. Med. Rehabil. 82, 322-328 (2001).
16. Mesulam, M. M. Spatial attention and neglect: parietal, frontal and cingulate contributions to the mental representation and attentional targeting of salient extrapersonal events. Phil. Trans. R. Soc. Lond. B 354, 1325-1346 (1999).
17. Heilman, K. M. & Watson, R. T. in Clinical Neuropsychology (eds Heilman, K. M. & Valenstein, E.) 243-293 (Oxford Univ. Press, New York, 2001).
18. Bisiach, E. & Vallar, G. in Handbook of Neuropsychology (ed. Rizzolatti, G.) 459-502 (Elsevier, Amsterdam, 2000).
19. Pouget, A. & Driver, J. Relating unilateral neglect to the neural coding of space. Curr. Opin. Neurobiol. 10, 242-249 (2000).
20. Halligan, P. W. & Marshall, J. C. Toward a principled explanation of unilateral neglect. Cogn. Neuropsychol. 11, 167-206 (1994).
21. Robertson, I. H. & Marshall, J. C. Unilateral Neglect: Clinical and Experimental Studies (Lawrence Erlbaum, Hove, 1993).
22. Rafal, R. D. Neglect. Curr. Opin. Neurobiol. 4, 231-236 (1994).
23. Milner, A. D. in Parietal Lobe Contributions to Orientation in 3D Space (eds Thier, P & Karnath, H.-O.) 3-22 (Springer, Berlin, 1997).
24. Bartolomeo, P. & Chokron, S. Orienting of attention in left unilateral neglect. Neurosci. Biobehav. Rev. 26, 217-234 (2002).
25. Calton, J., Dickinson, A. R. & Snyder, L. H. Non-spatial, motor-specific activation in posterior parietal cortex. Nature Neurosci. 5, 580-588 (2002).
26. Bisiach, E. Mental representation in unilateral neglect and related disorders: the twentieth Bartlett Memorial Lecture. Q. J. Exp. Psychol. A 46, 435-461 (1993).
27. Heilman, K. M., Bowers, D., Coslett, B., Whelan, H. & Watson, R. T. Directional hypokinesia: prolonged reaction times for leftward movements in patients with right hemisphere lesions and neglect. Neurology 35, 855-859 (1985).
28. Mattingley, J. B., Husain, M., Rorden, C., Kennard, C. & Driver, J. Motor role of human inferior parietal lobe revealed in unilateral neglect patients. Nature 392, 179-182
29. Husain, M., Mattingley, J. B., Rorden, C., Kennard, C. & Driver, J. Distinguishing sensory and motor biases in parietal and frontal neglect. Brain 123, 1643-1659 (2000).
30. Bisiach, E. & Luzzatti, C. Unilateral neglect of representational space. Cortex 14, 129-133 (1978).
31. Behrmann, M. & Tipper, S. P Attention accesses multiple reference frames: evidence from visual neglect. J. Exp. Psychol Hum. Percept. Perform. 25, 83-100 (1999).
32. Karnath, H. O., Schenkel, P. & Fischer, B. Trunk orientation as the determining factor of the ‘contralateral’ deficit in the neglect syndrome and as the physical anchor of the internal representation of body orientation in space. Brain 114, 1997-2014 (1991).
33. Driver, J., Baylis, G. C., Goodrich, S. J. & Rafal, R. D. Axis-based neglect of visual shapes. Neuropsychologia 32, 1353-1365 (1994).
34. Kinsbourne, M. in Unilateral Neglect: Clinical and Experimental Studies (eds Robertson, I. H. & Marshall, J. C.) 63-86 (Lawrence Erlbaum, Hove, 1993).
35. Smania, N. et al. The spatial distribution of visual attention in hemineglect and extinction patients. Brain 121, 1759-1770 (1998).
36. Posner, M. I., Walker, J. A., Friedrich, F. J. & Rafal, R. Effects of parietal injury on covert orienting of attention. J. Neurosci. 4, 1863-1874 (1984).
37. Duncan, J., Humphreys, G. & Ward, R. Competitive brain activity in visual attention. Curr. Opin. Neurobiol. 7, 255-261 (1997)
38. Friedrich, F. J., Egly, R., Rafal, R. D. & Beck, D. Spatial attention deficits in humans: a comparison of superior parietal and temporal-parietal junction lesions. Neuropsychology 12, 193-207 (1998).
