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Volumn 7, Issue , 2014, Pages 1001-1014

Emerging molecular targets in oncology: Clinical potential of MEeT/hepatocyte growth-factor inhibitors

Author keywords

Cabozantinib; Colorectal cancer; Gastric cancer; Hepatocellular cancer; HGF; MET; NSCLC; Onartuzumab; Renal cancer; Rilotumumab

Indexed keywords

CABOZANTINIB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FICLATUZUMAB; FORETINIB; GANITUMAB; GEFITINIB; IRINOTECAN; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MITOXANTRONE; MONOCLONAL ANTIBODY; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; ONARTUZUMAB; PANITUMUMAB; PREDNISONE; PROTEIN TYROSINE KINASE INHIBITOR; RILOTUMUMAB; RNA; ROSIGLITAZONE; SCATTER FACTOR RECEPTOR; SERINE PROTEINASE; TIVANTINIB; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN;

EID: 84902466769     PISSN: 11786930     EISSN: None     Source Type: Journal    
DOI: 10.2147/OTT.S44941     Document Type: Review
Times cited : (97)

References (140)
  • 1
    • 0021241398 scopus 로고
    • Molecular cloning of a new transforming gene from a chemically transformed human cell line
    • Cooper CS, Park M, Blair DG, et al. Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature. 1984; 311(5981): 29-33.
    • (1984) Nature , vol.311 , Issue.5981 , pp. 29-33
    • Cooper, C.S.1    Park, M.2    Blair, D.G.3
  • 2
    • 0024523622 scopus 로고
    • Tyrosine kinase receptor indistinguishable from the c-met protein
    • Giordano S, Ponzetto C, Di Renzo MF, Cooper CS, Comoglio PM. Tyrosine kinase receptor indistinguishable from the c-met protein. Nature. 1989; 339(6220): 155-156.
    • (1989) Nature , vol.339 , Issue.6220 , pp. 155-156
    • Giordano, S.1    Ponzetto, C.2    Di Renzo, M.F.3    Cooper, C.S.4    Comoglio, P.M.5
  • 3
    • 0025734655 scopus 로고
    • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET
    • Naldini L, Vigna E, Narsimhan RP, et al. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene. 1991; 6(4): 501-504.
    • (1991) Oncogene , vol.6 , Issue.4 , pp. 501-504
    • Naldini, L.1    Vigna, E.2    Narsimhan, R.P.3
  • 4
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 1994; 77(2): 261-271.
    • (1994) Cell , vol.77 , Issue.2 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3
  • 5
    • 0032796288 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering
    • Sipeki S, Bander E, Buday L, et al. Phosphatidylinositol 3-kinase contributes to Erk1/Erk2 MAP kinase activation associated with hepatocyte growth factor-induced cell scattering. Cell Signal. 1999; 11(12): 885-890.
    • (1999) Cell Signal , vol.11 , Issue.12 , pp. 885-890
    • Sipeki, S.1    Bander, E.2    Buday, L.3
  • 7
    • 0037050212 scopus 로고    scopus 로고
    • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
    • Zhang YW, Wang LM, Jove R, Vande Woude GF. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene. 2002; 21(2): 217-226.
    • (2002) Oncogene , vol.21 , Issue.2 , pp. 217-226
    • Zhang, Y.W.1    Wang, L.M.2    Jove, R.3    Vande Woude, G.F.4
  • 8
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol. 2010; 11(12): 834-848.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.12 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 9
    • 0028899952 scopus 로고
    • Scatter factor/hepatocyte growth factor is essential for liver development
    • Schmidt C, Bladt F, Goedecke S, et al. Scatter factor/hepatocyte growth factor is essential for liver development. Nature. 1995; 373(6516): 699-702.
    • (1995) Nature , vol.373 , Issue.6516 , pp. 699-702
    • Schmidt, C.1    Bladt, F.2    Goedecke, S.3
  • 10
    • 0028911690 scopus 로고
    • Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
    • Uehara Y, Minowa O, Mori C, et al. Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor. Nature. 1995; 373(6516): 702-705.
    • (1995) Nature , vol.373 , Issue.6516 , pp. 702-705
    • Uehara, Y.1    Minowa, O.2    Mori, C.3
  • 11
    • 0031440947 scopus 로고    scopus 로고
    • Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons
    • Maina F, Hilton MC, Ponzetto C, Davies AM, Klein R. Met receptor signaling is required for sensory nerve development and HGF promotes axonal growth and survival of sensory neurons. Genes Dev. 1997; 11(24): 3341-3350.
    • (1997) Genes Dev , vol.11 , Issue.24 , pp. 3341-3350
    • Maina, F.1    Hilton, M.C.2    Ponzetto, C.3    Davies, A.M.4    Klein, R.5
  • 12
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 1995; 376(6543): 768-771.
    • (1995) Nature , vol.376 , Issue.6543 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 13
    • 34247142787 scopus 로고    scopus 로고
    • c-Met is essential for wound healing in the skin
    • Chmielowiec J, Borowiak M, Morkel M, et al. c-Met is essential for wound healing in the skin. J Cell Biol. 2007; 177(1): 151-162.
    • (2007) J Cell Biol , vol.177 , Issue.1 , pp. 151-162
    • Chmielowiec, J.1    Borowiak, M.2    Morkel, M.3
  • 14
    • 1842428601 scopus 로고    scopus 로고
    • Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair
    • Huh CG, Factor VM, Sánchez A, Uchida K, Conner EA, Thorgeirsson SS. Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair. Proc Natl Acad Sci U S A. 2004; 101(13): 4477-4482.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.13 , pp. 4477-4482
    • Huh, C.G.1    Factor, V.M.2    Sánchez, A.3    Uchida, K.4    Conner, E.A.5    Thorgeirsson, S.S.6
  • 15
    • 2942635909 scopus 로고    scopus 로고
    • Hepatocyte growth factor in kidney fibrosis: Therapeutic potential and mechanisms of action
    • Liu Y. Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action. Am J Physiol Renal Physiol. 2004; 287(1): F7-F16.
    • (2004) Am J Physiol Renal Physiol , vol.287 , Issue.1
    • Liu, Y.1
  • 16
    • 17344381429 scopus 로고    scopus 로고
    • Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
    • Schmidt L, Duh FM, Chen F, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet. 1997; 16(1): 68-73.
    • (1997) Nat Genet , vol.16 , Issue.1 , pp. 68-73
    • Schmidt, L.1    Duh, F.M.2    Chen, F.3
  • 17
  • 18
    • 0033135820 scopus 로고    scopus 로고
    • The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas
    • Nakajima M, Sawada H, Yamada Y, et al. The prognostic significance of amplification and overexpression of c-met and c-erb B-2 in human gastric carcinomas. Cancer. 1999; 85(9): 1894-1902.
