Piplartine, an amide alkaloid from Piper tuberculatum, presents anxiolytic and antidepressant effects in mice

Phytomedicine

Volumn 14, Issue 9, 2007, Pages 605-612

  Cicero Bezerra Felipe F ^a   Trajano Sousa Filho, Jucélio ^a   de Oliveira Souza, Louise Emanuele ^a   Alexandre Silveira, Jefferson ^a   Esdras de Andrade Uchoa, Daniel ^a   Rocha Silveira, Edilberto ^a   Deusdênia Loiola Pessoa, Otília ^a   de Barros Viana, Glauce S ^a  

^a Faculty of Medicine of Juazeiro do Norte (FMJ)   (Brazil)

Author keywords

Antidepressant activity; Anxiolytic activity; P. tuberculatum; Piplartine

Indexed keywords

AMIDE; ANTIDEPRESSANT AGENT; BENZODIAZEPINE RECEPTOR; DIAZEPAM; FLUMAZENIL; IMIPRAMINE; MUSCLE RELAXANT AGENT; PENTETRAZOLE; PIPLARTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; FORCED SWIMMING TEST; GROOMING; LATENT PERIOD; MALE; MAZE TEST; MEDICINAL PLANT; MOUSE; MUSCLE RELAXATION; NONHUMAN; OPEN FIELD TEST; PIPER TUBERCULATUM; PIPERACEAE; PRIORITY JOURNAL; REARING; SEIZURE; TRANQUILIZING ACTIVITY;

ALKALOIDS; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAPERITONEAL; MALE; MAZE LEARNING; MICE; PENTYLENETETRAZOLE; PHYTOTHERAPY; PIPER; PIPERIDONES; PLANT EXTRACTS; PLANT ROOTS; SEIZURES;

ANIMALIA; MUS; PIPER TUBERCULATUM; PIPERACEAE;

EID: 34547430473     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.12.015     Document Type: Article

References (53)