39. Bisiach, E. et al. Dissociation of ophthalmokinetic and melokinetic attention in unilateral neglect. Cereb. Cortex 5, 439-447 (1995).
40. Mark, V. W., Kooistra, C. A. & Heilman, K. M. Hemispatial neglect affected by non-neglected stimuli. Neurology 38, 1207-1211 (1988).
41. Niemeier, M. & Karnath, H. O. Exploratory saccades show no direction-specific deficit in neglect. Neurology 54, 515-518 (2000).
42. Husain, M. et al. Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect. Brain 124, 941-952 (2001).
43. Eglin, M., Robertson, L. C. & Knight, R. T. Visual search performance in the neglect syndrome. J. Cogn. Neurosci. 1, 372-385 (1989).
44. Luria, A. R. Disorders of ‘simultaneous perception’ in a case of bilateral occipito-parietal brain injury. Brain 83, 437-449 (1959).
45. Humphreys, G. W., Romani, C., Olson, A., Riddoch, M. J. & Duncan, J. Non-spatial extinction following lesions of the parietal lobes in humans. Nature 372, 357-359 (1994).
46. Robertson, L. C., Lamb, M. R. & Knight, R. T. Effects of lesions of temporal-parietal junction on perceptual and attentional processing in humans. J. Neurosci. 8, 3757-3769 (1988).
47. Duncan, J., Ward, R. & Shapiro, K. Direct measurement of attentional dwell time in human vision. Nature 369, 313-315 (1994).
48. Raymond, J. E., Shapiro, K. L. & Arnell, K. M. Temporary suppression of visual processing in an RSVP task: an attentional blink? J. Exp. Psychol. Hum. Percept. Perform. 18, 849-860 (1992).
49. Shapiro, K., Hillstrom, A. & Husain, M. Control of visuotemporal attention by inferior parietal and superior temporal cortex. Curr. Biol. 12, 1320-1325 (2002).
50. Duncan, J. et al. Systematic analysis of deficits in visual attention. J. Exp. Psychol. Gen. 128, 450-478 (1999).
51. Battelli, L. et al. Unilateral right parietal damage leads to bilateral deficit for high-level motion. Neuron 32, 985-995 (2001).
52. Cusack, R., Carlyon, R. P. & Robertson, I. H. Neglect between but not within auditory objects. J. Cogn. Neurosci. 12, 1056-1065 (2000).
53. Coull, J. T. & Frith, C. D. Differential activation of right superior parietal cortex and intraparietal sulcus by spatial and nonspatial attention. Neuroimaqe 8, 176-187
54. Wojciulik, E. & Kanwisher, N. The generality of parietal involvement in visual attention. Neuron 23, 747-764 (1999).
55. Marois, R., Chun, M. M. & Gore, J. C. Neural correlates of the attentional blink. Neuron 28, 299-308 (2000).
56. Coull, J. T. & Nobre, A. C. Where and when to pay attention: the neural systems for directing attention to spatial locations and to time intervals as revealed by both PET and fMRI. J. Neurosci. 18, 7426-7435 (1998).
57. Sarter, M., Givens, B. & Bruno, J. P. The cognitive neuroscience of sustained attention: where top-down meets bottom-up. Brain Res. Rev. 35, 146-160 (2001).
58. Parasuraman, R., Warm, J. S. & See, J. E. in The Attentive Brain (ed. Parasuraman, R.) 221-256 (MIT Press, Cambridge, Massachusetts, 1998).
59. Samuelsson, H., Hjelmquist, E., Jensen, C., Ekholm, S. & Blomstrand, C. Nonlateralized attentional deficits: an important component behind persisting visuospatial neglect? J. Clin. Exp. Neuropsychol. 20, 73-88 (1998).
60. Wilkins, A. J., Shallice, T. & McCarthy, R. Frontal lesions and sustained attention. Neuropsychologia 25, 359-365 (1987).
61. Rueckart, L. & Grafman, J. Sustained attention deficits in patients with right frontal lesions. Neuropsychologia 34, 953-963 (1996).
62. Rueckart, L. & Grafman, J. Sustained attention deficits in patients with lesions of posterior cortex. Neuropsychologia 36, 653-660 (1998).
63. Robertson, I. H. et al. Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia 35, 1527-1532 (1997).
64. Hjaltason, H., Tegner, R., Tham, K., Levander, M. & Ericson, K. Sustained attention and awareness of disability in chronic neglect. Neuropsychologia 34, 1229-1233 (1996).
