-
1
-
-
71949118545
-
Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box?
-
Machado N.G., Alves M.G., Carvalho R.A., Oliveira P.J. Mitochondrial involvement in cardiac apoptosis during ischemia and reperfusion: can we close the box?. Cardiovasc. Toxicol. 2009, 9:211-227.
-
(2009)
Cardiovasc. Toxicol.
, vol.9
, pp. 211-227
-
-
Machado, N.G.1
Alves, M.G.2
Carvalho, R.A.3
Oliveira, P.J.4
-
2
-
-
68649090472
-
P38(MAPK): stress responses from molecular mechanisms to therapeutics
-
Coulthard L.R., White D.E., Jones D.L., McDermott M.F., Burchill S.A. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol. Med. 2009, 15:369-379.
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 369-379
-
-
Coulthard, L.R.1
White, D.E.2
Jones, D.L.3
McDermott, M.F.4
Burchill, S.A.5
-
3
-
-
0030036727
-
Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-jun N-terminal kinases are activated by ischemia/reperfusion
-
Bogoyevitch M.A., Gillespie-Brown J., Ketterman A.J., Fuller S.J., Ben-Levy R., Ashworth A., Marshall C.J., Sugden P.H. Stimulation of the stress-activated mitogen-activated protein kinase subfamilies in perfused heart. p38/RK mitogen-activated protein kinases and c-jun N-terminal kinases are activated by ischemia/reperfusion. Circ. Res. 1996, 79:162-173.
-
(1996)
Circ. Res.
, vol.79
, pp. 162-173
-
-
Bogoyevitch, M.A.1
Gillespie-Brown, J.2
Ketterman, A.J.3
Fuller, S.J.4
Ben-Levy, R.5
Ashworth, A.6
Marshall, C.J.7
Sugden, P.H.8
-
4
-
-
34548858159
-
Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease
-
Clark J.E., Sarafraz N., Marber M.S. Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease. Pharmacol. Ther. 2007, 116:192-206.
-
(2007)
Pharmacol. Ther.
, vol.116
, pp. 192-206
-
-
Clark, J.E.1
Sarafraz, N.2
Marber, M.S.3
-
5
-
-
78149478401
-
Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale
-
Rose B.A., Force T., Wang Y. Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol. Rev. 2010, 90:1507-1546.
-
(2010)
Physiol. Rev.
, vol.90
, pp. 1507-1546
-
-
Rose, B.A.1
Force, T.2
Wang, Y.3
-
6
-
-
73549093581
-
A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1
-
Cully M., Genevet A., Warne P., Treins C., Liu T., Bastien J., Baum B., Tapon N., Leevers S.J., Downward J. A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. Mol. Cell. Biol. 2010, 30:481-495.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 481-495
-
-
Cully, M.1
Genevet, A.2
Warne, P.3
Treins, C.4
Liu, T.5
Bastien, J.6
Baum, B.7
Tapon, N.8
Leevers, S.J.9
Downward, J.10
-
7
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., Hall M.N. TOR signaling in growth and metabolism. Cell 2006, 124:471-484.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
8
-
-
79952281400
-
Inactivation of rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1
-
Zheng M., Wang Y.H., Wu X.N., Wu S.Q., Lu B.J., Dong M.Q., Zhang H., Sun P., Lin S.C., Guan K.L., Han J. Inactivation of rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat. Cell Biol. 2011, 13:263-272.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 263-272
-
-
Zheng, M.1
Wang, Y.H.2
Wu, X.N.3
Wu, S.Q.4
Lu, B.J.5
Dong, M.Q.6
Zhang, H.7
Sun, P.8
Lin, S.C.9
Guan, K.L.10
Han, J.11
-
9
-
-
78650696123
-
A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse
-
Gao E., Lei Y.H., Shang X., Huang Z.M., Zuo L., Boucher M., Fan Q., Chuprun J.K., Ma X.L., Koch W.J. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ. Res. 2010, 107:1445-1453.
-
(2010)
Circ. Res.
, vol.107
, pp. 1445-1453
-
-
Gao, E.1
Lei, Y.H.2
Shang, X.3
Huang, Z.M.4
Zuo, L.5
Boucher, M.6
Fan, Q.7
Chuprun, J.K.8
Ma, X.L.9
Koch, W.J.10
-
10
-
-
33644841906
-
C-jun N-terminal kinases mediate reactivation of akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo
-
Shao Z., Bhattacharya K., Hsich E., Park L., Walters B., Germann U., Wang Y.M., Kyriakis J., Mohanlal R., Kuida K., Namchuk M., Salituro F., Yao Y.M., Hou W.M., Chen X., Aronovitz M., Tsichlis P.N., Bhattacharya S., Force T., Kilter H. c-jun N-terminal kinases mediate reactivation of akt and cardiomyocyte survival after hypoxic injury in vitro and in vivo. Circ. Res. 2006, 98:111-118.
-
(2006)
Circ. Res.
