FTY720-induced conversion of conventional Foxp3 -CD4 + T cells to Foxp3 + regulatory T cells in NOD mice

American Journal of Reproductive Immunology

Volumn 66, Issue 5, 2011, Pages 349-362

  Sun, Yun ^a   Wang, Wenjing ^a,b   Shan, Bin ^c   Di, Jingfang ^d   Chen, Linlin ^d   Ren, Lingling ^d   Li, Weiping ^b   Li, Da Jin ^e   Lin, Yi ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JINAN UNIVERSITY   (China)

^e FUDAN UNIVERSITY   (China)

Author keywords

Animal model; Immune modulation; Immunodeficiency; Pregnancy

Indexed keywords

CD4 ANTIGEN; FINGOLIMOD; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; EMBRYO; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; EMBRYO LOSS; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, SCID; PREGNANCY; PROPYLENE GLYCOLS; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; T-LYMPHOCYTES, REGULATORY;

EID: 80054032763     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2011.01010.x     Document Type: Article

References (39)

1. Zhang Z, Schluesener HJ: FTY720: a most promising immunosuppressant modulating immune cell functions. Mini Rev Med Chem 2007; 7:845-850.
2. Brinkmann V: Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 2007; 115:84-105.
3. Matloubian M, Lo CG, Cinamon G, Lesneski MJ, Xu Y, Brinkmann V, Allende ML, Proia RL, Cyster JG: Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004; 427:355-360.
4. Kataoka H, Sugahara K, Shimano K, Teshima K, Koyama M, Fukunari A, Chiba K: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol 2005; 2:439-448.
5. Muller H, Hofer S, Kaneider N, Neuwirt H, Mosheimer B, Mayer G, Konwalinka G, Heufler C, Tiefenthaler M: The immunomodulator FTY720 interferes with effector functions of human monocyte-derived dendritic cells. Eur J Immunol 2005; 35:533-545.
6. + regulatory T cells. J Immunol 2007; 178:2458-2468.
7. + T cell migration and prevents embryo loss in NOD mice. Fertil Steril 2009; 91:2687-2696.
8. + natural killer-cell transfer. Reproduction 2009; 137:943-955.
9. Aronovich EL, Bell JB, Khan SA, Belur LR, Gunther R, Koniar B, Schachern PA, Parker JB, Carlson CS, Whitley CB, McIvor RS, Gupta P, Hackett PB: Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. Mol Ther 2009; 17:1136-1144.
10. Lin Y, Liang Z, Chen Y, Zeng Y: TLR3-involved modulation of pregnancy tolerance in double-stranded RNA-stimulated NOD/SCID mice. J Immunol 2006; 176:4147-4154.
11. Levisetti MG, Suri A, Frederick K, Unanue ER: Absence of lymph nodes in NOD mice treated with lymphotoxin-β receptor immunoglobulin protects from diabetes. Diabetes 2004; 53:3115-3119.
12. + regulatory T cells by TGF-β induction of transcription factor Foxp3. J Exp Med 2003; 198:1875-1886.
13. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, Belkaid Y: Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 Treg cells via retinoic acid. J Exp Med 2007; 204:1775-1785.
14. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-238.
15. + regulators. J Immunol 2008; 180:7636-7647.
16. + regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J Immunol 2002; 168:4399-4405.
17. Fousteri G, Dave A, Bot A, Juntti T, Omid S, von Herrath M: Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNγ. Diabetologia 2010; 53:1958-1970.
18. Annacker O, Coombes JL, Malmstrom V, Uhlig HH, Bourne T, Johansson-Lindbom B, Agace WW, Parker CM, Powrie F: Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202:1051-1061.
19. Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ: The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009; 10:595-602.
20. + regulatory T cells control the severity of viral immunoinflammatory lesions. J Immunol 2004; 172:4123-4132.
21. Xin C, Ren S, Kleuser B, Shabahang S, Eberhardt W, Radeke H, Schafer-Korting M, Pfeilschifter J, Huwiler A: Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-β-induced cell responses. J Biol Chem 2004; 279:35255-35262.
22. Xin C, Ren S, Eberhardt W, Pfeilschifter J, Huwiler A: The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells. Br J Pharmacol 2006; 147:164-174.
23. Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK: Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest 2010; 120:1324-1336.
24. + T-regulatory cells and enhances their functional activity. J Immunol 2005; 175:7973-7980.
25. Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H: Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 2005; 6:1219-1227.
26. + regulatory T cells from peripheral Foxp3- precursors. Blood 2007; 110:4293-4302.
27. Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR: The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem 2002; 277:21453-21457.
28. Payne SG, Oskeritzian CA, Griffiths R, Subramanian P, Barbour SE, Chalfant CE, Milstien S, Spiegel S: The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors. Blood 2007; 109:1077-1085.
29. + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004; 22:531-562.
30. Tang Q, Bluestone JA: Regulatory T-cell physiology and application to treat autoimmunity. Immunol Rev 2006; 212:217-237.
31. + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12:431-440.
32. + T-cell-mediated regulation and type 1 diabetes development in NOD mice. Diabetes 2006; 55:2098-2105.
33. + T cell levels in NOD mice. Proc Natl Acad Sci USA 2002; 99:12287-12292.
34. + regulatory T cells. Immunology 2007; 121:15-28.
35. Gregori S, Giarratana N, Smiroldo S, Adorini L: Dynamics of pathogenic and suppressor T cells in autoimmune diabetes development. J Immunol 2003; 171:4040-4047.
36. + regulatory T cells during autoimmune diabetes. J Exp Med 2005; 201:1333-1346.
37. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY: Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22:329-341.
38. + regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci USA 2007; 104:18181-18186.
39. D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D: The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci USA 2008; 105:19857-19862.