Leonurine ameliorates LPS-induced acute kidney injury via suppressing ROS-mediated NF-κB signaling pathway

Fitoterapia

Volumn 97, Issue , 2014, Pages 148-155

  Xu, Daliang ^a,b   Chen, Maosheng ^c   Ren, Xianguo ^e   Ren, Xianzhi ^d   Wu, Yonggui ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Department of Pediatric Surgery   (China)

^c JIAXING UNIVERSITY   (China)

^d AFFILIATED HOSPITAL OF NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^e MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Leonurine; LPS; Nephroprotective effect; NF B

Indexed keywords

CREATININE; CYTOKINE; GLUTATHIONE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; LEONURINE; LIPID PEROXIDE; MALONALDEHYDE; NITROGEN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UREA; GALLIC ACID; LIPOPOLYSACCHARIDE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; KIDNEY FUNCTION; KIDNEY PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UREA NITROGEN BLOOD LEVEL; WESTERN BLOTTING; ACUTE KIDNEY INJURY; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; KIDNEY; KIDNEY FUNCTION TEST; MALE; METABOLISM; PATHOLOGY; RANDOMIZATION;

ACUTE KIDNEY INJURY; ANIMALS; GALLIC ACID; GLUTATHIONE; KIDNEY; KIDNEY FUNCTION TESTS; LIPOPOLYSACCHARIDES; MALE; MALONDIALDEHYDE; MICE, INBRED C57BL; NF-KAPPA B; RANDOM ALLOCATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84903270910     PISSN: 0367326X     EISSN: 18736971     Source Type: Journal    
DOI: 10.1016/j.fitote.2014.06.005     Document Type: Article

References (37)

