Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16372-16377

  Wen, Shuping ^a   Ai, Wei ^a   Alim, Zahara ^a   Boehm, Ulrich ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Cre recombinase; Diphtheria toxin; Gonadotrope development; Gonadotropin releasing; Gonadotropin releasing hormone neurons; Hormone receptor

Indexed keywords

FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; GONADORELIN RECEPTOR;

ADENOHYPOPHYSIS; ARTICLE; AUTOCRINE EFFECT; CONTROLLED STUDY; EMBRYO DEVELOPMENT; FEMALE; GONADORELIN RELEASE; HYPOTHALAMUS; LUTEINIZING HORMONE RELEASE; MALE; MOUSE; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; SEXUAL MATURATION; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; EMBRYOLOGY; GENE EXPRESSION REGULATION; GENETICS; HYPOGONADISM; METABOLISM; TRANSGENIC MOUSE;

ANIMALIA; MAMMALIA; MUS;

ANIMALS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GONADOTROPIN-RELEASING HORMONE; HYPOGONADISM; HYPOTHALAMUS; MALE; MICE; MICE, TRANSGENIC; PITUITARY GLAND, ANTERIOR; RECEPTORS, LHRH; SEXUAL MATURATION; SIGNAL TRANSDUCTION;

EID: 77958009229     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1000423107     Document Type: Article

References (38)

