메뉴 건너뛰기




Volumn 46, Issue 2, 2014, Pages 181-198

Molecular basis of pharmacological therapy in Cushing's disease

Author keywords

Adrenal; Cushing's disease; Medical therapy; Molecular; Pituitary

Indexed keywords

4 AMINOBUTYRIC ACID; AMINOGLUTETHIMIDE; BEVACIZUMAB; BROMOCRIPTINE; CABERGOLINE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYPROHEPTADINE; DESMOPRESSIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOMIDATE; HYDROCORTISONE; KETANSERIN; KETOCONAZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; METERGOLINE; METYRAPONE; MIFEPRISTONE; MITOTANE; OCTREOTIDE; PASIREOTIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE KINASE; RETINOIC ACID; RITANSERIN; ROSIGLITAZONE; TEMOZOLOMIDE; TRILOSTANE; UNINDEXED DRUG; VALPROIC ACID; GLUCOCORTICOID RECEPTOR;

EID: 84902342860     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-013-0098-5     Document Type: Review
Times cited : (28)

References (171)
  • 3
    • 84858776065 scopus 로고    scopus 로고
    • Intraoperative multiple-staged resection and tumor tissue identification using frozen sections provide the best result for the accurate localization and complete resection of tumors in Cushing's disease
    • J.S. Lim, S.K. Lee, S.H. Kim, E.J. Lee, S.H. Kim, Intraoperative multiple-staged resection and tumor tissue identification using frozen sections provide the best result for the accurate localization and complete resection of tumors in Cushing's disease. Endocrine 40, 452-461 (2011)
    • (2011) Endocrine , vol.40 , pp. 452-461
    • Lim, J.S.1    Lee, S.K.2    Kim, S.H.3    Lee, E.J.4    Kim, S.H.5
  • 4
    • 0029553957 scopus 로고
    • Neurotransmitter regulation of the hypothalamic corticotropin-releasing hormone neuron
    • A.E. Calogero, Neurotransmitter regulation of the hypothalamic corticotropin-releasing hormone neuron. Ann. N. Y. Acad. Sci. 771, 31-40 (1995)
    • (1995) Ann. N. Y. Acad. Sci. , vol.771 , pp. 31-40
    • Calogero, A.E.1
  • 5
    • 33645242869 scopus 로고    scopus 로고
    • Neuroregulation of the hypothalamus-pituitary-adrenal (HPA) axis in humans: Effects of GABA-, mineralocorticoid-, and GH-secretagogue-receptor modulation
    • R. Giordano, M. Pellegrino, A. Picu, L. Bonelli, M. Balbo, R. Berardelli, F. Lanfranco, E. Ghigo, E. Arvat, Neuroregulation of the hypothalamus- pituitary-adrenal (HPA) axis in humans: effects of GABA-, mineralocorticoid-, and GH-secretagogue-receptor modulation. Sci. World J. 6, 1-11 (2006)
    • (2006) Sci. World J. , vol.6 , pp. 1-11
    • Giordano, R.1    Pellegrino, M.2    Picu, A.3    Bonelli, L.4    Balbo, M.5    Berardelli, R.6    Lanfranco, F.7    Ghigo, E.8    Arvat, E.9
  • 6
    • 0026780458 scopus 로고
    • The involvement of serotonin in regulation of pituitary-adrenocortical function
    • R.W. Fuller, The involvement of serotonin in regulation of pituitary-adrenocortical function. Front. Neuroendocrinol. 13, 250-270 (1992)
    • (1992) Front. Neuroendocrinol. , vol.13 , pp. 250-270
    • Fuller, R.W.1
  • 7
    • 0018398709 scopus 로고
    • Lack of effect of antiserotoninergic and/or dopaminergic treatment in patients with pituitary-dependent Cushing's syndrome
    • B. Ambrosi, M. Gaggini, F. Secchi, G. Faglia, Lack of effect of antiserotoninergic and/or dopaminergic treatment in patients with pituitary-dependent Cushing's syndrome. Horm. Metab. Res. 11, 318-319 (1979)
    • (1979) Horm. Metab. Res. , vol.11 , pp. 318-319
