Cisplatin-induced apoptosis in p53-deficient renal cells via the intrinsic mitochondrial pathway

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 5, 2009, Pages

  Jiang, Man ^a   Wang, Cong Yi ^a   Huang, Shuang ^a   Yang, Tianxin ^b   Dong, Zheng ^a,c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Bak; Bax; Cytochrome c

Indexed keywords

CASPASE; CISPLATIN; CYTOCHROME C; PROTEIN BAK; PROTEIN BAX; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; KIDNEY CELL; KIDNEY PROXIMAL TUBULE; MITOCHONDRION; MOUSE; NEPHROTOXICITY; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN SECRETION;

EID: 66049128092     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90579.2008     Document Type: Article

References (41)

1. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998. (Pubitemid 28406819)
2. Arany I, Safirstein RL. Cisplatin nephrotoxicity. Semin Nephrol 23: 460-464, 2003. (Pubitemid 37176691)
3. Bae IH, Kang SW, Yoon SH, Um HD. Cellular components involved in the cell death induced by cisplatin in the absence of p53 activation. Oncol Rep 15: 1175-1180, 2006.
4. Bhatt K, Feng L, Pabla N, Liu K, Smith S, Dong Z. Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis. Am J Physiol Renal Physiol 294: F499-F507, 2008.
5. 2 in cisplatin-induced renal cell apoptosis. J Pharmacol Exp Ther 308: 921-928, 2004.
6. Cummings BS, Schnellmann RG. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther 302: 8-17, 2002.
7. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell 116: 205-219, 2004.
8. Degenhardt K, Sundararajan R, Lindsten T, Thompson C, White E. Bax and Bak independently promote cytochrome C release from mitochondria. J Biol Chem 277: 14127-14134, 2002. (Pubitemid 34309590)
9. Evans DL, Tilby M, Dive C. Differential sensitivity to the induction of apoptosis by cisplatin in proliferating and quiescent immature rat thymocytes is independent of the levels of drug accumulation and DNA adduct formation. Cancer Res 54: 1596-1603, 1994. (Pubitemid 24106428)
10. Flinterman M, Guelen L, Ezzati-Nik S, Killick R, Melino G, Tominaga K, Mymryk JS, Gaken J, Tavassoli M. E1A activates transcription of p73 and Noxa to induce apoptosis. J Biol Chem 280: 5945-5959, 2005. (Pubitemid 40280079)
11. Green DR, Kroemer G. The pathophysiology of mitochondrial cell death. Science 305: 626-629, 2004. (Pubitemid 39006738)
12. 1 renal cells. Pediatr Nephrol 20: 1067-1072, 2005.
13. Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther 1: 47-61, 2003.
14. Jiang M, Dong Z. Regulation and pathological role of p53 in cisplatin nephrotoxicity. J Pharmacol Exp Ther 327: 300-307, 2008.
15. Jiang M, Pabla N, Murphy RF, Yang T, Yin XM, Degenhardt K, White E, Dong Z. Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 282: 2636-2645, 2007. (Pubitemid 47076791)
16. Jiang M, Wei Q, Pabla N, Dong G, Wang CY, Yang T, Smith SB, Dong Z. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol 73: 1499-1510, 2007. (Pubitemid 46452592)
17. Jiang M, Wei Q, Wang J, Du Q, Yu J, Zhang L, Dong Z. Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25: 4056-4066, 2006. (Pubitemid 44024868)
18. Jiang M, Yi X, Hsu S, Wang CY, Dong Z. Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. Am J Physiol Renal Physiol 287: F1140-F1147, 2004. (Pubitemid 39507222)
19. Lasfer M, Davenne L, Vadrot N, Alexia C, Sadji-Ouatas Z, Bringuier AF, Feldmann G, Pessayre D, Reyl-Desmars F. Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor. FEBS Lett 580: 2547-2552, 2006.
