메뉴 건너뛰기




Volumn 75, Issue 1, 2009, Pages 1-18

The genetics of antiplatelet drug resistance

Author keywords

Aspirin; Clopidogrel; Genetical polymorphism; Resistance; Variability

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLIZING ENZYME; FIBRINOGEN RECEPTOR; GLUCURONOSYLTRANSFERASE; GLYCOPROTEIN IB ALPHA; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; THROMBOXANE A2; VERY LATE ACTIVATION ANTIGEN 2;

EID: 58149189837     PISSN: 00099163     EISSN: 13990004     Source Type: Journal    
DOI: 10.1111/j.1399-0004.2008.01105.x     Document Type: Review
Times cited : (76)

References (85)
  • 1
    • 0030748125 scopus 로고    scopus 로고
    • Mechanisms initiating platelet thrombus formation
    • Ruggeri ZM. Mechanisms initiating platelet thrombus formation. Thromb Haemost 1997: 78: 611-616.
    • (1997) Thromb Haemost , vol.78 , pp. 611-616
    • Ruggeri, Z.M.1
  • 2
    • 0036851876 scopus 로고    scopus 로고
    • Platelets in atherothrombosis
    • Ruggeri ZM. Platelets in atherothrombosis. Nat Med 2002: 8: 1227-1234.
    • (2002) Nat Med , vol.8 , pp. 1227-1234
    • Ruggeri, Z.M.1
  • 3
    • 33749510291 scopus 로고    scopus 로고
    • Pharmacology of thienopyridines: Rationale for dual pathway inhibition
    • Ibanez B, Vilahur G, Badimon JJ. Pharmacology of thienopyridines: rationale for dual pathway inhibition. Eur Heart J Suppl 2006: 8: G3-G9.
    • (2006) Eur Heart J Suppl , vol.8
    • Ibanez, B.1    Vilahur, G.2    Badimon, J.J.3
  • 4
    • 0038494921 scopus 로고    scopus 로고
    • Platelet-collagen interaction: Is GPVI the central receptor?
    • Nieswandt B, Watson SP. Platelet-collagen interaction: Is GPVI the central receptor? Blood 2003: 102: 449-461.
    • (2003) Blood , vol.102 , pp. 449-461
    • Nieswandt, B.1    Watson, S.P.2
  • 5
    • 1142273373 scopus 로고    scopus 로고
    • Role of platelets in coronary thrombosis and reperfusion of ischaemic myocardium
    • Gawaz M. Role of platelets in coronary thrombosis and reperfusion of ischaemic myocardium. Cardiovasc Res 2004: 61: 498-511.
    • (2004) Cardiovasc Res , vol.61 , pp. 498-511
    • Gawaz, M.1
  • 8
    • 18644372477 scopus 로고    scopus 로고
    • Structure and stereochemistry of the active metabolite of clopidogrel
    • Pereillo JM, Maftouh M, Andrieu A et al. Structure and stereochemistry of the active metabolite of clopidogrel. Drug Metab Dispos 2002: 30: 1288-1295.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1288-1295
    • Pereillo, J.M.1    Maftouh, M.2    Andrieu, A.3
  • 9
    • 0037588974 scopus 로고    scopus 로고
    • Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270
    • Ding Z, Kim S, Dorsam RT, Jin J, Kunapuli SP. Inactivation of the human P2Y12 receptor by thiol reagents requires interaction with both extracellular cysteine residues, Cys17 and Cys270. Blood 2003: 101: 3908-3914.
    • (2003) Blood , vol.101 , pp. 3908-3914
    • Ding, Z.1    Kim, S.2    Dorsam, R.T.3    Jin, J.4    Kunapuli, S.P.5
  • 10
    • 38949119325 scopus 로고    scopus 로고
    • Aspirin "resistance" and risk of cardiovascular morbidity: Systematic review and meta-analysis
    • Krasopoulos G, Brister SJ, Beattie WS, Buchanan MR Aspirin "resistance" and risk of cardiovascular morbidity: Systematic review and meta-analysis. BMJ 2008: 336: 195-198.
    • (2008) BMJ , vol.336 , pp. 195-198
    • Krasopoulos, G.1    Brister, S.J.2    Beattie, W.S.3    Buchanan, M.R.4
  • 11
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • Snoep JD, Hovens MM, Eikenboom JC, van der Bom JG, Jukema JW, Huisman MV. Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis. Am Heart J 2007: 154(2): 221-231.
    • (2007) Am Heart J , vol.154 , Issue.2 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.2    Eikenboom, J.C.3    van der Bom, J.G.4    Jukema, J.W.5    Huisman, M.V.6
  • 12
    • 33644886913 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance: An emerging clinical entity
    • Wang TH, Bhatt DL, Topol EJ. Aspirin and clopidogrel resistance: An emerging clinical entity. Eur Heart J 2006: 27: 647-654.