    • Ambrosi, B.1    Gaggini, M.2    Secchi, F.3    Faglia, G.4
  • 8
    • 0017125823 scopus 로고
    • Effect of an antiserotoninergic drug, metergoline, on the ACTH and cortisol response to insulin hypoglycemia and lysine-vasopressin in man
    • F. Cavagnini, U. Raggi, P. Micossi, A. Di Landro, C. Invitti, Effect of an antiserotoninergic drug, metergoline, on the ACTH and cortisol response to insulin hypoglycemia and lysine-vasopressin in man. J. Clin. Endocrinol. Metab. 43, 306-312 (1976)
    • (1976) J. Clin. Endocrinol. Metab. , vol.43 , pp. 306-312
    • Cavagnini, F.1    Raggi, U.2    Micossi, P.3    Di Landro, A.4    Invitti, C.5
  • 11
  • 12
    • 0020579342 scopus 로고
    • Effects of cyproheptadine, reserpine, and synthetic corticotropin- releasing factor on pituitary glands from patients with Cushing's disease
    • T. Suda, F. Tozawa, T. Mouri, A. Sasaki, T. Shibasaki, H. Demura, K. Shizume, Effects of cyproheptadine, reserpine, and synthetic corticotropin-releasing factor on pituitary glands from patients with Cushing's disease. J. Clin. Endocrinol. Metab. 56, 1094-1099 (1983)
    • (1983) J. Clin. Endocrinol. Metab. , vol.56 , pp. 1094-1099
    • Suda, T.1    Tozawa, F.2    Mouri, T.3    Sasaki, A.4    Shibasaki, T.5    Demura, H.6    Shizume, K.7
  • 13
    • 0016836437 scopus 로고
    • Cyproheptadine-induced remission of Cushing's disease
    • D.T. Krieger, L. Amorosa, F. Linick, Cyproheptadine-induced remission of Cushing's disease. N. Engl. J. Med. 293, 893-896 (1975)
    • (1975) N. Engl. J. Med. , vol.293 , pp. 893-896
    • Krieger, D.T.1    Amorosa, L.2    Linick, F.3
  • 15
    • 0018906789 scopus 로고
    • Stimulatory effects of gamma-aminohydroxybutyric acid (GABOB) on growth hormone, prolactin and cortisol release in man
    • J. Takahara, S. Yumoki, W. Yakushji, J. Yamauchi, H. Hosogi, T. Ofuji, Stimulatory effects of gamma-aminohydroxybutyric acid (GABOB) on growth hormone, prolactin and cortisol release in man. Horm. Metab. Res. 12, 31-34 (1980)
    • (1980) Horm. Metab. Res. , vol.12 , pp. 31-34
    • Takahara, J.1    Yumoki, S.2    Yakushji, W.3    Yamauchi, J.4    Hosogi, H.5    Ofuji, T.6
  • 16
    • 0023615406 scopus 로고
    • Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysialportal circulation
    • P.M. Plotsky, S. Otto, S. Sutton, Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysialportal circulation. Life Sci. 41, 1311-1317 (1987)
    • (1987) Life Sci. , vol.41 , pp. 1311-1317
    • Plotsky, P.M.1    Otto, S.2    Sutton, S.3
  • 17
    • 0020636150 scopus 로고
    • Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease
    • Copenh
    • H.P. Koppeschaar, R.J. Croughs, J.H. Thijssen, F. Schwarz, Sodium valproate and cyproheptadine may independently induce a remission in the same patient with Cushing's disease. Acta Endocrinol. (Copenh). 104, 160-163 (1983)
    • (1983) Acta Endocrinol. , vol.104 , pp. 160-163
    • Koppeschaar, H.P.1    Croughs, R.J.2    Thijssen, J.H.3    Schwarz, F.4
  • 20
    • 0023943439 scopus 로고
    • The combined use of sodium valproate and metyrapone in the treatment of Cushing's syndrome
    • Oxf
    • S.S. Nussey, P. Price, J.S. Jenkins, A.R. Altaher, B. Gillham, M.T. Jones, The combined use of sodium valproate and metyrapone in the treatment of Cushing's syndrome. Clin. Endocrinol. (Oxf). 28, 373-380 (1988)
    • (1988) Clin. Endocrinol. , vol.28 , pp. 373-380