, vol.98
, pp. 111-118
-
-
Shao, Z.1
Bhattacharya, K.2
Hsich, E.3
Park, L.4
Walters, B.5
Germann, U.6
Wang, Y.M.7
Kyriakis, J.8
Mohanlal, R.9
Kuida, K.10
Namchuk, M.11
Salituro, F.12
Yao, Y.M.13
Hou, W.M.14
Chen, X.15
Aronovitz, M.16
Tsichlis, P.N.17
Bhattacharya, S.18
Force, T.19
Kilter, H.20
more..
-
11
-
-
0034664958
-
Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes
-
Punn A., Mockridge J.W., Farooqui S., Marber M.S., Heads R.J. Sustained activation of p42/p44 mitogen-activated protein kinase during recovery from simulated ischaemia mediates adaptive cytoprotection in cardiomyocytes. Biochem. J. 2000, 350(Pt 3):891-899.
-
(2000)
Biochem. J.
, vol.350
, Issue.PART 3
, pp. 891-899
-
-
Punn, A.1
Mockridge, J.W.2
Farooqui, S.3
Marber, M.S.4
Heads, R.J.5
-
12
-
-
47049088906
-
SOK1 translocates from the golgi to the nucleus upon chemical anoxia and induces apoptotic cell death
-
Nogueira E., Fidalgo M., Molnar A., Kyriakis J., Force T., Zalvide J., Pombo C.M. SOK1 translocates from the golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. J. Biol. Chem. 2008, 283:16248-16258.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 16248-16258
-
-
Nogueira, E.1
Fidalgo, M.2
Molnar, A.3
Kyriakis, J.4
Force, T.5
Zalvide, J.6
Pombo, C.M.7
-
13
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth
-
Liu L., Cash T.P., Jones R.G., Keith B., Thompson C.B., Simon M.C. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol. Cell 2006, 21:521-531.
-
(2006)
Mol. Cell
, vol.21
, pp. 521-531
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
14
-
-
67650673258
-
Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue
-
Miyamoto S., Murphy A.N., Brown J.H. Akt mediated mitochondrial protection in the heart: metabolic and survival pathways to the rescue. J. Bioenerg. Biomembr. 2009, 41:169-180.
-
(2009)
J. Bioenerg. Biomembr.
, vol.41
, pp. 169-180
-
-
Miyamoto, S.1
Murphy, A.N.2
Brown, J.H.3
-
15
-
-
0026693493
-
Occurrence of oxidative stress during myocardial reperfusion
-
Ferrari R., Ceconi C., Curello S., Cargnoni A., De Giuli F., Visioli O. Occurrence of oxidative stress during myocardial reperfusion. Mol. Cell. Biochem. 1992, 111:61-69.
-
(1992)
Mol. Cell. Biochem.
, vol.111
, pp. 61-69
-
-
Ferrari, R.1
Ceconi, C.2
Curello, S.3
Cargnoni, A.4
De Giuli, F.5
Visioli, O.6
-
16
-
-
57649231164
-
AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes
-
Cao C., Lu S., Kivlin R., Wallin B., Card E., Bagdasarian A., Tamakloe T., Chu W.M., Guan K.L., Wan Y. AMP-activated protein kinase contributes to UV- and H2O2-induced apoptosis in human skin keratinocytes. J. Biol. Chem. 2008, 283:28897-28908.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28897-28908
-
-
Cao, C.1
Lu, S.2
Kivlin, R.3
Wallin, B.4
Card, E.5
Bagdasarian, A.6
Tamakloe, T.7
Chu, W.M.8
Guan, K.L.9
Wan, Y.10
-
17
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward rheb
-
Tee A.R., Manning B.D., Roux P.P., Cantley L.C., Blenis J. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward rheb. Curr. Biol. 2003, 13:1259-1268.
-
(2003)
Curr. Biol.
, vol.13
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
Cantley, L.C.4
Blenis, J.5
-
18
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee A.R., Fingar D.C., Manning B.D., Kwiatkowski D.J., Cantley L.C., Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:13571-13576.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
19
-
-
34548695952
-
Mitogen-activated protein kinases in heart development and diseases
-
Wang Y. Mitogen-activated protein kinases in heart development and diseases. Circulation 2007, 116:1413-1423.
-
(2007)
Circulation
, vol.116
, pp. 1413-1423
-
-
Wang, Y.1
-
20
-
-
78649668307
-
MTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy
-
Song X., Kusakari Y., Xiao C.Y., Kinsella S.D., Rosenberg M.A., Scherrer-Crosbie M., Hara K., Rosenzweig A., Matsui T. mTOR attenuates the inflammatory response in cardiomyocytes and prevents cardiac dysfunction in pathological hypertrophy. Am. J. Physiol. Cell Physiol. 2010, 299:C1256-C1266.
-
(2010)
Am. J. Physiol. Cell Physiol.
