Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis

Biomaterials

Volumn 35, Issue 26, 2014, Pages 7574-7587

  Xu, Pengfei ^a   Yu, Haijun ^a   Zhang, Zhiwen ^a   Meng, Qingshuo ^a   Sun, Huiping ^a,b   Chen, Xianzhi ^a,b   Yin, Qi ^a   Li, Yaping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Atorvastatin; Metastasis; Micelles; Polyethylene glycol s s vitamin E succinate; Reduction responsive

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; DRUG DELIVERY; ENCAPSULATION; ENZYME INHIBITION; HYDROGEN BONDS; MICELLES; MOTION PICTURE EXPERTS GROUP STANDARDS; POLYETHYLENE GLYCOLS; TOXICITY; TUMORS;

AMPHIPHILIC CO-POLYMERS; ATORVASTATIN; ATORVASTATIN CALCIUMS; CLINICAL TRANSLATION; DRUG DELIVERY SYSTEM; ENCAPSULATION EFFICIENCY; METASTASIS; REDUCTION-RESPONSIVE;

PATHOLOGY;

ALPHA TOCOPHEROL SUCCINATE; ATORVASTATIN; GELATINASE B; GLUTATHIONE; MACROGOL; ALPHA TOCOPHEROL; DELAYED RELEASE FORMULATION; HEPTANOIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MACROGOL DERIVATIVE; MICELLE; PYRROLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CELL MIGRATION; CONTROLLED STUDY; CYTOSOL; DISTANT METASTASIS; DOWN REGULATION; DRUG LIVER LEVEL; DRUG RELEASE; DRUG TISSUE LEVEL; FEMALE; HEART; HYDROGEN BOND; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY; LIVER METASTASIS; LUNG; LUNG METASTASIS; MICELLE; MOUSE; NANOENCAPSULATION; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TUMOR INVASION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BAGG ALBINO MOUSE; BREAST; BREAST NEOPLASMS; CHEMICAL PHENOMENA; CHEMISTRY; DELAYED RELEASE FORMULATION; DRUG EFFECTS; HUMAN; LIVER; LIVER NEOPLASMS; LUNG NEOPLASMS; NUDE MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; SECONDARY; TUMOR CELL LINE;

ANIMALS; BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; FEMALE; HEPTANOIC ACIDS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; LIVER NEOPLASMS; LUNG; LUNG NEOPLASMS; MICE, INBRED BALB C; MICE, NUDE; MICELLES; OXIDATION-REDUCTION; POLYETHYLENE GLYCOLS; PYRROLES; VITAMIN E;

EID: 84902549308     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.05.030     Document Type: Article

References (48)