    • (1999) Cancer , vol.85 , Issue.9 , pp. 1894-1902
    • Nakajima, M.1    Sawada, H.2    Yamada, Y.3
  • 21
    • 38849116986 scopus 로고    scopus 로고
    • Recurrent gene amplifications in human type I endometrial adenocarcinoma detected by fluorescence in situ hybridization
    • Samuelson E, Levan K, Adamovic T, Levan G, Horvath G. Recurrent gene amplifications in human type I endometrial adenocarcinoma detected by fluorescence in situ hybridization. Cancer Genet Cytogenet. 2008; 181(1): 25-30.
    • (2008) Cancer Genet Cytogenet , vol.181 , Issue.1 , pp. 25-30
    • Samuelson, E.1    Levan, K.2    Adamovic, T.3    Levan, G.4    Horvath, G.5
  • 22
    • 41749097250 scopus 로고    scopus 로고
    • MET gene copy number in non-small cell lung cancer: Molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
    • Beau-Faller M, Ruppert AM, Voegeli AC, et al. MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J Thorac Oncol. 2008; 3(4): 331-339.
    • (2008) J Thorac Oncol , vol.3 , Issue.4 , pp. 331-339
    • Beau-Faller, M.1    Ruppert, A.M.2    Voegeli, A.C.3
  • 23
    • 43949111293 scopus 로고    scopus 로고
    • c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases
    • Zeng ZS, Weiser MR, Kuntz E, et al. c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases. Cancer Lett. 2008; 265(2): 258-269.
    • (2008) Cancer Lett , vol.265 , Issue.2 , pp. 258-269
    • Zeng, Z.S.1    Weiser, M.R.2    Kuntz, E.3
  • 24
    • 84881542709 scopus 로고    scopus 로고
    • The emerging role of MET/HGF inhibitors in oncology
    • Scagliotti GV, Novello S, von Pawel J. The emerging role of MET/HGF inhibitors in oncology. Cancer Treat Rev. 2013; 39(7): 793-801.
    • (2013) Cancer Treat Rev , vol.39 , Issue.7 , pp. 793-801
    • Scagliotti, G.V.1    Novello, S.2    von Pawel, J.3
  • 26
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007; 316(5827): 1039-1043.
    • (2007) Science , vol.316 , Issue.5827 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 27
    • 84890781022 scopus 로고    scopus 로고
    • Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells
    • Troiani T, Martinelli E, Napolitano S, et al. Increased TGF-α as a mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab through EGFR-MET interaction and activation of MET signaling in colon cancer cells. Clin Cancer Res. 2013; 19(24): 6751-6765.
    • (2013) Clin Cancer Res , vol.19 , Issue.24 , pp. 6751-6765
    • Troiani, T.1    Martinelli, E.2    Napolitano, S.3
  • 28
    • 84878862323 scopus 로고    scopus 로고
    • Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer
    • Bardelli A, Corso S, Bertotti A, et al. Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov. 2013; 3(6): 658-673.
    • (2013) Cancer Discov , vol.3 , Issue.6 , pp. 658-673
    • Bardelli, A.1    Corso, S.2    Bertotti, A.3
  • 29
    • 70149095573 scopus 로고    scopus 로고
    • Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells
    • Sulpice E, Ding S, Muscatelli-Groux B, et al. Cross-talk between the VEGF-A and HGF signalling pathways in endothelial cells. Biol Cell. 2009; 101(9): 525-539.
    • (2009) Biol Cell , vol.101 , Issue.9 , pp. 525-539
    • Sulpice, E.1    Ding, S.2    Muscatelli-Groux, B.3
  • 30
    • 77951975325 scopus 로고    scopus 로고
    • Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
    • Vermeulen L, De Sousa EMF, van der Heijden M, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Bioly. 2010; 12(5): 468-476.
    • (2010) Nat Cell Bioly , vol.12 , Issue.5 , pp. 468-476
    • Vermeulen, L.1    De Sousa, E.M.F.2    van der Heijden, M.3
  • 31
    • 49249100382 scopus 로고    scopus 로고
    • MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin H, Yang R, Zheng Z, et al. MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Can Res. 2008; 68(11): 4360-4368.
    • (2008) Can Res , vol.68 , Issue.11 , pp. 4360-4368
    • Jin, H.1    Yang, R.2    Zheng, Z.3
  • 32
    • 76649131263 scopus 로고    scopus 로고
    • Biochemical characterization of AMG 102: A neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor
    • Burgess TL, Sun J, Meyer S, et al. Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor. Mol Cancer Ther. 2010; 9(2): 400-409.
    • (2010) Mol Cancer Ther , vol.9 , Issue.2 , pp. 400-409
    • Burgess, T.L.1    Sun, J.2    Meyer, S.3
  • 33
    • 84881405670 scopus 로고    scopus 로고
    • Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent
    • Merchant M, Ma X, Maun HR, et al. Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent. Proc Natl Acad Sci U S A. 2013; 110(32): E2987-E2996.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.32
    • Merchant, M.1    Ma, X.2    Maun, H.R.3
  • 34
    • 84879071011 scopus 로고    scopus 로고
    • Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
    • Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med. 2013; 368(25): 2385-2394.
    • (2013) N Engl J Med , vol.368 , Issue.25 , pp. 2385-2394
    • Shaw, A.T.1    Kim, D.W.2    Nakagawa, K.3
  • 35
    • 84876966952 scopus 로고    scopus 로고
    • Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: A Children's Oncology Group phase 1 consortium study
    • Mosse YP, Lim MS, Voss SD, et al. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium study. Lancet Oncol. 2013; 14(6): 472-480.
    • (2013) Lancet Oncol , vol.14 , Issue.6 , pp. 472-480
    • Mosse, Y.P.1    Lim, M.S.2    Voss, S.D.3
  • 36
    • 70350230210 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
    • Qian F, Engst S, Yamaguchi K, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res. 2009; 69(20): 8009-8016.
    • (2009) Cancer Res , vol.69 , Issue.20 , pp. 8009-8016
    • Qian, F.1    Engst, S.2    Yamaguchi, K.3
  • 37
    • 77954236265 scopus 로고    scopus 로고
    • A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2
    • Eder JP, Shapiro GI, Appleman LJ, et al. A phase I study of foretinib, a multi-targeted inhibitor of c-Met and vascular endothelial growth factor receptor 2. Clin Cancer Res. 2010; 16(13): 3507-3516.