1. Gore AC (2002) GnRH: The Master Molecule of Reproduction (Kluwer, Dordrecht, The Netherlands).
2. Herbison AE (2006) Physiology of the Gonadotropin-Releasing Hormone Neuronal Network. Knobil and Neill's Physiology of Reproduction, ed Neill JD (Elsevier, Amsterdam), pp 1415-1482.
3. Childs GV (2006) Gonadotropes and Lactotropes. Knobil and Neill's Physiology of Reproduction, ed Neill JD (Elsevier, Amsterdam), pp 1483-1579.
4. Jeong K-H, Kaiser UB (2006) Gonadotropin-releasing hormone regulation of gonadotropin biosynthesis and secretion. Knobil and Neill's Physiology of Reproduction, ed Neill JD (Elsevier, Amsterdam), pp 1635-1726.
5. Tobet SA, Schwarting GA (2006) Minireview: Recent progress in gonadotropin-releasing hormone neuronal migration. Endocrinology 147:1159-1165.
6. Schwanzel-Fukuda M, Pfaff DW (1989) Origin of luteinizing hormone-releasing hormone neurons. Nature 338:161-164. (Pubitemid 19074106)
7. Wray S, Grant P, Gainer H (1989) Evidence that cells expressing luteinizing hormone-releasing hormone mRNA in the mouse are derived from progenitor cells in the olfactory placode. Proc Natl Acad Sci USA 86:8132-8136. (Pubitemid 19265333)
8. Pointis G, Mahoudeau JA (1979) [Study of Leydig cells and gonadotropin activity in 14-18 days old fetal mouse (author's transl)]. Ann Endocrinol (Paris) 40:431-432.
9. Pointis G, Mahoudeau JA (1976) Release of immuno-reactive and biologically active LH from fetal mouse pituitary in response to synthetic gonadotropin releasing factor (LRF). Experientia 32:1347-1348.
10. Pointis G, Mahoudeau JA (1976) Demonstration of a pituitary gonadotrophin hormone activity in the male foetal mouse. Acta Endocrinol (Copenh) 83:158-165.
11. Pointis G, Latreille MT, Cedard L (1980) Gonado-pituitary relationships in the fetal mouse at various times during sexual differentiation. J Endocrinol 86:483-488.
12. Wen S, et al. (2008) Functional characterization of genetically labeled gonadotropes. Endocrinology 149:2701-2711.
13. Brockschnieder D, Pechmann Y, Sonnenberg-Riethmacher E, Riethmacher D (2006) An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 44:322-327. (Pubitemid 44182448)
14. Soriano P (1999) Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 21:70-71.
15. Collier RJ (2001) Understanding the mode of action of diphtheria toxin: A perspective on progress during the 20th century. Toxicon 39:1793-1803.
16. Skinner DC, et al. (2009) Effects of gonadotrophin-releasing hormone outside the hypothalamic-pituitary-reproductive axis. J Neuroendocrinol 21:282-292.
17. Martinez-Fuentes AJ, Hu L, Krsmanovic LZ, Catt KJ (2004) Gonadotropin-releasing hormone (GnRH) receptor expression and membrane signaling in early embryonic GnRH neurons: role in pulsatile neurosecretion. Mol Endocrinol 18:1808-1817.
18. Xu C, Xu XZ, Nunemaker CS, Moenter SM (2004) Dose-dependent switch in response of gonadotropin-releasing hormone (GnRH) neurons to GnRH mediated through the type I GnRH receptor. Endocrinology 145:728-735.
19. Baker BL, Gross DS (1978) Cytology and distribution of secretory cell types in the mouse hypophysis as demonstrated with immunocytochemistry. Am J Anat 153:193-215.
20. Szarek E, et al. (2008) Hypothalamic input is required for development of normal numbers of thyrotrophs and gonadotrophs, but not other anterior pituitary cells in late gestation sheep. J Physiol 586:1185-1194.
21. Weiss J, Guendner MJ, Halvorson LM, Jameson JL (1995) Transcriptional activation of the follicle-stimulating hormone beta-subunit gene by activin. Endocrinology 136:1885-1891.
22. Lamba P, Santos MM, Philips DP, Bernard DJ (2006) Acute regulation of murine follicle-stimulating hormone beta subunit transcription by activin A. J Mol Endocrinol 36:201-220. (Pubitemid 43273676)
23. Kendall SK, et al. (1991) Targeted ablation of pituitary gonadotropes in transgenic mice. Mol Endocrinol 5:2025-2036.
24. Seuntjens E, Vankelecom H, Quaegebeur A, Vande Vijver V, Denef C (1999) Targeted ablation of gonadotrophs in transgenic mice affects embryonic development of lactotrophs. Mol Cell Endocrinol 150:129-139. (Pubitemid 29292858)
25. Vankelecom H, Seuntjens E, Hauspie A, Denef C (2003) Targeted ablation of gonadotrophs in transgenic mice depresses prolactin but not growth hormone gene expression at birth as measured by quantitative mRNA detection. J Biomed Sci 10:805-812.
26. Zhu X, Gleiberman AS, Rosenfeld MG (2007) Molecular physiology of pituitary development: Signaling and transcriptional networks. Physiol Rev 87:933-963.
27. Japón MA, Rubinstein M, Low MJ (1994) In situ hybridization analysis of anterior pituitary hormone gene expression during fetal mouse development. J Histochem Cytochem 42:1117-1125.
28. Aubert ML, et al. (1985) Ontogeny of hypothalamic luteinizing hormone-releasing hormone (GnRH) and pituitary GnRH receptors in fetal and neonatal rats. Endocrinology 116:1565-1576.
29. Mason AJ, et al. (1986) A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234:1366-1371.
30. Muscatelli F, et al. (2000) Disruption of the mouse Necdin gene results in hypothalamic and behavioral alterations reminiscent of the human Prader-Willi syndrome. Hum Mol Genet 9:3101-3110.
31. Krüger M, Ruschke K, Braun T (2004) NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression. EMBO J 23:4353-4364.
32. d'Anglemont de Tassigny X, et al. (2007) Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA 104:10714-10719.
33. Gill JC, et al. (2008) The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology 149:4596-4604.
34. Buch T, et al. (2005) A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nat Methods 2:419-426. (Pubitemid 40916560)
35. Romanelli RG, et al. (2004) Expression and function of gonadotropin-releasing hormone (GnRH) receptor in human olfactory GnRH-secreting neurons: An autocrine GnRH loop underlies neuronal migration. J Biol Chem 279:117-126.
36. Abraham E, et al. (2008) Early development of forebrain gonadotrophin-releasing hormone (GnRH) neurones and the role of GnRH as an autocrine migration factor. J Neuroendocrinol 20:394-405.
37. Agulnik AI, Bishop CE, Lerner JL, Agulnik SI, Solovyev VV (1997) Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven. Mamm Genome 8:134-138.
38. Paxinos G, Franklin KBJ (2001) The Mouse Brain in Stereotaxic Coordinates (Elsevier, Amsterdam).