1. K. Singbartl, and J.A. Kellum AKI in the ICU: definition, epidemiology, risk stratification, and outcomes Kidney Int 81 2012 819 825
2. L.S. Chawla, and J.A. Kellum Acute kidney injury in 2011: biomarkers are transforming our understanding of AKI Nat Rev Nephrol 8 2012 68 70
3. G. Gursel, and N. Demir Incidence and risk factors for the development of acute renal failure in patients with ventilator-associated pneumonia Nephrology 11 2006 159 164
4. M. Matejovic, J. Chvojka, J. Radej, L. Ledvinova, T. Karvunidis, and A. Krouzecky et al. Sepsis and acute kidney injury are bidirectional Contrib Nephrol 174 2011 78 88
5. P.R. Mayeux Pathobiology of lipopolysaccharide J Toxicol Environ Health 51 1997 415 435
6. A. Zarjou, and A. Agarwal Sepsis and acute kidney injury J Am Soc Nephrol 22 2011 999 1006
7. S.M. Bagshaw, S. Lapinsky, S. Dial, Y. Arabi, P. Dodek, and G. Wood et al. Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy Intensive Care Med 35 2009 871 881
8. R. Karima, S. Matsumoto, H. Higashi, and K. Matsushima The molecular pathogenesis of endotoxic shock and organ failure Mol Med Today 5 1999 123 132
9. H. Bosshart, and M. Heinzelmann Targeting bacterial endotoxin: two sides of a coin Ann N Y Acad Sci 1096 2007 1 17
10. K. Doi, A. Leelahavanichkul, P.S. Yuen, and R.A. Star Animal models of sepsis and sepsis-induced kidney injury J Clin Invest 119 2009 2868 2878
11. D. Zhang, Y. Li, Y. Liu, X. Xiang, and Z. Dong Paclitaxel ameliorates lipopolysaccharide-induced kidney injury by binding myeloid differentiation protein-2 to block Toll-like receptor 4-mediated nuclear factor-kappaB activation and cytokine production J Pharmacol Exp Ther 345 2013 69 75
12. Z.G. Zhao, C.Y. Niu, L.L. Zhang, J. Zhang, R. Han, and Y.P. Zhang et al. Exogenous normal lymph alleviates lipopolysaccharide-induced acute kidney injury in rats Ren Fail 35 2013 806 811
13. K. Wojtyniak, M. Szymanski, and I. Matlawska Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology Phytother Res 27 2013 1115 1120
14. X.H. Liu, L.L. Pan, H.B. Yang, Q.H. Gong, and Y.Z. Zhu Leonurine attenuates lipopolysaccharide-induced inflammatory responses in human endothelial cells: involvement of reactive oxygen species and NF-kappaB pathways Eur J Pharmacol 680 2012 108 114
15. J. Qi, Z.Y. Hong, H. Xin, and Y.Z. Zhu Neuroprotective effects of leonurine on ischemia/reperfusion-induced mitochondrial dysfunctions in rat cerebral cortex Biol Pharm Bull 33 2010 1958 1964
16. X.H. Liu, L.L. Pan, H.Y. Deng, Q.H. Xiong, D. Wu, and G.Y. Huang et al. Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4 Free Radic Biol Med 54 2013 93 104
17. G.K. Shinomol, and Muralidhara Differential induction of oxidative impairments in brain regions of male mice following subchronic consumption of Khesari dhal (Lathyrus sativus) and detoxified Khesari dhal Neurotoxicology 28 2007 798 806
18. J. Lu, D.M. Wu, Y.L. Zheng, B. Hu, Z.F. Zhang, and Q. Ye et al. Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-kappaB pathway activation Cereb Cortex 20 2010 2540 2548
19. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72 1976 248 254
20. R.J. Trof, F. Di Maggio, J. Leemreis, and A.B. Groeneveld Biomarkers of acute renal injury and renal failure Shock 26 2006 245 253
21. F.H. Verbrugge, M. Dupont, Z. Shao, K. Shrestha, D. Singh, and M. Finucan et al. Novel urinary biomarkers in detecting acute kidney injury, persistent renal impairment, and all-cause mortality following decongestive therapy in acute decompensated heart failure J Card Fail 19 2013 621 628
22. M.R. Lattanzio, and N.P. Kopyt Acute kidney injury: new concepts in definition, diagnosis, pathophysiology, and treatment J Am Osteopath Assoc 109 2009 13 19
23. J.D. Bauerle, A. Grenz, J.H. Kim, H.T. Lee, and H.K. Eltzschig Adenosine generation and signaling during acute kidney injury J Am Soc Nephrol 22 2011 14 20
24. P.M. Honore, R. Jacobs, O. Joannes-Boyau, J. De Regt, W. Boer, and E. De Waele et al. Septic AKI in ICU patients. diagnosis, pathophysiology, and treatment type, dosing, and timing: a comprehensive review of recent and future developments Ann Intensive Care 1 2011 32
25. M. Han, Y. Li, M. Liu, Y. Li, and B. Cong Renal neutrophil gelatinase associated lipocalin expression in lipopolysaccharide-induced acute kidney injury in the rat BMC Nephrol 13 2012 25
26. B. Beutler, and V. Kruys Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself J Cardiovasc Pharmacol 25 Suppl. 2 1995 S1 S8
27. H. Sebai, M. Ben-Attia, M. Sani, E. Aouani, and N. Ghanem-Boughanmi Protective effect of resveratrol on acute endotoxemia-induced nephrotoxicity in rat through nitric oxide independent mechanism Free Radic Res 42 2008 913 920
28. J.O. Moskaug, H. Carlsen, M.C. Myhrstad, and R. Blomhoff Polyphenols and glutathione synthesis regulation Am J Clin Nutr 81 2005 277S 283S
29. G. Wu, Y.Z. Fang, S. Yang, J.R. Lupton, and N.D. Turner Glutathione metabolism and its implications for health J Nutr 134 2004 489 492
30. D.J. Reed, and M.K. Savage Influence of metabolic inhibitors on mitochondrial permeability transition and glutathione status Biochim Biophys Acta 1271 1995 43 50
31. A.R. Nair, G.S. Masson, P.J. Ebenezer, F. Del Piero, and J. Francis Role of TLR4 in lipopolysaccharide-induced acute kidney injury: protection by blueberry Free Radic Biol Med 71C 2014 16 25
32. M.C. Mulero, A. Bigas, and L. Espinosa IkappaBalpha beyond the NF-kB dogma Oncotarget 4 2013 1550 1551
33. C. Myskiw, J. Arsenio, R. van Bruggen, Y. Deschambault, and J. Cao Vaccinia virus E3 suppresses expression of diverse cytokines through inhibition of the PKR, NF-kappaB, and IRF3 pathways J Virol 83 2009 6757 6768
34. M. Nakayama, Y. Niki, T. Kawasaki, Y. Takeda, H. Ikegami, and Y. Toyama et al. IL-32-PAR2 axis is an innate immunity sensor providing alternative signaling for LPS-TRIF axis Sci Rep 3 2013 2960
35. G. Gloire, S. Legrand-Poels, and J. Piette NF-kappaB activation by reactive oxygen species: fifteen years later Biochem Pharmacol 72 2006 1493 1505
36. S.L. Dodd, B.J. Gagnon, S.M. Senf, B.A. Hain, and A.R. Judge Ros-mediated activation of NF-kappaB and Foxo during muscle disuse Muscle Nerve 41 2010 110 113
37. K. Jin Jung, D. Hyun Kim, E. Kyeong Lee, C. Woo Song, B. Pal Yu, and H. Young Chung Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-kappaB in aged rat kidney Free Radic Biol Med 61C 2013 206 217