Comparison of intrinsic metabolic clearance in fresh and cryopreserved human hepatocytes

Xenobiotica

Volumn 39, Issue 9, 2009, Pages 656-662

  Floby, E ^a   Johansson, J ^a   Hoogstraate, J ^a   Hewitt, N J ^b   Hill, J ^c   Sohlenius Sternbeck, A K ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b Scientific Writing Services   (Germany)

^c CellzDirect Inc   (United States)

Author keywords

Cryopreserved; Drug development; Drug metabolism; Fresh; Human hepatocytes; Intrinsic clearance

Indexed keywords

BUFURALOL; DIAZEPAM; DICLOFENAC; MIDAZOLAM; PHENACETIN; UMBELLIFERONE; DRUG;

ADULT; AGED; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CRYOPRESERVATION; DONOR; DRUG CLEARANCE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; MALE; METABOLIC CLEARANCE RATE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TANDEM MASS SPECTROMETRY;

ADULT; AGED; AGED, 80 AND OVER; CHROMATOGRAPHY, LIQUID; CRYOPRESERVATION; FEMALE; HEPATOCYTES; HUMANS; MALE; METABOLIC CLEARANCE RATE; MIDDLE AGED; PHARMACEUTICAL PREPARATIONS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 70350496617     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.1080/00498250902974229     Document Type: Article

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