Acquired resistance of non-small cell lung cancer cells to MET kinase inhibition is mediated by a switch to epidermal growth factor receptor dependency

Cancer Research

Volumn 70, Issue 4, 2010, Pages 1625-1634

  McDermott, Ultan ^a   Pusapati, Raju V ^a   Christensen, James G ^b   Gray, Nathanael S ^c   Settleman, Jeff ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; EPIDERMAL GROWTH FACTOR RECEPTOR; SCATTER FACTOR RECEPTOR;

ARTICLE; CANCER CELL CULTURE; CANCER RESISTANCE; CANCER THERAPY; CELL VIABILITY; DRUG EXPOSURE; DRUG SENSITIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; GENE AMPLIFICATION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; TREATMENT RESPONSE;

ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL SURVIVAL; DRUG COMBINATIONS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; GENE AMPLIFICATION; HUMANS; INDOLES; LUNG NEOPLASMS; PIPERIDINES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PYRIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION; SULFONES; TUMOR CELLS, CULTURED;

EID: 76749157917     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-3620     Document Type: Article

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