Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: A mechanism involving an initial effect on gonadotropin synthesis in the pituitary

Life Sciences

Volumn 80, Issue 14, 2007, Pages 1259-1267

  Taketoh, Junko ^a   Mutoh, Junpei ^a   Takeda, Tomoki ^a   Ogishima, Tadashi ^a   Takeda, Shuso ^a   Ishii, Yuji ^a   Ishida, Takumi ^a   Yamada, Hideyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; CYP17; Cytochrome P450 17; Dioxins; Fetus; Luteinizing hormone; Pituitary; Testis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; CYCLIC AMP DERIVATIVE; CYTOCHROME P450 17; GONADOTROPIN; LUTEINIZING HORMONE; MESSENGER RNA; PROTEIN; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; FEMALE; GONADOTROPIN RELEASE; HYPOPHYSIS TESTIS SYSTEM; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CYCLIC AMP; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION; GONADOTROPINS, EQUINE; INJECTIONS; LIVER; LUTEINIZING HORMONE; MALE; MATERNAL EXPOSURE; ORGAN CULTURE TECHNIQUES; PITUITARY GLAND; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROID 17-ALPHA-HYDROXYLASE; TESTIS; TETRACHLORODIBENZODIOXIN;

EQUIDAE; RATTUS NORVEGICUS;

EID: 33847254341     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2006.12.029     Document Type: Article

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