Comparative analysis of the substrate specificity of trans - Versus cis- acyltransferases of assembly line polyketide synthases

Biochemistry

Volumn 53, Issue 23, 2014, Pages 3796-3806

  Dunn, Briana J ^a   Watts, Katharine R ^b   Robbins, Thomas ^b   Cane, David E ^c   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSEMBLY; ASSEMBLY MACHINES; BIOCHEMISTRY; KETONES; PLANTS (BOTANY);

6-DEOXYERYTHRONOLIDE B SYNTHASE; ACYL CARRIER PROTEINS; CATALYTIC MECHANISMS; COMPARATIVE ANALYSIS; PING-PONG MECHANISM; POLYKETIDE BIOSYNTHESIS; POLYKETIDE SYNTHASES; SUBSTRATE SPECIFICITY;

SUBSTRATES;

6 DEOXYERYTHRONOLIDE B SYNTHASE; ACYL CARRIER PROTEIN; ACYL COENZYME A; ACYLTRANSFERASE; CARBOXYACYL COENZYME A; CIS ACYLTRANSFERASE; DISORAZOLE SYNTHASE; ETHYLMALONYL COENZYME A; KIRROMYCIN SYNTHASE; MALONYL COENZYME A; METHYLMALONYLCOENZYME A; MOCIMYCIN; POLYKETIDE SYNTHASE; TRANS ACYLTRANSFERASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CONTROLLED STUDY; ENZYME ISOLATION; ENZYME KINETICS; ENZYME SPECIFICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; TRANSACYLATION;

ACYL COENZYME A; ACYLTRANSFERASES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; MACROLIDES; MALONYL COENZYME A; MODELS, MOLECULAR; MUTANT PROTEINS; OXAZOLES; PEPTIDE FRAGMENTS; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN ENGINEERING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN SUBUNITS; PYRIDONES; RECOMBINANT FUSION PROTEINS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84902584388     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi5004316     Document Type: Article

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