65. Maguire, A. M. & Ogden, J. A. MRI brain scan analyses and neuropsychological profiles of nine patients with persistent unilateral neglect. Neuropsychologia 40, 879-887 (2002).
66. Pardo, J. V., Fox, P. T. & Raichle, M. E. Localization of a human system for sustained attention by positron emission tomography. Nature 349, 61-64 (1991).
67. Hager, F. et al. Challenging the anterior attentional system with a continuous performance task: a functional magnetic resonance imaging approach. Eur. Arch. Psychiatry Clin. Neurosci. 248, 161 -170 (1998).
68. Sturm, W. et al. Functional anatomy of intrinsic alertness: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia 37, 797-805 (1999).
69. Johannsen, P. et al. Cortical sites of sustained and divided attention in normal elderly humans. Neuroimage6, 145-155 (1997).
70. Vandenberghe, R., Gitelman, D. R., Parrish, T. B. & Mesulam, M. M. Functional specificity of superior parietal mediation of spatial shifting. Neuroimage 14, 661-673 (2001).
71. Adler, C. M. et al. Changes in neuronal activation with increasing attention demand in healthy volunteers: an fMRI study. Synapse 42, 266-272 (2001).
72. Gottlieb, J. P, Kusunoki, M. & Goldberg, M. E. The representation of visual salience in monkey parietal cortex. Nature 391, 481-484 (1998).
73. Constantinidis, C. & Steinmetz, M. A. Neuronal responses in area 7a to multiple-stimulus displays: I. neurons encode the location of the salient stimulus. Cereb. Cortex 11, 581-591 (2001).
74. Knight, R. T., Scabini, D., Woods, D. L. & Clayworth, C. C. Contributions of temporal-parietal junction to the human auditory P3. Brain Res. 502, 109-116 (1989).
75. Barcelo, F., Suwazono, S. & Knight, R. T. Prefrontal modulation of visual processing in humans. Nature Neurosci. 3, 399-403 (2000).
76. Downar, J., Crawley, A. P, Mikulis, D. J. & Davis, K. D. A cortical network sensitive to stimulus salience in a neutral behavioral context across multiple sensory modalities. J. Neurophysiol. 87, 615-620 (2002).
77. Downar, J., Crawley, A. P, Mikulis, D. J. & Davis, K. D. The effect of task relevance on the cortical response to changes in visual and auditory stimuli: an event-related fMRI study. Neuroimage 14, 1256-1267 (2001).
78. Clark, V. P, Fannon, S., Lai, S., Benson, R. & Bauer, L. Responses to rare visual target and distractor stimuli using event-related fMRI. J. Neurophysiol. 83, 3133-3139 (2000).
79. Marois, R., Leung, H. C. & Gore, J. C. A stimulus-driven approach to object identity and location processing in the human brain. Neuron 25, 717-728 (2000).
80. Braver, T. S., Barch, D. M., Gray, J. R., Molfese, D. L. & Snyder, A. Anterior cingulate cortex and response conflict: effects of frequency, inhibition and errors. Cereb. Cortex 11, 825-836 (2001).
81. Linden, D. E. et ai. The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. Cereb. Cortex 9, 815-823 (1999).
82. Behrmann, M., Watt, S., Black, S. E. & Barton, J. J. Impaired visual search in patients with unilateral neglect: an oculographic analysis. Neuropsychologia 35, 1445-1458 (1997).
83. Wojciulik, E., Husain, M., Clarke, K. & Driver, J. Spatial working memory deficit in unilateral neglect. Neuropsychologia 39, 390-396 (2001).
84. Driver, J. & Husain, M. in The Cognitive and Neural Bases of Spatial Neglect (eds Karnath, H.-O., Milner, A. D. & Vallar, G.) 351-362 (Oxford Univ. Press, Oxford, 2002).
85. Husain, M. et al. Impaired spatial working memory contributes to unilateral neglect. J. Neurol. Neurosurg. Psychiatry 73, 221 (2002).
86. Husain, M. et al. Trans-saccadic spatial working memory deficit in neglect patients. Soc. Neurosci. Meeting 16.7 (2002).
87. Heide, W. et al. Activation of frontoparietal cortices during memorized triple-step sequences of saccadic eye movements: an fMRI study. Eur. J. Neurosci. 13, 1177-1189 (2001).
