Discovery of novel GPVI receptor antagonists by structure-based repurposing

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Taylor, Lewis ^a   Vasudevan, Sridhar R ^a   Jones, Chris I ^b   Gibbins, Jonathan M ^b   Churchill, Grant C ^a   Campbell, R Duncan ^a   Coxon, Carmen H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CINANSERIN; COLLAGEN; GLYCOPROTEIN VI; LOSARTAN; CARDIOTONIC AGENT; FIBRINOGEN RECEPTOR; MOLECULAR LIBRARY; PLATELET MEMBRANE GLYCOPROTEIN VI; PROTEIN BINDING;

ARTICLE; BINDING SITE; BLOOD CLOTTING; CALCIUM TRANSPORT; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG REPOSITIONING; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY;

AMINO ACID SEQUENCE; CARDIOTONIC AGENTS; CINANSERIN; HUMANS; LOSARTAN; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; PLATELET ACTIVATION; PLATELET MEMBRANE GLYCOPROTEINS; PROTEIN BINDING; SMALL MOLECULE LIBRARIES;

EID: 84903398922     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101209     Document Type: Article

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