Antiproliferative action of Xylopia aethiopica fruit extract on human cervical cancer cells

Phytotherapy Research

Volumn 25, Issue 10, 2011, Pages 1558-1563

  Adaramoye, Oluwatosin A ^a,b   Sarkar, Jayanta ^a   Singh, Neetu ^a   Meena, Sanjeev ^a   Changkija, Bendangla ^a   Yadav, Prem P ^a   Kanojiya, Sanjeev ^a   Sinha, Sudhir ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

apoptosis; C 33A; cell cycle; Xylopia aethiopica

Indexed keywords

ANTINEOPLASTIC AGENT; FLAVONOID; FLAVONOL DERIVATIVE; PHENOL DERIVATIVE; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG; XYLOPIA AETHIOPICA EXTRACT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG MECHANISM; FRUIT; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; MEDICINAL PLANT; P21 GENE; P53 GENE; UPREGULATION; UTERINE CERVIX CANCER; XYLOPIA AETHIOPICA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FRUIT; G2 PHASE; GENE EXPRESSION; HUMANS; NUCLEAR PROTEINS; PHYTOTHERAPY; PLANT EXTRACTS; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION; UTERINE CERVICAL NEOPLASMS; XYLOPIA;

XYLOPIA AETHIOPICA;

EID: 80053355073     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3551     Document Type: Article

References (30)

1. Abdulaev FI,. 1993. Plant-derived agents against cancer. In Pharmacology and Therapeutics in the New Millennium, Gupta SK, (ed.). Narosa Publishing House: New Delhi, 345-354.
2. Adams JM, Cory S,. 2001. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci 26: 61-66. (Pubitemid 32124712)
3. Asekun OT, Adeniyi BA,. 2004. Antimicrobial and cytotoxic activities of the fruit essential oil of Xylopia aethiopica from Nigeria. Fitoterapia 75: 368-370. (Pubitemid 38670569)
4. Boyom FF, Ngouana V, Zollo PH, et al,. 2003. Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry 64: 1269-1275. (Pubitemid 37442434)
5. Brunelle JK, Letai A,. 2009. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci 122: 437-441.
6. Burkill I,. 1985. Useful Plants of Tropical West Africa. Pergamon Press: London, 231-237.
7. Cain K, Bratton SB, Cohen GM,. 2002. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84: 203-214. (Pubitemid 34946950)
8. Chipuk JE, Kuwana T, Bouchier-Hayes L, et al,. 2004. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-1014. (Pubitemid 38209704)
9. Dulic V, Stein GH, Far DF, Reed SI,. 1998. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2-M-phase transition. Mol Cell Biol 18: 546-557. (Pubitemid 28021065)
10. el-Deiry WS, Tokino T, Velculescu VE, et al,. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825. (Pubitemid 23346378)
11. Faulkner DF, Lebby D, Waterman PG,. 1985. Chemical studies in the Annonaceae. Part 19; Further diterpenes from the stem bark of Xylopia aethiopica. Planta Med 51: 354-355.
12. Folin O, Ciocalteu V,. 1927. On tyrosine and tryptophan determination in proteins. J Biol Chem 27: 627-650.
13. Ghana Herbal Pharmacopoeia. 1992. Policy Research and Strategic Planning Institute (PORSPI). The Advent Press: Accra, 150-152.
14. Haldar S, Basu A,. 1998. The relationship between Bcl2, Bax and p53: consequences for cell cycle progression and cell death. Mol Hum Reprod 4: 1099-1109. (Pubitemid 28552792)
15. Härkönen PL, Mäkelä SI,. 2004. Role of estrogens in development of prostate cancer. J Steroid Biochem Mol Biol 92: 297-305. (Pubitemid 40136584)
16. Harms K, Nozell S, Chen X,. 2004. The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61: 822-842. (Pubitemid 38651002)
17. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ,. 1993. The p21 Cdk interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816. (Pubitemid 23346377)
18. Houghton P, Fang R, Techatanawat I, Steventon G, Hylands PJ, Lee CC,. 2007. The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods 42: 377-387. (Pubitemid 46860387)
19. Karioti A, Hadjipavlou-Litina D, Mensah ML, Fleischer TC, Skaltsa H,. 2004. Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana. J Agric Food Chem 52: 8094-8098. (Pubitemid 40053699)
20. Neuhouser ML,. 2004. Dietary flavonoids and cancer risk: evidence from human population studies. Nutr Cancer 50: 1-7. (Pubitemid 39587599)
21. Ozasa K, Nakao M, Watanabe Y, et al,. 2004. Serum phytoestrogens and prostate cancer risk in a nested case-control study among Japanese men. Cancer Sci 95: 65-71. (Pubitemid 38208409)
22. Pezzuto JM,. 1997. Plant-derived anticancer agents. Biochem Pharmacol 53: 121-133. (Pubitemid 27013467)
23. Radhakrishnan SK, Feliciano CS, Najmabadi F, et al,. 2004. Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle. Oncogene 23: 4173-4176. (Pubitemid 38747949)
24. Sarkar J, Singh N, Meena S, Sinha S,. 2009. Staurosporine induces apoptosis in human papillomavirus positive oral cancer cells at G2/M phase by disrupting mitochondrial membrane potential and modulation of cell cytoskeleton. Oral Oncol 45: 974-979.
25. State Pharmacopeia. 1989. USSR, Moscow. Medicina 2: 324-334.
26. Tatsadjieu LN, Essia Ngang JJ, Ngassoum MB, Etoa FX,. 2003. Antibacterial and antifungal activity of Xylopia aethiopica, Monodora myristica, Zanthoxylum xanthoxyloides and Zanthoxylum leprieurii from Cameroon. Fitoterapia 74: 469-472. (Pubitemid 36802124)
27. Waga S, Hannon GJ, Beach D, Stillman B,. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature 369: 574-578. (Pubitemid 24192528)
28. Waldman T, Kinzler KW, Vogelstein B,. 1995. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 55: 5187-5190.
29. Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ,. 1997. Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139: 1281-1292. (Pubitemid 27523214)
30. Yermakov AI, Arasimov VV, Yarosh NP,. 1987. Methods of Biochemical Analysis of Plants. Agropromizdat: Leningrad.