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Volumn 9, Issue 6, 2014, Pages

Fingolimod attenuates splenocyte-induced demyelination in cerebellar slice cultures

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; GAMMA INTERFERON; INTERLEUKIN 6; LYSOPHOSPHATIDYLCHOLINE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; AUTACOID; CYTOKINE; IMMUNOSUPPRESSIVE AGENT; PROPANEDIOL DERIVATIVE; SPHINGOSINE;

EID: 84902603087     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099444     Document Type: Article
Times cited : (27)

References (59)
  • 1
    • 0032489574 scopus 로고    scopus 로고
    • Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1
    • Lee M, Van Brocklyn JR, Thangada S, Liu CH, Hand AR, et al. (1998) Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1. Science (80-) 279: 1552-1555.
    • (1998) Science , vol.279 , Issue.80 , pp. 1552-1555
    • Lee, M.1    Van Brocklyn, J.R.2    Thangada, S.3    Liu, C.H.4    Hand, A.R.5
  • 4
    • 0033600173 scopus 로고    scopus 로고
    • EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16
    • DOI 10.1006/bbrc.1999.0886
    • Okamoto H, Takuwa N, Yatomi Y, Gonda K, Shigematsu H, et al. (1999) EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. Biochem Biophys Res Commun 260: 203-208. (Pubitemid 29351808)
    • (1999) Biochemical and Biophysical Research Communications , vol.260 , Issue.1 , pp. 203-208
    • Okamoto, H.1    Takuwa, N.2    Yatomi, Y.3    Gonda, K.4    Shigematsu, H.5    Takuwa, Y.6
  • 5
    • 0030829750 scopus 로고    scopus 로고
    • Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids
    • DOI 10.1016/S0014-5793(97)01301-X, PII S001457939701301X
    • An S, Bleu T, Huang W, Hallmark OG, Coughlin SR, et al. (1997) Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids. FEBS Lett 417: 279-282. (Pubitemid 27511604)
    • (1997) FEBS Letters , vol.417 , Issue.3 , pp. 279-282
    • An, S.1    Bleu, T.2    Huang, W.3    Hallmark, O.G.4    Coughlin, S.R.5    Goetzl, E.J.6
  • 7
    • 76149093586 scopus 로고    scopus 로고
    • A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis
    • Kappos L, Radue E-W, O'Connor P, Polman C, Hohlfeld R, et al. (2010) A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis. N Engl J Med 362: 387-401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.-W.2    O'Connor, P.3    Polman, C.4    Hohlfeld, R.5
  • 8
    • 33645278951 scopus 로고    scopus 로고
    • Sphingosine kinase: Biochemical and cellular regulation and role in disease
    • Taha T, Hannun Y, Obeid L (2006) Sphingosine kinase: biochemical and cellular regulation and role in disease. J Biochem Mol Biol 39: 113-131.
    • (2006) J Biochem Mol Biol , vol.39 , pp. 113-131
    • Taha, T.1    Hannun, Y.2    Obeid, L.3
  • 9
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active sphingolipids in cancer pathogenesis and treatment
    • Ogretmen B, Hannun YA (2004) Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 4: 604-616. (Pubitemid 39025055)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.8 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 14
    • 80054032763 scopus 로고    scopus 로고
    • FTY720-induced conversion of conventional Foxp3- CD4 + T cells to Foxp3+ regulatory T cells in NOD mice
    • Sun Y, Wang W, Shan B, Di J, Chen L, et al. (2011) FTY720-induced conversion of conventional Foxp3- CD4 + T cells to Foxp3+ regulatory T cells in NOD mice. Am J Reprod Immunol 66: 349-362.
    • (2011) Am J Reprod Immunol , vol.66 , pp. 349-362
    • Sun, Y.1    Wang, W.2    Shan, B.3    Di, J.4    Chen, L.5
  • 15
    • 47249141222 scopus 로고    scopus 로고
    • Anti-inflammatory effects of FTY720 against viral-induced immunopathology: Role of drug-induced conversion of T cells to become Foxp3+ regulators
    • Sehrawat S, Rouse BT (2008) Anti-inflammatory effects of FTY720 against viral-induced immunopathology: role of drug-induced conversion of T cells to become Foxp3+ regulators. J Immunol 180: 7636-7647.