    • (2006) Eur Heart J , vol.27 , pp. 647-654
    • Wang, T.H.1    Bhatt, D.L.2    Topol, E.J.3
  • 13
    • 8344231455 scopus 로고    scopus 로고
    • Aspirin and clopidogrel. Efficacy, safety, and the issue of drug resistance
    • Cattaneo M. Aspirin and clopidogrel. Efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol 2004: 24: 1980-1987.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1980-1987
    • Cattaneo, M.1
  • 14
    • 34247521816 scopus 로고    scopus 로고
    • Variable platelet response to aspirin and clopidogrel in atherothrombotic disease
    • Maree AO, Fitzgerald DJ. Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation 2007: 115: 2196-2207.
    • (2007) Circulation , vol.115 , pp. 2196-2207
    • Maree, A.O.1    Fitzgerald, D.J.2
  • 15
    • 36949037990 scopus 로고    scopus 로고
    • Alternative splicing of platelet cyclooxygenase-2 mRNA in patients after coronary artery bypass grafting
    • Censarek P, Steger G, Paolini C et al. Alternative splicing of platelet cyclooxygenase-2 mRNA in patients after coronary artery bypass grafting. Thromb Haemost 2007: 98: 1309-1315.
    • (2007) Thromb Haemost , vol.98 , pp. 1309-1315
    • Censarek, P.1    Steger, G.2    Paolini, C.3
  • 16
    • 18044394007 scopus 로고    scopus 로고
    • Genetic factors underlying differential blood platelet sensitivity to inhibitors
    • Rozalski M, Boncler M, Luzak B, Watala C. Genetic factors underlying differential blood platelet sensitivity to inhibitors. Pharmacol Rep 2005: 57: 1-13.
    • (2005) Pharmacol Rep , vol.57 , pp. 1-13
    • Rozalski, M.1    Boncler, M.2    Luzak, B.3    Watala, C.4
  • 17
    • 1642309585 scopus 로고    scopus 로고
    • Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke
    • Hillarp A, Palmquist B, Lethagen S, Villoutreix BO, Mattiasson I. Mutations within the cyclooxygenase-1 gene in aspirin non-responders with recurrence of stroke. Thromb Res 2003: 112: 275-283.
    • (2003) Thromb Res , vol.112 , pp. 275-283
    • Hillarp, A.1    Palmquist, B.2    Lethagen, S.3    Villoutreix, B.O.4    Mattiasson, I.5
  • 18
    • 0037256309 scopus 로고    scopus 로고
    • Genetic variation in cyclooxygenase 1: Effects on response to aspirin
    • Halushka MK, Walker LP, Halushka PV. Genetic variation in cyclooxygenase 1: Effects on response to aspirin. Clin Pharmacol Ther 2003: 73: 122-130.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 122-130
    • Halushka, M.K.1    Walker, L.P.2    Halushka, P.V.3
  • 19
    • 28444484957 scopus 로고    scopus 로고
    • Cyclooxygenase-1 haplotype modulates platelet response to aspirin
    • Maree AO, Curtin RJ, Chubb A. Cyclooxygenase-1 haplotype modulates platelet response to aspirin. J Thromb Haemost 2005: 3: 2340-2345.
    • (2005) J Thromb Haemost , vol.3 , pp. 2340-2345
    • Maree, A.O.1    Curtin, R.J.2    Chubb, A.3
  • 20
    • 33645546989 scopus 로고    scopus 로고
    • Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients
    • Lepäntalo A, Mikkelsson J, Reséndiz JC et al. Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thromb Haemost 2006: 95: 253-259.
    • (2006) Thromb Haemost , vol.95 , pp. 253-259
    • Lepäntalo, A.1    Mikkelsson, J.2    Reséndiz, J.C.3
  • 21
    • 33646940781 scopus 로고    scopus 로고
    • Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism
    • Kranzhofer R, Ruef J. Aspirin resistance in coronary artery disease is correlated to elevated markers for oxidative stress but not to the expression of cyclooxygenase (COX) 1/2, a novel COX-1 polymorphism or the PlA(1/2) polymorphism. Platelets 2006: 17: 163-169.
    • (2006) Platelets , vol.17 , pp. 163-169
    • Kranzhofer, R.1    Ruef, J.2
  • 22
    • 34250625249 scopus 로고    scopus 로고
    • Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin
    • Li Q, Chen BL, Ozdemir V et al. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. Pharmacogenomics 2007: 8: 577-586.