1. Jemal A., Center M.M., DeSantis C., Ward E.M. Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev 2010, 19:1893-1907.
2. Ma L., Reinhardt F., Pan E., Soutschek J., Bhat B., Marcusson E.G., et al. Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 2010, 28:341-347.
3. Fidler I.J. The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nat Rev Cancer 2003, 3:453-458.
4. Wulfkuhle J.D., Liotta L.A., Petricoin E.F. Proteomic applications for the early detection of cancer. Nat Rev Cancer 2003, 3:267-275.
5. Steeg P.S. Tumor metastasis: mechanistic insights and clinical challenges. Nat Med 2006, 12:895-904.
6. Chen Y., Xu P., Chen H., Li Y., Bu W., Shu Z., et al. Colloidal HPMO nanoparticles: silica-etching chemistry tailoring, topological transformation, and nano-biomedical applications. Adv Mater 2013, 25:3100-3105.
7. Veiseh O., Kievit F.M., Ellenbogen R.G., Zhang M. Cancer cell invasion: treatment and monitoring opportunities in nanomedicine. Adv Drug Deliv Rev 2011, 63:582-596.
8. Wang H., Wu Y., Zhao R., Nie G. Engineering the assemblies of biomaterial nanocarriers for delivery of multiple theranostic agents with enhanced antitumor efficacy. Adv Mater 2013, 25:1616-1622.
9. Li H.M., Yu S.S., Miteva M., Nelson C.E., Werfel T., Giorgio T.D., et al. Matrix metalloproteinase responsive, proximity-activated polymeric nanoparticles for siRNA delivery. Adv Funct Mater 2013, 23:3040-3052.
10. Gao Z.G., Tian L., Hu J., Park I.S., Bae Y.H. Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. JControl Release 2011, 152:84-89.
11. Niu C., Wang Z., Lu G., Krupka T.M., Sun Y., You Y., et al. Doxorubicin loaded superparamagnetic PLGA-iron oxide multifunctional microbubbles for dual-mode US/MR imaging and therapy of metastasis in lymph nodes. Biomaterials 2013, 34:2307-2317.
12. Shen J., Sun H., Xu P., Yin Q., Zhang Z., Wang S., et al. Simultaneous inhibition of metastasis and growth of breast cancer by co-delivery of twist shRNA and paclitaxel using pluronic P85-PEI/TPGS complex nanoparticles. Biomaterials 2013, 34:1581-1590.
13. Chaudhari K.R., Kumar A., Khandelwal V.K.M., Mishra A.K., Monkkonen J., Murthy R.S.R. Targeting efficiency and biodistribution of zoledronate conjugated docetaxel loaded pegylated PBCA nanoparticles for bone metastasis. Adv Funct Mater 2012, 22:4101-4114.
14. Lu B., Xiong S.B., Yang H., Yin X.D., Chao R.B. Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases. Eur J Pharm Sci 2006, 28:86-95.
15. Bandyopadhyay A., Wang L., Agyin J., Tang Y., Lin S., Yeh I.T., et al. Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PLoS One 2010, 5:e10365.
16. Fromigue O., Hamidouche Z., Marie P.J. Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion. JBiol Chem 2008, 283:30549-30556.
17. Collisson E.A., Kleer C., Wu M., De A., Gambhir S.S., Merajver S.D., et al. Atorvastatin prevents RhoC isoprenylation, invasion, and metastasis in human melanoma cells. Mol Cancer Ther 2003, 2:941-948.
18. Sun T.M., Du J.Z., Yan L.F., Mao H.Q., Wang J. Self-assembled biodegradable micellar nanoparticles of amphiphilic and cationic block copolymer for siRNA delivery. Biomaterials 2008, 29:4348-4355.
19. Stapelberg M., Gellert N., Swettenham E., Tomasetti M., Witting P.K., Procopio A., et al. Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. JBiol Chem 2005, 280:25369-25376.
20. Zhang M., Altuwaijri S., Yeh S. RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Oncogene 2004, 23:3080-3088.
21. Wang Y.-C., Wang F., Sun T.-M., Wang J. Redox-responsive nanoparticles from the single disulfide bond-bridged block copolymer as drug carriers for overcoming multidrug resistance in cancer cells. Bioconjug Chem 2011, 22:1939-1945.
22. Sheng R., Luo T., Zhu Y., Li H., Sun J., Chen S., et al. The intracellular plasmid DNA localization of cationic reducible cholesterol-disulfide lipids. Biomaterials 2011, 32:3507-3519.
23. Nam H.Y., Nam K., Lee M., Kim S.W., Bull D.A. Dendrimer type bio-reducible polymer for efficient gene delivery. JControl Release 2012, 160:592-600.