    • (2008) J Immunol , vol.180 , pp. 7636-7647
    • Sehrawat, S.1    Rouse, B.T.2
  • 16
    • 0037385330 scopus 로고    scopus 로고
    • + regulatory T cells
    • DOI 10.1038/ni904
    • Fontenot J, Gavin M, Rudensky A (2003) Foxp3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol 4: 330-336. (Pubitemid 36432314)
    • (2003) Nature Immunology , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 17
    • 34548564632 scopus 로고    scopus 로고
    • In vitro generation of CD4+ CD25 + regulatory cells from murine naive T cells
    • Fantini MC, Dominitzki S, Rizzo A, Neurath MF, Becker C (2007) In vitro generation of CD4+ CD25 + regulatory cells from murine naive T cells. Nat Protoc 2: 1789-1794.
    • (2007) Nat Protoc , vol.2 , pp. 1789-1794
    • Fantini, M.C.1    Dominitzki, S.2    Rizzo, A.3    Neurath, M.F.4    Becker, C.5
  • 18
    • 70349333237 scopus 로고    scopus 로고
    • The Sphingosine 1-phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo
    • Wolf AM, Eller K, Zeiser R, Gerlach U V, Sixt M, et al. (2009) The Sphingosine 1-phosphate Receptor Agonist FTY720 Potently Inhibits Regulatory T Cell Proliferation In Vitro and In Vivo. J Immunol 183: 3751-3760.
    • (2009) J Immunol , vol.183 , pp. 3751-3760
    • Wolf, A.M.1    Eller, K.2    Zeiser, R.3    Gerlach, U.V.4    Sixt, M.5
  • 19
    • 36549047503 scopus 로고    scopus 로고
    • Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis
    • DOI 10.1016/j.pharmthera.2007.08.005, PII S0163725807001738
    • Dev KK, Mullershausen F, Mattes H, Kuhn RR, Bilbe G, et al. (2008) Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol Ther 117: 77-93. (Pubitemid 350192672)
    • (2008) Pharmacology and Therapeutics , vol.117 , Issue.1 , pp. 77-93
    • Dev, K.K.1    Mullershausen, F.2    Mattes, H.3    Kuhn, R.R.4    Bilbe, G.5    Hoyer, D.6    Mir, A.7
  • 20
    • 84902584920 scopus 로고    scopus 로고
    • The role of S1P receptors in the treatment of demyelinating diseases
    • Pritchard AJ, Dev KK (2013) The role of S1P receptors in the treatment of demyelinating diseases. Future Neurology 8: 487-489.
    • (2013) Future Neurology , vol.8 , pp. 487-489
    • Pritchard, A.J.1    Dev, K.K.2
  • 21
    • 77953225859 scopus 로고    scopus 로고
    • Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    • Miron VE, Ludwin SK, Darlington PJ, Jarjour AA, Soliven B, et al. (2010) Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices. Am J Pathol 176: 2682-2694.
    • (2010) Am J Pathol , vol.176 , pp. 2682-2694
    • Miron, V.E.1    Ludwin, S.K.2    Darlington, P.J.3    Jarjour, A.A.4    Soliven, B.5
  • 22
    • 84856219980 scopus 로고    scopus 로고
    • S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures
    • Sheridan GK, Dev KK (2012) S1P1 receptor subtype inhibits demyelination and regulates chemokine release in cerebellar slice cultures. Glia 60: 382-392.
    • (2012) Glia , vol.60 , pp. 382-392
    • Sheridan, G.K.1    Dev, K.K.2
  • 23
    • 50949097403 scopus 로고    scopus 로고
    • In situ activation of antigen-specific CD8+ T cells in the presence of antigen in organotypic brain slices
    • Ling C, Verbny Y, Banks M (2008) In situ activation of antigen-specific CD8+ T cells in the presence of antigen in organotypic brain slices. J Immunol 180: 8393-8399.
    • (2008) J Immunol , vol.180 , pp. 8393-8399
    • Ling, C.1    Verbny, Y.2    Banks, M.3
  • 24
    • 79953675959 scopus 로고    scopus 로고
    • CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system
    • Prodinger C, Bunse J, Krüger M, Schiefenhövel F, Brandt C, et al. (2011) CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system. Acta Neuropathol 121: 445-458.
    • (2011) Acta Neuropathol , vol.121 , pp. 445-458
    • Prodinger, C.1    Bunse, J.2    Krüger, M.3    Schiefenhövel, F.4    Brandt, C.5
  • 25
    • 79955645727 scopus 로고    scopus 로고
    • Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model
    • Kim HJ, Miron VE, Dukala D, Proia RL, Ludwin SK, et al. (2011) Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model. FASEB J 25: 1509-1518.
