-
1
-
-
70649107750
-
Breast cancer as a global health concern
-
10.1016/j.canep.2009.10.003, 19896917
-
Coughlin SS, Ekwueme DU. Breast cancer as a global health concern. Cancer epidemiology 2009, 33:315-318. 10.1016/j.canep.2009.10.003, 19896917.
-
(2009)
Cancer epidemiology
, vol.33
, pp. 315-318
-
-
Coughlin, S.S.1
Ekwueme, D.U.2
-
2
-
-
14944384245
-
Apoptosis signaling in tumor therapy
-
10.1196/annals.1322.016, 15650241
-
Fulda S, Debatin KM. Apoptosis signaling in tumor therapy. Ann N Y Acad Sci 2004, 1028:150-156. 10.1196/annals.1322.016, 15650241.
-
(2004)
Ann N Y Acad Sci
, vol.1028
, pp. 150-156
-
-
Fulda, S.1
Debatin, K.M.2
-
3
-
-
2342459790
-
DNA damage-induced apoptosis
-
10.1038/sj.onc.1207532, 15077143
-
Norbury CJ, Zhivotovsky B. DNA damage-induced apoptosis. Oncogene 2004, 23:2797-808. 10.1038/sj.onc.1207532, 15077143.
-
(2004)
Oncogene
, vol.23
, pp. 2797-2808
-
-
Norbury, C.J.1
Zhivotovsky, B.2
-
4
-
-
0033013980
-
Differential roles of cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
84004, 10022898
-
Stein GH, Drullinger LF, Soulard A, Dulic V. Differential roles of cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 1999, 19:2109-2117. 84004, 10022898.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2109-2117
-
-
Stein, G.H.1
Drullinger, L.F.2
Soulard, A.3
Dulic, V.4
-
5
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
10.1038/sj.onc.1207518, 15077154
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004, 23:2919-33. 10.1038/sj.onc.1207518, 15077154.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
6
-
-
46249125488
-
How Shelterin protects mammalian telomeres
-
10.1146/annurev.genet.41.110306.130350, 18680434
-
Palm W, de Lange T. How Shelterin protects mammalian telomeres. Annu Rev Genet 2008, 42:301-334. 10.1146/annurev.genet.41.110306.130350, 18680434.
-
(2008)
Annu Rev Genet
, vol.42
, pp. 301-334
-
-
Palm, W.1
de Lange, T.2
-
7
-
-
0032489012
-
TRF2 protects human telomeres from end-to-end fusions
-
10.1016/S0092-8674(00)80932-0, 9476899
-
Van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998, 92:401-413. 10.1016/S0092-8674(00)80932-0, 9476899.
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
de Lange, T.3
-
8
-
-
22144490491
-
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion
-
10.1038/ncb1275, 15968270
-
Celli GB, de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat Cell Biol 2005, 7:712-718. 10.1038/ncb1275, 15968270.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 712-718
-
-
Celli, G.B.1
de Lange, T.2
-
9
-
-
18844396775
-
Accumalation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells
-
10.1038/sj.onc.1208482, 15735711
-
Nijjar T, Bassett E, Garbe J, Takenaka Y, Stampfer MR, Gilley D, Yaswen P. Accumalation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells. Oncogene 2005, 24:3369-3376. 10.1038/sj.onc.1208482, 15735711.
-
(2005)
Oncogene
, vol.24
, pp. 3369-3376
-
-
Nijjar, T.1
Bassett, E.2
Garbe, J.3
Takenaka, Y.4
Stampfer, M.R.5
Gilley, D.6
Yaswen, P.7
-
10
-
-
0033605145
-
P53 and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
10.1126/science.283.5406.1321, 10037601
-
Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T. P53 and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 1999, 283:1321-1325. 10.1126/science.283.5406.1321, 10037601.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
11
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
10.1126/science.1069523, 11923537
-
Karlseder J, Smogorzewska A, de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 2002, 295:2446-2449. 10.1126/science.1069523, 11923537.
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
de Lange, T.3
-
12
-
-
33746599027
-
TRF2 inhibition triggers apoptosis and reduces tumorigenicity of human melanoma cells
-
10.1016/j.ejca.2006.03.010, 16750909
-
Biroccio A, Rizz A, Elli R, Koering CE, Belleville A, Benassi B, Leonetti C, Stevens MFG, D'Incalci M, Zupi G, Gilson E. TRF2 inhibition triggers apoptosis and reduces tumorigenicity of human melanoma cells. Eur J Cancer 2006, 42:1881-1888. 10.1016/j.ejca.2006.03.010, 16750909.
