Molecular mechanism of regulation of the atypical protein kinase C by N-terminal domains and an allosteric small compound

Chemistry and Biology

Volumn 21, Issue 6, 2014, Pages 754-765

  Zhang, Hua ^a   Neimanis, Sonja ^a   Lopez Garcia, Laura A ^a   Arencibia, José M ^a   Amon, Sabine ^c   Stroba, Adriana ^b   Zeuzem, Stefan ^a   Proschak, Ewgen ^d   Stark, Holger ^a,d   Bauer, Angelika F ^a   Busschots, Katrien ^a   Jørgensen, Thomas J D ^c   Engel, Matthias ^b   Schulze, Jörg O ^a   Biondi, Ricardo M ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; PROTEIN KINASE C; BIPHENYL DERIVATIVE; CINNAMIC ACID DERIVATIVE; PKC-3 PROTEIN; PROTEIN KINASE INHIBITOR; PS315;

ALLOSTERISM; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CELL FUNCTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEIN STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; THERMOSTABILITY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; METABOLISM; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; BIPHENYL COMPOUNDS; CINNAMATES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84903134318     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.04.007     Document Type: Article

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