-
1
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
Pao W, Miller VA, Politi KA et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005; 2: E73.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
-
2
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005; 352: 786-792.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
-
3
-
-
33746133158
-
Biological and clinical implications of EGFR mutations in lung cancer
-
Mitsudomi T, Kosaka T, Yatabe Y. Biological and clinical implications of EGFR mutations in lung cancer. Int J Clin Oncol 2006; 11: 190-198.
-
(2006)
Int J Clin Oncol
, vol.11
, pp. 190-198
-
-
Mitsudomi, T.1
Kosaka, T.2
Yatabe, Y.3
-
4
-
-
15744372810
-
KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
-
Pao W, Wang TY, Riely GJ et al. KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2005; 2: E17.
-
(2005)
PLoS Med
, vol.2
-
-
Pao, W.1
Wang, T.Y.2
Riely, G.J.3
-
5
-
-
33750700477
-
Erlotinib for frontline treatment of advanced non-small cell lung cancer: A phase II study
-
Giaccone G, Gallegos Ruiz M, Le Chevalier T et al. Erlotinib for frontline treatment of advanced non-small cell lung cancer: A phase II study. Clin Cancer Res 2006; 12: 6049-6055.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6049-6055
-
-
Giaccone, G.1
Gallegos Ruiz, M.2
Le Chevalier, T.3
-
6
-
-
0037499945
-
Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways
-
Janmaat ML, Kruyt FA, Rodriguez JA, Giaccone G. Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways. Clin Cancer Res 2003; 9: 2316-2326.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2316-2326
-
-
Janmaat, M.L.1
Kruyt, F.A.2
Rodriguez, J.A.3
Giaccone, G.4
-
7
-
-
0141960451
-
Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
-
She QB, Solit D, Basso A, Moasser MM. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Clin Cancer Res 2003; 9: 4340-4346.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4340-4346
-
-
She, Q.B.1
Solit, D.2
Basso, A.3
Moasser, M.M.4
-
8
-
-
33746709922
-
Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells
-
Qin B, Ariyama H, Baba E et al. Activated Src and Ras induce gefitinib resistance by activation of signaling pathways downstream of epidermal growth factor receptor in human gallbladder adenocarcinoma cells. Cancer Chemother Pharmacol 2006; 58: 577-584.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 577-584
-
-
Qin, B.1
Ariyama, H.2
Baba, E.3
-
9
-
-
0036595629
-
Epithelial-mesenchymal transitions in tumour progression
-
Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-454.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 442-454
-
-
Thiery, J.P.1
-
10
-
-
31544452076
-
Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
-
Witta SE, Gemmill RM, Hirsch FR et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006; 66: 944-950.
-
(2006)
Cancer Res
, vol.66
, pp. 944-950
-
-
Witta, S.E.1
Gemmill, R.M.2
Hirsch, F.R.3
-
11
-
-
29344465338
-
Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
-
Yauch RL, Januario T, Eberhard DA et al. Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res 2005; 11: 8686-8698.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8686-8698
-
-
Yauch, R.L.1
Januario, T.2
Eberhard, D.A.3
-
12
-
-
0030016981
-
Overexpression of the met/HGF receptor in renal cell carcinomas
-
Natali PG, Prat M, Nicotra MR et al. Overexpression of the met/HGF receptor in renal cell carcinomas. Int J Cancer 1996; 69: 212-217.
-
(1996)
Int J Cancer
, vol.69
, pp. 212-217
-
-
Natali, P.G.1
Prat, M.2
Nicotra, M.R.3
-
13
-
-
8044219670
-
Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas
-
Olivero M, Rizzo M, Madeddu R et al. Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas. Br J Cancer 1996; 74: 1862-1868.
-
(1996)
Br J Cancer
, vol.74
, pp. 1862-1868
-
-
Olivero, M.1
Rizzo, M.2
Madeddu, R.3
-
14
-
-
0036188465
-
Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer
-
Maulik G, Kijima T, Ma PC et al. Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res 2002; 8: 620-627.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 620-627
-
-
Maulik, G.1
Kijima, T.2
Ma, P.C.3
-
15
-
-
13944276728
-
Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
-
Ma PC Jagadeeswaran, R, Jagadeesh S et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 2005; 65: 1479-1488.