    • (2007) Pharmacogenomics , vol.8 , pp. 577-586
    • Li, Q.1    Chen, B.L.2    Ozdemir, V.3
  • 23
    • 12844269195 scopus 로고    scopus 로고
    • Biological assessment of aspirin efficacy on healthy individuals: Heterogeneous response or aspirin failure?
    • Gonzalez-Conejero R, Rivera J, Corral J, Acuña C, Guerrero JA, Vicente V. Biological assessment of aspirin efficacy on healthy individuals: Heterogeneous response or aspirin failure? Stroke 2005: 36: 276-280.
    • (2005) Stroke , vol.36 , pp. 276-280
    • Gonzalez-Conejero, R.1    Rivera, J.2    Corral, J.3    Acuña, C.4    Guerrero, J.A.5    Vicente, V.6
  • 24
    • 38649098154 scopus 로고    scopus 로고
    • Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms
    • Takahashi S, Ushida M, Komine R et al. Platelet responsiveness to in vitro aspirin is independent of COX-1 and COX-2 protein levels and polymorphisms. Thromb Res 2008: 121: 509-517.
    • (2008) Thromb Res , vol.121 , pp. 509-517
    • Takahashi, S.1    Ushida, M.2    Komine, R.3
  • 25
    • 37549011400 scopus 로고    scopus 로고
    • Cyclooxygenase polymorphisms and risk of cardiovascular events: The Atherosclerosis Risk in Communities (ARIC) study
    • Lee CR, North KE, Bray MS, Couper DJ, Heiss G, Zeldin DC. Cyclooxygenase polymorphisms and risk of cardiovascular events: The Atherosclerosis Risk in Communities (ARIC) study. Clin Pharmacol Ther 2008: 83: 52-60.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 52-60
    • Lee, C.R.1    North, K.E.2    Bray, M.S.3    Couper, D.J.4    Heiss, G.5    Zeldin, D.C.6
  • 27
    • 18444377050 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets
    • Rocca B, Secchiero P, Ciabattoni G et al. Cyclooxygenase-2 expression is induced during human megakaryopoiesis and characterizes newly formed platelets. Proc Natl Acad Sci U S A 2002: 99: 7634-7639.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7634-7639
    • Rocca, B.1    Secchiero, P.2    Ciabattoni, G.3
  • 28
    • 0041572921 scopus 로고    scopus 로고
    • Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery
    • Zimmermann N, Wenk A, Kim U et al. Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery. Circulation 2003: 108: 542-547.
    • (2003) Circulation , vol.108 , pp. 542-547
    • Zimmermann, N.1    Wenk, A.2    Kim, U.3
  • 29
    • 9144224879 scopus 로고    scopus 로고
    • Cyclooxygenase COX-2a, a novel COX-2 mRNA variant, in platelets from patients after coronary artery bypass grafting
    • Censarek P, Freidel K, Udelhoven M et al. Cyclooxygenase COX-2a, a novel COX-2 mRNA variant, in platelets from patients after coronary artery bypass grafting. Thromb Haemost 2004: 92: 925-9288.
    • (2004) Thromb Haemost , vol.92 , pp. 925-9288
    • Censarek, P.1    Freidel, K.2    Udelhoven, M.3
  • 30
    • 0036252408 scopus 로고    scopus 로고
    • Flow cytometry analysis of platelet cyclooxygenase-2 expression: Induction of platelet cyclooxygenase-2 in patients undergoing coronary artery bypass grafting
    • Weber AA, Przytulski B, Schumacher M et al. Flow cytometry analysis of platelet cyclooxygenase-2 expression: Induction of platelet cyclooxygenase-2 in patients undergoing coronary artery bypass grafting. Br J Haematol 2002: 117: 424-426.
    • (2002) Br J Haematol , vol.117 , pp. 424-426
    • Weber, A.A.1    Przytulski, B.2    Schumacher, M.3
  • 31
    • 34247574729 scopus 로고    scopus 로고
    • Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin
    • Guthikonda S, Lev EI, Patel R et al. Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirin. J Thromb Haemost 2007: 5: 490-496.
    • (2007) J Thromb Haemost , vol.5 , pp. 490-496
    • Guthikonda, S.1    Lev, E.I.2    Patel, R.3
  • 32
    • 0034702914 scopus 로고    scopus 로고
    • Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis
    • Belton O, Byrne D, Kearney D, Leahy A, Fitzgerald DJ. Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis. Circulation 2000: 102: 840-845.
    • (2000) Circulation , vol.102 , pp. 840-845
    • Belton, O.1    Byrne, D.2    Kearney, D.3    Leahy, A.4    Fitzgerald, D.J.5
  • 33
    • 33747088257 scopus 로고    scopus 로고
    • Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: A 700-patient study of aspirin resistance
    • Frelinger AL 3rd, Furman MI, Linden MD et al. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: A 700-patient study of aspirin resistance. Circulation 2006: 113: 2888-2896.