1. Archer J. Tests for emotionality in rats and mice: a review. Animal Behav. 21 (1973) 205-235
2. Battacharya S.K. Behavioural studies on BR-16A (Mentat), a herbal psychotropic formulation. Indian J. Exp. Biol. 32 (1994) 37-43
3. Bhattacharya S.K., and Mitra S.K. Anxiolytic activity of Panax ginseng roots: an experimental study. J. Ethnopharmacol. 34 (1991) 87-92
4. Bilia A.R., Gallon S., and Vincieri F.F. Kava-kava and anxiety: growing knowledge about the efficacy and safety. Life Sci. 70 22 (2002) 2581-2597
5. Braz-Filho R., Souza M.P., and Matos M.E.O. Piplartine-dimer A, a new alkaloid from Piper tuberculatum. Phytochemistry 20 (1981) 345-346
6. Cabib S., and Puglissi-Allerga S. Opposite responses of mesolimbic dopamine system to controllable and uncontrollable aversive experiences. J. Neurosci. 14 (1994) 3333-3340
7. Cagnacci A., Arangino S., Renzi A., Zanni A.L., Malmusi S., and Volpe A. Kava-kava administration reduces anxiety in perimenopausal women. Maturitas 44 2 (2003) 103-109
8. Connor K.M., and Davidson J.RT. A placebo-controlled study of kava kava in generalized anxiety disorder. Internat. Clin. Psychopharmacol. 17 4 (2002) 185-188
9. Costall B., Hendrie C.A., Kelly M.E., and Naylor R.J. Actions of sulpiride and tiapride in a simple model of anxiety in mice. Neuropharmacology 26 (1987) 195-200
10. Cryan J.F., Markou A., and Lucki I. Assessing antidepressant activity in rodents: recent developments and future needs. Trends Pharmacol. Sci. 23 5 (2002) 238-245
11. Cunha G.M.A., Bezerra P.J.P., Saldanha M.D.D., Cavalcante M.C., Bruin V.M.S., and Viana G.S.B. Pentoxifylline improves learning and memory in glutamate-lesioned rats. Pharmacol. Biochem. Behav. 66 (2000) 687-694
12. D'Aquila O.S., Collu M., Gessa G.L., and Serra G. The role of dopamine in the mechanism of action of antidepressant drugs. Eur. J. Pharmacol. 405 (2000) 365-373
13. Decker M.W., and Mcgaugh J.L. The role of interactions between the cholinergic system and other neuromodulatory systems in learning and memory. Synapse 7 (1991) 151-168
14. Del-Bel E.A., Oliveira P.R., Oliveira J.A.C., Mishra P.K., Jobe P.C., and Garcia-Cairasco N. Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models. Braz. J. Med. Biol. Res. 30 (1997) 971-979
15. Dunham N.W., and Miya T.S. A note on a simple apparatus for detecting neurological deficits in rats and mice. J. Am. Pharm. Assoc. 46 (1957) 208
16. Dunn A.J. Stress-related activation of cerebral dopaminergic systems. Ann. NY Acad. Sci. 537 (1988) 188-205
17. Gao B., and Cutler M.G. Effects of quipirole on the behavior shown by mice in the light-dark box and during social interactions. Neuropharmacology 32 (1993) 93-100
18. Garrett K.M., Basmadjian G., Khan I.A., Schaneberg B.T., and Seale T.W. Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. Psychopharmacology 170 1 (2003) 33-41
19. Kasture V.S., Deshmukh V.K., and Chopde C.T. Anticonvulsant and behavioral actions of triterpene isolated from Rubia cordifolia Linn. Indian J. Exp. Biol. 38 (2000) 675-680
20. Khanam R., Siddiqui M.A., Pillai K.K., and Pal S.N. Antidepressant augmentation with buspirone: effects on seizure threshold and brain serotonin levels in mice. Indian J. Pharmacol. 33 (2001) 198-202
21. Lehrl S. Clinical efficacy of kava extract WS1490 in sleep disturbances associated with anxiety disorders. Results of a multicenter, randomized, placebo-controlled, double-blind clinical trial. J. Affect. Disord. 83 (2004) 287
22. Lemos T., and Cavalheiro E.A. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats. Exp. Brain Res. 102 (1995) 423-428
23. Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psycopharmacology 92 (1987) 180-185
24. Maj J., Dziedzicka-Wasylewska M., Rógoz R., and Rógoz Z. Effect of antidepressant drugs administered repeatedly on the dopamine D3 receptors in the rat brain. Eur. J. Pharmacol. 351 (1998) 31-37
25. Malsch U., and Kieser M. Efficacy of kava-kava in the treatment of non-psychotic anxiety, following pretreatment with benzodiazepines. Psychopharmacology 157 3 (2001) 277-283
26. Marescaux C., Micheletti G., Vergnes M., Depaulis A., Rumbach L., and Warter J.M. A model of chronic spontaneous petite mal-like seizures in the rat: comparison with pentylenetetrazole-induced seizures. Epilepsia 25 (1984) 326-331
27. Navickiene H.M., Alecio A.C., Kato M.J., Bolzani V.D., Young M.C., Cavalheiro A.J., and Furlan M. Antifungal amides from Piper hispidum and Piper tuberculatum. Phytochemistry 55 (2000) 621-626