-
(2005)
Cancer Res
, vol.65
, pp. 1479-1488
-
-
Ma PC Jagadeeswaran, R.1
Jagadeesh, S.2
-
16
-
-
33749367676
-
The Met pathway: Master switch and drug target in cancer progression
-
Mazzone M, Comoglio PM. The Met pathway: Master switch and drug target in cancer progression. FASEB J 2006; 20: 1611-1621.
-
(2006)
FASEB J
, vol.20
, pp. 1611-1621
-
-
Mazzone, M.1
Comoglio, P.M.2
-
17
-
-
0032467401
-
The clinical significance of hepatocyte growth factor for non-small cell lung cancer
-
Siegfried JM, Weissfeld LA, Luketich JD et al. The clinical significance of hepatocyte growth factor for non-small cell lung cancer, Ann Thorac Surg 1998; 66: 1915-1918.
-
(1998)
Ann Thorac Surg
, vol.66
, pp. 1915-1918
-
-
Siegfried, J.M.1
Weissfeld, L.A.2
Luketich, J.D.3
-
18
-
-
33645518840
-
Antibody-induced ectodomain shedding mediates HGF receptor down-regulation and hampers biological activity
-
Petrelli A, Circosta P, Granziero L et al. Antibody-induced ectodomain shedding mediates HGF receptor down-regulation and hampers biological activity. Proc Natl Acad Sci USA 2006; 103: 5090-5095.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 5090-5095
-
-
Petrelli, A.1
Circosta, P.2
Granziero, L.3
-
19
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007; 316: 1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
20
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
Therasse P. New guidelines to evaluate the response to treatment in solid tumors. J Natl Cancer Inst 2000; 92: 205-216.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
-
21
-
-
0030727172
-
Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta
-
Meier R, Alessi DR, Cron P et al. Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta. J Biol Chem 1997; 272: 30491-30497.
-
(1997)
J Biol Chem
, vol.272
, pp. 30491-30497
-
-
Meier, R.1
Alessi, D.R.2
Cron, P.3
-
22
-
-
4444332925
-
Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
-
Cappuzzo F, Magrini E, Ceresoli GL et al. Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2004; 96: 1133-1141.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1133-1141
-
-
Cappuzzo, F.1
Magrini, E.2
Ceresoli, G.L.3
-
23
-
-
27944444486
-
Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells
-
Janmaat ML, Rodriguez JA, Gallegos-Ruiz M et al. Enhanced cytotoxicity induced by gefitinib and specific inhibitors of the Ras or phosphatidyl inositol-3 kinase pathways in non-small cell lung cancer cells. Int J Cancer 2006; 118: 209-214.
-
(2006)
Int J Cancer
, vol.118
, pp. 209-214
-
-
Janmaat, M.L.1
Rodriguez, J.A.2
Gallegos-Ruiz, M.3
-
24
-
-
0031906957
-
Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF
-
Prat M, Crepaldi T, Pennacchietti S et al. Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF. J Cell Sci 1998; 111: 237-247.
-
(1998)
J Cell Sci
, vol.111
, pp. 237-247
-
-
Prat, M.1
Crepaldi, T.2
Pennacchietti, S.3
-
25
-
-
0028153260
-
Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
-
Chou TC, Motzer RJ, Tong Y, Bosl GJ. Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design. J Natl Cancer Inst 1994; 86: 1517-1524.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 1517-1524
-
-
Chou, T.C.1
Motzer, R.J.2
Tong, Y.3
Bosl, G.J.4
-
26
-
-
33947207989
-
Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival
-
Lutterbach B, Zeng Q, Davis LJ et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res 2007; 67: 2081-2088.
-
(2007)
Cancer Res
, vol.67
, pp. 2081-2088
-
-
Lutterbach, B.1
Zeng, Q.2
Davis, L.J.3
|