    • Nussey, S.S.1    Price, P.2    Jenkins, J.S.3    Altaher, A.R.4    Gillham, B.5    Jones, M.T.6
  • 22
    • 0036852624 scopus 로고    scopus 로고
    • Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas
    • A.P. Heaney, M. Fernando, W.H. Yong, S. Melmed, Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat. Med. 8, 1281-1287 (2002)
    • (2002) Nat. Med. , vol.8 , pp. 1281-1287
    • Heaney, A.P.1    Fernando, M.2    Yong, W.H.3    Melmed, S.4
  • 23
    • 65349141324 scopus 로고    scopus 로고
    • Effects of rosiglitazone-peroxisome proliferators-activated receptor gamma (PPARgamma) agonist on cell viability of human pituitary adenomas in vitro
    • K. Winczyk, J. Kunert-Radek, A. Gruszka, M. Radek, H. Ławnicka, M. Pawlikowski, Effects of rosiglitazone-peroxisome proliferators-activated receptor gamma (PPARgamma) agonist on cell viability of human pituitary adenomas in vitro. Neuro. Endocrinol. Lett. 30, 107-110 (2009)
    • (2009) Neuro. Endocrinol. Lett. , vol.30 , pp. 107-110
    • Winczyk, K.1    Kunert-Radek, J.2    Gruszka, A.3    Radek, M.4    Ławnicka, H.5    Pawlikowski, M.6
  • 24
    • 70549112955 scopus 로고    scopus 로고
    • No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo
    • L. Kreutzer, I. Jeske, B. Hofmann, I. Blumcke, R. Fahlbusch, M. Buchfelder, R. Buslei, No effect of the PPAR-gamma agonist rosiglitazone on ACTH or cortisol secretion in Nelson's syndrome and Cushing's disease in vitro and in vivo. Clin. Neuropathol. 28, 430-439 (2009)
    • (2009) Clin. Neuropathol. , vol.28 , pp. 430-439
    • Kreutzer, L.1    Jeske, I.2    Hofmann, B.3    Blumcke, I.4    Fahlbusch, R.5    Buchfelder, M.6    Buslei, R.7
  • 26
    • 84878388594 scopus 로고    scopus 로고
    • Vasopressin receptor antagonists and their role in clinical medicine
    • G. Narayen, S.N. Mandal, Vasopressin receptor antagonists and their role in clinical medicine. Indian J. Endocrinol. Metab. 16, 183-191 (2012)
    • (2012) Indian J. Endocrinol. Metab. , vol.16 , pp. 183-191
    • Narayen, G.1    Mandal, S.N.2
  • 27
    • 71649099818 scopus 로고    scopus 로고
    • Drugs in the medical treatment of Cushing's syndrome
    • D.E. Schteingart, Drugs in the medical treatment of Cushing's syndrome. Expert Opin. Emerg. Drugs 14, 661-671 (2009)
    • (2009) Expert Opin. Emerg. Drugs , vol.14 , pp. 661-671
    • Schteingart, D.E.1
  • 33
    • 0037627835 scopus 로고    scopus 로고
    • Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs
    • D. Cervia, D. Fehlmann, D. Hoyer, Native somatostatin sst2 and sst5 receptors functionally coupled to Gi/o-protein, but not to the serum response element in AtT-20 mouse tumour corticotrophs. Naunyn Schmiedebergs Arch. Pharmacol. 367, 387-578 (2003)
    • (2003) Naunyn Schmiedebergs Arch. Pharmacol. , vol.367 , pp. 387-578
    • Cervia, D.1    Fehlmann, D.2    Hoyer, D.3
  • 34
    • 0036282611 scopus 로고    scopus 로고
    • Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells
    • M.Z. Strowski, M.P. Dashkevicz, R.M. Parmar, H. Wilkinson, M. Kohler, J.M. Schaeffer, A.D. Blake, Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 75, 339-346 (2002)
    • (2002) Neuroendocrinology , vol.75 , pp. 339-346
    • Strowski, M.Z.1    Dashkevicz, M.P.2    Parmar, R.M.3    Wilkinson, H.4    Kohler, M.5    Schaeffer, J.M.6    Blake, A.D.7
  • 36
    • 0019367724 scopus 로고
    • Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture
    • U.I. Richardson, A. Schonbrunn, Inhibition of adrenocorticotropin secretion by somatostatin in pituitary cells in culture. Endocrinology 108, 281-290 (1981)
    • (1981) Endocrinology , vol.108 , pp. 281-290
    • Richardson, U.I.1    Schonbrunn, A.2
  • 42
    • 34250862862 scopus 로고    scopus 로고
    • Octreotide and the novel multi-receptor ligand somatostatin receptor agonist pasireotide (SOM230), block the adrenalectomy-induced increase in mitotic activity in male rat anterior pituitary
    • L.A. Nolan, H.A. Schmid, A. Levy, Octreotide and the novel multi-receptor ligand somatostatin receptor agonist pasireotide (SOM230), block the adrenalectomy-induced increase in mitotic activity in male rat anterior pituitary. Endocrinology 148, 2821-2827 (2007)
    • (2007) Endocrinology , vol.148 , pp. 2821-2827
    • Nolan, L.A.1    Schmid, H.A.2    Levy, A.3
  • 43
    • 30944449710 scopus 로고    scopus 로고
    • The role of somatostatin analogs in Cushing's disease
    • J. van der Hoek, S.W. Lamberts, L.J. Hofland, The role of somatostatin analogs in Cushing's disease. Pituitary 7, 257-264 (2004)
    • (2004) Pituitary , vol.7 , pp. 257-264
    • Van Der Hoek, J.1    Lamberts, S.W.2    Hofland, L.J.3
  • 44
    • 77956538048 scopus 로고    scopus 로고
    • Role of somatostatin receptors in normal and tumoral pituitary corticotropic cells
    • L.J. Hofland, S.W.J. Lamberts, R.A. Feelders, Role of somatostatin receptors in normal and tumoral pituitary corticotropic cells. Neuroendocrinology 92(suppl 1), 11-16 (2010)
    • (2010) Neuroendocrinology , vol.92 , Issue.SUPPL. 1 , pp. 11-16
    • Hofland, L.J.1    Lamberts, S.W.J.2    Feelders, R.A.3
  • 46
    • 0025852671 scopus 로고
    • Effect of Sandostatin on CRF-stimulated secretion of ACTH, beta-lipotropin and beta-endorphin
    • C. Invitti, F. Pecori Giraldi, A. Dubini, M. Piolini, F. Cavagnini, Effect of Sandostatin on CRF-stimulated secretion of ACTH, beta-lipotropin and beta-endorphin. Horm. Metab. Res. 23, 233-235 (1991)
    • (1991) Horm. Metab. Res. , vol.23 , pp. 233-235
    • Invitti, C.1    Pecori Giraldi, F.2    Dubini, A.3    Piolini, M.4    Cavagnini, F.5
  • 49
    • 0017175286 scopus 로고
    • Effects of growth hormone release-inhibiting hormone and bromocryptine (CB 154) in states of abnormal pituitary-adrenal function
    • Oxf
    • G. Benker, K. Hackenberg, B. Hamburger, D. Reinwein, Effects of growth hormone release-inhibiting hormone and bromocryptine (CB 154) in states of abnormal pituitary-adrenal function. Clin. Endocrinol. (Oxf). 5, 187-190 (1976)
    • (1976) Clin. Endocrinol. , vol.5 , pp. 187-190
    • Benker, G.1    Hackenberg, K.2    Hamburger, B.3    Reinwein, D.4
  • 51
    • 0025277838 scopus 로고
    • Failure of somatostatin and octreotide to acutely affect the hypothalamic- pituitary-adrenal function in patients with corticotropin hypersecretion
    • B. Ambrosi, D. Bochicchio, C. Fadin, P. Colombo, G. Faglia, Failure of somatostatin and octreotide to acutely affect the hypothalamic- pituitary-adrenal function in patients with corticotropin hypersecretion. J. Endocrinol. Invest. 13, 257-261 (1990)
    • (1990) J. Endocrinol. Invest. , vol.13 , pp. 257-261
    • Ambrosi, B.1    Bochicchio, D.2    Fadin, C.3    Colombo, P.4    Faglia, G.5
  • 52
    • 0024400759 scopus 로고