    • (2006) Circulation , vol.113 , pp. 2888-2896
    • Frelinger III, A.L.1    Furman, M.I.2    Linden, M.D.3
  • 34
    • 0026098059 scopus 로고
    • Developing relationships: Arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins
    • Roth GJ. Developing relationships: Arterial platelet adhesion, glycoprotein Ib, and leucine-rich glycoproteins. Blood 1991: 77: 5-19.
    • (1991) Blood , vol.77 , pp. 5-19
    • Roth, G.J.1
  • 35
    • 0033980198 scopus 로고    scopus 로고
    • Association between platelet glycoprotein Ibalpha genotype and ischemic cerebrovascular disease
    • Sonoda A, Murata M, Ito D et al. Association between platelet glycoprotein Ibalpha genotype and ischemic cerebrovascular disease. Stroke 2000: 31: 493-497.
    • (2000) Stroke , vol.31 , pp. 493-497
    • Sonoda, A.1    Murata, M.2    Ito, D.3
  • 36
    • 0032079569 scopus 로고    scopus 로고
    • Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans
    • Sperr WR, Huber K, Roden M et al. Inherited platelet glycoprotein polymorphisms and a risk for coronary heart disease in young central Europeans. Thromb Res 1998: 90: 117-123.
    • (1998) Thromb Res , vol.90 , pp. 117-123
    • Sperr, W.R.1    Huber, K.2    Roden, M.3
  • 37
    • 1642459358 scopus 로고    scopus 로고
    • The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease
    • Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu KK, Lopez JA. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease. Blood 2004: 103: 963-965.
    • (2004) Blood , vol.103 , pp. 963-965
    • Afshar-Kharghan, V.1    Matijevic-Aleksic, N.2    Ahn, C.3    Boerwinkle, E.4    Wu, K.K.5    Lopez, J.A.6
  • 38
    • 0034654358 scopus 로고    scopus 로고
    • Kozak sequence polymorphism in the platelet GPIbalpha gene is not associated with risk of myocardial infarction
    • Croft SA, Hampton KK, Daly ME, Steeds RP, Channer KS, Samani NJ. Kozak sequence polymorphism in the platelet GPIbalpha gene is not associated with risk of myocardial infarction. Blood 2000: 95: 2183-2184.
    • (2000) Blood , vol.95 , pp. 2183-2184
    • Croft, S.A.1    Hampton, K.K.2    Daly, M.E.3    Steeds, R.P.4    Channer, K.S.5    Samani, N.J.6
  • 39
    • 0031878376 scopus 로고    scopus 로고
    • Platelet GP IIIa PlA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke
    • Carter AM, Catto AJ, Bamford JM, Grant PJ. Platelet GP IIIa PlA and GP Ib variable number tandem repeat polymorphisms and markers of platelet activation in acute stroke. Arterioscler Thromb Vasc Biol 1998: 18: 1124-1131.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1124-1131
    • Carter, A.M.1    Catto, A.J.2    Bamford, J.M.3    Grant, P.J.4
  • 40
    • 0035928604 scopus 로고    scopus 로고
    • Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death
    • Mikkelsson J, Perola M, Penttila A, Karhunen PJ. Platelet glycoprotein Ibalpha HPA-2 Met/VNTR B haplotype as a genetic predictor of myocardial infarction and sudden cardiac death. Circulation 2001: 104: 876-880.
    • (2001) Circulation , vol.104 , pp. 876-880
    • Mikkelsson, J.1    Perola, M.2    Penttila, A.3    Karhunen, P.J.4
  • 41
    • 34848889330 scopus 로고    scopus 로고
    • Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity
    • Fujiwara T, Ikeda M, Esumi K et al. Exploratory aspirin resistance trial in healthy Japanese volunteers (J-ART) using platelet aggregation as a measure of thrombogenicity. Pharmacogenomics J 2007: 7: 395-403.
    • (2007) Pharmacogenomics J , vol.7 , pp. 395-403
    • Fujiwara, T.1    Ikeda, M.2    Esumi, K.3
  • 42
    • 34548100282 scopus 로고    scopus 로고
    • The BC genotype of the VNTR polymorphism of platelet glycoprotein Ibalpha is overrepresented in patients with recurrent stroke regardless of aspirin therapy
    • Cervera A, Tassies D, Obach V, Amaro S, Reverter JC, Chamorro A. The BC genotype of the VNTR polymorphism of platelet glycoprotein Ibalpha is overrepresented in patients with recurrent stroke regardless of aspirin therapy. Cerebrovasc Dis 2007: 24: 242-246.