28. Navickiene H.M., Bolzani V.S., Kato M.J., Pereira A.M., Bertoni B.W., Franca S.C., and Furlan M. Quantitative determination of anti-fungal and insecticide amides in adult plants, plantlets and callus from Piper tuberculatum by reverse-phase high-performance liquid chromatography. Phytochem. Anal. 14 (2003) 281-284
29. Novas M.L., Wolfman C., Medina J.H., and de Robertis E. Proconvulsant and anxiogenic effects of n-butyl beta carboline-3-carboxylate, an endogenous benzodiazepine binding inhibitor from brain. Pharmacol. Biochem. Behav. 30 (1988) 331-336
30. Pich E.M., and Samanin R. Disinhibitory effects of buspirone and low doses of sulpiride and haloperidol in two experimental anxiety models in rats: possible role of dopamine. Psychopharmacology 89 (1986) 125-130
31. Pittler, M.H., Ernst, E., 2003. Kava extract for treating anxiety. Cochrane Database Syst. Rev. CD003383.
32. Porsolt R.D., Anton G., Blavet N., and Jalfre M. Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur. J. Pharmacol. 47 (1978) 371-379
33. Przegalinski E., Tatarezynska E., and Chojnackawojcik E. Antidepressant-like activity of Ipsapirone, Buspirone and Gepirone in the forced swimming test in rats pretreated with Proadifen. J. Psychopharmacol. 4 (1990) 204-209
34. Rex A., Morgenstern E., and Fink H. Anxiolytic-like effects of kava-kava in the elevated plus maze test - a comparison with diazepam. Prog. Neuropsychopharmacol. Biol. Psychiat. 26 (2002) 855-860
35. Rogóz Z., Skuza G., and Klodzinska A. Anxiolytic- and antidepressant-like effects of 7-OH-DPAT, preferential dopamine D3 receptor agonist in rats. Polish J. Pharmacol. 56 (2004) 519-526
36. Rosenstein D.L., Nelson C.J., and Jacobs S.C. Seizures associated with antidepressants: a review. J. Clin. Psych. 54 (1993) 289-299
37. Rogoz Z., Wrobel A., Dlaboga D., and Dziedzicka-Wasylewska M. Effect of repeated treatment with mirtazapine on the central dopaminergic D2/D3 receptors. Pol. J. Pharmacol. 54 (2002) 381-389
38. Rogoz Z., and Dziedzicka-Wasylewska M. Antidepressant drugs attenuate 7-OH-DPAT-induced hypoactivity in rats. Pol. J. Pharmacol. 52 (2000) 331-336
39. Salamone J.D. The involvement of nucleus accumbens dopamine in appetitive and aversive motivation. Behav. Brain Res. 61 2 (1994) 117-133
40. Santos Jr. J.G., Monte F.H., Russi M., Agustine P.E., and Lanziotti V.M. Proconvulsant effects of high doses of venlafaxine in pentylenetetrazole-convulsive rats. Braz. J. Med. Biol. Res. 35 4 (2002) 469-472
41. Scott I.M., Jensen H., Nicol R., Lesage L., Bradbury R., Sánchez-Vindas P., Poveda L., Arnason J.T., and Philogène B.J.R. Efficacy of Piper (Piperaceae) extracts for Control of common home and garden insect pests. J. Econ. Entomol. 97 4 (2004) 1390-1403
42. Simon P., Panissaud C., and Costentin J. Anxiogenic-like effects induced by stimulation of dopamine receptors. Pharmacol. Biochem. Behav. 45 (1993) 685-690
43. Singh Y.N., and Devkota A.K. Aqueous kava extracts do not affect liver function tests in rats. Planta Med. 69 6 (2003) 496-499
44. Singh Y.N., and Singh N.N. Therapeutic potential of kava in the treatment of anxiety disorders. CNS Drugs 16 11 (2002) 731-743
45. Sokoloff P., Giros B., Martres M.P., Bouthenet M.L., and Schwartz J.C. Molecular cloning and characterization of a novel receptor D3 as a target for neuroleptics. Nature 347 (1990) 146-151
46. Steiner H., Fuchs S., and Accili D. D3 dopamine receptor-deficient mouse: evidence for reduced anxiety. Physiol. Behav. 63 (1998) 137-141
47. Thompson R., Ruch W., and Hasenohrl R.U. Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (kava-kava). Hum. Psychopharmacol. 19 4 (2004) 243-250
48. Trimble M., Anlezark G., and Meldrum B. Seizure activity in photosensitive baboons following antidepressants drugs and the role of serotonergic mechanisms. Psychopharmacology 51 (1977) 159-164
49. Trimble M.R. Monoamineoxidade inhibitor antidepressants and epilepsy: a review. Epilepsia 19 (1978) 241-250
50. Vasques S.R., Navickiene H.M., Kato M.J., Bolzani V.S., Meda C.I., Young M.C., and Furlan M. Antifungal amides from Piper arboreum and Piper tuberculatum. Phytochemistry 59 (2002) 521-527
51. Ventulani J., and Nalepa I. Antidepressants: past, present and future. Eur. J. Pharmacol. 405 (2000) 351-363
52. Vohora D., and Pillai K.K. Proconvulsant effect of buspirone and its modulation by a 2-adrenoceptor agonist in mice. Indian J. Pharmacol. 30 5 (1998) 329-333
53. Witte S., Loew D., and Gaus W. Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders. Phytother. Res. 19 3 (2005) 183-188