Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux

Cancer Letters

Volumn 307, Issue 2, 2011, Pages 174-181

  Zhang, Xuguang ^a   Peng, Xiangwen ^a   Yu, Weiping ^b   Hou, Shaoying ^a   Zhao, Yan ^a   Zhang, Zhihong ^a   Huang, Xiaoli ^a   Wu, Kun ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Alpha tocopheryl succinate ( TOS); Apoptosis; Doxorubicin (DOXO); MDR1; SGC 7901 gastric cancer cells

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CASPASE 8; CASPASE 9; DOXORUBICIN; FAS ANTIGEN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BAX;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG POTENTIATION; DRUG TRANSPORT; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; STOMACH CANCER;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; DNA PRIMERS; DOXORUBICIN; DRUG SYNERGISM; HUMANS; MICROSCOPY, CONFOCAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TOCOPHEROLS;

TOSCANA VIRUS;

EID: 79957654479     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2011.04.001     Document Type: Article

References (44)

1. Shen D.W., Cardarelli C., Hwang J., Cornwell M., Richert N., Ishii S., Pastan I., Gottesman M.M. Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine adriamycin, or vinblastine show changes in expression of specific proteins. J. Biol. Chem. 1986, 261:7762-7770.
2. Mirski S.E., Gerlach J.H., Cole S.P. Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin. Cancer Res. 1987, 47:2594-2598.
3. Pathan R.A., Singh B.K., Pillai K.K., Dubey K. Naproxen aggravates doxorubicin-induced cardiomyopathy in rats. Indian J. Pharmacol. 2010, 42:44-49.
4. Von Hoff D.D., Layard M.W., Basa P., Davis H.L., Von Hoff A.L., Rozencweig M., Muggia F.M. Risk factors for doxorubicin-induced congestive heart failure. Ann. Int. Med. 1979, 91:710-717.
5. D'Arpa P., Liu L.F. Topoisomerase-targeting antitumor drugs. Biochim. Biophys. Acta 1989, 989:163-177.
6. Sinha B.K., Mimnaugh E.G. Free radicals and anticancer drug resistance. oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors. Free Radic. Biol. Med. 1990, 8:567-581.
7. Nielsen D., Maare C., Skovsgaard T. Cellular resistance to anthracyclines. Gen. Pharmacol. 1996, 27:251-255.
8. Goasguen J.E., Dossot J.M., Fardel O., Le Mee F., Le Gall E., Leblay R., LePrise P.Y., Chaperon J., Fauchet R. Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications. Blood 1993, 81:2394-2398.
9. Ueda K., Cardarelli C., Gottesman M.M., Pastan I. Expression of a full-length cDNA for the human MDR1. Gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc. Natl Acad. Sci. USA 1987, 84:3004-3008.
10. Liu B., Wu K., Zhao D. Inhibition of human gastric carcinoma cell growth by vitamin E succinate. Wei Sheng Yan Jiu 2000, 29:172-174.
11. Sahu S.N., Edwards-Prasad J., Prasad K.N. Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture. J. Am. Coll. Nutr. 1988, 7:285-293.
12. Neuzil J., Weber T., Gellert N., Weber C. Selective cancer cell killing by alpha-tocopheryl succinate. Br. J. Cancer 2001, 84:87-89.
13. Rama B.N., Prasad K.N. Study on the specificity of alpha-tocopheryl (vitamin E) acid succinate effects on melanoma. Glioma and neuroblastoma cells in culture. Proc. Soc. Exp. Biol. Med. 1983, 174:302-307.
14. Wu K., Zhao Y., Liu B.H., Li Y., Liu F., Guo J., Yu W.P. RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. World J. Gastroenterol. 2002, 8:26-30.
15. Yu W., Israel K., Liao Q.Y., Aldaz C.M., Sanders B.G., Kline K. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43, 000 Fas in VES-triggered apoptosis. Cancer Res. 1999, 59:953-961.
16. Israel K., Yu W., Sanders B.G., Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis. Nutr. Cancer 2000, 36:90-100.
17. Bang O.S., Park J.H., Kang S.S. Activation of PKC but not of ERK is required for vitamin E-succinate-induced apoptosis of HL-60 cells. Biochem. Biophys. Res. Commun. 2001, 288:789-797.
18. Jha M.N., Bedford J.S., Cole W.C., Edward-Prasad J., Prasad K.N. Vitamin E (d-alpha-tocopheryl succinate) decreases mitotic accumulation in gamma-irradiated human tumor but not in normal, cells. Nutr. Cancer 1999, 35:189-194.
19. Fariss M.W., Fortuna M.B., Everett C.K., Smith J.D., Trent D.F., Djuric Z. The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. Cancer Res. 1994, 54:3346-3351.
20. Kumar B., Cole W.C., Prasad K.N. Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture. J. Am. Colloid Nutr. 2001, 20:628-636.