    • (2011) FASEB J , vol.25 , pp. 1509-1518
    • Kim, H.J.1    Miron, V.E.2    Dukala, D.3    Proia, R.L.4    Ludwin, S.K.5
  • 27
    • 79960895505 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo
    • Hu Y, Lee X, Ji B, Guckian K, Apicco D, et al. (2011) Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo. Mol Cell Neurosci 48: 72-81.
    • (2011) Mol Cell Neurosci , vol.48 , pp. 72-81
    • Hu, Y.1    Lee, X.2    Ji, B.3    Guckian, K.4    Apicco, D.5
  • 28
    • 79959846854 scopus 로고    scopus 로고
    • Fingolimod modulates microglial activation to augment markers of remyelination
    • Jackson SJ, Giovannoni G, Baker D (2011) Fingolimod modulates microglial activation to augment markers of remyelination. J Neuroinflammation 8: 76.
    • (2011) J Neuroinflammation , vol.8 , pp. 76
    • Jackson, S.J.1    Giovannoni, G.2    Baker, D.3
  • 29
    • 0038523790 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis
    • DOI 10.1084/jem.20021603
    • Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, et al. (2003) Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med 197: 1073-1081. (Pubitemid 36570063)
    • (2003) Journal of Experimental Medicine , vol.197 , Issue.9 , pp. 1073-1081
    • Bettelli, E.1    Pagany, M.2    Weiner, H.L.3    Linington, C.4    Sobel, R.A.5    Kuchroo, V.K.6
  • 31
    • 78651251056 scopus 로고    scopus 로고
    • Interactions between oligodendrocyte precursors control the onset of CNS myelination
    • Yang Y, Lewis R, Miller RH (2011) Interactions between oligodendrocyte precursors control the onset of CNS myelination. Dev Biol. 350:127-38.
    • (2011) Dev Biol , vol.350 , pp. 127-138
    • Yang, Y.1    Lewis, R.2    Miller, R.H.3
  • 32
    • 84864077241 scopus 로고    scopus 로고
    • Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: A model to study myelination and myelin maintenance
    • Bin JM, Leong SY, Bull SJ, Antel JP, Kennedy TE (2012) Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance. PLoS One. 7:e41237.
    • (2012) PLoS One , vol.7
    • Bin, J.M.1    Leong, S.Y.2    Bull, S.J.3    Antel, J.P.4    Kennedy, T.E.5
  • 33
    • 84886591737 scopus 로고    scopus 로고
    • Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways
    • Shrestha R, Millington O, Brewer J, Dev KK, Bushell TJ (2014) Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways. Neuropharmacology 76:184-93.
    • (2014) Neuropharmacology , vol.76 , pp. 184-193
    • Shrestha, R.1    Millington, O.2    Brewer, J.3    Dev, K.K.4    Bushell, T.J.5
  • 35
    • 34247575723 scopus 로고    scopus 로고
    • Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate
    • Liao J-J, Huang M-C, Goetzl EJ (2007) Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. J Immunol 178: 5425-5428. (Pubitemid 46674335)
    • (2007) Journal of Immunology , vol.178 , Issue.9 , pp. 5425-5428
    • Liao, J.-J.1    Huang, M.-C.2    Goetzl, E.J.3
  • 36
    • 77951879282 scopus 로고    scopus 로고
    • Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis
    • Murphy AC, Lalor SJ, Lynch MA, Mills KHG (2010) Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis. Brain Behav Immun 24: 641-651.
    • (2010) Brain Behav Immun , vol.24 , pp. 641-651
    • Murphy, A.C.1    Lalor, S.J.2    Lynch, M.A.3    Mills, K.H.G.4
  • 37
    • 84874099546 scopus 로고    scopus 로고
    • In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling
    • Schneider A, Long SA, Cerosaletti K, Ni CT, Samuels P, et al. (2013) In active relapsing-remitting multiple sclerosis, effector T cell resistance to adaptive T(regs) involves IL-6-mediated signaling. Sci Transl Med 5: 170ra15.
