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Volumn 34, Issue 25, 2014, Pages 8630-8645

Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4

Author keywords

Adult hippocampal neurogenesis; Anxiety; GABAergic signaling; NFATc4

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CALCINEURIN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFATC4; TRANSCRIPTOME; UNCLASSIFIED DRUG; VIRUS VECTOR;

EID: 84902531805     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0047-14.2014     Document Type: Article
Times cited : (36)

References (56)
  • 1
    • 33745698913 scopus 로고    scopus 로고
    • Potential role for adult neurogenesis in the encoding of time in new memories
    • CrossRef Medline
    • Aimone JB, Wiles J, Gage FH (2006) Potential role for adult neurogenesis in the encoding of time in new memories. Nat Neurosci 9:723-727. CrossRef Medline
    • (2006) Nat Neurosci , vol.9 , pp. 723-727
    • Aimone, J.B.1    Wiles, J.2    Gage, F.H.3
  • 2
    • 1842481232 scopus 로고    scopus 로고
    • Lower hippocampal volume in patients suffering from depression: A meta-analysis
    • CrossRef Medline
    • Campbell S, Marriott M, Nahmias C, MacQueen GM (2004) Lower hippocampal volume in patients suffering from depression: a meta-analysis. Am J Psychiatry 161:598-607. CrossRef Medline
    • (2004) Am J Psychiatry , vol.161 , pp. 598-607
    • Campbell, S.1    Marriott, M.2    Nahmias, C.3    McQueen, G.M.4
  • 4
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • CrossRef Medline
    • Clipstone NA, Crabtree GR (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357:695-697. CrossRef Medline
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 5
    • 67649667324 scopus 로고    scopus 로고
    • SnapShot: Ca2+-calcineurin-NFAT signaling
    • CrossRef Medline
    • Crabtree GR, Schreiber SL (2009) SnapShot: Ca2+-calcineurin-NFAT signaling. Cell 138:210, 210, e211. CrossRef Medline
    • (2009) Cell , vol.138
    • Crabtree, G.R.1    Schreiber, S.L.2
  • 7
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: How does adult hippocampal neurogenesis affect learning and memory?
    • CrossRef Medline
    • Deng W, Aimone JB, Gage FH (2010) New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? Nat Rev Neurosci 11:339-350. CrossRef Medline
    • (2010) Nat Rev Neurosci , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 11
    • 80355132707 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation from dorsal root ganglia tissue following axonal injury
    • CrossRef Medline
    • Floriddia E, Nguyen T, Di Giovanni S (2011) Chromatin immunoprecipitation from dorsal root ganglia tissue following axonal injury. J Vis Exp 2011(5):pii:2803. CrossRef Medline
    • (2011) J Vis Exp , vol.2011 , Issue.5 , pp. 2803
    • Floriddia, E.1    Nguyen, T.2    Di Giovanni, S.3
  • 13
    • 65549133778 scopus 로고    scopus 로고
    • Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    • CrossRef Medline
    • Garthe A, Behr J, Kempermann G (2009) Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies. PLoS One 4:e5464. CrossRef Medline
    • (2009) PLoS One , vol.4
    • Garthe, A.1    Behr, J.2    Kempermann, G.3
  • 14
    • 31844447757 scopus 로고    scopus 로고
    • GABA regulates synaptic integration of newly generated neurons in the adult brain
    • CrossRef Medline
    • Ge S, Goh EL, Sailor KA, Kitabatake Y, Ming GL, Song H (2006) GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439:589-593. CrossRef Medline
    • (2006) Nature , vol.439 , pp. 589-593
    • Ge, S.1    Goh, E.L.2    Sailor, K.A.3    Kitabatake, Y.4    Ming, G.L.5    Song, H.6
  • 15
    • 33845787007 scopus 로고    scopus 로고
    • GABA sets the tempo for activitydependent adult neurogenesis
    • CrossRef Medline
    • Ge S, Pradhan DA, Ming GL, SongH (2007) GABA sets the tempo for activitydependent adult neurogenesis. Trends Neurosci 30:1-8. CrossRef Medline
    • (2007) Trends Neurosci , vol.30 , pp. 1-8
    • Ge, S.1    Pradhan, D.A.2    Ming, G.L.3    Song, H.4
  • 18
    • 0037806030 scopus 로고    scopus 로고
    • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons
    • CrossRef Medline
    • Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR (2003) Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell 113:657-670. CrossRef Medline
    • (2003) Cell , vol.113 , pp. 657-670
    • Graef, I.A.1    Wang, F.2    Charron, F.3    Chen, L.4    Neilson, J.5    Tessier-Lavigne, M.6    Crabtree, G.R.7
  • 19
    • 80355130125 scopus 로고    scopus 로고
    • Studying the integration of adult-born neurons
    • CrossRef Medline
    • Gu Y, Janoschka S, Ge S (2011) Studying the integration of adult-born neurons. J Vis Exp 2011(49):pii:2548. CrossRef Medline
    • (2011) J Vis Exp , vol.2011 , Issue.49 , pp. 2548
    • Gu, Y.1    Janoschka, S.2    Ge, S.3
  • 20
    • 0028794938 scopus 로고
    • Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the alpha 1 and alpha 5 GABAA receptor subunits
    • CrossRef Medline
    • Harris BT, Costa E, Grayson DR (1995) Exposure of neuronal cultures to K+ depolarization or to N-methyl-D-aspartate increases the transcription of genes encoding the alpha 1 and alpha 5 GABAA receptor subunits. Brain Res Mol Brain Res 28:338-342. CrossRef Medline
    • (1995) Brain Res Mol Brain Res , vol.28 , pp. 338-342
    • Harris, B.T.1    Costa, E.2    Grayson, D.R.3
  • 21
    • 0029867314 scopus 로고    scopus 로고
    • A review of the validity and variability of the elevated plusmaze as an animal model of anxiety
    • CrossRef Medline
    • Hogg S (1996) A review of the validity and variability of the elevated plusmaze as an animal model of anxiety. Pharmacol Biochem Behav 54:21-30. CrossRef Medline
    • (1996) Pharmacol Biochem Behav , vol.54 , pp. 21-30
    • Hogg, S.1
  • 23
    • 34548420558 scopus 로고    scopus 로고
    • In silico comparative genomic analysis of GABAA receptor transcriptional regulation
    • CrossRef Medline
    • Joyce CJ (2007) In silico comparative genomic analysis of GABAA receptor transcriptional regulation. BMC Genomics 8:203. CrossRef Medline
    • (2007) BMC Genomics , vol.8 , pp. 203
    • Joyce, C.J.1
  • 24
    • 0030987612 scopus 로고    scopus 로고
    • Genetic influence on neurogenesis in the dentate gyrus of adult mice
    • CrossRef Medline
    • Kempermann G, Kuhn HG, Gage FH (1997) Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A 94:10409-10414. CrossRef Medline
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10409-10414
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 25
    • 84878852857 scopus 로고    scopus 로고
    • (Radio)active Neurogenesis in the Human Hippocampus
    • CrossRef Medline
    • Kheirbek MA, Hen R (2013) (Radio)active Neurogenesis in the Human Hippocampus. Cell 153:1183-1184. CrossRef Medline
    • (2013) Cell , vol.153 , pp. 1183-1184
    • Kheirbek, M.A.1    Hen, R.2
  • 26
    • 84870558067 scopus 로고    scopus 로고
    • Neurogenesis and generalization: A new approach to stratify and treat anxiety disorders
    • CrossRef Medline
    • Kheirbek MA, Klemenhagen KC, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci 15:1613-1620. CrossRef Medline
    • (2012) Nat Neurosci , vol.15 , pp. 1613-1620
    • Kheirbek, M.A.1    Klemenhagen, K.C.2    Sahay, A.3    Hen, R.4
  • 28
    • 23844438717 scopus 로고    scopus 로고
    • Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: A meta-analysis
    • CrossRef Medline
    • Kitayama N, Vaccarino V, Kutner M, Weiss P, Bremner JD (2005) Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis. J Affect Disord 88:79-86. CrossRef Medline
    • (2005) J Affect Disord , vol.88 , pp. 79-86
    • Kitayama, N.1    Vaccarino, V.2    Kutner, M.3    Weiss, P.4    Bremner, J.D.5
  • 30
    • 77955368742 scopus 로고    scopus 로고
    • Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging
    • CrossRef Medline
    • Lugert S, Basak O, Knuckles P, Haussler U, Fabel K, Götz M, Haas CA, Kempermann G, Taylor V, GiachinoC (2010) Quiescent and active hippocampal neural stem cells with distinct morphologies respond selectively to physiological and pathological stimuli and aging. Cell Stem Cell 6:445-456. CrossRef Medline
    • (2010) Cell Stem Cell , vol.6 , pp. 445-456
    • Lugert, S.1    Basak, O.2    Knuckles, P.3    Haussler, U.4    Fabel, K.5    Götz, M.6    Haas, C.A.7    Kempermann, G.8    Taylor, V.9    Giachino, C.10
  • 31
    • 0037237412 scopus 로고    scopus 로고
    • The role of GABA in anxiety disorders