    • (2010) Clin Cancer Res , vol.16 , Issue.13 , pp. 3507-3516
    • Eder, J.P.1    Shapiro, G.I.2    Appleman, L.J.3
  • 38
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011; 10(12): 2298-2308.
    • (2011) Mol Cancer Ther , vol.10 , Issue.12 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 39
    • 77953458271 scopus 로고    scopus 로고
    • ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity
    • Munshi N, Jeay S, Li Y, et al. ARQ 197, a novel and selective inhibitor of the human c-Met receptor tyrosine kinase with antitumor activity. Mol Cancer Ther. 2010; 9(6): 1544-1553.
    • (2010) Mol Cancer Ther , vol.9 , Issue.6 , pp. 1544-1553
    • Munshi, N.1    Jeay, S.2    Li, Y.3
  • 40
    • 0029803612 scopus 로고    scopus 로고
    • Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance
    • Ichimura E, Maeshima A, Nakajima T, Nakamura T. Expression of c-met/HGF receptor in human non-small cell lung carcinomas in vitro and in vivo and its prognostic significance. Jpn J Cancer Res. 1996; 87(10): 1063-1069.
    • (1996) Jpn J Cancer Res , vol.87 , Issue.10 , pp. 1063-1069
    • Ichimura, E.1    Maeshima, A.2    Nakajima, T.3    Nakamura, T.4
  • 41
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
    • Smolen GA, Sordella R, Muir B, et al. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A. 2006; 103(7): 2316-2321.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.7 , pp. 2316-2321
    • Smolen, G.A.1    Sordella, R.2    Muir, B.3
  • 42
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol. 2009; 4(1): 5-11.
    • (2009) J Thorac Oncol , vol.4 , Issue.1 , pp. 5-11
    • Onozato, R.1    Kosaka, T.2    Kuwano, H.3    Sekido, Y.4    Yatabe, Y.5    Mitsudomi, T.6
  • 43
    • 60549110433 scopus 로고    scopus 로고
    • MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients
    • Cappuzzo F, Janne PA, Skokan M, et al. MET increased gene copy number and primary resistance to gefitinib therapy in non-small-cell lung cancer patients. Ann Oncol. 2009; 20(2): 298-304.
    • (2009) Ann Oncol , vol.20 , Issue.2 , pp. 298-304
    • Cappuzzo, F.1    Janne, P.A.2    Skokan, M.3
  • 44
    • 0141988690 scopus 로고    scopus 로고
    • c-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
    • Ma PC, Kijima T, Maulik G, et al. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res. 2003; 63(19): 6272-6281.
    • (2003) Cancer Res , vol.63 , Issue.19 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3
  • 45
    • 84876412641 scopus 로고    scopus 로고
    • MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma: Molecular analysis of 25 ALK-positive cases
    • Boland JM, Jang JS, Li J, et al. MET and EGFR mutations identified in ALK-rearranged pulmonary adenocarcinoma: molecular analysis of 25 ALK-positive cases. J Thorac Oncol. 2013; 8(5): 574-581.
    • (2013) J Thorac Oncol , vol.8 , Issue.5 , pp. 574-581
    • Boland, J.M.1    Jang, J.S.2    Li, J.3
  • 46
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K, Sasaki H, Yukiue H, Yano M, Fujii Y. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci. 2008; 99(11): 2280-2285.
    • (2008) Cancer Sci , vol.99 , Issue.11 , pp. 2280-2285
    • Okuda, K.1    Sasaki, H.2    Yukiue, H.3    Yano, M.4    Fujii, Y.5
  • 47
    • 61549108028 scopus 로고    scopus 로고
    • Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC)
    • Lim EH, Zhang SL, Li JL, et al. Using whole genome amplification (WGA) of low-volume biopsies to assess the prognostic role of EGFR, KRAS, p53, and CMET mutations in advanced-stage non-small cell lung cancer (NSCLC). J Thorac Oncol. 2009; 4(1): 12-21.
    • (2009) J Thorac Oncol , vol.4 , Issue.1 , pp. 12-21
    • Lim, E.H.1    Zhang, S.L.2    Li, J.L.3
  • 48
    • 0031057905 scopus 로고    scopus 로고
    • Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer
    • Siegfried JM, Weissfeld LA, Singh-Kaw P, Weyant RJ, Testa JR, Landreneau RJ. Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer. Cancer Res. 1997; 57(3): 433-439.
    • (1997) Cancer Res , vol.57 , Issue.3 , pp. 433-439
    • Siegfried, J.M.1    Weissfeld, L.A.2    Singh-Kaw, P.3    Weyant, R.J.4    Testa, J.R.5    Landreneau, R.J.6
  • 49
    • 77951879838 scopus 로고    scopus 로고
    • Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
    • Onitsuka T, Uramoto H, Ono K, et al. Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status. J Thorac Oncol. 2010; 5(5): 591-596.
    • (2010) J Thorac Oncol , vol.5 , Issue.5 , pp. 591-596
    • Onitsuka, T.1    Uramoto, H.2    Ono, K.3
  • 50
    • 84857466158 scopus 로고    scopus 로고
    • Plasma hepatocyte growth factor elevation may be associated with early metastatic disease in primary lung cancer patients
    • Hosoda H, Izumi H, Tukada Y, et al. Plasma hepatocyte growth factor elevation may be associated with early metastatic disease in primary lung cancer patients. Ann Thorac Cardiovasc Surg. 2012; 18(1): 1-7.
    • (2012) Ann Thorac Cardiovasc Surg , vol.18 , Issue.1 , pp. 1-7
    • Hosoda, H.1    Izumi, H.2    Tukada, Y.3
  • 51
    • 84865676436 scopus 로고    scopus 로고
    • Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer
    • Ujiie H, Tomida M, Akiyama H, et al. Serum hepatocyte growth factor and interleukin-6 are effective prognostic markers for non-small cell lung cancer. Anticancer Res. 2012; 32(8): 3251-3258.
    • (2012) Anticancer Res , vol.32 , Issue.8 , pp. 3251-3258
    • Ujiie, H.1    Tomida, M.2    Akiyama, H.3
  • 52
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke AB, Zejnullahu K, Wu YL, et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell. 2010; 17(1): 77-88.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.L.3
  • 53
    • 81755185464 scopus 로고    scopus 로고
    • Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort
    • Yano S, Yamada T, Takeuchi S, et al. Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohort. J Thorac Oncol. 2011; 6(12): 2011-2017.
    • (2011) J Thorac Oncol , vol.6 , Issue.12 , pp. 2011-2017
    • Yano, S.1    Yamada, T.2    Takeuchi, S.3
  • 54
    • 50849141873 scopus 로고    scopus 로고
    • Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors
    • Zucali PA, Ruiz MG, Giovannetti E, et al. Role of cMET expression in non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors. Ann Oncol. 2008; 19(9): 1605-1612.
