Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells

Journal of Cell Science

Volumn 127, Issue 6, 2014, Pages 1346-1356

  Atkin, Jane ^a   Halova, Lenka ^a   Ferguson, Jennifer ^a   Hitchin, James R ^b   Lichawska Cieslar, Agata ^c   Jordan, Allan M ^b   Pines, Jonathon ^c   Wellbrock, Claudia ^a   Petersen, Janni ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

HeLa; S. pombe; TOR; Torin1; Wee1

Indexed keywords

CDR2 KINASE; CELL PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; POLO LIKE KINASE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TORIN 1; TRYPTOPHAN; UNCLASSIFIED DRUG; WEE1 PROTEIN; 1-(4-(4-PROPIONYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL)-9-(QUINOLIN-3-YL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; CELL CYCLE PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; NAPHTHYRIDINE DERIVATIVE; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; SCHIZOSACCHAROMYCES POMBE PROTEIN; TOR COMPLEX 2; TOR2 PROTEIN, S POMBE; WEE1 PROTEIN, HUMAN; WEE1 PROTEIN, S POMBE;

ANTIFUNGAL ACTIVITY; ARTICLE; CATALYSIS; CELL DIVISION; CONTROLLED STUDY; DRUG SPECIFICITY; FEMALE; FUNGUS MUTATION; G1 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SCHIZOSACCHAROMYCES POMBE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANTAGONISTS AND INHIBITORS; CELL DEATH; DRUG EFFECTS; DRUG RESISTANCE; ENZYME ACTIVE SITE; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; HELA CELL LINE; METABOLISM; MOLECULAR GENETICS; PROTEIN TRANSPORT; SCHIZOSACCHAROMYCES; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CELL CYCLE PROTEINS; CELL DEATH; DRUG RESISTANCE; G1 PHASE CELL CYCLE CHECKPOINTS; HELA CELLS; HUMANS; MITOSIS; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; NAPHTHYRIDINES; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84903370918     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.146373     Document Type: Article

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