    • (2013) Sci Transl Med , vol.5
    • Schneider, A.1    Long, S.A.2    Cerosaletti, K.3    Ni, C.T.4    Samuels, P.5
  • 38
    • 0031659763 scopus 로고    scopus 로고
    • Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: Models for multiple sclerosis with primary oligodendrogliopathy
    • Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, et al. (1998) Oligodendrocyte apoptosis and primary demyelination induced by local TNF/ p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153: 801-813. (Pubitemid 28419033)
    • (1998) American Journal of Pathology , vol.153 , Issue.3 , pp. 801-813
    • Akassoglou, K.1    Bauer, J.2    Kassiotis, G.3    Pasparakis, M.4    Lassmann, H.5    Kollias, G.6    Probert, L.7
  • 39
    • 0032977543 scopus 로고    scopus 로고
    • Multiple sclerosis: Levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment
    • DOI 10.1046/j.1365-3083.1999.00546.x
    • Ozenci V, Kouwenhoven M, Huang YM, Xiao B, Kivisäkk P, et al. (1999) Multiple sclerosis: levels of interleukin-10-secreting blood mononuclear cells are low in untreated patients but augmented during interferon-beta-1b treatment. Scand J Immunol 49: 554-561. (Pubitemid 29243129)
    • (1999) Scandinavian Journal of Immunology , vol.49 , Issue.5 , pp. 554-561
    • Ozenci, V.1    Kouwenhoven, M.2    Huang, Y.-M.3    Xiao, B.-G.4    Kivisakk, P.5    Fredrikson, S.6    Link, H.7
  • 42
    • 84879087036 scopus 로고    scopus 로고
    • KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice
    • PotìF, Gualtieri F, Sacchi S, Weiben-Plenz G, Varga G, et al. (2013) KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol 33: 1505-1512.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1505-1512
    • Potì, F.1    Gualtieri, F.2    Sacchi, S.3    Weiben-Plenz, G.4    Varga, G.5
  • 43
    • 84875367110 scopus 로고    scopus 로고
    • Fingolimod phosphate promotes the neuroprotective effects of microglia
    • Noda H, Takeuchi H, Mizuno T, Suzumura A (2013) Fingolimod phosphate promotes the neuroprotective effects of microglia. J Neuroimmunol 256: 13-18.
    • (2013) J Neuroimmunol , vol.256 , pp. 13-18
    • Noda, H.1    Takeuchi, H.2    Mizuno, T.3    Suzumura, A.4
  • 44
    • 62449300643 scopus 로고    scopus 로고
    • Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy
    • Sensken S, Bode C, Gräler M (2009) Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy. J. Pharmacol. Exp. Ther. 328: 963-969.
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 963-969
    • Sensken, S.1    Bode, C.2    Gräler, M.3
  • 45
    • 65949105042 scopus 로고    scopus 로고
    • Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
    • Mullershausen F, Zecri F, Cetin C, Billich A, Guerini D, et al. (2009) Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat Chem Biol 5: 428-435.
    • (2009) Nat Chem Biol , vol.5 , pp. 428-435
    • Mullershausen, F.1    Zecri, F.2    Cetin, C.3    Billich, A.4    Guerini, D.5
  • 46
    • 79957925060 scopus 로고    scopus 로고
    • Engagement of S1P1-degradative mechanisms leads to vascular leak in mice
    • Oo ML, Chang SH, Thangada S, Wu MT, Rezaul K, et al. (2011) Engagement of S1P1-degradative mechanisms leads to vascular leak in mice. J Clin Invest 121: 2290-2300.
    • (2011) J Clin Invest , vol.121 , pp. 2290-2300
    • Oo, M.L.1    Chang, S.H.2    Thangada, S.3    Wu, M.T.4    Rezaul, K.5
  • 47
    • 34247874512 scopus 로고    scopus 로고
    • Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
    • DOI 10.1074/jbc.M610318200
    • Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, et al. (2007) Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J Biol Chem 282: 9082-9089. (Pubitemid 47093504)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.12 , pp. 9082-9089
    • Myat, L.O.1    Thangada, S.2    Wu, M.-T.3    Liu, C.H.4    Macdonald, T.L.5    Lynch, K.R.6    Lin, C.-Y.7    Hla, T.8
  • 48
    • 79551674537 scopus 로고    scopus 로고
    • FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation
    • Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, et al. (2011) FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proc Natl Acad Sci U S A. 108:751-756.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 751-756
    • Choi, J.W.1    Gardell, S.E.2    Herr, D.R.3    Rivera, R.4    Lee, C.W.5
  • 50
    • 0036551246 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses
    • Idzko M, Panther E, Corinti S, Morelli A, Ferrari D, et al. (2002) Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J 16: 625-627.
