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Volumn 25, Issue 5, 2011, Pages 1509-1518

Neurobiological effects of sphingosine 1-phosphate receptor modulation in the cuprizone model

Author keywords

Demyelination; Fingolimod; FTY720; Multiple sclerosis; Oligodendrocytes; Remyelination

Indexed keywords

CUPRIZONE; FINGOLIMOD; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELIN; SPHINGOSINE 1 PHOSPHATE RECEPTOR;

EID: 79955645727     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-173203     Document Type: Article
Times cited : (93)

References (62)
  • 1
    • 0038218405 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate: An enigmatic signalling lipid
    • Spiegel, S., and Milstien, S. (2003) Sphingosine-1-phosphate: an enigmatic signalling lipid. Mol. Cell. Biol. 4, 397-407
    • (2003) Mol. Cell. Biol. , vol.4 , pp. 397-407
    • Spiegel, S.1    Milstien, S.2
  • 4
    • 3242683494 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice
    • Webb, M., Tham, C. S., Lin, F. F., Lariosa-Willingham, K., Yu, N., Hale, J., Mandala, S., Chun, J., and Rao, T. S. (2004) Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol. 153, 108-121
    • (2004) J. Neuroimmunol. , vol.153 , pp. 108-121
    • Webb, M.1    Tham, C.S.2    Lin, F.F.3    Lariosa-Willingham, K.4    Yu, N.5    Hale, J.6    Mandala, S.7    Chun, J.8    Rao, T.S.9
  • 9
    • 2442679391 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors
    • Graler, M. H., and Goetzl, E. J. (2004) The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors. FASEB J. 18, 551-553
    • (2004) FASEB J. , vol.18 , pp. 551-553
    • Graler, M.H.1    Goetzl, E.J.2
  • 10
    • 0036773971 scopus 로고    scopus 로고
    • FTY720: Targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity
    • Brinkmann, V., and Lynch, K. R. (2002) FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr. Opin. Immunol. 14, 569-575
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 569-575
    • Brinkmann, V.1    Lynch, K.R.2
  • 11
    • 30044441314 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses
    • Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M. G., Wang, S. K., Jo, E., Wong, C. H., Parker, I., and Cahalan, M. D. (2005) Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. Nat. Immunol. 6, 1228-1235
    • (2005) Nat. Immunol. , vol.6 , pp. 1228-1235
    • Wei, S.H.1    Rosen, H.2    Matheu, M.P.3    Sanna, M.G.4    Wang, S.K.5    Jo, E.6    Wong, C.H.7    Parker, I.8    Cahalan, M.D.9
  • 14
    • 35348970884 scopus 로고    scopus 로고
    • Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: Consequences for mode of action in multiple sclerosis
    • Foster, C. A., Howard, L. M., Schweitzer, A., Persohn, E., Hiestand, P. C., Balatoni, B., Reuschel, R., Beerli, C., Schwartz, M., and Billich, A. (2007) Brain penetration of the oral immunomodulatory drug FTY720 and its phosphorylation in the central nervous system during experimental autoimmune encephalomyelitis: consequences for mode of action in multiple sclerosis. J. Pharmacol. Exp. Ther. 323, 469-475
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 469-475
    • Foster, C.A.1    Howard, L.M.2    Schweitzer, A.3    Persohn, E.4    Hiestand, P.C.5    Balatoni, B.6    Reuschel, R.7    Beerli, C.8    Schwartz, M.9    Billich, A.10
  • 15
    • 0141918792 scopus 로고    scopus 로고
    • Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes
    • Rao, T. S., Lariosa-Willingham, K. D., Lin, F. F., Palfreyman, E. L., Yu, N., Chun, J., and Webb, M. (2003) Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res. 990, 182-194
    • (2003) Brain Res. , vol.990 , pp. 182-194
    • Rao, T.S.1    Lariosa-Willingham, K.D.2    Lin, F.F.3    Palfreyman, E.L.4    Yu, N.5    Chun, J.6    Webb, M.7
  • 16
    • 0034924474 scopus 로고    scopus 로고
    • Sphingosine- 1-phosphate induces proliferation of astrocytes: Regulation by intracellular signalling cascades
    • Pebay, A., Toutant, M., Premont, J., Calvo, C. F., Venance, L., Cordier, J., Glowinski, J., and Tence, M. (2001) Sphingosine- 1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. Eur. J. Neurosci. 13, 2067-2076
    • (2001) Eur. J. Neurosci. , vol.13 , pp. 2067-2076
    • Pebay, A.1    Toutant, M.2    Premont, J.3    Calvo, C.F.4    Venance, L.5    Cordier, J.6    Glowinski, J.7    Tence, M.8