    • (2008) Ann Oncol , vol.19 , Issue.9 , pp. 1605-1612
    • Zucali, P.A.1    Ruiz, M.G.2    Giovannetti, E.3
  • 55
    • 84890108571 scopus 로고    scopus 로고
    • Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer
    • November 10
    • Spigel DR, Ervin TJ, Ramlau RA, et al. Randomized phase II trial of onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer. J Clin Oncol. November 10, 2013; 31(32): 4105-4114.
    • (2013) J Clin Oncol , vol.31 , Issue.32 , pp. 4105-4114
    • Spigel, D.R.1    Ervin, T.J.2    Ramlau, R.A.3
  • 57
    • 84902459352 scopus 로고    scopus 로고
    • Pharmacodynamic (PD)-pharmacokinetic (PK) study of ficlatuzumab (F), a monoclonal antibody (MAB) directed to the hepatocyte growth factor (HGF), in patients (Pts) with advanced solid tumors who have live metastases (Mets)
    • Elez E, Tabernero J, Prudkin L. Pharmacodynamic (PD)-pharmacokinetic (PK) study of ficlatuzumab (F), a monoclonal antibody (MAB) directed to the hepatocyte growth factor (HGF), in patients (Pts) with advanced solid tumors who have live metastases (Mets). Ann Oncol. 2012; (23 Suppl 9): 443PD.
    • (2012) Ann Oncol , Issue.23 SUPPL. 9
    • Elez, E.1    Tabernero, J.2    Prudkin, L.3
  • 58
    • 84874909621 scopus 로고    scopus 로고
    • Anti-tumor activity of SCH 900105 (AV299), an anti-HGF antibody, in non-small cell lung cancer models
    • Meetze K, Boudrow A, Connoly K. Anti-tumor activity of SCH 900105 (AV299), an anti-HGF antibody, in non-small cell lung cancer models. Mol Cancer Ther. 2009; 8 Suppl 12: C173.
    • (2009) Mol Cancer Ther , vol.8 , Issue.SUPPL. 12
    • Meetze, K.1    Boudrow, A.2    Connoly, K.3
  • 59
    • 77958463931 scopus 로고    scopus 로고
    • Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors
    • Patnaik A, Weiss GJ, Papadopoulos K, et al. Phase I study of SCH 900105 (SC), an anti-hepatocyte growth factor (HGF) monoclonal antibody (MAb), as a single agent and in combination with erlotinib (E) in patients (pts) with advanced solid tumors. J Clin Oncol. 2010; 28 Suppl 15: 2525.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15 , pp. 2525
    • Patnaik, A.1    Weiss, G.J.2    Papadopoulos, K.3
  • 60
    • 84884241108 scopus 로고    scopus 로고
    • A randomized phase (Ph) 2 study with exploratory biomarker analysis of ficlatuzumab (F) a humanized hepatocyte growth factor (HGF) inhibitory MAB in combination with gefitinib (G) versus G in Asian patients (pts) with lung adenocarcinoma (LA)
    • Mok T, Park K, Geater SL. A randomized phase (Ph) 2 study with exploratory biomarker analysis of ficlatuzumab (F) a humanized hepatocyte growth factor (HGF) inhibitory MAB in combination with gefitinib (G) versus G in Asian patients (pts) with lung adenocarcinoma (LA). Ann Oncol. 2012; 23 Suppl 9: 1198P.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Mok, T.1    Park, K.2    Geater, S.L.3
  • 61
    • 80051974548 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
    • Sequist LV, von Pawel J, Garmey EG, et al. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J Clin Oncol. 2011; 29(24): 3307-3315.
    • (2011) J Clin Oncol , vol.29 , Issue.24 , pp. 3307-3315
    • Sequist, L.V.1    von Pawel, J.2    Garmey, E.G.3
  • 64
    • 0026595807 scopus 로고
    • Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas
    • Liu C, Park M, Tsao MS. Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas. Oncogene. 1992; 7(1): 181-185.
    • (1992) Oncogene , vol.7 , Issue.1 , pp. 181-185
    • Liu, C.1    Park, M.2    Tsao, M.S.3
  • 65
    • 0031309169 scopus 로고    scopus 로고
    • Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases
    • Fujita S, Sugano K. Expression of c-met proto-oncogene in primary colorectal cancer and liver metastases. Jpn J Clin Oncol. 1997; 27(6): 378-383.
    • (1997) Jpn J Clin Oncol , vol.27 , Issue.6 , pp. 378-383
    • Fujita, S.1    Sugano, K.2
  • 66
    • 0031470998 scopus 로고    scopus 로고
    • Expression of the HGF/SF receptor, c-met, and its ligand in human colorectal cancers
    • Hiscox SE, Hallett MB, Puntis MC, Nakamura T, Jiang WG. Expression of the HGF/SF receptor, c-met, and its ligand in human colorectal cancers. Cancer Invest. 1997; 15(6): 513-521.
    • (1997) Cancer Invest , vol.15 , Issue.6 , pp. 513-521
    • Hiscox, S.E.1    Hallett, M.B.2    Puntis, M.C.3    Nakamura, T.4    Jiang, W.G.5
  • 67
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas Network
    • Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012; 487(7407): 330-337.
    • (2012) Nature , vol.487 , Issue.7407 , pp. 330-337
  • 68
    • 0035681524 scopus 로고    scopus 로고
    • Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis
    • Fazekas K, Csuka O, Köves I, Rásó E, Tímár J. Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis. Clin Exp Metastasis. 2000; 18(8): 639-649.
    • (2000) Clin Exp Metastasis , vol.18 , Issue.8 , pp. 639-649
    • Fazekas, K.1    Csuka, O.2    Köves, I.3    Rásó, E.4    Tímár, J.5
  • 69
    • 0037386758 scopus 로고    scopus 로고
    • c-MET expression level in primary colon cancer: A predictor of tumor invasion and lymph node metastases
    • Takeuchi H, Bilchik A, Saha S, et al. c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases. Clin Cancer Res. 2003; 9(4): 1480-1488.
    • (2003) Clin Cancer Res , vol.9 , Issue.4 , pp. 1480-1488
    • Takeuchi, H.1    Bilchik, A.2    Saha, S.3
  • 70
    • 33847326735 scopus 로고    scopus 로고
    • Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
    • Kammula US, Kuntz EJ, Francone TD, et al. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett. 2007; 248(2): 219-228.
