Upregulation of DR5 receptor by the diaminothiazole DAT1 [4-amino-5-benzoyl-2-(4-methoxy phenyl amino) thiazole] triggers an independent extrinsic pathway of apoptosis in colon cancer cells with compromised pro and antiapoptotic proteins

Apoptosis

Volumn 18, Issue 6, 2013, Pages 713-726

  Thomas, Sannu A ^a   Vasudevan, Smreti ^a   Thamkachy, Reshma ^a   Lekshmi, Swathi U ^a   Santhoshkumar, Thankayyan R ^a   Rajasekharan, Kallikat N ^b   Sengupta, Suparna ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

^b UNIVERSITY OF KERALA   (India)

Author keywords

Diaminothiazoles; DR5; Extrinsic pathway; Intrinsic pathway; Microtubules

Indexed keywords

4 AMINO 5 BENZOYL 2 (4 METHOXY PHENYL AMINO)THIAZOLE; ANTINEOPLASTIC AGENT; DEATH RECEPTOR 5; SMALL INTERFERING RNA; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HCT116; COLON CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; RNA INTERFERENCE;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; CASPASE 8; COLONIC NEOPLASMS; DOWN-REGULATION; HCT116 CELLS; HUMANS; MITOCHONDRIA; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SERPINS; TRIAZOLES; UP-REGULATION; VIRAL PROTEINS;

EID: 84880573267     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0826-6     Document Type: Article

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