  • 19
    • 0346024177 scopus 로고    scopus 로고
    • Characterization of lysophosphatidic acid and sphingosine-1-phosphate- mediated signal transduction in rat cortical oligodendrocytes
    • Yu, N., Lariosa-Willingham, K. D., Lin, F. F., Webb, M., and Rao, T. S. (2004) Characterization of lysophosphatidic acid and sphingosine-1-phosphate- mediated signal transduction in rat cortical oligodendrocytes. Glia 45, 17-27
    • (2004) Glia , vol.45 , pp. 17-27
    • Yu, N.1    Lariosa-Willingham, K.D.2    Lin, F.F.3    Webb, M.4    Rao, T.S.5
  • 20
    • 34247554847 scopus 로고    scopus 로고
    • Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration
    • Novgorodov, A. S., El-Alwani, M., Bielawski, J., Obeid, L. M., and Gudz, T. I. (2007) Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration. FASEB J. 21, 1503-1514
    • (2007) FASEB J. , vol.21 , pp. 1503-1514
    • Novgorodov, A.S.1    El-Alwani, M.2    Bielawski, J.3    Obeid, L.M.4    Gudz, T.I.5
  • 21
    • 0033198306 scopus 로고    scopus 로고
    • Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes
    • Hida, H., Nagano, S., Takeda, M., and Soliven, B. (1999) Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes. J. Neurosci. 19, 7458-7467
    • (1999) J. Neurosci. , vol.19 , pp. 7458-7467
    • Hida, H.1    Nagano, S.2    Takeda, M.3    Soliven, B.4
  • 22
    • 0037213603 scopus 로고    scopus 로고
    • PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors
    • Soliven, B., Ma, L., Bae, H., Attali, B., Sobko, A., and Iwase, T. (2003) PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors. Am. J. Physiol. Cell Physiol. 284, C85-C93
    • (2003) Am. J. Physiol. Cell Physiol. , vol.284
    • Soliven, B.1    Ma, L.2    Bae, H.3    Attali, B.4    Sobko, A.5    Iwase, T.6
  • 24
    • 35348940243 scopus 로고    scopus 로고
    • Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells
    • Jung, C. G., Kim, H. J., Miron, V. E., Cook, S., Kennedy, T. E., Foster, C. A., Antel, J. P., and Soliven, B. (2007) Functional consequences of S1P receptor modulation in rat oligodendroglial lineage cells. Glia 55, 1656-1667
    • (2007) Glia , vol.55 , pp. 1656-1667
    • Jung, C.G.1    Kim, H.J.2    Miron, V.E.3    Cook, S.4    Kennedy, T.E.5    Foster, C.A.6    Antel, J.P.7    Soliven, B.8
  • 25
    • 35548984947 scopus 로고    scopus 로고
    • The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors
    • Coelho, R. P., Payne, S. G., Bittman, R., Spiegel, S., and Sato-Bigbee, C. (2007) The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. J. Pharmacol. Exp. Ther. 323, 626-635
    • (2007) J. Pharmacol. Exp. Ther. , vol.323 , pp. 626-635
    • Coelho, R.P.1    Payne, S.G.2    Bittman, R.3    Spiegel, S.4    Sato-Bigbee, C.5
  • 26
    • 39049125218 scopus 로고    scopus 로고
    • FTY720 modulates human oligodendrocyte progenitor process extension and survival
    • Miron, V. E., Jung, C. G., Kim, H. J., Kennedy, T. E., Soliven, B., and Antel, J. P. (2008) FTY720 modulates human oligodendrocyte progenitor process extension and survival. Ann. Neurol. 63, 61-71
    • (2008) Ann. Neurol. , vol.63 , pp. 61-71
    • Miron, V.E.1    Jung, C.G.2    Kim, H.J.3    Kennedy, T.E.4    Soliven, B.5    Antel, J.P.6
  • 27
    • 53149089045 scopus 로고    scopus 로고
    • Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod
    • Miron, V. E., Hall, J. A., Kennedy, T. E., Soliven, B., and Antel, J. P. (2008) Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod. Am. J. Pathol. 173, 1143-1152
    • (2008) Am. J. Pathol. , vol.173 , pp. 1143-1152
    • Miron, V.E.1    Hall, J.A.2    Kennedy, T.E.3    Soliven, B.4    Antel, J.P.5
  • 28
    • 0018234553 scopus 로고
    • Central nervous system demyelination and remyelination in the mouse: An ultrastructural study of cuprizone toxicity
    • Ludwin, S. K. (1978) Central nervous system demyelination and remyelination in the mouse: an ultrastructural study of cuprizone toxicity. Lab. Invest. 39, 597-612
    • (1978) Lab. Invest. , vol.39 , pp. 597-612
    • Ludwin, S.K.1
  • 29
    • 0032440093 scopus 로고    scopus 로고
    • Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice
    • Hiremath, M., Saito, Y., Knapp, G., Ting, J.-Y., Suzuki, K., and Matsushima, G. (1998) Microglial/macrophage accumulation during cuprizone-induced demyelination in C57BL/6 mice. J. Neuroimmunol. 92, 38-49