    • (2007) Cerebrovasc Dis , vol.24 , pp. 242-246
    • Cervera, A.1    Tassies, D.2    Obach, V.3    Amaro, S.4    Reverter, J.C.5    Chamorro, A.6
  • 43
    • 0042735242 scopus 로고    scopus 로고
    • Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms
    • Macchi L, Christiaens L, Brabant S et al. Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol 2003: 42: 1115-1119.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1115-1119
    • Macchi, L.1    Christiaens, L.2    Brabant, S.3
  • 44
    • 38849189504 scopus 로고    scopus 로고
    • Association of the platelet membrane glycoprotein I a C807T gene polymorphism with aspirin resistance
    • Su G, Wang Z, Ding Y. Association of the platelet membrane glycoprotein I a C807T gene polymorphism with aspirin resistance. J Huazhong Univ Sci Technolog Med Sci 2007: 27: 664-667.
    • (2007) J Huazhong Univ Sci Technolog Med Sci , vol.27 , pp. 664-667
    • Su, G.1    Wang, Z.2    Ding, Y.3
  • 45
    • 33846472607 scopus 로고    scopus 로고
    • Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis
    • Nikolopoulos GK, Tsantes AE, Bagos PG, Travlou A, Vaiopoulos G. Integrin, alpha 2 gene C807T polymorphism and risk of ischemic stroke: A meta-analysis. Thromb Res 2007: 119: 501-510.
    • (2007) Thromb Res , vol.119 , pp. 501-510
    • Nikolopoulos, G.K.1    Tsantes, A.E.2    Bagos, P.G.3    Travlou, A.4    Vaiopoulos, G.5
  • 47
    • 0029875770 scopus 로고    scopus 로고
    • A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis
    • Weiss EJ, Bray PF, Tayback M et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996: 334: 1090-1094.
    • (1996) N Engl J Med , vol.334 , pp. 1090-1094
    • Weiss, E.J.1    Bray, P.F.2    Tayback, M.3
  • 48
    • 0031586491 scopus 로고    scopus 로고
    • Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis
    • Walter DH, Schachinger V, Elsner M, Dimmeler S, Zeiher AM. Platelet glycoprotein IIIa polymorphisms and risk of coronary stent thrombosis. Lancet 1997: 350: 1217-12199.
    • (1997) Lancet , vol.350 , pp. 1217-12199
    • Walter, D.H.1    Schachinger, V.2    Elsner, M.3    Dimmeler, S.4    Zeiher, A.M.5
  • 49
    • 0031052297 scopus 로고    scopus 로고
    • Glycoprotein IIIa polymorphism and risk of myocardial infarction
    • Samani NJ, Lodwick D. Glycoprotein IIIa polymorphism and risk of myocardial infarction. Cardiovasc Res 1997: 33: 693-697.
    • (1997) Cardiovasc Res , vol.33 , pp. 693-697
    • Samani, N.J.1    Lodwick, D.2
  • 50
    • 0032105480 scopus 로고    scopus 로고
    • PlA1/A2 polymorphism of glycoprotein IIIa and risk of coronary artery disease and restenosis following coronary angioplasty
    • Mamotte CD, van Bockxmeer FM, Taylor RR. PlA1/A2 polymorphism of glycoprotein IIIa and risk of coronary artery disease and restenosis following coronary angioplasty. Am J Cardiol 1998: 82: 13-16.
    • (1998) Am J Cardiol , vol.82 , pp. 13-16
    • Mamotte, C.D.1    van Bockxmeer, F.M.2    Taylor, R.R.3
  • 51
    • 0033761053 scopus 로고    scopus 로고
    • Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa
    • Szczeklik A, Undas A, Sanak M, Frolow M, Wegrzyn W. Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa. Br J Haematol 2000: 110: 965-967.
    • (2000) Br J Haematol , vol.110 , pp. 965-967
    • Szczeklik, A.1    Undas, A.2    Sanak, M.3    Frolow, M.4    Wegrzyn, W.5
  • 52
    • 0033586430 scopus 로고    scopus 로고
    • Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation
    • Undas A, Sanak M, Musial J, Szczeklik A. Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation. Lancet 1999: 353: 982-983.
    • (1999) Lancet , vol.353 , pp. 982-983
    • Undas, A.1    Sanak, M.2    Musial, J.3    Szczeklik, A.4
  • 53
    • 0035960620 scopus 로고    scopus 로고
    • Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury
    • Undas A, Brummel K, Musial J, Mann KG, Szczeklik A. Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation 2001: 104: 2666-2672.
