Noninvasive imaging of tumor redox status and its modification by tissue glutathione levels

Cancer Research

Volumn 62, Issue 1, 2002, Pages 307-312

  Kuppusamy, Periannan ^a   Li, Haiquan ^a   Ilangovan, Govindasamy ^a   Cardounel, Arturo J ^a   Zweier, Jay L ^a   Yamada, Kenichi ^b   Krishna, Murali C ^b   Mitchell, James B ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BUTHIONINE SULFOXIMINE; GLUTATHIONE; NITROXIDE; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL HETEROGENEITY; CELL LEVEL; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; FEMALE; FIBROSARCOMA; HYPOXIA; IMAGING; IN VIVO STUDY; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN TENSION; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; RADIATION CARCINOGENESIS; TUMOR GROWTH;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BUTHIONINE SULFOXIMINE; ELECTRON SPIN RESONANCE SPECTROSCOPY; FEMALE; FIBROSARCOMA; GLUTATHIONE; MICE; MICE, INBRED C3H; NITROGEN OXIDES; OXIDATION-REDUCTION;

EID: 0036144680     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
2. The role of glutathione in radiation and drug induced cytotoxicity
3. Manipulation and exploitation of the tumour environment for therapeutic benefit
4. Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508
5. SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
6. Transforming growth factor β: A promotor of late connective tissue injury following radiotherapy?
7. Factors affecting nitroxide reduction in ascorbate solution and tissue homogenates
8. Principles of the metabolism of nitroxides and their implications for spin trapping
9. In vivo analysis of nitroxide radicals injected into small animals by L-BAND ESR technique
10. In vivo pharmacokinetics by electron magnetic resonance spectroscopy
11. In vivo ESR measurements of free radical reactions in living mice
12. Electron paramagnetic resonance imaging of rat heart with nitroxide and polynitroxyl-albumin
13. In vivo spin-label murine pharmacodynamics using low-frequency electron paramagnetic resonance imaging
14. Evaluation of tempol radioprotection in a murine tumor model
15. In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model
16. Reduction mechanism of the spin probe Tempol in liver microsomes
17. Validated high-performance liquid chromatography-electrochemical method for determination of glutathione and glutathione disulfide in small tissue samples
18. Three-dimensional spectral-spatial EPR imaging of free radicals in the heart: A technique for imaging tissue metabolism and oxygenation
19. Development and optimization of three-dimensional spatial EPR imaging for biological organs and tissues
20. In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl-albumin
21. A forward-subtraction procedure for removing hyperfine artifacts in electron paramagnetic resonance imaging
22. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis
23. Cell and environment interactions in tumor microregions: The multicell spheroid model
24. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
25. Barriers to drug delivery in solid tumors
26. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
27. Analysis of oxygen transport to tumor tissue by microvascular networks
28. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide
29. Reduction and destruction rates of nitroxide spin probes
30. Use of nitroxides for assessing perfusion, oxygenation, and viability of tissues: In vivo EPR and MRI studies
31. The role of thiols in cellular response to radiation and drugs
32. Cellular glutathione depletion by diethyl maleate or buthionine sulfoximine: No effect of glutathione depletion on the oxygen enhancement ratio
33. The role of glutathione in the aerobic radioresponse. I. Sensitization and recovery in the absence of intracellular glutathione
34. The effect of L-buthionine sulfoximine on the aerobic radiation response of A549 human lung carcinoma cells
35. Glutathione deficiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy
36. Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer
37. Time-dependent pharmacodynamic models in cancer chemotherapy: Population pharmacodynamic model for glutathione depletion following modulation by buthionine sulfoximine (BSO) in a Phase I trial of melphalan and BSO
38. ARCON: Accelerated radiotherapy with carbogen and nicotinamide in head and neck squamous cell carcinomas. The experience of the co-operative group of radiotherapy of the European Organization for Research and Treatment of Cancer (EORTC)
39. ARCON: Accelerated radiotherapy with carbogen and nicotinamide in non small cell lung cancer: A phase I/II study by the EORTC
40. Phase I study of continuous-infusion L-S, R-buthionine sulfoximine with intravenous melphalan