    • (1998) J. Neuroimmunol. , vol.92 , pp. 38-49
    • Hiremath, M.1    Saito, Y.2    Knapp, G.3    Ting, J.-Y.4    Suzuki, K.5    Matsushima, G.6
  • 30
    • 0034254162 scopus 로고    scopus 로고
    • Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination
    • Mason, J., Jones, J., Taniike, M., Morell, P., Suzuki, K., and Matsushima, G. (2000) Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. J. Neurosci. Res. 61, 251-262
    • (2000) J. Neurosci. Res. , vol.61 , pp. 251-262
    • Mason, J.1    Jones, J.2    Taniike, M.3    Morell, P.4    Suzuki, K.5    Matsushima, G.6
  • 34
    • 0242411518 scopus 로고    scopus 로고
    • G protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
    • Allende, M. L., Yamashita, T., and Proia, R. L. (2003) G protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood 102, 3665-3667
    • (2003) Blood , vol.102 , pp. 3665-3667
    • Allende, M.L.1    Yamashita, T.2    Proia, R.L.3
  • 36
    • 0035705454 scopus 로고    scopus 로고
    • TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination
    • Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., and Ting, J. P. (2001) TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4, 1116-1122
    • (2001) Nat. Neurosci. , vol.4 , pp. 1116-1122
    • Arnett, H.A.1    Mason, J.2    Marino, M.3    Suzuki, K.4    Matsushima, G.K.5    Ting, J.P.6
  • 37
    • 9144274528 scopus 로고    scopus 로고
    • + channel blockade impairs remyelination in the cuprizone model
    • + channel blockade impairs remyelination in the cuprizone model. Glia 48, 156-165
    • (2004) Glia , vol.48 , pp. 156-165
    • Bacia, A.1    Wollmann, R.2    Soliven, B.3
  • 40
    • 61449187249 scopus 로고    scopus 로고
    • Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination
    • Lindner, M., Fokuhl, J., Linsmeier, F., Trebst, C., and Stangel, M. (2009) Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination. Neurosci. Lett. 453, 120-125
    • (2009) Neurosci. Lett. , vol.453 , pp. 120-125
    • Lindner, M.1    Fokuhl, J.2    Linsmeier, F.3    Trebst, C.4    Stangel, M.5
  • 42
    • 1542425338 scopus 로고    scopus 로고
    • Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination
    • DOI 10.1016/j.mcn.2003.10.014, PII S1044743103003361
    • Woodruff, R. H., Fruttiger, M., Richardson, W. D., and Franklin, R. J. (2004) Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination. Mol. Cell. Neurosci. 25, 252-262 (Pubitemid 38344108)
    • (2004) Molecular and Cellular Neuroscience , vol.25 , Issue.2 , pp. 252-262
    • Woodruff, R.H.1    Fruttiger, M.2    Richardson, W.D.3    Franklin, R.J.M.4
  • 43
    • 0034255494 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination
    • Mason, J. L., Ye, P., Suzuki, K., D'Ercole, A. J., and Matsushima, G. K. (2000) Insulin-like growth factor-1 inhibits mature oligodendrocyte apoptosis during primary demyelination. J. Neurosci. 20, 5703-5708
    • (2000) J. Neurosci. , vol.20 , pp. 5703-5708
    • Mason, J.L.1    Ye, P.2    Suzuki, K.3    D'Ercole, A.J.4    Matsushima, G.K.5
  • 44
    • 56349129572 scopus 로고    scopus 로고
    • Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repair
    • Biancotti, J. C., Kumar, S., and de Vellis, J. (2008) Activation of inflammatory response by a combination of growth factors in cuprizone-induced demyelinated brain leads to myelin repair. Neurochem. Res. 33, 2615-2628
    • (2008) Neurochem. Res. , vol.33 , pp. 2615-2628
    • Biancotti, J.C.1    Kumar, S.2    De Vellis, J.3
  • 45
    • 0026570540 scopus 로고
    • Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination
    • Komoly, S., Hudson, L., Webster, H., and Bondy, C. (1992) Insulin-like growth factor I gene expression is induced in astrocytes during experimental demyelination. Proc. Natl. Acad. Sci. U. S. A. 89, 1894-1898
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 1894-1898
    • Komoly, S.1    Hudson, L.2    Webster, H.3    Bondy, C.4
  • 46
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang, D. R., Wang, J., Kivisakk, P., Rollins, B. J., and Ransohoff, R. M. (2001) Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193, 713-726
    • (2001) J. Exp. Med. , vol.193 , pp. 713-726
    • Huang, D.R.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 50
    • 34250864496 scopus 로고    scopus 로고