24. Luo Z., Cai K., Hu Y., Li J., Ding X., Zhang B., et al. Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles. Adv Mater 2012, 24:431-435.
25. Zhang Z.P., Tan S.W., Feng S.S. Vitamin E TPGS as a molecular biomaterial for drug delivery. Biomaterials 2012, 33:4889-4906.
26. Sadoqi M., Lau-Cam C.A., Wu S.H. Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry. JColloid Interface Sci 2009, 333:585-589.
27. Tevis I.D., Palmer L.C., Herman D.J., Murray I.P., Stone D.A., Stupp S.I. Self-assembly and orientation of hydrogen-bonded oligothiophene polymorphs at liquid-membrane-liquid interfaces. JAm Chem Soc 2011, 133:16486-16494.
28. Boal A.K., Ilhan F., DeRouchey J.E., Thurn-Albrecht T., Russell T.P., Rotello V.M. Self-assembly of nanoparticles into structured spherical and network aggregates. Nature 2000, 404:746-748.
29. Dong H., Dube N., Shu J.Y., Seo J.W., Mahakian L.M., Ferrara K.W., et al. Long-circulating 15 nm micelles based on amphiphilic 3-helix peptide-PEG conjugates. ACS Nano 2012, 6:5320-5329.
30. Chung J.W., Lee K., Neikirk C., Nelson C.M., Priestley R.D. Photoresponsive coumarin-stabilized polymeric nanoparticles as a detectable drug carrier. Small 2012, 8:1693-1700.
31. Zhang P., Cheetham A.G., Lin Y.A., Cui H. Self-assembled Tat nanofibers as effective drug carrier and transporter. ACS Nano 2013, 7:5965-5977.
32. Bao L., Haque A., Jackson K., Hazari S., Moroz K., Jetly R., et al. Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model. Am J Pathol 2011, 178:838-852.
33. Zhang X., Peng X., Yu W., Hou S., Zhao Y., Zhang Z., et al. Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux. Cancer Lett 2011, 307:174-181.
34. Kim Y., Pourgholami M.H., Morris D.L., Stenzel M.H. Effect of cross-linking on the performance of micelles as drug delivery carriers: a cell uptake study. Biomacromolecules 2012, 13:814-825.
35. Egeblad M., Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002, 2:161-174.
36. Gialeli C., Theocharis A.D., Karamanos N.K. Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 2011, 278:16-27.
37. Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
38. Thiery J.P., Acloque H., Huang R.Y.J., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
39. Basel M.T., Shrestha T.B., Troyer D.L., Bossmann S.H. Protease-sensitive, polymer-caged liposomes: a method for making highly targeted liposomes using triggered release. ACS Nano 2011, 5:2162-2175.
40. Kunigal S., Lakka S.S., Good C.S., Estes N., Rao J.S. RNAi-mediated downregulation of urokinase plasminogen activator receptor and matrix metalloprotease-9 in human breast cancer cells results in decreased tumor invasion, angiogenesis and growth. Int J Cancer 2007, 121:2307-2316.
41. Xu P., Yin Q., Shen J., Chen L., Yu H., Zhang Z., et al. Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS. Int J Pharm 2013, 454:21-30.
42. Esmaeili F., Dinarvand R., Ghahremani M.H., Amini M., Rouhani H., Sepehri N., et al. Docetaxel-albumin conjugates: preparation, invitro evaluation and biodistribution studies. JPharm Sci 2009, 98:2718-2730.
43. Alexis F., Pridgen E., Molnar L.K., Farokhzad O.C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 2008, 5:505-515.
44. Kievit F.M., Wang F.Y., Fang C., Mok H., Wang K., Silber J.R., et al. Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer invitro. JControl Release 2011, 152:76-83.
45. Cabral H., Matsumoto Y., Mizuno K., Chen Q., Murakami M., Kimura M., et al. Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size. Nat Nanotechnol 2011, 6:815-823.
46. Lee H., Fonge H., Hoang B., Reilly R.M., Allen C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol Pharm 2010, 7:1195-1208.
47. Kuppusamy P., Li H., Ilangovan G., Cardounel A.J., Zweier J.L., Yamada K., et al. Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels. Cancer Res 2002, 62:307-312.
48. Fang Y., Chen Y., Yu L., Zheng C., Qi Y., Li Z., et al. Inhibition of breast cancer metastases by a novel inhibitor of TGF receptor 1. JNatl Cancer Inst 2012, 105:47-58.