The prognostic significance of RON and MET receptor coexpression in patients with colorectal cancer

Diseases of the Colon and Rectum

Volumn 51, Issue 8, 2008, Pages 1268-1274

  Lee, Chung Ta ^a   Chow, Nan Haw ^a,b   Su, Pei Fang ^b   Lin, Shao Chieh ^c   Lin, Peng Chan ^a   Lee, Jenq Chang ^a  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c Tainan Hospital   (Taiwan)

Author keywords

Colorectal neoplasm; MET; Prognosis; Recepteur d'Origine Nantais; Tyrosine kinase receptor

Indexed keywords

FLUOROURACIL; PROTEIN RON; PROTEIN TYROSINE KINASE; SCATTER FACTOR RECEPTOR;

ADJUVANT THERAPY; ARTICLE; CANCER SURVIVAL; COLORECTAL CARCINOMA; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; TUMOR RECURRENCE;

COLORECTAL NEOPLASMS; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS C-MET; RECEPTOR PROTEIN-TYROSINE KINASES; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 48349119885     PISSN: 00123706     EISSN: 15300358     Source Type: Journal    
DOI: 10.1007/s10350-008-9297-1     Document Type: Article

References (34)

1. F Glenn CK McSherry 1966 Carcinoma of the distal large bowel: 32-year review of 1026 cases Ann Surg 163 838 849
2. SH Itzkowitz EJ Bloom WA Kokal 1990 Sialosyl-Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients Cancer 66 1960 1966
3. M Miyahara T Saito K Kaketani 1991 Clinical significance of ras p21 overexpression for patients with an advanced colorectal cancer Dis Colon Rectum 34 1097 1102
4. DT Leahy HE Mulcahy DP O'Donoghue 1999 bcl-2 protein expression is associated with better prognosis in colorectal cancer Histopathology 35 360 367
5. L Trusolino PM Comoglio 2002 Scatter-factor and semaphorin receptors: cell signalling for invasive growth Nat Rev Cancer 2 289 300
6. C Liu M Park MS Tsao 1992 Overexpression of c-met proto-oncogene but not epidermal growth factor receptor or c-erbB-2 in primary human colorectal carcinomas Oncogene 7 181 185
7. K Fazekas O Csuka I Koves E Raso J Timar 2001 Experimental and clinicopathologic studies on the function of the HGF receptor in human colon cancer metastasis Clin Exp Metastasis 18 639 649
8. VJ Wielenga R van der Voort TE Taher 2000 Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer Am J Pathol 157 1563 1573
9. H Takeuchi A Bilchik S Saha 2003 c-MET expression level in primary colon cancer: a predictor of tumor invasion and lymph node metastases Clin Cancer Res 9 1480 1488
10. MB Resnick J Routhier T Konkin E Sabo VE Pricolo 2004 Epidermal growth factor receptor, c-MET, beta-catenin, and p53 expression as prognostic indicators in stage II colon cancer: a tissue microarray study Clin Cancer Res 10 3069 3075
11. Z Zeng MR Weiser M D'Alessio A Grace J Shia PB Paty 2004 Immunoblot analysis of c-Met expression in human colorectal cancer: Overexpression is associated with advanced stage cancer Clin Exp Metastasis 21 409 417
12. C Ronsin F Muscatelli MG Mattei R Breathnach 1993 A novel putative receptor protein tyrosine kinase of the met family Oncogene 8 1195 1202
13. MH Wang C Ronsin MC Gesnel 1994 Identification of the ron gene product as the receptor for the human macrophage stimulating protein Science 266 117 119
14. C Collesi MM Santoro G Gaudino PM Comoglio 1996 A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype Mol Cell Biol 16 5518 5526
15. P Maggiora S Marchio MC Stella 1998 Overexpression of the RON gene in human breast carcinoma Oncogene 16 2927 2933
16. YQ Chen YQ Zhou D Angeloni AL Kurtz XZ Qiang MH Wang 2000 Overexpression and activation of the RON receptor tyrosine kinase in a panel of human colorectal carcinoma cell lines Exp Cell Res 261 229 338
17. MH Wang AL Kurtz Y Chen 2000 Identification of a novel splicing product of the RON receptor tyrosine kinase in human colorectal carcinoma cells Carcinogenesis 21 1507 1512
18. BE Peace MJ Hughes SJ Degen SE Waltz 2001 Point mutations and overexpression of Ron induce transformation, tumor formation, and metastasis Oncogene 20 6142 6151
19. YQ Zhou C He YQ Chen D Wang MH Wang 2003 Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential Oncogene 22 186 197
20. JM O'Toole KE Rabenau K Burns 2006 Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member Cancer Res 66 9162 9170
21. CH Heldin 1995 Dimerization of cell surface receptors in signal transduction Cell 80 213 223
22. T Wada XL Qian MI Greene 1990 Intermolecular association of the p185neu protein and EGF receptor modulates EGF receptor function Cell 61 1339 1347
23. MX Sliwkowski G Schaefer RW Akita 1994 Coexpression of erbB2 and erbB3 proteins reconstitutes a high affinity receptor for heregulin J Biol Chem 269 14661 1465
24. NH Chow SH Chan TS Tzai CL Ho HS Liu 2001 Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder Clin Cancer Res 7 1957 1962
25. JC Lee ST Wang NH Chow HB Yang 2002 Investigation of the prognostic value of coexpressed erbB family members for the survival of colorectal cancer patients after curative surgery Eur J Cancer 38 1065 1071
26. A Follenzi S Bakovic P Gual MC Stella P Longati PM Comoglio 2000 Cross-talk between the proto-oncogenes Met and Ron Oncogene 19 3041 3049
27. Q Chen DW Seol B Carr R Zarnegar 1997 Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines Hepatology 26 59 66
28. P Maggiora A Lorenzato S Fracchioli 2003 The RON and MET oncogenes are coexpressed in human ovarian carcinomas and cooperate in activating invasiveness Exp Cell Res 288 382 389
29. HL Cheng HS Liu YJ Lin 2005 Co-expression of RON and MET is a prognostic indicator for patients with transitional-cell carcinoma of the bladder Br J Cancer 92 1906 1914
30. WY Lee HH Chen NH Chow 2005 Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients Clin Cancer Res 11 2222 2228
31. Greene FL, Balch CM, Fleming ID, et al. AJCC cancer staging handbook: TNM classification of malignant tumors. 6th ed. New York: Springer, 2002.
32. R Pai T Nakamura WS Moon AS Tarnawski 2003 Prostaglandins promote colon cancer cell invasion; signaling by cross-talk between two distinct growth factor receptors FASEB J 17 1640 1647
33. R Worthylake LK Opresko HS Wiley 1999 ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors J Biol Chem 27 8865 8874
34. S Ding T Merkulova-Rainon ZC Han G Tobelem 2003 HGF receptor up-regulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro Blood 101 4816 4822