-
(2006)
Eur J Cancer
, vol.42
, pp. 1881-1888
-
-
Biroccio, A.1
Rizz, A.2
Elli, R.3
Koering, C.E.4
Belleville, A.5
Benassi, B.6
Leonetti, C.7
Stevens, M.F.G.8
D'Incalci, M.9
Zupi, G.10
Gilson, E.11
-
13
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
10.1016/j.mad.2004.09.034, 15610769
-
Von Zglinicki T, Saretzki G, Ladhoff J, d'Adda di Fagagna F, Jackson SP. Human cell senescence as a DNA damage response. Mech Aging Dev 2005, 126:111-117. 10.1016/j.mad.2004.09.034, 15610769.
-
(2005)
Mech Aging Dev
, vol.126
, pp. 111-117
-
-
Von Zglinicki, T.1
Saretzki, G.2
Ladhoff, J.3
d'Adda di Fagagna, F.4
Jackson, S.P.5
-
14
-
-
0037365789
-
ATM and related protein kinases: Safe guarding genome integrity
-
10.1038/nrc1011, 12612651
-
Shiloh Y. ATM and related protein kinases: Safe guarding genome integrity. Nat Rev Cancer 2003, 3:155-168. 10.1038/nrc1011, 12612651.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
15
-
-
0036948433
-
Toward maintaining the genome: DNA damage and replication check points
-
10.1146/annurev.genet.36.060402.113540, 12429704
-
Nyberg KA, Michelson RJ, Putnam CW, Weinert TA. Toward maintaining the genome: DNA damage and replication check points. Annu Rev Genet 2002, 36:617-656. 10.1146/annurev.genet.36.060402.113540, 12429704.
-
(2002)
Annu Rev Genet
, vol.36
, pp. 617-656
-
-
Nyberg, K.A.1
Michelson, R.J.2
Putnam, C.W.3
Weinert, T.A.4
-
16
-
-
0038496703
-
Mediator DNA damage check point protein1 regulates BRCA1 localization and phosphorylation in DNA damage check point control
-
10.1074/jbc.C300060200, 12611903
-
Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator DNA damage check point protein1 regulates BRCA1 localization and phosphorylation in DNA damage check point control. J Biol Chem 2003, 278:13599-602. 10.1074/jbc.C300060200, 12611903.
-
(2003)
J Biol Chem
, vol.278
, pp. 13599-13602
-
-
Lou, Z.1
Chini, C.C.2
Minter-Dykhouse, K.3
Chen, J.4
-
17
-
-
2342570379
-
Hallmarks of senescence in carcinogenesis and cancer therapy
-
10.1038/sj.onc.1207518, 15077154
-
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy. Oncogene 2004, 23:2919-33. 10.1038/sj.onc.1207518, 15077154.
-
(2004)
Oncogene
, vol.23
, pp. 2919-2933
-
-
Shay, J.W.1
Roninson, I.B.2
-
18
-
-
0025326011
-
Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines
-
10.1007/BF02940301, 2322992
-
Mc Gown AT, Fox BW. Differential cytotoxicity of Combretastatins A1 and A4 in two daunorubicin-resistant P388 cell lines. Cancer Chemother Pharmacol 1990, 26:79-81. 10.1007/BF02940301, 2322992.
-
(1990)
Cancer Chemother Pharmacol
, vol.26
, pp. 79-81
-
-
Mc Gown, A.T.1
Fox, B.W.2
-
19
-
-
0029044610
-
Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs
-
Petitt GR, Temple C, Narayanan VL, Varma R, Simpson MJ. Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs. Anti-cancer Drug Des 1995, 10:299-309.
-
(1995)
Anti-cancer Drug Des
, vol.10
, pp. 299-309
-
-
Petitt, G.R.1
Temple, C.2
Narayanan, V.L.3
Varma, R.4
Simpson, M.J.5
-
20
-
-
4544277194
-
Combretastatin A4 phosphate: background and current clinical status
-
Young SL, Chaplin DJ. Combretastatin A4 phosphate: background and current clinical status. Expert Opin Invest Drugs 2004, 13:1171-1182.
-
(2004)
Expert Opin Invest Drugs
, vol.13
, pp. 1171-1182
-
-
Young, S.L.1
Chaplin, D.J.2
-
21
-
-
0032080796
-
Potent antimitotic and cell growth inhibitory properties of substituted chalcones
-
10.1016/S0960-894X(98)00162-0, 9871706
-
Ducki S, Forrest R, Hadfield JA, Kendall A, Lawrence NJ, Mc Gown AT, Rennison D. Potent antimitotic and cell growth inhibitory properties of substituted chalcones. Bioorg Med Chem Lett 1998, 8:1051-1056. 10.1016/S0960-894X(98)00162-0, 9871706.
