Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: A possible mechanism for a fetus-specific reduction in steroidogenesis

Journal of Toxicological Sciences

Volumn 35, Issue 3, 2010, Pages 365-373

  Matsumoto, Yuki ^a   Ishida, Takumi ^a   Takeda, Tomoki ^a   Koga, Takayuki ^a   Fujii, Misaki ^a   Ishii, Yuji ^a   Fujimura, Yoshinori ^a   Miura, Daisuke ^a   Wariishi, Hiroyuki ^a   Yamada, Hideyuki ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Dioxin; Fetal rat; Hypothalamus; Metabolome; Multivariate analysis; Pituitary

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4 AMINOBUTYRIC ACID; BETA ACTIN; DIOXIN; FOLLITROPIN BETA SUBUNIT; GLUTAMINE; GONADOTROPIN; LUTEINIZING HORMONE BETA SUBUNIT; MESSENGER RNA; NEUROTRANSMITTER; PROLACTIN;

ALPHA CHAIN; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; ENERGY RESOURCE; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; GAS CHROMATOGRAPHY; GESTATIONAL AGE; HORMONE DETERMINATION; HYPOPHYSIS; HYPOTHALAMUS; MALE; MASS SPECTROMETRY; METABOLOME; MULTIVARIATE ANALYSIS; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STEROIDOGENESIS; WISTAR RAT; ANIMAL; BIOSYNTHESIS; CHEMICAL PHENOMENA; DRUG EFFECTS; FETOMATERNAL TRANSFUSION; MASS FRAGMENTOGRAPHY; METABOLISM; PREGNANCY;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; DEPRESSION, CHEMICAL; FEMALE; GAMMA-AMINOBUTYRIC ACID; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMINE; GONADOTROPINS; HYPOTHALAMUS; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; METABOLOME; PITUITARY GLAND; PREGNANCY; RATS; RATS, WISTAR; TETRACHLORODIBENZODIOXIN;

EID: 77953314689     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.365     Document Type: Article

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