Critical role of Jak2 in the maintenance and function of adult hematopoietic stem cells

Stem Cells

Volumn 32, Issue 7, 2014, Pages 1878-1889

  Akada, Hajime ^a   Akada, Saeko ^a   Hutchison, Robert E ^a   Sakamoto, Kazuhito ^b,c   Wagner, Kay Uwe ^b,c   Mohi, Golam ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Conditional knockout; Hematopoietic stem cells; JAK2 kinase; Proliferation; Self renewal; Signal transduction

Indexed keywords

JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STAT5 PROTEIN; STEM CELL FACTOR; THROMBOPOIETIN; JAK2 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ERYTHROCYTE COUNT; GENE EXPRESSION PROFILING; HEMATOCRIT; HEMATOPOIETIC STEM CELL; HUMAN; LEUKOCYTE COUNT; LYMPHOID PROGENITOR CELL; MEGAKARYOCYTE ERYTHROID PROGENITOR; MOUSE; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE NEOPLASM; NEUTROPHIL COUNT; NONHUMAN; PROTEIN DEPLETION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THROMBOCYTE COUNT; ADULT STEM CELL; ANIMAL; C57BL MOUSE; ENZYMOLOGY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; METABOLISM; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PHYSIOLOGY; TRANSGENIC MOUSE;

ADULT STEM CELLS; ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HEMOGLOBINURIA, PAROXYSMAL; JANUS KINASE 2; MICE, INBRED C57BL; MICE, TRANSGENIC; REACTIVE OXYGEN SPECIES; STEM CELL FACTOR; THROMBOPOIETIN;

EID: 84902593202     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1711     Document Type: Article

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