    • (2001) Circulation , vol.104 , pp. 2666-2672
    • Undas, A.1    Brummel, K.2    Musial, J.3    Mann, K.G.4    Szczeklik, A.5
  • 54
    • 17044417617 scopus 로고    scopus 로고
    • The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis
    • Pamukcu B, Oflaz H, Nisanci Y. The role of platelet glycoprotein IIIa polymorphism in the high prevalence of in vitro aspirin resistance in patients with intracoronary stent restenosis. Am Heart J 2005: 149: 675-680.
    • (2005) Am Heart J , vol.149 , pp. 675-680
    • Pamukcu, B.1    Oflaz, H.2    Nisanci, Y.3
  • 55
    • 21044459956 scopus 로고    scopus 로고
    • Glycoprotein III/a gene (PlA) polymorphism and acetylsalicylic acid resistance: Is there any correlation?
    • Papp E, Havasi V, Bene J et al. Glycoprotein III/a gene (PlA) polymorphism and acetylsalicylic acid resistance: Is there any correlation? Ann Pharmacother 2005: 39: 1013-1018.
    • (2005) Ann Pharmacother , vol.39 , pp. 1013-1018
    • Papp, E.1    Havasi, V.2    Bene, J.3
  • 56
    • 11144357704 scopus 로고    scopus 로고
    • PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation. Blood Coagul Fibrinolysis 2004: 15: 89-93.
    • (2004) Blood Coagul Fibrinolysis , vol.15 , pp. 89-93
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 57
    • 34247200411 scopus 로고    scopus 로고
    • Does glycoprotein IIIa gene (Pl(A)) polymorphism influence clopidogrel resistance?: A study in older patients
    • Papp E, Havasi V, Bene J et al. Does glycoprotein IIIa gene (Pl(A)) polymorphism influence clopidogrel resistance?: A study in older patients. Drugs Aging 2007: 24: 345-350.
    • (2007) Drugs Aging , vol.24 , pp. 345-350
    • Papp, E.1    Havasi, V.2    Bene, J.3
  • 58
    • 33845490833 scopus 로고    scopus 로고
    • Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel
    • Lev EI, Patel RT, Guthikonda S, Lopez D, Bray PF, Kleiman NS. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. Thromb Res 2007: 119: 355-360.
    • (2007) Thromb Res , vol.119 , pp. 355-360
    • Lev, E.I.1    Patel, R.T.2    Guthikonda, S.3    Lopez, D.4    Bray, P.F.5    Kleiman, N.S.6
  • 59
    • 17844368900 scopus 로고    scopus 로고
    • Platelet glycoprotein IIb/IIIa polymorphism and coronary artery disease: Implications for clinical practice
    • Di Castelnuovo A, de Gaetano G, Benedetta Donati M, Iacoviello L. Platelet glycoprotein IIb/IIIa polymorphism and coronary artery disease: implications for clinical practice. Am J Pharmacogenomics 2005: 5: 93-99.
    • (2005) Am J Pharmacogenomics , vol.5 , pp. 93-99
    • Di Castelnuovo, A.1    de Gaetano, G.2    Benedetta Donati, M.3    Iacoviello, L.4
  • 60
    • 34447336152 scopus 로고    scopus 로고
    • UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin
    • Chen Y, Kuehl GE, Bigler J et al. UGT1A6 polymorphism and salicylic acid glucuronidation following aspirin. Pharmacogenet Genomics 2007: 17: 571-519.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 519-571
    • Chen, Y.1    Kuehl, G.E.2    Bigler, J.3
  • 61
    • 0033128384 scopus 로고    scopus 로고
    • The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation
    • Léon C, Vial C, Gachet C et al. The P2Y1 receptor is normal in a patient presenting a severe deficiency of ADP-induced platelet aggregation. Thromb Haemost 1999: 81: 775-781.
    • (1999) Thromb Haemost , vol.81 , pp. 775-781
    • Léon, C.1    Vial, C.2    Gachet, C.3
  • 63
    • 33644972034 scopus 로고    scopus 로고
    • P2Y1 gene A1622G dimorphism is not associated with adenosine diphosphate-induced platelet activation and aggregation after administration of a single high dose of clopidogrel
    • Sibbing D, von Beckerath O, Schomig A, Kastrati A, von Beckerath N. P2Y1 gene A1622G dimorphism is not associated with adenosine diphosphate-induced platelet activation and aggregation after administration of a single high dose of clopidogrel. J Thromb Haemost 2006: 4: 912-914.
    • (2006) J Thromb Haemost , vol.4 , pp. 912-914
    • Sibbing, D.1    von Beckerath, O.2    Schomig, A.3    Kastrati, A.4    von Beckerath, N.5
  • 64
    • 0042859862 scopus 로고    scopus 로고
    • Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
    • Fontana P, Dupont A, Gandrille S et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 2003: 108: 989-995.