    • (2007) Cancer Lett , vol.248 , Issue.2 , pp. 219-228
    • Kammula, U.S.1    Kuntz, E.J.2    Francone, T.D.3
  • 71
    • 48349119885 scopus 로고    scopus 로고
    • The prognostic significance of RON and MET receptor coexpression in patients with colorectal cancer
    • Lee CT, Chow NH, Su PF, Lin SC, Lin PC, Lee JC. The prognostic significance of RON and MET receptor coexpression in patients with colorectal cancer. Dis Colon Rectum. 2008; 51(8): 1268-1274.
    • (2008) Dis Colon Rectum , vol.51 , Issue.8 , pp. 1268-1274
    • Lee, C.T.1    Chow, N.H.2    Su, P.F.3    Lin, S.C.4    Lin, P.C.5    Lee, J.C.6
  • 73
    • 80054746340 scopus 로고    scopus 로고
    • A randomized, phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-type (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses
    • Eng C, Van Cutsem E, Nowara E, et al. A randomized, phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-type (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses. J Clin Oncol. 2011; 29 Suppl: 3500.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. , pp. 3500
    • Eng, C.1    Van Cutsem, E.2    Nowara, E.3
  • 75
    • 84883176380 scopus 로고    scopus 로고
    • Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer
    • Bendell JC, Ervin TJ, Gallinson D, et al. Treatment rationale and study design for a randomized, double-blind, placebo-controlled phase II study evaluating onartuzumab (MetMAb) in combination with bevacizumab plus mFOLFOX-6 in patients with previously untreated metastatic colorectal cancer. Clin Colorectal Cancer. 2013; 12(3): 218-222.
    • (2013) Clin Colorectal Cancer , vol.12 , Issue.3 , pp. 218-222
    • Bendell, J.C.1    Ervin, T.J.2    Gallinson, D.3
  • 76
    • 84883643499 scopus 로고    scopus 로고
    • A randomized, placebo-controlled, phase I/II study of tivantinib (ARQ 197) in combination with cetuximab and irinotecan in patients (pts) with KRAS wild-type (WT) metastatic colorectal cancer (CRC) who had received previous front-line systemic therapy
    • Eng C, Hart LL, Severtsev A, et al. A randomized, placebo-controlled, phase I/II study of tivantinib (ARQ 197) in combination with cetuximab and irinotecan in patients (pts) with KRAS wild-type (WT) metastatic colorectal cancer (CRC) who had received previous front-line systemic therapy. J Clin Oncol. 2013; Suppl 31: 3508.
    • (2013) J Clin Oncol , Issue.SUPPL. 31 , pp. 3508
    • Eng, C.1    Hart, L.L.2    Severtsev, A.3
  • 77
    • 84902531102 scopus 로고    scopus 로고
    • Phase I/II study of tivantinib (ARQ197), irinotecan, and cetuximab in patients with KRAS wild type, previously treated, metastatic colorectal cancer patients
    • PD-0018
    • Eng C, Bessudo A, Gabrail N. Phase I/II study of tivantinib (ARQ197), irinotecan, and cetuximab in patients with KRAS wild type, previously treated, metastatic colorectal cancer patients. Ann Oncol. 2012; 23 Suppl 4: PD-0018.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 4
    • Eng, C.1    Bessudo, A.2    Gabrail, N.3
  • 78
    • 84889095358 scopus 로고    scopus 로고
    • MET overexpression assessed by new interpretation method predicts gene amplification and poor survival in advanced gastric carcinomas
    • Ha SY, Lee J, Kang SY, et al. MET overexpression assessed by new interpretation method predicts gene amplification and poor survival in advanced gastric carcinomas. Mod Pathol. 2013; 26(12): 1632-1641.
    • (2013) Mod Pathol , vol.26 , Issue.12 , pp. 1632-1641
    • Ha, S.Y.1    Lee, J.2    Kang, S.Y.3
  • 79
    • 84863719409 scopus 로고    scopus 로고
    • MET in gastric carcinomas: Comparison between protein expression and gene copy number and impact on clinical outcome
    • Lee HE, Kim MA, Lee HS, et al. MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcome. Br J Cancer. 2012; 107(2): 325-333.
    • (2012) Br J Cancer , vol.107 , Issue.2 , pp. 325-333
    • Lee, H.E.1    Kim, M.A.2    Lee, H.S.3
  • 80
    • 84555202718 scopus 로고    scopus 로고
    • Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer
    • Graziano F, Galluccio N, Lorenzini P, et al. Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer. J Clin Oncol. 2011; 29(36): 4789-4795.
    • (2011) J Clin Oncol , vol.29 , Issue.36 , pp. 4789-4795
    • Graziano, F.1    Galluccio, N.2    Lorenzini, P.3
  • 81
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011; 29(36): 4803-4810.
    • (2011) J Clin Oncol , vol.29 , Issue.36 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 82
    • 0030668305 scopus 로고    scopus 로고
    • Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer
    • Tsujimoto H, Sugihara H, Hagiwara A, Hattori T. Amplification of growth factor receptor genes and DNA ploidy pattern in the progression of gastric cancer. Virchows Arch. 1997; 431(6): 383-389.
    • (1997) Virchows Arch , vol.431 , Issue.6 , pp. 383-389
    • Tsujimoto, H.1    Sugihara, H.2    Hagiwara, A.3    Hattori, T.4
  • 83
    • 84892394160 scopus 로고    scopus 로고
    • c-Met as a prognostic marker in gastric cancer: A systematic review and meta-analysis
    • Yu S, Yu Y, Zhao N, Cui J, Li W, Liu T. c-Met as a prognostic marker in gastric cancer: a systematic review and meta-analysis. PloS One. 2013; 8(11): e79137.
    • (2013) PloS One , vol.8 , Issue.11
    • Yu, S.1    Yu, Y.2    Zhao, N.3    Cui, J.4    Li, W.5    Liu, T.6
  • 84
    • 84862777035 scopus 로고    scopus 로고
    • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets
    • Deng N, Goh LK, Wang H, et al. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut. 2012; 61(5): 673-684.
    • (2012) Gut , vol.61 , Issue.5 , pp. 673-684
    • Deng, N.1    Goh, L.K.2    Wang, H.3
  • 85
    • 79953885749 scopus 로고    scopus 로고
    • Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies
    • Yap TA, Olmos D, Brunetto AT, et al. Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol. 2011; 29(10): 1271-1279.
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1271-1279
    • Yap, T.A.1    Olmos, D.2    Brunetto, A.T.3
  • 86
    • 84864281453 scopus 로고    scopus 로고
    • Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence
    • Catenacci DV, Henderson L, Xiao SY, et al. Durable complete response of metastatic gastric cancer with anti-Met therapy followed by resistance at recurrence. Cancer Discov. 2011; 1(7): 573-579.