    • Medline
    • Lydiard RB (2003) The role of GABA in anxiety disorders. J Clin Psychiatry 64:21-27. Medline
    • (2003) J Clin Psychiatry , vol.64 , pp. 21-27
    • Lydiard, R.B.1
  • 32
    • 0035971436 scopus 로고    scopus 로고
    • Partners in transcription: NFAT and AP-1
    • CrossRef Medline
    • Macián F, López-Rodríguez C, Rao A (2001) Partners in transcription: NFAT and AP-1. Oncogene 20:2476-2489. CrossRef Medline
    • (2001) Oncogene , vol.20 , pp. 2476-2489
    • Macián, F.1    López-Rodríguez, C.2    Rao, A.3
  • 33
    • 33845199073 scopus 로고    scopus 로고
    • GABAA receptors in central nervous system disease: Anxiety, epilepsy, and insomnia
    • CrossRef Medline
    • Möhler H (2006) GABAA receptors in central nervous system disease: anxiety, epilepsy, and insomnia. J Recept Signal Transduct Res 26:731-740. CrossRef Medline
    • (2006) J Recept Signal Transduct Res , vol.26 , pp. 731-740
    • Möhler, H.1
  • 34
    • 4644336231 scopus 로고    scopus 로고
    • The role of GABA in the pathophysiology and treatment of anxiety disorders
    • Medline
    • Nemeroff CB (2003) The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacol Bull 37:133-146. Medline
    • (2003) Psychopharmacol Bull , vol.37 , pp. 133-146
    • Nemeroff, C.B.1
  • 35
    • 85027922397 scopus 로고    scopus 로고
    • Runninginduced anxiety is dependent on increases in hippocampal neurogenesis
    • CrossRef Medline
    • Onksen JL, Briand LA, Galante RJ, Pack AI, Blendy JA (2012) Runninginduced anxiety is dependent on increases in hippocampal neurogenesis. Genes Brain Behav 11:529-538. CrossRef Medline
    • (2012) Genes Brain Behav , vol.11 , pp. 529-538
    • Onksen, J.L.1    Briand, L.A.2    Galante, R.J.3    Pack, A.I.4    Blendy, J.A.5
  • 36
    • 80054118405 scopus 로고    scopus 로고
    • The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
    • CrossRef Medline
    • Petrik D, Lagace DC, Eisch AJ (2012) The neurogenesis hypothesis of affective and anxiety disorders: are we mistaking the scaffolding for the building? Neuropharmacology 62:21-34. CrossRef Medline
    • (2012) Neuropharmacology , vol.62 , pp. 21-34
    • Petrik, D.1    Lagace, D.C.2    Eisch, A.J.3
  • 38
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: Regulation and function
    • CrossRef Medline
    • Rao A, Luo C, Hogan PG (1997) Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol 15:707-747. CrossRef Medline
    • (1997) Annu Rev Immunol , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 40
    • 0033779701 scopus 로고    scopus 로고
    • Calcineurin: Form and function
    • Medline
    • Rusnak F, Mertz P (2000) Calcineurin: form and function. Physiol Rev 80: 1483-1521. Medline
    • (2000) Physiol Rev , vol.80 , pp. 1483-1521
    • Rusnak, F.1    Mertz, P.2
  • 43
    • 78650254503 scopus 로고    scopus 로고
    • Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress
    • CrossRef Medline
    • Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M (2010) Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry 15:1152-1163. CrossRef Medline
    • (2010) Mol Psychiatry , vol.15 , pp. 1152-1163
    • Schloesser, R.J.1    Lehmann, M.2    Martinowich, K.3    Manji, H.K.4    Herkenham, M.5
  • 44
    • 0028885878 scopus 로고
    • Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells
    • CrossRef Medline
    • Shaw KT, Ho AM, Raghavan A, Kim J, Jain J, Park J, Sharma S, Rao A, Hogan PG (1995) Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc Natl Acad Sci U S A 92:11205-11209. CrossRef Medline
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11205-11209
    • Shaw, K.T.1    Ho, A.M.2    Raghavan, A.3    Kim, J.4    Jain, J.5    Park, J.6    Sharma, S.7    Rao, A.8    Hogan, P.G.9
  • 45
    • 80052050190 scopus 로고    scopus 로고
    • Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    • CrossRef Medline
    • Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476:458-461. CrossRef Medline
    • (2011) Nature , vol.476 , pp. 458-461
    • Snyder, J.S.1    Soumier, A.2    Brewer, M.3    Pickel, J.4    Cameron, H.A.5
  • 46
    • 65549083493 scopus 로고    scopus 로고
    • Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
    • CrossRef Medline