-
(1998)
Bioorg Med Chem Lett
, vol.8
, pp. 1051-1056
-
-
Ducki, S.1
Forrest, R.2
Hadfield, J.A.3
Kendall, A.4
Lawrence, N.J.5
Mc Gown, A.T.6
Rennison, D.7
-
22
-
-
0034087870
-
The interaction of chalcones with tubulin
-
Lawrence NJ, Mc Gown AT, Ducki S, Hadfield JA. The interaction of chalcones with tubulin. Anticancer Drug Des 2000, 15:135-141.
-
(2000)
Anticancer Drug Des
, vol.15
, pp. 135-141
-
-
Lawrence, N.J.1
Mc Gown, A.T.2
Ducki, S.3
Hadfield, J.A.4
-
23
-
-
2442507656
-
Antibacterial chalcones-bioisosteric replacement of the 4-hydroxy group
-
10.1016/j.bmc.2004.03.071, 15142563
-
Nielsen SF, Boesen T, Larsen M, Schonnig K, Kromann H. Antibacterial chalcones-bioisosteric replacement of the 4-hydroxy group. Bioorg Med Chem 2004, 12:3047-3054. 10.1016/j.bmc.2004.03.071, 15142563.
-
(2004)
Bioorg Med Chem
, vol.12
, pp. 3047-3054
-
-
Nielsen, S.F.1
Boesen, T.2
Larsen, M.3
Schonnig, K.4
Kromann, H.5
-
24
-
-
77955429772
-
Synthesis and anti-cancer activity of chalcone linked imidazolones
-
10.1016/j.bmcl.2010.06.097, 20637611
-
Kamal A, Ramakrishna G, Raju P, Viswanath A, Ramaiah MJ, Balakishan G, Pal-Bhadra M. Synthesis and anti-cancer activity of chalcone linked imidazolones. Bioorg Med Chem Lett 2010, 20:4865-9. 10.1016/j.bmcl.2010.06.097, 20637611.
-
(2010)
Bioorg Med Chem Lett
, vol.20
, pp. 4865-4869
-
-
Kamal, A.1
Ramakrishna, G.2
Raju, P.3
Viswanath, A.4
Ramaiah, M.J.5
Balakishan, G.6
Pal-Bhadra, M.7
-
25
-
-
0029906828
-
BAX-induced cell death may not require interleukin1 beta converting enzyme like proteases
-
10.1073/pnas.93.25.14559, 26172, 8962091
-
Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin1 beta converting enzyme like proteases. Proc Natl Acad Sci 1996, 93:14559-14563. 10.1073/pnas.93.25.14559, 26172, 8962091.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 14559-14563
-
-
Xiang, J.1
Chao, D.T.2
Korsmeyer, S.J.3
-
26
-
-
0030670244
-
Characterization of interior Cleavage of Retinoblastoma Protein in apoptosis
-
10.1002/(SICI)1097-4644(19971201)67:3<399::AID-JCB11>3.0.CO;2-8, 9361194
-
Fattman CL, An B, Dou PQ. Characterization of interior Cleavage of Retinoblastoma Protein in apoptosis. J Cell Biochem 1997, 67:399-408. 10.1002/(SICI)1097-4644(19971201)67:3<399::AID-JCB11>3.0.CO;2-8, 9361194.
-
(1997)
J Cell Biochem
, vol.67
, pp. 399-408
-
-
Fattman, C.L.1
An, B.2
Dou, P.Q.3
-
27
-
-
0034676455
-
Surfing the p53 network
-
10.1038/35042675, 11099028
-
Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000, 408:307-310. 10.1038/35042675, 11099028.
-
(2000)
Nature
, vol.408
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
28
-
-
0034832956
-
Regulation of cellular senescence by p53
-
10.1046/j.1432-1327.2001.02228.x, 11358493
-
Ithahana K, Dimri G, Campisi J. Regulation of cellular senescence by p53. Eur J Biochem 2001, 268:2784-2791. 10.1046/j.1432-1327.2001.02228.x, 11358493.
-
(2001)
Eur J Biochem
, vol.268
, pp. 2784-2791
-
-
Ithahana, K.1
Dimri, G.2
Campisi, J.3
-
29
-
-
2942568163
-
N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA
-
10.1186/1476-4598-3-1, 324565, 14723797
-
Jaiswal AS, Multani AS, Pathak S, Narayan S. N-Methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Mol cancer 2004, 3:1-13. 10.1186/1476-4598-3-1, 324565, 14723797.