    • (2003) Circulation , vol.108 , pp. 989-995
    • Fontana, P.1    Dupont, A.2    Gandrille, S.3
  • 65
    • 0346365089 scopus 로고    scopus 로고
    • P2Y12 H2 haplotype is associated with peripheral arterial disease: A case-control study
    • Fontana P, Gaussem P, Aiach M, Fiessinger JN, Emmerich J, Reny JL. P2Y12 H2 haplotype is associated with peripheral arterial disease: A case-control study. Circulation 2003: 108: 2971-2973.
    • (2003) Circulation , vol.108 , pp. 2971-2973
    • Fontana, P.1    Gaussem, P.2    Aiach, M.3    Fiessinger, J.N.4    Emmerich, J.5    Reny, J.L.6
  • 66
    • 22044450322 scopus 로고    scopus 로고
    • Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease
    • Ziegler S, Schillinger M, Funk M et al. Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease. Stroke 2005: 36: 1394-1399.
    • (2005) Stroke , vol.36 , pp. 1394-1399
    • Ziegler, S.1    Schillinger, M.2    Funk, M.3
  • 67
    • 24944465039 scopus 로고    scopus 로고
    • Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease. Thromb Res 2005: 116: 491-497.
    • (2005) Thromb Res , vol.116 , pp. 491-497
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 68
    • 33745167304 scopus 로고    scopus 로고
    • Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy
    • Smith SM, Judge HM, Peters G et al. Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy. Platelets 2006: 17: 250-258.
    • (2006) Platelets , vol.17 , pp. 250-258
    • Smith, S.M.1    Judge, H.M.2    Peters, G.3
  • 69
    • 34548722718 scopus 로고    scopus 로고
    • Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome
    • Cuisset T, Frere C, Quilici J et al. Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome. Thromb Res 2007: 120: 893-899.
    • (2007) Thromb Res , vol.120 , pp. 893-899
    • Cuisset, T.1    Frere, C.2    Quilici, J.3
  • 70
    • 40549095422 scopus 로고    scopus 로고
    • P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease
    • Bierend A, Rau T, Maas R, Schwedhelm E, Böger RH. P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease. Br J Clin Pharmacol 2008: 65: 540-547.
    • (2008) Br J Clin Pharmacol , vol.65 , pp. 540-547
    • Bierend, A.1    Rau, T.2    Maas, R.3    Schwedhelm, E.4    Böger, R.H.5
  • 71
    • 1642453779 scopus 로고    scopus 로고
    • Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    • Lau WC, Gurbel PA, Watkins PB et al. Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance. Circulation 2004: 109: 166-171.
    • (2004) Circulation , vol.109 , pp. 166-171
    • Lau, W.C.1    Gurbel, P.A.2    Watkins, P.B.3
  • 72
    • 33746792912 scopus 로고    scopus 로고
    • Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
    • Angiolillo DJ, Fernandez-Ortiz A, Bernardo E et al. Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel. Arterioscler Thromb Vasc Biol 2006: 26: 1895-1900.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1895-1900
    • Angiolillo, D.J.1    Fernandez-Ortiz, A.2    Bernardo, E.3
  • 73
    • 33744968214 scopus 로고    scopus 로고
    • Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel
    • Suh JW, Koo BK, Zhang SY et al. Increased risk of atherothrombotic events associated with cytochrome P450 3A5 polymorphism in patients taking clopidogrel. CMAJ 2006: 174: 1715-1722.
    • (2006) CMAJ , vol.174 , pp. 1715-1722
    • Suh, J.W.1    Koo, B.K.2    Zhang, S.Y.3
  • 74
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • Hulot JS, Bura A, Villard E et al. Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 2006: 108: 2244-2247.
    • (2006) Blood , vol.108 , pp. 2244-2247
    • Hulot, J.S.1    Bura, A.2    Villard, E.3
  • 75
    • 36348943475 scopus 로고    scopus 로고
    • Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel
    • Brandt JT, Close SL, Iturria SJ et al. Common polymorphisms of CYP2C19 and CYP2C9 affect the pharmacokinetic and pharmacodynamic response to clopidogrel but not prasugrel. J Thromb Haemost 2007: 5: 2429-2436.
    • (2007) J Thromb Haemost , vol.5 , pp. 2429-2436
    • Brandt, J.T.1    Close, S.L.2    Iturria, S.J.3
  • 76
    • 41349113774 scopus 로고    scopus 로고
    • Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome
    • Frere C, Cuisset T, Morange PE et al. Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome. Am J Cardiol 2008: 101: 1088-1093.
