Leonurine (SCM-198) attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4

Free Radical Biology and Medicine

Volumn 54, Issue , 2013, Pages 93-104

  Liu, Xin Hua ^a   Pan, Li Long ^a   Deng, Hai Yan ^a   Xiong, Qing Hui ^a   Wu, Dan ^a   Huang, Guo Ying ^a   Gong, Qi Hai ^a   Zhu, Yi Zhun ^a,b  

^a FUDAN UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Cardiac fibroblasts; Free radicals; Leonurine; Myocardial fibrosis; NADPH oxidase 4

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEONURINE; MITOGEN ACTIVATED PROTEIN KINASE 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE 4; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SCM 198; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRESSLER SYNDROME; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; FIBROBLAST; GENE SILENCING; HEART MUSCLE FIBROSIS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; DOWN-REGULATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; FIBROSIS; GALLIC ACID; LEONURUS; MALE; MATRIX METALLOPROTEINASE 2; MYOCARDIAL INFARCTION; MYOCARDIUM; NADPH OXIDASE; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

RATTUS;

EID: 84870848872     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.10.555     Document Type: Article

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