Aberrant Autolysosomal Regulation Is Linked to The Induction of Embryonic Senescence: Differential Roles of Beclin 1 and p53 in Vertebrate Spns1 Deficiency

PLoS Genetics

Volumn 10, Issue 6, 2014, Pages

  Sasaki, Tomoyuki ^a   Lian, Shanshan ^a   Qi, Jie ^a,g   Bayliss, Peter E ^b   Carr, Christopher E ^c   Johnson, Jennifer L ^d   Guha, Sujay ^a   Kobler, Patrick ^e   Catz, Sergio D ^d   Gill, Matthew ^a   Jia, Kailiang ^e   Klionsky, Daniel J ^f   Kishi, Shuji ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b University Health Network   (Canada)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e FLORIDA ATLANTIC UNIVERSITY   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^g OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; BETA GALACTOSIDASE; HISTONE H3; MICROTUBULE ASSOCIATED PROTEIN 1; PROTEIN P53; SENESCENCE ASSOCIATED BETA GALACTOSIDASE; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BAFILOMYCIN A1; BECLIN 1 PROTEIN, ZEBRAFISH; ENHANCED GREEN FLUORESCENT PROTEIN; ENZYME INHIBITOR; GREEN FLUORESCENT PROTEIN; MACROLIDE; MEMBRANE PROTEIN; P53 PROTEIN, ZEBRAFISH; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SPINSTER-LIKE PROTEIN, ZEBRAFISH; ZEBRAFISH PROTEIN;

ACIDIFICATION; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; BIOGENESIS; CELL MIGRATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC SENESCENCE; GENE; GENE FUNCTION; GENE MUTATION; GENE REPRESSION; GENE SILENCING; GENETIC REGULATION; IMMUNOBLOTTING; NONHUMAN; PHENOTYPE; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN INDUCTION; SENESCENCE; SPNS1 GENE; TUMOR SUPPRESSOR GENE; VERTEBRATE; ZEBRA FISH; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; DNA DAMAGE; DNA REPAIR; GENETICS; LYSOSOME; METABOLISM; MITOCHONDRION;

AGING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; DNA DAMAGE; DNA REPAIR; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; LYSOSOMES; MACROLIDES; MEMBRANE PROTEINS; MITOCHONDRIA; TUMOR SUPPRESSOR PROTEIN P53; VACUOLAR PROTON-TRANSLOCATING ATPASES; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84903450121     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1004409     Document Type: Article

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