    • (2002) FASEB J , vol.16 , pp. 625-627
    • Idzko, M.1    Panther, E.2    Corinti, S.3    Morelli, A.4    Ferrari, D.5
  • 51
    • 73349109123 scopus 로고    scopus 로고
    • FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration
    • Hwang SJ, Kim JH, Kim HY, Kim S, Chung DH (2010) FTY720, a sphingosine 1-phosphate receptor modulator, inhibits CD1d-restricted NKT cells by suppressing cytokine production but not migration. Lab Investig 90: 9-19.
    • (2010) Lab Investig , vol.90 , pp. 9-19
    • Hwang, S.J.1    Kim, J.H.2    Kim, H.Y.3    Kim, S.4    Chung, D.H.5
  • 52
    • 27644518406 scopus 로고    scopus 로고
    • Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis
    • DOI 10.1016/j.cyto.2005.08.005, PII S1043466605002735, Cytokine Medicine
    • Sepulcre J, Sanchez-Ibarrola A, Moreno C, de Castro P (2005) Association between peripheral IFN-gamma producing CD8+ T-cells and disability score in relapsing-remitting multiple sclerosis. Cytokine 32: 111-116. (Pubitemid 41563041)
    • (2005) Cytokine , vol.32 , Issue.2 , pp. 111-116
    • Sepulcre, J.1    Sanchez-Ibarrola, A.2    Moreno, C.3    De Castro, P.4
  • 53
    • 0036198691 scopus 로고    scopus 로고
    • Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: A complementary mechanism for T cell activation?
    • DOI 10.1016/S0165-5728(01)00495-7, PII S0165572801004957
    • Buntinx M, Ameloot M, Steels P, Janssen P, Medaer R, et al. (2002) Interferon-gamma-induced calcium influx in T lymphocytes of multiple sclerosis and rheumatoid arthritis patients: a complementary mechanism for T cell activation? J Neuroimmunol 124: 70-82. (Pubitemid 34212012)
    • (2002) Journal of Neuroimmunology , vol.124 , Issue.1-2 , pp. 70-82
    • Buntinx, M.1    Ameloot, M.2    Steels, P.3    Janssen, P.4    Medaer, R.5    Geusens, P.6    Raus, J.7    Stinissen, P.8
  • 54
    • 0023126661 scopus 로고
    • Exacerbations of multiple sclerosis in patients treated with gamma interferon
    • Panitch H, Haley A, Hirsch R, Johnson K (1987) Exacerbations of multiple sclerosis in patients treated with gamma interferon. Lancet 329: 893-895.
    • (1987) Lancet , vol.329 , pp. 893-895
    • Panitch, H.1    Haley, A.2    Hirsch, R.3    Johnson, K.4
  • 55
    • 0033999887 scopus 로고    scopus 로고
    • Regulation of T-cell responses by CNS antigen-presenting cells: Different roles for microglia and astrocytes
    • Aloisi F, Ria F, Adorini L (2000) Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today 21: 141-147.
    • (2000) Immunol Today , vol.21 , pp. 141-147
    • Aloisi, F.1    Ria, F.2    Adorini, L.3
  • 56
    • 0034528814 scopus 로고    scopus 로고
    • Interleukin-6 concentration in serum and cerebrospinal fluid in multiple sclerosis patients
    • Stelmasiak Z, Koziol-Montewka M, Dobosz B, Rejdak K, Bartosik-Psujek H, et al. (2000) Interleukin-6 concentration in serum and cerebrospinal fluid in multiple sclerosis patients. Med Sci Monit 6: 1108-1108.
    • (2000) Med Sci Monit , vol.6 , pp. 1108-1108
    • Stelmasiak, Z.1    Koziol-Montewka, M.2    Dobosz, B.3    Rejdak, K.4    Bartosik-Psujek, H.5
  • 57
    • 55949104665 scopus 로고    scopus 로고
    • TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease
    • McCoy MK, Tansey MG (2008) TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5: 45.
    • (2008) J Neuroinflammation , vol.5 , pp. 45
    • McCoy, M.K.1    Tansey, M.G.2
  • 59
    • 0035960624 scopus 로고    scopus 로고
    • Onset of multiple sclerosis associated with anti-TNF therapy
    • Sicotte NL, Voskuhl RR (2001) Onset of multiple sclerosis associated with anti-TNF therapy. Neurology 57: 1885-1888. (Pubitemid 33096700)
    • (2001) Neurology , vol.57 , Issue.10 , pp. 1885-1888
    • Sicotte, N.L.1    Voskuhl, R.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.