Recurrent gene amplifications in human type I endometrial adenocarcinoma detected by fluorescence in situ hybridization

Cancer Genetics and Cytogenetics

Volumn 181, Issue 1, 2008, Pages 25-30

  Samuelson, Emma ^a   Levan, Kristina ^a   Adamovic, Tatjana ^a   Levan, Göran ^a   Horvath, György ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 6; CYTOCHROME P450; DEAD BOX POLYPEPTIDE 1; DEAD BOX PROTEIN; ORNITHINE DECARBOXYLASE; PHOSPHOPROTEIN PHOSPHATASE; PREPROTACHYKININ; PROOPIOMELANOCORTIN; PROTEIN KINASE C EPSILON; PROTEIN PHOSPHATASE 1 BETA; RIBONUCLEOTIDE REDUCTASE; SYNDECAN 1; UNCLASSIFIED DRUG; XANTHINE DEHYDROGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CANCER SUSCEPTIBILITY; CHROMOSOME 2P; CHROMOSOME 7Q; CONTROLLED STUDY; CYTOGENETICS; ENDOMETRIUM CARCINOMA; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; RAT;

ADENOCARCINOMA; ARYL HYDROCARBON HYDROXYLASES; CHROMOSOME MAPPING; CLONING, MOLECULAR; CYCLIN-DEPENDENT KINASE 6; ENDOMETRIAL NEOPLASMS; FEMALE; GENE AMPLIFICATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; NEOPLASM STAGING; NUCLEIC ACID HYBRIDIZATION; PROTO-ONCOGENE PROTEINS; RECEPTORS, GROWTH FACTOR; SYNDECAN-1;

ANIMALIA; RATTUS;

EID: 38849116986     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2007.11.006     Document Type: Article

References (22)

1. Karlsson A., Helou K., Walentinsson A., Hedrich H.J., Szpirer C., and Levan G. Amplification of Mycn, Ddx1, Rrm2, and Odc1 in rat uterine endometrial carcinomas. Genes Chromosomes Cancer 31 (2001) 345-356
2. Adamovic T., Trossö F., Roshani L., Andersson L., Petersen G., Rajaei S., Helou K., and Levan G. Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinomas as revealed by combined BAC/PAC FISH analysis, chromosome painting, zoo-FISH, and allelotyping analysis. Genes Chromosomes Cancer 44 (2005) 139-153
3. Walentinsson A., Helou K., Wallenius V., Hedrich H.J., Szpirer C., and Levan G. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Cancer Res 61 (2001) 8263-8273
4. Samuelson E., Nordlander C., Levan G., and Behboudi A. Amplification studies of Met and Cdk6 in a rat endometrial tumor model and the correlation to human type I endometrial carcinoma tumors. In: Li J.J., Li S.A., Mohla S., Rochefort H., and Maudelone T. (Eds). Hormonal carcinogenesis V: Proceedings of the Fifth International Symposium (2008), Springer, New York (in press)
5. Levan K., Partheen K., Osterberg L., Helou K., and Horvath G. Chromosomal alterations in 98 endometrioid adenocarcinomas analyzed with comparative genomic hybridization. Cytogenet Genome Res 115 (2006) 16-22
6. Botti C., Pescatore B., Mottolese M., Sciarretta F., Greco C., Di Filippo F., Gandolfo G.M., Cavaliere F., Bovani R., Varanese A., and Cianciulli A.M. Incidence of chromosomes 1 and 17 aneusomy in breast cancer and adjacent tissue: an interphase cytogenetic study. J Am Coll Surg 190 (2000) 530-539
7. Walentinsson A., Helou K., and Levan G. A dual-color FISH gene map of the proximal region of rat chromosome 4 and comparative analysis in human and mouse. Mamm Genome 12 (2001) 900-908
8. Pinkel D., Landegent J., Collins C., Fuscose J., Segraves R., Lucas J., and Gray J. Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc Natl Acad Sci U S A 85 (1988) 9138-9142
9. Schwab M. Amplification of oncogenes in human cancer cells. Bioessays 20 (1998) 473-479
10. Hirasawa A., Aoki D., Inoue J., Imoto I., Susumu N., Sugano K., Nozawa S., and Inazawa J. Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer. Clin Cancer Res 9 (2003) 5675-5682
11. Seeger R.C., Brodeur G.M., Sather H., Dalton A., Siegel S.E., Wong K.Y., and Hammond D. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N Engl J Med 313 (1985) 1111-1116
12. Pascual-Le Tallec L., Dulmet E., Bertagna X., and de Keyzer Y. Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors. J Clin Endocrinol Metab 87 (2002) 5015-5022
13. Maeda T., Alexander C.M., and Friedl A. Induction of syndecan-1 expression in stromal fibroblasts promotes proliferation of human breast cancer cells. Cancer Res 64 (2004) 612-621
14. Tsanou E., Ioachim E., Briasoulis E., Charchanti A., Damala K., Karavasilis V., Pavlidis N., and Agnantis N.J. Clinicopathological study of the expression of syndecan-1 in invasive breast carcinomas: correlation with extracellular matrix components. J Exp Clin Cancer Res 23 (2004) 641-650
15. Sasaki M., Tanaka Y., Kaneuchi M., Sakuragi N., and Dahiya R. CYP1B1 gene polymorphisms have higher risk for endometrial cancer, and positive correlations with estrogen receptor α and estrogen receptor β expressions. Cancer Res 63 (2003) 3913-3918
16. McGrath M., Hankinson S.E., Arbeitman L., Colditz G.A., Hunter D.J., and De Vivo I. Cytochrome P450 1B1 and catechol-O-methyltransferase polymorphisms and endometrial cancer susceptibility. Carcinogenesis 4 (2004) 559-565
17. Tokizane T., Shiina H., Igawa M., Enokida H., Urakami S., Kawakami T., Ogishima T., Okino S.T., Li L.C., Tanaka Y., Nonomura N., Okuyama A., and Dahiya R. Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin Cancer Res 11 (2005) 5793-5801
18. Meyerson M., and Harlow E. Identification of G1 kinase activity for Cdk6, a novel cyclin D partner. Mol Cell Biol 14 (1994) 2077-2086
19. Hirai Y., Utsugi K., Takeshima N., Kawamata Y., Furuta R., Kitagawa T., Kawaguchi T., Hasumi K., and Noda T. Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH. Am J Obstet Gynecol 191 (2004) 1173-1182
20. Costello J.F., Plass C., Arap W., Chapman V.M., Held W.A., Berger M.S., Su Huang H.J., and Cavenee W.K. Cyclin-dependent kinase 6 (CDK6) amplification in human gliomas identified using two-dimensional separation of genomic DNA. Cancer Res 57 (1997) 1250-1254
21. Lim J., Mansukhani M., and Weinstein I. Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells. [Erratum in: Proc Natl Acad Sci U S A 2005;102:8786-7]. Proc Natl Acad Sci U S A 14 (2005) 5156-5161
22. Ma P.C., Maulik G., Christensen J., and Salgia R. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev 22 (2003) 309-325