    • (2011) Cancer Discov , vol.1 , Issue.7 , pp. 573-579
    • Catenacci, D.V.1    Henderson, L.2    Xiao, S.Y.3
  • 87
    • 84875035582 scopus 로고    scopus 로고
    • Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer
    • Shah MA, Wainberg ZA, Catenacci DV, et al. Phase II study evaluating 2 dosing schedules of oral foretinib (GSK1363089), cMET/VEGFR2 inhibitor, in patients with metastatic gastric cancer. PloS One. 2013; 8(3): e54014.
    • (2013) PloS One , vol.8 , Issue.3
    • Shah, M.A.1    Wainberg, Z.A.2    Catenacci, D.V.3
  • 88
    • 84870511276 scopus 로고    scopus 로고
    • Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer
    • Oliner KS, Tang R, Anderson A, et al. Evaluation of MET pathway biomarkers in a phase II study of rilotumumab (R, AMG 102) or placebo (P) in combination with epirubicin, cisplatin, and capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric (G) or esophagogastric junction (EGJ) cancer. J Clin Oncol. 2012; 30 Suppl: 4005.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 4005
    • Oliner, K.S.1    Tang, R.2    Anderson, A.3
  • 89
    • 84890552610 scopus 로고    scopus 로고
    • Exposure-response (E-R) analysis of rilotumumab (R, AMG 102) plus epirubicin/cisplatin/capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric or esophagogastric junction (G/EGJ) cancer
    • Zhu M, Tang R, Doshi S, et al. Exposure-response (E-R) analysis of rilotumumab (R, AMG 102) plus epirubicin/cisplatin/capecitabine (ECX) in patients (pts) with locally advanced or metastatic gastric or esophagogastric junction (G/EGJ) cancer. J Clin Oncol. 2012; 30 Suppl: 2535.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 2535
    • Zhu, M.1    Tang, R.2    Doshi, S.3
  • 92
    • 0030857813 scopus 로고    scopus 로고
    • Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met, TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas
    • Kiss A, Wang NJ, Xie JP, Thorgeirsson SS. Analysis of transforming growth factor (TGF)-alpha/epidermal growth factor receptor, hepatocyte growth factor/c-met, TGF-beta receptor type II, and p53 expression in human hepatocellular carcinomas. Clin Cancer Res. 1997; 3(7): 1059-1066.
    • (1997) Clin Cancer Res , vol.3 , Issue.7 , pp. 1059-1066
    • Kiss, A.1    Wang, N.J.2    Xie, J.P.3    Thorgeirsson, S.S.4
  • 93
    • 0031022607 scopus 로고    scopus 로고
    • Expression of HGF, its receptor c-met, c-myc, and albumin in cirrhotic and neoplastic human liver tissue
    • Ljubimova JY, Petrovic LM, Wilson SE, Geller SA, Demetriou AA. Expression of HGF, its receptor c-met, c-myc, and albumin in cirrhotic and neoplastic human liver tissue. J Histochem Cytochem. 1997; 45(1): 79-87.
    • (1997) J Histochem Cytochem , vol.45 , Issue.1 , pp. 79-87
    • Ljubimova, J.Y.1    Petrovic, L.M.2    Wilson, S.E.3    Geller, S.A.4    Demetriou, A.A.5
  • 94
    • 0033065805 scopus 로고    scopus 로고
    • Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: An immunohistochemical study
    • Okano J, Shiota G, Kawasaki H. Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver. 1999; 19(2): 151-159.
    • (1999) Liver , vol.19 , Issue.2 , pp. 151-159
    • Okano, J.1    Shiota, G.2    Kawasaki, H.3
  • 95
    • 84880917333 scopus 로고    scopus 로고
    • Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma
    • Kondo S, Ojima H, Tsuda H, et al. Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma. Int J Clin Oncol. 2013; 18(2): 207-213.
    • (2013) Int J Clin Oncol , vol.18 , Issue.2 , pp. 207-213
    • Kondo, S.1    Ojima, H.2    Tsuda, H.3
  • 96
    • 84891370054 scopus 로고    scopus 로고
    • A Survey of c-MET expression and amplification in 287 patients with hepatocellular carcinoma
    • Lee SJ, Lee J, Sohn I, et al. A Survey of c-MET expression and amplification in 287 patients with hepatocellular carcinoma. Anticancer Res. 2013; 33(11): 5179-5186.
    • (2013) Anticancer Res , vol.33 , Issue.11 , pp. 5179-5186
    • Lee, S.J.1    Lee, J.2    Sohn, I.3
  • 97
    • 44349155339 scopus 로고    scopus 로고
    • Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma
    • Osada S, Kanematsu M, Imai H, Goshima S. Clinical significance of serum HGF and c-Met expression in tumor tissue for evaluation of properties and treatment of hepatocellular carcinoma. Hepatogastroenterology. 2008; 55(82-83): 544-549.
    • (2008) Hepatogastroenterology , vol.55 , Issue.82-83 , pp. 544-549
    • Osada, S.1    Kanematsu, M.2    Imai, H.3    Goshima, S.4
  • 98
    • 61949226823 scopus 로고    scopus 로고
    • Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma
    • Ke AW, Shi GM, Zhou J, et al. Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma. Hepatology. 2009; 49(2): 491-503.
    • (2009) Hepatology , vol.49 , Issue.2 , pp. 491-503
    • Ke, A.W.1    Shi, G.M.2    Zhou, J.3
  • 99
    • 47749103018 scopus 로고    scopus 로고
    • Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: A retrospective study
    • Wang ZL, Liang P, Dong BW, Yu XL, Yu de J. Prognostic factors and recurrence of small hepatocellular carcinoma after hepatic resection or microwave ablation: a retrospective study. J Gastrointest Surg. 2008; 12(2): 327-337.
    • (2008) J Gastrointest Surg , vol.12 , Issue.2 , pp. 327-337
    • Wang, Z.L.1    Liang, P.2    Dong, B.W.3    Yu, X.L.4    de Yu, J.5
  • 100
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
    • Santoro A, Rimassa L, Borbath I, et al. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 2013; 14(1): 55-63.
    • (2013) Lancet Oncol , vol.14 , Issue.1 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 101
    • 84883272840 scopus 로고    scopus 로고
    • c-MET and HGF mRNA expression in hepatocellular carcinoma: Correlation with clinicopathological features and survival
    • Ang CS, Sun MY, Huitzil-Melendez DF, et al. c-MET and HGF mRNA expression in hepatocellular carcinoma: correlation with clinicopathological features and survival. Anticancer Res. 2013; 33(8): 3241-3245.