21. Ripoll E.A., Rama B.N., Webber M.M. Vitamin E enhances the chemotherapeutic effects of adriamycin on human prostatic carcinoma cells in vitro. J. Urol. 1986, 136:529-531.
22. Prasad K.N., Hernandez C., Edwards-Prasad J., Nelson J., Borus T., Robinson W.A. Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma cells in culture by a mixture of vitamins. Nutr. Cancer 1994, 22:233-245.
23. Wu K., Li Y., Zhao Y., Shan Y.J., Xia W., Yu W.P., Zhao L. Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. World J. Gastroenterol. 2002, 8:982-986.
24. Wu K., Zhao Y., Li G.C., Yu W.P. C-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells. World J. Gastroenterol. 2004, 10:1110-1114.
25. Huang X., Zhang Z., Jia L., Zhao Y., Zhang X., Wu K. Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Cancer Lett. 2010, 296:123-131.
26. Yu W., Park S.K., Jia L., Tiwary R., Scott W.W., Li J., Wang P., Simmons-Menchaca M., Sanders B.G., Kline K. RRR-gamma-tocopherol induces human breast cancer cells to undergo apoptosis via death receptor 5 (DR5)-mediated apoptotic signaling. Cancer Lett. 2008, 259:165-176.
27. Bandyopadhyay A., Wang L., Agyin J., Tang Y., Lin S., Yeh I.T., De K., Sun L.Z. Doxorubicin in combination with a small TGFbeta inhibitor: a potential novel therapy for metastatic breast cancer in mouse models. PLoS ONE 2010, 5:e10365.
28. Wong H.L., Bendayan R., Rauth A.M., Xue H.Y., Babakhanian K., Wu X.Y. A mechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle system. J. Pharmacol. Exp. Ther. 2006, 317:1372-1381.
29. Bisby R.H., Mead C., Morgan C.G. Active uptake of drugs into photosensitive liposomes and rapid release on UV photolysis. Photochem. Photobiol. 2000, 72:57-61.
30. Cao N., Feng S.S. Doxorubicin conjugated to D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS): conjugation chemistry, characterization, in vitro and in vivo evaluation. Biomaterials 2008, 29(1000):3856-3865.
31. Neuzil J. Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity. Br. J. Cancer 2003, 89:1822-1826.
32. Chen L.M., Liang Y.J., Zhang X., Su X.D., Dai C.L., Wang F.P., Yan Y.Y., Tao L.Y., Fu L.W. Reversal of P-gp-mediated multidrug resistance by Bromotetrandrine in vivo is associated with enhanced accumulation of chemotherapeutical drug in tumor tissue. Anticancer Res. 2009, 29:4597-4604.
33. Xu H.B., Li L., Liu G.Q. Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells. Pharmazie 2009, 64:660-665.
34. Wu J., Lu Y., Lee A., Pan X., Yang X., Zhao X., Lee R.J. Reversal of multidrug resistance by transferrin-conjugated liposomes co-encapsulating doxorubicin and verapamil. J. Pharm. Pharm. Sci. 2007, 10:350-357.
35. Ji B.S., He L. CJY, an isoflavone, reverses P-glycoprotein-mediated multidrug-resistance in doxorubicin-resistant human myelogenous leukaemia (K562/DOX) cells. J. Pharm. Pharmacol. 2007, 59:1011-1015.
36. Garcia M.G., Alaniz L.D., Cordo Russo R.I., Alvarez E., Hajos S.E. PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines. Leuk. Res. 2009, 33:288-296.
37. Liang J., Ge F., Guo C., Luo G., Wang X., Han G., Zhang D., Wang J., Li K., Pan Y., Yao L., Yin Z., Guo X., Wu K., Ding J., Fan D. Inhibition of PI3K/Akt partially leads to the inhibition of PrP(C)-induced drug resistance in gastric cancer cells. FEBS J. 2009, 276:685-694.
38. Seo S.B., Hur J.G., Kim M.J., Lee J.W., Kim H.B., Bae J.H., Kim D.W., Kang C.D., Kim S.H. TRAIL sensitize MDR cells to MDR-related drugs by down-regulation of P-glycoprotein through inhibition of DNA-PKcs/Akt/GSK-3beta pathway and activation of caspases. Mol. Cancer 2010, 9:199.
39. Li X., Lu Y., Liang K., Liu B., Fan Z. Differential responses to doxorubicin-induced phosphorylation and activation of Akt in human breast cancer cells. Breast Cancer Res. 2005, 7:R589-597.
40. Das K.C., White C.W. Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C. J. Biol. Chem. 1997, 272:14914-14920.
41. Shim M., Eling T.E. Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism. Mol. Cancer Ther. 2008, 7:961-971.
42. Crispen P.L., Uzzo R.G., Golovine K., Makhov P., Pollack A., Horwitz E.M., Greenberg R.E., Kolenko V.M. Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. Prostate 2007, 67:582-590.
43. Jiang X.H., Wong B.C., Lin M.C., Zhu G.H., Kung H.F., Jiang S.H., Yang D., Lam S.K. Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene 2001, 20:8009-8018.
44. Seitz S.J., Schleithoff E.S., Koch A., Schuster A., Teufel A., Staib F., Stremmel W., Melino G., Krammer P.H., Schilling T., Muller M. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int. J. Cancer 2010, 126:2049-2066.