    • Soto-Nieves N, Puga I, Abe BT, Bandyopadhyay S, Baine I, Rao A, Macián F (2009) Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance. J Exp Med 206:867-876. CrossRef Medline
    • (2009) J Exp Med , vol.206 , pp. 867-876
    • Soto-Nieves, N.1    Puga, I.2    Abe, B.T.3    Bandyopadhyay, S.4    Baine, I.5    Rao, A.6    Macián, F.7
  • 49
    • 24644506108 scopus 로고    scopus 로고
    • GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells
    • CrossRef Medline
    • Tozuka Y, Fukuda S, Namba T, Seki T, Hisatsune T (2005) GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells. Neuron 47:803-815. CrossRef Medline
    • (2005) Neuron , vol.47 , pp. 803-815
    • Tozuka, Y.1    Fukuda, S.2    Namba, T.3    Seki, T.4    Hisatsune, T.5
  • 50
    • 0028286083 scopus 로고
    • In situ hybridization evidence of differential modulation by pentobarbital of GABAA receptor alpha 1-and beta 3-subunit mRNAs
    • Medline
    • Tseng YT, Wellman SE, Ho IK (1994) In situ hybridization evidence of differential modulation by pentobarbital of GABAA receptor alpha 1-and beta 3-subunit mRNAs. J Neurochem 63:301-309. Medline
    • (1994) J Neurochem , vol.63 , pp. 301-309
    • Tseng, Y.T.1    Wellman, S.E.2    Ho, I.K.3
  • 51
    • 72849145265 scopus 로고    scopus 로고
    • Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons
    • CrossRef Medline
    • Vashishta A, Habas A, Pruunsild P, Zheng JJ, Timmusk T, HetmanM (2009) Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons. J Neurosci 29:15331-15340. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 15331-15340
    • Vashishta, A.1    Habas, A.2    Pruunsild, P.3    Zheng, J.J.4    Timmusk, T.5    Hetman, M.6
  • 52
    • 68249117473 scopus 로고    scopus 로고
    • New insights into the role of brain-derived neurotrophic factor in synaptic plasticity
    • CrossRef Medline
    • Waterhouse EG, Xu B (2009) New insights into the role of brain-derived neurotrophic factor in synaptic plasticity. Mol Cell Neurosci 42:81-89. CrossRef Medline
    • (2009) Mol Cell Neurosci , vol.42 , pp. 81-89
    • Waterhouse, E.G.1    Xu, B.2
  • 53
    • 84867266696 scopus 로고    scopus 로고
    • BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission
    • CrossRef Medline
    • Waterhouse EG, An JJ, Orefice LL, Baydyuk M, Liao GY, Zheng K, Lu B, Xu B (2012) BDNF promotes differentiation and maturation of adult-born neurons through GABAergic transmission. J Neurosci 32:14318-14330. CrossRef Medline
    • (2012) J Neurosci , vol.32 , pp. 14318-14330
    • Waterhouse, E.G.1    An, J.J.2    Orefice, L.L.3    Baydyuk, M.4    Liao, G.Y.5    Zheng, K.6    Lu, B.7    Xu, B.8
  • 54
    • 0036837672 scopus 로고    scopus 로고
    • Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth
    • CrossRef Medline
    • Wilkins BJ, De Windt LJ, Bueno OF, Braz JC, Glascock BJ, Kimball TF, Molkentin JD (2002) Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol 22:7603-7613. CrossRef Medline
    • (2002) Mol Cell Biol , vol.22 , pp. 7603-7613
    • Wilkins, B.J.1    De Windt, L.J.2    Bueno, O.F.3    Braz, J.C.4    Glascock, B.J.5    Kimball, T.F.6    Molkentin, J.D.7
  • 55
    • 77957075547 scopus 로고    scopus 로고
    • GABA(A) Increases calcium in subventricular zone astrocyte-like cells through Land T-type voltage-gated calcium channels
    • CrossRef Medline
    • Young SZ, Platel JC, Nielsen JV, Jensen NA, Bordey A (2010) GABA(A) Increases calcium in subventricular zone astrocyte-like cells through Land T-type voltage-gated calcium channels. Front Cell Neurosci 4:8. CrossRef Medline
    • (2010) Front Cell Neurosci , vol.4 , pp. 8
    • Young, S.Z.1    Platel, J.C.2    Nielsen, J.V.3    Jensen, N.A.4    Bordey, A.5
  • 56
    • 0034988351 scopus 로고    scopus 로고
    • GABA(A) but not GABA(B) receptor stimulation induces antianxiety profile in rats
    • CrossRef Medline
    • Zarrindast M, Rostami P, Sadeghi-Hariri M (2001) GABA(A) but not GABA(B) receptor stimulation induces antianxiety profile in rats. Pharmacol Biochem Behav 69:9-15. CrossRef Medline
    • (2001) Pharmacol Biochem Behav , vol.69 , pp. 9-15
    • Zarrindast, M.1    Rostami, P.2    Sadeghi-Hariri, M.3


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