    • Studies on the conditions determining the inhibitory effect of somatostatin on adrenocorticotropin, prolactin and thyrotropin release by cultured rat pituitary cells
    • S.W. Lamberts, J. Zuyderwijk, F. den Holder, P. van Koetsveld, L. Hofland, Studies on the conditions determining the inhibitory effect of somatostatin on adrenocorticotropin, prolactin and thyrotropin release by cultured rat pituitary cells. Neuroendocrinology 50, 44-50 (1989)
    • (1989) Neuroendocrinology , vol.50 , pp. 44-50
    • Lamberts, S.W.1    Zuyderwijk, J.2    Den Holder, F.3    Van Koetsveld, P.4    Hofland, L.5
  • 53
    • 0019202526 scopus 로고
    • Effects of somatostatin and bromocryptine on the plasma ACTH level in bilaterally adrenalectomized patients with Cushing's disease
    • J. Julesz, F. Laczi, T. Janáky, F. László, Effects of somatostatin and bromocryptine on the plasma ACTH level in bilaterally adrenalectomized patients with Cushing's disease. Endokrinologie 76, 68-72 (1980)
    • (1980) Endokrinologie , vol.76 , pp. 68-72
    • Julesz, J.1    Laczi, F.2    Janáky, T.3    László, F.4
  • 55
    • 67349160224 scopus 로고    scopus 로고
    • Somatostatin-dopamine ligands in the treatment of pituitary adenomas
    • A. Saveanu, P. Jaquet, Somatostatin-dopamine ligands in the treatment of pituitary adenomas. Rev. Endocr. Metab. Disord. 10, 83-90 (2009)
    • (2009) Rev. Endocr. Metab. Disord. , vol.10 , pp. 83-90
    • Saveanu, A.1    Jaquet, P.2
  • 57
    • 68449089018 scopus 로고    scopus 로고
    • Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas
    • T. Tateno, M. Kato, Y. Tani, K. Oyama, S. Yamada, Y. Hirata, Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas. Endocr. J. 56, 579-584 (2009)
    • (2009) Endocr. J. , vol.56 , pp. 579-584
    • Tateno, T.1    Kato, M.2    Tani, Y.3    Oyama, K.4    Yamada, S.5    Hirata, Y.6
  • 61
    • 59749083610 scopus 로고    scopus 로고
    • Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro
    • S. Lesche, D. Lehmann, F. Nagel, H.A. Schmid, S. Schulz, Differential effects of octreotide and pasireotide on somatostatin receptor internalization and trafficking in vitro. J. Clin. Endocrinol. Metab. 94, 654-661 (2009)
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 654-661
    • Lesche, S.1    Lehmann, D.2    Nagel, F.3    Schmid, H.A.4    Schulz, S.5
  • 62
    • 0035989072 scopus 로고    scopus 로고
    • Somatostatin, but not somatostatin receptor subtypes 2 and 5 selective agonists, inhibits calcitonin secretion and gene expression in the human medullary thyroid carcinoma cell line, TT
    • M.C. Zatelli, F. Tagliati, J.E. Taylor, D. Piccin, M.D. Culler, E.C. degli Uberti, Somatostatin, but not somatostatin receptor subtypes 2 and 5 selective agonists, inhibits calcitonin secretion and gene expression in the human medullary thyroid carcinoma cell line, TT. Horm. Metab. Res. 34, 229-233 (2002)
    • (2002) Horm. Metab. Res. , vol.34 , pp. 229-233
    • Zatelli, M.C.1    Tagliati, F.2    Taylor, J.E.3    Piccin, D.4    Culler, M.D.5    Degli Uberti, E.C.6
  • 67
    • 0032230258 scopus 로고    scopus 로고
    • Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice
    • A. Saiardi, E. Borrelli, Absence of dopaminergic control on melanotrophs leads to Cushing's-like syndrome in mice. Mol. Endocrinol. 12, 1133-1139 (1998)
    • (1998) Mol. Endocrinol. , vol.12 , pp. 1133-1139
    • Saiardi, A.1    Borrelli, E.2
  • 70
    • 0026783672 scopus 로고
    • Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines
    • W.E. Farrell, A.J. Clark, M.F. Stewart, S.R. Crosby, A. White, Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines. J Clin Invest. 90, 705-710 (1992)
    • (1992) J Clin Invest. , vol.90 , pp. 705-710
    • Farrell, W.E.1    Clark, A.J.2    Stewart, M.F.3    Crosby, S.R.4    White, A.5
  • 71
    • 0028328912 scopus 로고
    • Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine
    • D. Yin, S. Kondo, J. Takeuchi, T. Morimura, Induction of apoptosis in murine ACTH-secreting pituitary adenoma cells by bromocriptine. FEBS Lett. 339, 73-75 (1994)
    • (1994) FEBS Lett. , vol.339 , pp. 73-75
    • Yin, D.1    Kondo, S.2    Takeuchi, J.3    Morimura, T.4
  • 73
    • 0034616021 scopus 로고    scopus 로고
    • Receptors for dopamine and somatostatin: Formation of hetero-oligomers with enhanced functional activity
    • M. Rocheville, D.C. Lange, U. Kumar, S.C. Patel, R.C. Patel, Y.C. Patel, Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity. Science 288, 154-157 (2000)
    • (2000) Science , vol.288 , pp. 154-157
    • Rocheville, M.1    Lange, D.C.2    Kumar, U.3    Patel, S.C.4    Patel, R.C.5    Patel, Y.C.6
  • 75
    • 33750090081 scopus 로고    scopus 로고
    • Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas
    • A. Saveanu, G. Gunz, S. Guillen, H. Dufour, M.D. Culler, P. Jaquet, Somatostatin and dopamine-somatostatin multiple ligands directed towards somatostatin and dopamine receptors in pituitary adenomas. Neuroendocrinology 83, 258-263 (2006)
    • (2006) Neuroendocrinology , vol.83 , pp. 258-263
    • Saveanu, A.1    Gunz, G.2    Guillen, S.3    Dufour, H.4    Culler, M.D.5    Jaquet, P.6
  • 77
    • 67349112176 scopus 로고    scopus 로고
    • Somatostatin and dopamine receptors as targets for medical treatment of Cushing's syndrome
    • C. De Bruin, R.A. Feelders, S.W. Lamberts, L.J. Hofland, Somatostatin and dopamine receptors as targets for medical treatment of Cushing's syndrome. Rev. Endocr. Metab. Disord. 10, 91-102 (2009)
    • (2009) Rev. Endocr. Metab. Disord. , vol.10 , pp. 91-102
    • De Bruin, C.1    Feelders, R.A.2    Lamberts, S.W.3    Hofland, L.J.4
  • 78
    • 84898812395 scopus 로고    scopus 로고
    • Combination therapy for CushingGúøs disease: Effectiveness of two schedules of treatment. Should we start with cabergoline or ketoconazole?
    • doi:10.1007/s11102-013-0475-3
    • M. Barbot, N. Albiger, F. Ceccato, M. Zilio, A.C. Frigo, L. Denaro, F. Mantero, C. Scaroni, Combination therapy for CushingGúøs disease: effectiveness of two schedules of treatment. Should we start with cabergoline or ketoconazole? Pituitary (2013). doi:10.1007/s11102-013-0475-3
    • (2013) Pituitary
    • Barbot, M.1    Albiger, N.2    Ceccato, F.3    Zilio, M.4    Frigo, A.C.5    Denaro, L.6    Mantero, F.7    Scaroni, C.8
  • 80
    • 16844375686 scopus 로고    scopus 로고
    • Chemical approaches to the discovery and development of cancer therapies
    • S. Neidle, D.E. Thurston, Chemical approaches to the discovery and development of cancer therapies. Nat. Rev. Cancer 5, 285-296 (2005)
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 285-296
    • Neidle, S.1    Thurston, D.E.2
  • 89
    • 0034005995 scopus 로고    scopus 로고
    • Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma
    • S.S. Agarwala, J.M. Kirkwood, Temozolomide, a novel alkylating agent with activity in the central nervous system, may improve the treatment of advanced metastatic melanoma. Oncologist 5, 144-151 (2000)
    • (2000) Oncologist , vol.5 , pp. 144-151
    • Agarwala, S.S.1    Kirkwood, J.M.2
  • 90
  • 91
    • 0031967165 scopus 로고    scopus 로고
    • Growth factors and human pituitary adenomas
    • A. Spada, Growth factors and human pituitary adenomas. Eur. J. Endocrinol. 138, 255-257 (1998)
    • (1998) Eur. J. Endocrinol. , vol.138 , pp. 255-257
    • Spada, A.1
  • 92
    • 26644447156 scopus 로고    scopus 로고
    • Immunohistochemical analysis of tumor angiogenic factors in human pituitary adenomas
    • M. Niveiro, F.I. Aranda, G. Peiró, C. Alenda, A. Picó, Immunohistochemical analysis of tumor angiogenic factors in human pituitary adenomas. Hum. Pathol. 36, 1090-1095 (2005)
    • (2005) Hum. Pathol. , vol.36 , pp. 1090-1095
    • Niveiro, M.1    Aranda, F.I.2    Peiró, G.3    Alenda, C.4    Picó, A.5
  • 95
    • 0030791088 scopus 로고    scopus 로고
    • The c-erbB-2/neu proto-oncogene in human pituitary tumours
    • Oxf
    • S. Ezzat, L. Zheng, H.S. Smyth, S.L. Asa, The c-erbB-2/neu proto-oncogene in human pituitary tumours. Clin. Endocrinol. (Oxf). 46, 599-606 (1997)
    • (1997) Clin. Endocrinol. , vol.46 , pp. 599-606
    • Ezzat, S.1    Zheng, L.2    Smyth, H.S.3    Asa, S.L.4
  • 96
    • 0002848925 scopus 로고    scopus 로고
    • Localization of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFr) in human pituitary adenomas and nontumorous pituitaries: An immunocytochemical study
    • G. Kontogeorgos, L. Stefaneanu, K. Kovacs, Z. Cheng, Localization of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFr) in human pituitary adenomas and nontumorous pituitaries: an immunocytochemical study. Endocr. Pathol. 7, 63-70 (1996)
    • (1996) Endocr. Pathol. , vol.7 , pp. 63-70
    • Kontogeorgos, G.1    Stefaneanu, L.2    Kovacs, K.3    Cheng, Z.4
  • 98
    • 0002539948 scopus 로고
    • Proliferation markers and EGF in ACTH-secreting adenomas and carcinomas of the pituitary
    • D. Lubke, W. Saeger, D.K. Ludecke, Proliferation markers and EGF in ACTH-secreting adenomas and carcinomas of the pituitary. Endocr. Pathol. 6, 45-55 (1995)
    • (1995) Endocr. Pathol. , vol.6 , pp. 45-55
    • Lubke, D.1    Saeger, W.2    Ludecke, D.K.3
  • 99
    • 0029066674 scopus 로고
    • Proliferation of the murine corticotropic tumour cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids
    • P.A. van Wijk, J.W. van Neck, A. Rijnberk, R.J. Croughs, J.A. Mol, Proliferation of the murine corticotropic tumour cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids. Mol. Cell. Endocrinol. 111, 13-19 (1995)
    • (1995) Mol. Cell. Endocrinol. , vol.111 , pp. 13-19
    • Van Wijk, P.A.1    Van Neck, J.W.2    Rijnberk, A.3    Croughs, R.J.4    Mol, J.A.5
  • 101
    • 72749102942 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GHsecreting pituitary tumor cells in vitro
    • A. Gorshtein, H. Rubinfeld, E. Kendler, M. Theodoropoulou, V. Cerovac, G.K. Stalla, Z.R. Cohen, M. Hadani, I. Shimon, Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GHsecreting pituitary tumor cells in vitro. Endocr. Relat. Cancer 16, 1017-1027 (2009)
    • (2009) Endocr. Relat. Cancer , vol.16 , pp. 1017-1027
    • Gorshtein, A.1    Rubinfeld, H.2    Kendler, E.3    Theodoropoulou, M.4    Cerovac, V.5    Stalla, G.K.6    Cohen, Z.R.7    Hadani, M.8    Shimon, I.9