    • (2013) Anticancer Res , vol.33 , Issue.8 , pp. 3241-3245
    • Ang, C.S.1    Sun, M.Y.2    Huitzil-Melendez, D.F.3
  • 102
    • 85047696179 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine
    • Horiguchi N, Takayama H, Toyoda M, et al. Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine. Oncogene. 2002; 21(12): 1791-1799.
    • (2002) Oncogene , vol.21 , Issue.12 , pp. 1791-1799
    • Horiguchi, N.1    Takayama, H.2    Toyoda, M.3
  • 103
    • 27644488740 scopus 로고    scopus 로고
    • Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo
    • Zhang SZ, Pan FY, Xu JF, et al. Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol Cancer Ther. 2005; 4(10): 1577-1584.
    • (2005) Mol Cancer Ther , vol.4 , Issue.10 , pp. 1577-1584
    • Zhang, S.Z.1    Pan, F.Y.2    Xu, J.F.3
  • 104
    • 80052033164 scopus 로고    scopus 로고
    • c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma
    • You H, Ding W, Dang H, Jiang Y, Rountree CB. c-Met represents a potential therapeutic target for personalized treatment in hepatocellular carcinoma. Hepatology. 2011; 54(3): 879-889.
    • (2011) Hepatology , vol.54 , Issue.3 , pp. 879-889
    • You, H.1    Ding, W.2    Dang, H.3    Jiang, Y.4    Rountree, C.B.5
  • 106
    • 84872549428 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in hepatocellular carcinoma: Results from a phase II randomized discontinuation trial (RDT)
    • Verslype C, Cohn AL, Kelley RK, et al. Activity of cabozantinib (XL184) in hepatocellular carcinoma: results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. 2012; 30 Suppl: 4007.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 4007
    • Verslype, C.1    Cohn, A.L.2    Kelley, R.K.3
  • 107
    • 84875025156 scopus 로고    scopus 로고
    • A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC)
    • Yau TC, Sukeepaisarnjaroen W, Chao Y, et al. A phase I/II study of foretinib, an oral multikinase inhibitor targeting MET, RON, AXL, TIE-2, and VEGFR in advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2012; 30 Suppl: 4108.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. , pp. 4108
    • Yau, T.C.1    Sukeepaisarnjaroen, W.2    Chao, Y.3
  • 108
    • 84922595140 scopus 로고    scopus 로고
    • Phase I/II study of E7050 (golvantinib) in combination with sorafenib in patients (pts) with advanced hepatocellular carcinoma (HCC): Phase I results
    • O'Neil BH, Bendell JC, Modiano MR, et al. Phase I/II study of E7050 (golvantinib) in combination with sorafenib in patients (pts) with advanced hepatocellular carcinoma (HCC): Phase I results. J Clin Oncol. 2012; 30 Suppl 34: 294.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 34 , pp. 294
    • O'Neil, B.H.1    Bendell, J.C.2    Modiano, M.R.3
  • 111
    • 0036899998 scopus 로고    scopus 로고
    • High expression of the Met receptor in prostate cancer metastasis to bone
    • Knudsen BS, Gmyrek GA, Inra J, et al. High expression of the Met receptor in prostate cancer metastasis to bone. Urology. 2002; 60(6): 1113-1117.
    • (2002) Urology , vol.60 , Issue.6 , pp. 1113-1117
    • Knudsen, B.S.1    Gmyrek, G.A.2    Inra, J.3
  • 112
    • 0028979240 scopus 로고
    • C-met proto-oncogene expression in benign and malignant human prostate tissues
    • Pisters LL, Troncoso P, Zhau HE, Li W, von Eschenbach AC, Chung LW. C-met proto-oncogene expression in benign and malignant human prostate tissues. J Urol. 1995; 154(1): 293-298.
    • (1995) J Urol , vol.154 , Issue.1 , pp. 293-298
    • Pisters, L.L.1    Troncoso, P.2    Zhau, H.E.3    Li, W.4    von Eschenbach, A.C.5    Chung, L.W.6
  • 113
  • 114
    • 33847057016 scopus 로고    scopus 로고
    • The androgen receptor negatively regulates the expression of c-Met: Implications for a novel mechanism of prostate cancer progression
    • Verras M, Lee J, Xue H, Li TH, Wang Y, Sun Z. The androgen receptor negatively regulates the expression of c-Met: implications for a novel mechanism of prostate cancer progression. Cancer Res. 2007; 67(3): 967-975.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 967-975
    • Verras, M.1    Lee, J.2    Xue, H.3    Li, T.H.4    Wang, Y.5    Sun, Z.6
  • 115
    • 84874787799 scopus 로고    scopus 로고
    • Cabozantinib in patients with advanced prostate cancer: Results of a phase II randomized discontinuation trial
    • Smith DC, Smith MR, Sweeney C, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol. 2013; 31(4): 412-419.
    • (2013) J Clin Oncol , vol.31 , Issue.4 , pp. 412-419
    • Smith, D.C.1    Smith, M.R.2    Sweeney, C.3
  • 116
    • 84878961883 scopus 로고    scopus 로고
    • A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases
    • Lee RJ, Saylor PJ, Michaelson MD, et al. A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases. Clin Cancer Res. 2013; 19(11): 3088-3094.
    • (2013) Clin Cancer Res , vol.19 , Issue.11 , pp. 3088-3094
    • Lee, R.J.1    Saylor, P.J.2    Michaelson, M.D.3
  • 117
    • 84893431484 scopus 로고    scopus 로고
    • Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions
    • Dai J, Zhang H, Karatsinides A, et al. Cabozantinib inhibits prostate cancer growth and prevents tumor-induced bone lesions. Clin Cancer Res. 2014; 20(3): 617-630.
    • (2014) Clin Cancer Res , vol.20 , Issue.3 , pp. 617-630
    • Dai, J.1    Zhang, H.2    Karatsinides, A.3
  • 121
    • 84871962904 scopus 로고    scopus 로고
    • Targeted MET inhibition in castration-resistant prostate cancer: A randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone
    • Ryan CJ, Rosenthal M, Ng S, et al. Targeted MET inhibition in castration-resistant prostate cancer: a randomized phase II study and biomarker analysis with rilotumumab plus mitoxantrone and prednisone. Clin Cancer Res. 2013; 19(1): 215-224.
    • (2013) Clin Cancer Res , vol.19 , Issue.1 , pp. 215-224
    • Ryan, C.J.1    Rosenthal, M.2    Ng, S.3
  • 122
    • 33645731190 scopus 로고    scopus 로고
    • Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma
    • Nakaigawa N, Yao M, Baba M, et al. Inactivation of von Hippel-Lindau gene induces constitutive phosphorylation of MET protein in clear cell renal carcinoma. Cancer Res. 2006; 66(7): 3699-3705.