    • Microglial recruitment, activation, and proliferation in response to primary demyelination
    • DOI 10.2353/ajpath.2007.060783
    • Remington, L. T., Babcock, A. A., Zehntner, S. P., and Owens, T. (2007) Microglial recruitment, activation, and proliferation in response to primary demyelination. Am. J. Pathol. 170, 1713-1724 (Pubitemid 47339315)
    • (2007) American Journal of Pathology , vol.170 , Issue.5 , pp. 1713-1724
    • Remington, L.T.1    Babcock, A.A.2    Zehntner, S.P.3    Owens, T.4
  • 51
  • 52
    • 48049096529 scopus 로고    scopus 로고
    • Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease
    • Wu, Y. P., Mizugishi, K., Bektas, M., Sandhoff, R., and Proia, R. L. (2008) Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease. Hum. Mol. Genet. 17, 2257-2264
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2257-2264
    • Wu, Y.P.1    Mizugishi, K.2    Bektas, M.3    Sandhoff, R.4    Proia, R.L.5
  • 54
    • 33645978074 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors
    • Bassi, R., Anelli, V., Giussani, P., Tettamanti, G., Viani, P., and Riboni, L. (2006) Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. Glia 53, 621-630
    • (2006) Glia , vol.53 , pp. 621-630
    • Bassi, R.1    Anelli, V.2    Giussani, P.3    Tettamanti, G.4    Viani, P.5    Riboni, L.6
  • 55
    • 0037440379 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes
    • DOI 10.1002/glia.10180
    • Yamagata, K., Tagami, M., Torii, Y., Takenaga, F., Tsumagari, S., Itoh, S., Yamori, Y., and Nara, Y. (2003) Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. Glia 41, 199-206 (Pubitemid 36262197)
    • (2003) GLIA , vol.41 , Issue.2 , pp. 199-206
    • Yamagata, K.1    Tagami, M.2    Torii, Y.3    Takenaga, F.4    Tsumagari, S.5    Itoh, S.6    Yamori, Y.7    Nara, Y.8
  • 56
    • 74449093467 scopus 로고    scopus 로고
    • Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia
    • Nayak, D., Huo, Y., Kwang, W. X., Pushparaj, P. N., Kumar, S. D., Ling, E. A., and Dheen, S. T. Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience 166, 132-144
    • Neuroscience , vol.166 , pp. 132-144
    • Nayak, D.1    Huo, Y.2    Kwang, W.X.3    Pushparaj, P.N.4    Kumar, S.D.5    Ling, E.A.6    Dheen, S.T.7
  • 58
    • 0033395436 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells
    • DOI 10.1016/S0169-328X(99)00279-X, PII S0169328X9900279X
    • Sato, K., Ishikawa, K., Ui, M., and Okajima, F. (1999) Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. Brain Res. Mol. Brain Res. 74, 182-189 (Pubitemid 30038192)
    • (1999) Molecular Brain Research , vol.74 , Issue.1-2 , pp. 182-189
    • Sato, K.1    Ishikawa, K.2    Ui, M.3    Okajima, F.4
  • 60
    • 0030602822 scopus 로고    scopus 로고
    • Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability
    • DOI 10.1016/S0092-8674(00)80093-8
    • Coetzee, T., Fujita, N., Dupree, J., Shi, R., Blight, A., Suzuki, K., and Popko, B. (1996) Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 86, 209-219 (Pubitemid 26286104)
    • (1996) Cell , vol.86 , Issue.2 , pp. 209-219
    • Coetzee, T.1    Fujita, N.2    Dupree, J.3    Shi, R.4    Blight, A.5    Suzuki, K.6    Suzuki, K.7    Popko, B.8
  • 61
    • 34247874512 scopus 로고    scopus 로고
    • Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor
    • DOI 10.1074/jbc.M610318200
    • Oo, M. L., Thangada, S., Wu, M. T., Liu, C. H., Macdonald, T. L., Lynch, K. R., Lin, C. Y., and Hla, T. (2007) Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. J. Biol. Chem. 282, 9082-9089 (Pubitemid 47093504)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.12 , pp. 9082-9089
    • Myat, L.O.1    Thangada, S.2    Wu, M.-T.3    Liu, C.H.4    Macdonald, T.L.5    Lynch, K.R.6    Lin, C.-Y.7    Hla, T.8
  • 62
    • 65949105042 scopus 로고    scopus 로고
    • Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors
    • Mullershausen, F., Zecri, F., Cetin, C., Billich, A., Guerini, D., and Seuwen, K. (2009) Persistent signaling induced by FTY720-phosphate is mediated by internalized S1P1 receptors. Nat. Chem. Biol. 5, 428-434
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 428-434
    • Mullershausen, F.1    Zecri, F.2    Cetin, C.3    Billich, A.4    Guerini, D.5    Seuwen, K.6


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