88. Tobler, P. N. et al. Functional organisation of the saccadic reference system processing extraretinal signals in humans. Vision Res. 41, 1351-1358 (2001).
89. Duhamel, J. R., Goldberg, M. E., Fitzgibbon, E. J., Sirigu, A. & Grafman, J. Saccadic dysmetria in a patient with a right frontoparietal lesion. The importance of corollary discharge for accurate spatial behaviour. Brain 115, 1387-1402 (1992).
90. Heide, W., Blankenburg, M., Zimmermann, E. & Kompf, D. Cortical control of double-step saccades: implications for spatial orientation. Ann. Neurol. 38, 739-748 (1995).
91. Corbetta, M., Miezin, F. M., Shulman, G. L. & Petersen, S. E. A PET study of visuospatial attention. J. Neurosci. 13, 1202-1226 (1993).
92. Corbetta, M. & Shulman, G. L. Control of goal-directed and stimulus-driven attention in the brain. Nature Rev. Neurosci. 3, 215-229 (2002).
93. di Pellegrino, G., Basso, G. & Frassinetti, F. Visual extinction as a spatio-temporal disorder of selective attention. Neuroreport 9, 835-839 (1998).
94. Husain, M. in The Limits of Attention (ed. Shapiro, K.) 229-246 (Oxford Univ. Press, Oxford, 2001).
95. Cassidy, T P, Lewis, S. & Gray, C. S. Recovery from visuospatial neglect in stroke patients. J. Neurol. Neurosurg. Psychiatry 64, 555-557 (1998).
96. Robertson, I. H., Mattingley, J. B., Rorden, C. & Driver, J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature 395, 169-172 (1998).
97. Weinberg, J. et al. Visual scanning training effect on reading- related tasks in acquired right brain damage. Arch. Phys. Med. Rehabil. 58, 479-486 (1977).
98. Rossetti, Y. et al. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature 395, 166-169 (1998).
99. Frassinetti, F., Angeli, V., Meneghello, F., Avanzi, S. & Ladavas, E. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain 125, 608-623 (2002).
100. Robertson, I. H., Tegner, R., Tham, K., Lo, A. & Nimmo- Smith, I. Sustained attention training for unilateral neglect: theoretical and rehabilitation implications. J. Ciin. Exp. Neuropsychoi. 17, 416-430 (1995).
101. Robbins, T. W. Arousal systems and attentional processes. Biol. Psychol. 45, 57-71 (1997).
102. Andersen, R. A. Multimodal integration for the representation of space in the posterior parietal cortex. Phil. Trans. R. Soc. Lond. B352, 1421-1428 (1997).
103. Williams, S. & Goldman-Rakic, P. S. Modulation of memory fields by dopamine D1 receptors in prefrontal cortex. Nature 376, 572-575 (1995).
104. Grujic, Z. et al. Dopamine agonists reorient visual exploration away from the neglected hemispace. Neurology 51, 1395-1398 (1998).
105. Fleet, W. S., Valenstein, E., Watson, R. T. & Heilman, K. M. Dopamine agonist therapy for neglect in humans. Neurology 1765-1771 (1987).
106. Marshall, J. C., Fink, G. R., Halligan, P W. & Vallar, G. Spatial awareness: a function of the posterior parietal lobe? Cortex 253-257; discussion 258-260 (2002).
107. Bisiach, E., Geminiani, G., Berti, A. & Rusconi, M. L. Perceptual and premotor factors of unilateral neglect. Neurology 40, 1278-1281 (1990).
108. Milner, A. D. in Neurophysioiogicai and Neuropsychological Aspects of Spatial Neglect (ed. Jeannerod, M.) 259-288 (Elsevier, Amsterdam, 1987).
109. Marshall, J. W. et al. Clomethiazole protects against hemineglect in a primate model of stroke. Brain Res. Bull. 52, 21-29 (2000).
110. Husain, M. & Jackson, S. R. Vision: visual space is not what it appears to be. Curr. Biol. 11, R753-755 (2001).
111. Duhamel, J. R., Colby, C. & Goldberg, M. E. The updating of the representation of visual space in parietal cortex by intended eye movements. Science 255, 90-92 (1992).
112. Colby, C. & Goldberg, M. E. Space and attention in parietal cortex. Annu. Rev. Neurosci. 22, 319-349 (1999).