    • (2008) Am J Cardiol , vol.101 , pp. 1088-1093
    • Frere, C.1    Cuisset, T.2    Morange, P.E.3
  • 77
    • 43049179414 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    • Trenk D, Hochholzer W, Fromm MF et al. Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents. J Am Coll Cardiol 2008: 51: 1925-1934.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 1925-1934
    • Trenk, D.1    Hochholzer, W.2    Fromm, M.F.3
  • 78
    • 38649131003 scopus 로고    scopus 로고
    • Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness
    • Fontana P, Senouf D, Mach F. Biological effect of increased maintenance dose of clopidogrel in cardiovascular outpatients and influence of the cytochrome P450 2C19*2 allele on clopidogrel responsiveness. Thromb Res 2008: 121: 463-468.
    • (2008) Thromb Res , vol.121 , pp. 463-468
    • Fontana, P.1    Senouf, D.2    Mach, F.3
  • 79
    • 34547760330 scopus 로고    scopus 로고
    • A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
    • LordkipanidzéM, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 2007: 28: 1702-1708.
    • (2007) Eur Heart J , vol.28 , pp. 1702-1708
    • Lordkipanidzé, M.1    Pharand, C.2    Schampaert, E.3    Turgeon, J.4    Palisaitis, D.A.5    Diodati, J.G.6
  • 80
    • 34347340649 scopus 로고    scopus 로고
    • Evaluation of dose-related effects of aspirin on platelet function. Results from the Aspirin-Induced Platelet Effect (ASPECT) Study
    • Gurbel PA, Bliden KP, DiChiara J et al. Evaluation of dose-related effects of aspirin on platelet function. Results from the Aspirin-Induced Platelet Effect (ASPECT) Study. Circulation 2007: 115: 3156-3164.
    • (2007) Circulation , vol.115 , pp. 3156-3164
    • Gurbel, P.A.1    Bliden, K.P.2    DiChiara, J.3
  • 81
    • 33746218509 scopus 로고    scopus 로고
    • Platelet inhibition beyond conventional antiplatelet agents: Expanding role of angiotensin receptor blockers, statins and selective serotonin reuptake inhibitors
    • Malinin AI, Ong S, Makarov LM, Petukhova EY, Serebruany VL. Platelet inhibition beyond conventional antiplatelet agents: Expanding role of angiotensin receptor blockers, statins and selective serotonin reuptake inhibitors. Int J Clin Pract 2006: 60: 993-1002.
    • (2006) Int J Clin Pract , vol.60 , pp. 993-1002
    • Malinin, A.I.1    Ong, S.2    Makarov, L.M.3    Petukhova, E.Y.4    Serebruany, V.L.5
  • 82
    • 34447282174 scopus 로고    scopus 로고
    • Clopidogrel resistance: Role of body mass and concomitant medications
    • Feher G, Koltai K, Alkonyi B et al. Clopidogrel resistance: Role of body mass and concomitant medications. Int J Cardiol 2007: 120: 188-192.
    • (2007) Int J Cardiol , vol.120 , pp. 188-192
    • Feher, G.1    Koltai, K.2    Alkonyi, B.3
  • 83
    • 33748190263 scopus 로고    scopus 로고
    • Aspirin resistance: Possible roles of cardiovascular risk factors, previous disease history, concomitant medications and haemorrheological variables
    • Feher G, Koltai K, Papp E et al. Aspirin resistance: Possible roles of cardiovascular risk factors, previous disease history, concomitant medications and haemorrheological variables. Drugs Aging 2006: 23: 559-567.
    • (2006) Drugs Aging , vol.23 , pp. 559-567
    • Feher, G.1    Koltai, K.2    Papp, E.3
  • 84
    • 36448968201 scopus 로고    scopus 로고
    • Pharmacogenomics of platelet responsiveness to aspirin
    • Faraday N, Becker DM, Becker LC. Pharmacogenomics of platelet responsiveness to aspirin. Pharmacogenomics 2007: 8: 1413-1425.
    • (2007) Pharmacogenomics , vol.8 , pp. 1413-1425
    • Faraday, N.1    Becker, D.M.2    Becker, L.C.3
  • 85
    • 17444429227 scopus 로고    scopus 로고
    • P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose
    • von Beckerath N, von Beckerath O, Koch W, Eichinger M, Schömig A, Kastrati A. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. Blood Coagul Fibrinolysis 2005: 16: 199-204.
    • (2005) Blood Coagul Fibrinolysis , vol.16 , pp. 199-204
    • von Beckerath, N.1    von Beckerath, O.2    Koch, W.3    Eichinger, M.4    Schömig, A.5    Kastrati, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.