20. Lee RH, Song JM, Park MY, Kang SK, Kim YK, Jung JS. Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells. Biochem Pharmacol 62: 1013-1023, 2001.
21. Martinou JC, Green DR. Breaking the mitochondrial barrier. Nat Rev 2: 63-67, 2001.
22. Megyesi J, Udvarhelyi N, Safirstein RL, Price PM. The p53-independent activation of transcription of p21 WAF1/CIP1/SDI1 after acute renal failure. Am J Physiol Renal Fluid Electrolyte Physiol 271: F1211-F1216, 1996. (Pubitemid 126832975)
23. Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson C, Vousden KH. p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279: 8076-8083, 2004. (Pubitemid 38294697)
24. Meyer KB, Madias NE. Cisplatin nephrotoxicity. Miner Electrolyte Metab 20: 201-213, 1994.
25. Mikhailov V, Mikhailova M, Degenhardt K, Venkatachalam MA, White E, Saikumar P. Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release. J Biol Chem 278: 5367-5376, 2003. (Pubitemid 36801053)
26. Mueller S, Schittenhelm M, Honecker F, Malenke E, Lauber K, Wesselborg S, Hartmann JT, Bokemeyer C, Mayer F. Cell-cycle progression and response of germ cell tumors to cisplatin in vitro. Int J Oncol 29: 471-479, 2006.
27. Oniscu A, Sphyris N, Morris RG, Bader S, Harrison DJ. p73alpha is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes. J Clin Pathol 57: 492-498, 2004. (Pubitemid 38621794)
28. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73: 994-1007, 2008.
29. Pabla N, Huang S, Mi QS, Daniel R, Dong Z. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem 283: 6572-7583, 2008.
30. 1 cells via activation of mitochondrial pathways. J Am Soc Nephrol 13: 858-865, 2002.
31. Schweyer S, Soruri A, Meschter O, Heintze A, Zschunke F, Miosge N, Thelen P, Schlott T, Radzun HJ, Fayyazi A. Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK/ERK activation. Br J Cancer 91: 589-598, 2004. (Pubitemid 39093583)
32. Seth R, Yang C, Kaushal V, Shah SV, Kaushal GP. p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. J Biol Chem 280: 31230-31239, 2005. (Pubitemid 41291860)
33. Sundararajan R, Cuconati A, Nelson D, White E. Tumor necrosis factor-alpha induces Bax-Bak interaction and apoptosis, which is inhibited by adenovirus E1B 19K. J Biol Chem 276: 45120-45127, 2001. (Pubitemid 37391304)
34. Taguchi T, Nazneen A, Abid MR, Razzaque MS. Cisplatin-associated nephrotoxicity and pathological events. Contrib Nephrol 148: 107-121, 2005.
35. Upreti M, Chu R, Galitovskaya E, Smart SK, Chambers TC. Key role for Bak activation and Bak-Bax interaction in the apoptotic response to vinblastine. Mol Cancer Ther 7: 2224-2232, 2008.
36. Wang J, Wei Q, Wang CY, Hill WD, Hess DC, Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem 279: 19948-19954, 2004. (Pubitemid 38623437)
37. Wei Q, Dong G, Franklin J, Dong Z. The pathological role of Bax in cisplatin nephrotoxicity. Kidney Int 72: 53-62, 2007. (Pubitemid 47014446)
38. Wei Q, Dong G, Yang T, Megyesi J, Price PM, Dong Z. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol 293: F1282-F1291, 2007. (Pubitemid 47583963)
39. Yang C, Kaushal V, Haun RS, Seth R, Shah SV, Kaushal GP. Transcriptional activation of caspase-6 and -7 genes by cisplatin-induced p53 and its functional significance in cisplatin nephrotoxicity. Cell Death Differ 15: 530-544, 2007.
40. Yi X, Yin XM, Dong Z. Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressed. J Biol Chem 278: 16992-16999, 2003. (Pubitemid 36799574)
41. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 7: 673-682, 2001. (Pubitemid 32706358)