, vol.299
-
-
Song, X.1
Kusakari, Y.2
Xiao, C.Y.3
Kinsella, S.D.4
Rosenberg, M.A.5
Scherrer-Crosbie, M.6
Hara, K.7
Rosenzweig, A.8
Matsui, T.9
-
21
-
-
79952235006
-
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation
-
Marin T.M., Keith K., Davies B., Conner D.A., Guha P., Kalaitzidis D., Wu X., Lauriol J., Wang B., Bauer M., Bronson R., Franchini K.G., Neel B.G., Kontaridis M.I. Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J. Clin. Invest. 2011, 121:1026-1043.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1026-1043
-
-
Marin, T.M.1
Keith, K.2
Davies, B.3
Conner, D.A.4
Guha, P.5
Kalaitzidis, D.6
Wu, X.7
Lauriol, J.8
Wang, B.9
Bauer, M.10
Bronson, R.11
Franchini, K.G.12
Neel, B.G.13
Kontaridis, M.I.14
-
22
-
-
0035824907
-
Myocardial protection by insulin at reperfusion requires early administration and is mediated via akt and p70s6 kinase cell-survival signaling
-
Jonassen A.K., Sack M.N., Mjos O.D., Yellon D.M. Myocardial protection by insulin at reperfusion requires early administration and is mediated via akt and p70s6 kinase cell-survival signaling. Circ. Res. 2001, 89:1191-1198.
-
(2001)
Circ. Res.
, vol.89
, pp. 1191-1198
-
-
Jonassen, A.K.1
Sack, M.N.2
Mjos, O.D.3
Yellon, D.M.4
-
23
-
-
58149229482
-
Pretreatment with insulin before ischaemia reduces infarct size in langendorff-perfused rat hearts
-
Fuglesteg B.N., Tiron C., Jonassen A.K., Mjos O.D., Ytrehus K. Pretreatment with insulin before ischaemia reduces infarct size in langendorff-perfused rat hearts. Acta Physiol (Oxf.) 2009, 195:273-282.
-
(2009)
Acta Physiol (Oxf.)
, vol.195
, pp. 273-282
-
-
Fuglesteg, B.N.1
Tiron, C.2
Jonassen, A.K.3
Mjos, O.D.4
Ytrehus, K.5
-
24
-
-
33746090919
-
Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes
-
Khan S., Salloum F., Das A., Xi L., Vetrovec G.W., Kukreja R.C. Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes. J. Mol. Cell. Cardiol. 2006, 41:256-264.
-
(2006)
J. Mol. Cell. Cardiol.
, vol.41
, pp. 256-264
-
-
Khan, S.1
Salloum, F.2
Das, A.3
Xi, L.4
Vetrovec, G.W.5
Kukreja, R.C.6
-
25
-
-
0042410540
-
Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase
-
Kis A., Yellon D.M., Baxter G.F. Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase. J. Mol. Cell. Cardiol. 2003, 35:1063-1071.
-
(2003)
J. Mol. Cell. Cardiol.
, vol.35
, pp. 1063-1071
-
-
Kis, A.1
Yellon, D.M.2
Baxter, G.F.3
-
26
-
-
71649084135
-
Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction
-
Buss S.J., Muenz S., Riffel J.H., Malekar P., Hagenmueller M., Weiss C.S., Bea F., Bekeredjian R., Schinke-Braun M., Izumo S., Katus H.A., Hardt S.E. Beneficial effects of mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J. Am. Coll. Cardiol. 2009, 54:2435-2446.
-
(2009)
J. Am. Coll. Cardiol.
, vol.54
, pp. 2435-2446
-
-
Buss, S.J.1
Muenz, S.2
Riffel, J.H.3
Malekar, P.4
Hagenmueller, M.5
Weiss, C.S.6
Bea, F.7
Bekeredjian, R.8
Schinke-Braun, M.9
Izumo, S.10
Katus, H.A.11
Hardt, S.E.12
-
27
-
-
67449124604
-
Infarct size is increased in female post-MI rats treated with rapamycin
-
Lajoie C., El-Helou V., Proulx C., Clement R., Gosselin H., Calderone A. Infarct size is increased in female post-MI rats treated with rapamycin. Can. J. Physiol. Pharmacol. 2009, 87:460-470.
-
(2009)
Can. J. Physiol. Pharmacol.
, vol.87
, pp. 460-470
-
-
Lajoie, C.1
El-Helou, V.2
Proulx, C.3
Clement, R.4
Gosselin, H.5
Calderone, A.6
-
28
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
Sofer A., Lei K., Johannessen C.M., Ellisen L.W. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 2005, 25:5834-5845.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
29
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E., Witters L.A., Ellisen L.W., Kaelin W.G. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 2004, 18:2893-2904.
-
(2004)
Genes Dev.
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
Lei, K.2
Hurley, R.L.3
Manning, B.D.4
Reiling, J.H.5
Hafen, E.6
Witters, L.A.7
Ellisen, L.W.8
Kaelin, W.G.9
-
30
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung M.P., Horak P., Sofer A., Sgroi D., Ellisen L.W. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 2008, 22:239-251.
-
(2008)
Genes Dev.
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
31
-
-
78650510609
-
MTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R., Efeyan A., Sabatini D.M. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12:21-35.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
32
-
-
0038190932
-
The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3
-
Li Y., Inoki K., Vacratsis P., Guan K.L. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 2003, 278:13663-13671.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13663-13671
-
-
Li, Y.1
Inoki, K.2
Vacratsis, P.3
Guan, K.L.4
|