-
(2004)
Mol cancer
, vol.3
, pp. 1-13
-
-
Jaiswal, A.S.1
Multani, A.S.2
Pathak, S.3
Narayan, S.4
-
30
-
-
0034598919
-
Secondary structure of vertebrate telomerase RNA
-
10.1016/S0092-8674(00)80687-X, 10721988
-
Chen J, Blasco M, Greider C. Secondary structure of vertebrate telomerase RNA. Cell 2000, 100:503-514. 10.1016/S0092-8674(00)80687-X, 10721988.
-
(2000)
Cell
, vol.100
, pp. 503-514
-
-
Chen, J.1
Blasco, M.2
Greider, C.3
-
31
-
-
0042420304
-
DNA damage foci at dysfunctional telomeres
-
Takai H, Smogorzewska A, de lange T. DNA damage foci at dysfunctional telomeres. Curr Biol 2003, 3:1549-1556.
-
(2003)
Curr Biol
, vol.3
, pp. 1549-1556
-
-
Takai, H.1
Smogorzewska, A.2
de lange, T.3
-
32
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
10.1038/nature02118, 14608368
-
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, VonZglinicki T, Saretzki G, Carter NP, Jackson SP. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198. 10.1038/nature02118, 14608368.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
VonZglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
33
-
-
0036510163
-
BRCA1 regulates the G2/M check point by activating Chk1 kinase up on DNA damage
-
10.1038/ng837, 11836499
-
Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH, Brody LC. BRCA1 regulates the G2/M check point by activating Chk1 kinase up on DNA damage. Nat Genet 2002, 30:285-289. 10.1038/ng837, 11836499.
-
(2002)
Nat Genet
, vol.30
, pp. 285-289
-
-
Yarden, R.I.1
Pardo-Reoyo, S.2
Sgagias, M.3
Cowan, K.H.4
Brody, L.C.5
-
34
-
-
0042928366
-
Targeting cancer cells by exploring their resistance
-
10.1016/S1471-4914(03)00111-4, 12900218
-
Blagosklonny MV. Targeting cancer cells by exploring their resistance. Trends Mol Med 2003, 9(7):307-312. 10.1016/S1471-4914(03)00111-4, 12900218.
-
(2003)
Trends Mol Med
, vol.9
, Issue.7
, pp. 307-312
-
-
Blagosklonny, M.V.1
-
35
-
-
33751541194
-
Role of alterations in apoptotic machinery in sensitivity of cancer cells to treatment
-
10.2174/138161206779010495, 17168751
-
Rodriguez-nieto S, Zhivotovsky B. Role of alterations in apoptotic machinery in sensitivity of cancer cells to treatment. Curr Pharm Des 2006, 12(34):4411-4425. 10.2174/138161206779010495, 17168751.
-
(2006)
Curr Pharm Des
, vol.12
, Issue.34
, pp. 4411-4425
-
-
Rodriguez-nieto, S.1
Zhivotovsky, B.2
-
36
-
-
0034641918
-
The biochemistry of apoptosis
-
10.1038/35037710, 11048727
-
Hengartner MO. The biochemistry of apoptosis. Nature 2000, 407:770-776. 10.1038/35037710, 11048727.
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
37
-
-
0030829777
-
Apoptosis: an overview
-
Wyllie AH. Apoptosis: an overview. Br Med Bull 1997, 53:451-465.
-
(1997)
Br Med Bull
, vol.53
, pp. 451-465
-
-
Wyllie, A.H.1
-
38
-
-
18344377030
-
The p53 pathway: positive and negative feedback loops
-
10.1038/sj.onc.1208615, 15838523
-
Harris SL, Levin AJ. The p53 pathway: positive and negative feedback loops. Oncogene 2005, 24:2899-2908. 10.1038/sj.onc.1208615, 15838523.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levin, A.J.2
-
39
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53 and p21CIP1, but not p16INK4a
-
10.1016/S1097-2765(04)00256-4, 15149599
-
Herbig U, Jobling WA, Chen BPC, Chen DJ, Sedivy JM. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53 and p21CIP1, but not p16INK4a. Mol Cell 2004, 14:501-513. 10.1016/S1097-2765(04)00256-4, 15149599.
-
(2004)
Mol Cell
, vol.14
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.A.2
Chen, B.P.C.3
Chen, D.J.4
Sedivy, J.M.5
|