    • (2006) Cancer Res , vol.66 , Issue.7 , pp. 3699-3705
    • Nakaigawa, N.1    Yao, M.2    Baba, M.3
  • 123
    • 84873832718 scopus 로고    scopus 로고
    • c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma
    • Gibney GT, Aziz SA, Camp RL, et al. c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma. Ann Oncol. 2013; 24(2): 343-349.
    • (2013) Ann Oncol , vol.24 , Issue.2 , pp. 343-349
    • Gibney, G.T.1    Aziz, S.A.2    Camp, R.L.3
  • 124
    • 80051991655 scopus 로고    scopus 로고
    • A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma
    • Schoffski P, Garcia JA, Stadler WM, et al. A phase II study of the efficacy and safety of AMG 102 in patients with metastatic renal cell carcinoma. BJU Int. 2011; 108(5): 679-686.
    • (2011) BJU Int , vol.108 , Issue.5 , pp. 679-686
    • Schoffski, P.1    Garcia, J.A.2    Stadler, W.M.3
  • 125
    • 84867827863 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in patients (pts) with metastatic, refractory renal cell carcinoma (RCC)
    • Choueiri TK, Pal SK, McDermott DF, et al. Activity of cabozantinib (XL184) in patients (pts) with metastatic, refractory renal cell carcinoma (RCC). J Clin Oncol. 2012; 30 Suppl 5: 364.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL. 5 , pp. 364
    • Choueiri, T.K.1    Pal, S.K.2    McDermott, D.F.3
  • 128
    • 84872548337 scopus 로고    scopus 로고
    • Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma
    • Choueiri TK, Vaishampayan U, Rosenberg JE, et al. Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol. 2013; 31(2): 181-186.
    • (2013) J Clin Oncol , vol.31 , Issue.2 , pp. 181-186
    • Choueiri, T.K.1    Vaishampayan, U.2    Rosenberg, J.E.3
  • 129
    • 74549174584 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a Fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors
    • Gordon MS, Sweeney CJ, Mendelson DS, et al. Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a Fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Clin Cancer Res. 2010; 16(2): 699-710.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 699-710
    • Gordon, M.S.1    Sweeney, C.J.2    Mendelson, D.S.3
  • 130
    • 84896514016 scopus 로고    scopus 로고
    • Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies
    • Salgia R, Patel P, Bothos J, et al. Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies. Clin Cancer Res. 2014; 20(6): 1666-1675.
    • (2014) Clin Cancer Res , vol.20 , Issue.6 , pp. 1666-1675
    • Salgia, R.1    Patel, P.2    Bothos, J.3
  • 131
    • 15244345941 scopus 로고    scopus 로고
    • The MET oncogene drives a genetic programme linking cancer to haemostasis
    • Boccaccio C, Sabatino G, Medico E, et al. The MET oncogene drives a genetic programme linking cancer to haemostasis. Nature. 2005; 434(7031): 396-400.
    • (2005) Nature , vol.434 , Issue.7031 , pp. 396-400
    • Boccaccio, C.1    Sabatino, G.2    Medico, E.3
  • 132
    • 84877097337 scopus 로고    scopus 로고
    • Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET
    • Basilico C, Pennacchietti S, Vigna E, et al. Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET. Clin Cancer Res. 2013; 19(9): 2381-2392.
    • (2013) Clin Cancer Res , vol.19 , Issue.9 , pp. 2381-2392
    • Basilico, C.1    Pennacchietti, S.2    Vigna, E.3
  • 133
    • 56249137901 scopus 로고    scopus 로고
    • HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells
    • Bachleitner-Hofmann T, Sun MY, Chen CT, et al. HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells. Mol Cancer Ther. 2008; 7(11): 3499-3508.
    • (2008) Mol Cancer Ther , vol.7 , Issue.11 , pp. 3499-3508
    • Bachleitner-Hofmann, T.1    Sun, M.Y.2    Chen, C.T.3
  • 134
    • 79551559942 scopus 로고    scopus 로고
    • Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors
    • Qi J, McTigue MA, Rogers A, et al. Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitors. Cancer Res. 2011; 71(3): 1081-1091.
    • (2011) Cancer Res , vol.71 , Issue.3 , pp. 1081-1091
    • Qi, J.1    McTigue, M.A.2    Rogers, A.3
  • 135
    • 76749157917 scopus 로고    scopus 로고
    • Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency
    • McDermott U, Pusapati RV, Christensen JG, Gray NS, Settleman J. Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency. Cancer Res. 2010; 70(4): 1625-1634.
    • (2010) Cancer Res , vol.70 , Issue.4 , pp. 1625-1634
    • McDermott, U.1    Pusapati, R.V.2    Christensen, J.G.3    Gray, N.S.4    Settleman, J.5
  • 136
    • 77957328515 scopus 로고    scopus 로고
    • MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors
    • Cepero V, Sierra JR, Corso S, et al. MET and KRAS gene amplification mediates acquired resistance to MET tyrosine kinase inhibitors. Cancer Res. 2010; 70(19): 7580-7590.
    • (2010) Cancer Res , vol.70 , Issue.19 , pp. 7580-7590
    • Cepero, V.1    Sierra, J.R.2    Corso, S.3
  • 137
    • 84862697903 scopus 로고    scopus 로고
    • A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
    • Lee NV, Lira ME, Pavlicek A, et al. A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation. PloS One. 2012; 7(6): e39653.
    • (2012) PloS One , vol.7 , Issue.6
    • Lee, N.V.1    Lira, M.E.2    Pavlicek, A.3
  • 138
    • 84892607231 scopus 로고    scopus 로고
    • Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer
    • Fong JT, Jacobs RJ, Moravec DN, et al. Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer. PloS One. 2013; 8(11): e78398.
    • (2013) PloS One , vol.8 , Issue.11
    • Fong, J.T.1    Jacobs, R.J.2    Moravec, D.N.3
  • 139
    • 76749097199 scopus 로고    scopus 로고
    • MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor
    • Pan B-S, Chan GKY, Chenard M, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010; 70(4): 1524-1533.
    • (2010) Cancer Res , vol.70 , Issue.4 , pp. 1524-1533
    • Pan, B.-S.1    Chan, G.K.Y.2    Chenard, M.3
  • 140
    • 41449107739 scopus 로고    scopus 로고
    • c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations
    • Bellon SF, Kaplan-Lefko P, Yang Y, et al. c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations. J Biol Chem. 2008; 283(5): 2675-2683.
    • (2008) J Biol Chem , vol.283 , Issue.5 , pp. 2675-2683
    • Bellon, S.F.1    Kaplan-Lefko, P.2    Yang, Y.3


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