Dioxin-induced retardation of development through a reduction in the expression of pituitary hormones and possible involvement of an aryl hydrocarbon receptor in this defect: A comparative study using two strains of mice with different sensitivities to dioxin

Toxicology and Applied Pharmacology

Volumn 278, Issue 3, 2014, Pages 220-229

  Takeda, Tomoki ^a   Taura, Junki ^a   Hattori, Yukiko ^a   Ishii, Yuji ^a   Yamada, Hideyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

2,3,7.8 Tetrachlorodibenzo p dioxin (TCDD); Aryl hydrocarbon receptor; Gonadotropin; Growth hormone; Steroidogenesis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; GONADOTROPIN; GROWTH HORMONE; MESSENGER RNA; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIRTH WEIGHT; C57BL 6 MOUSE; CHEMOSENSITIVITY; COMPARATIVE STUDY; CONTROLLED STUDY; DBA 2 MOUSE; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; GENE EXPRESSION; GESTATIONAL AGE; GROWTH RETARDATION; HORMONE SYNTHESIS; HYPOPHYSIS; LITTER SIZE; MALE; MOUSE; NEWBORN; NONHUMAN; PERINATAL PERIOD; PROTEIN EXPRESSION; SEXUAL MATURATION; STEROIDOGENESIS; STRAIN DIFFERENCE; TESTIS; TESTOSTERONE BLOOD LEVEL;

MUS; RATTUS;

2,3,7.8-TETRACHLORODIBENZO-P-DIOXIN (TCDD); ARYL HYDROCARBON RECEPTOR; GONADOTROPIN; GROWTH HORMONE; STEROIDOGENESIS;

ANIMALS; ANIMALS, NEWBORN; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ENVIRONMENTAL POLLUTANTS; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MATERNAL EXPOSURE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; PITUITARY GLAND; PITUITARY HORMONES, ANTERIOR; PREGNANCY; RECEPTORS, ARYL HYDROCARBON; SEXUAL DEVELOPMENT; SPECIFIC PATHOGEN-FREE ORGANISMS; TERATOGENS; TESTIS; TETRACHLORODIBENZODIOXIN;

EID: 84902354409     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.04.022     Document Type: Article

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