  • 107
    • 73149093180 scopus 로고    scopus 로고
    • Rationale for treatment and therapeutic options in Cushing's disease
    • P.M. Stewart, S. Petersenn, Rationale for treatment and therapeutic options in Cushing's disease. Best Pract. Res. Clin. Endocrinol. Metab. 23(Suppl 1), S15-S22 (2009)
    • (2009) Best Pract. Res. Clin. Endocrinol. Metab. , vol.23 , Issue.SUPPL. 1
    • Stewart, P.M.1    Petersenn, S.2
  • 108
    • 0023635811 scopus 로고
    • Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment
    • Oxf
    • M. Boscaro, N. Sonino, A. Rampazzo, F. Mantero, Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment. Clin. Endocrinol. (Oxf). 27, 461-467 (1987)
    • (1987) Clin. Endocrinol. , vol.27 , pp. 461-467
    • Boscaro, M.1    Sonino, N.2    Rampazzo, A.3    Mantero, F.4
  • 110
    • 0023273646 scopus 로고
    • The use of ketoconazole as an inhibitor of steroid production
    • N. Sonino, The use of ketoconazole as an inhibitor of steroid production. N. Engl. J. Med. 317, 812-818 (1987)
    • (1987) N. Engl. J. Med. , vol.317 , pp. 812-818
    • Sonino, N.1
  • 111
    • 77956515048 scopus 로고    scopus 로고
    • Medical treatment of Cushing's syndrome: Adrenal-blocking drugs and ketaconazole
    • R.A. Feelders, L.J. Hofland, W.W. de Herder, Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. Neuroendocrinology 92(Suppl 1), 111-115 (2010)
    • (2010) Neuroendocrinology , vol.92 , Issue.SUPPL. 1 , pp. 111-115
    • Feelders, R.A.1    Hofland, L.J.2    De Herder, W.W.3
  • 113
    • 0021959199 scopus 로고
    • Ketoconazole therapy in Cushing's disease
    • A. Angeli, R. Frairia, Ketoconazole therapy in Cushing's disease. Lancet 1, 821 (1985)
    • (1985) Lancet , vol.1 , pp. 821
    • Angeli, A.1    Frairia, R.2
  • 114
    • 0023635811 scopus 로고
    • Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment
    • Oxf
    • M. Boscaro, N. Sonino, A. Rampazzo, F. Mantero, Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment. Clin. Endocrinol. (Oxf). 27, 461-467 (1987)
    • (1987) Clin. Endocrinol. , vol.27 , pp. 461-467
    • Boscaro, M.1    Sonino, N.2    Rampazzo, A.3    Mantero, F.4
  • 116
    • 0028067785 scopus 로고
    • Therapy of Cushing's syndrome with steroid biosynthesis inhibitors
    • D. Engelhardt, M.M. Weber, Therapy of Cushing's syndrome with steroid biosynthesis inhibitors. J. Steroid Biochem. Mol. Biol. 49, 261-267 (1994)
    • (1994) J. Steroid Biochem. Mol. Biol. , vol.49 , pp. 261-267
    • Engelhardt, D.1    Weber, M.M.2
  • 117
    • 0023865658 scopus 로고
    • Cholesterol metabolism during ketoconazole treatment in man
    • T.A. Miettinen, Cholesterol metabolism during ketoconazole treatment in man. J. Lipid Res. 29, 43-51 (1988)
    • (1988) J. Lipid Res. , vol.29 , pp. 43-51
    • Miettinen, T.A.1
  • 120
    • 38649088260 scopus 로고    scopus 로고
    • Pharmacological management of Cushing's syndrome: An update
    • C.N. Dang, O. Trainer, Pharmacological management of Cushing's syndrome: an update. Arq. Bras. Endocrinol. Metabol. 51, 1339-1348 (2007)
    • (2007) Arq. Bras. Endocrinol. Metabol. , vol.51 , pp. 1339-1348
    • Dang, C.N.1    Trainer, O.2
  • 123
    • 80051954574 scopus 로고    scopus 로고
    • Treatment of Cushing disease: Overview and recent findings
    • T. Mancini, T. Porcelli, A. Giustina, Treatment of Cushing disease: overview and recent findings. Ther. Clin. Risk Manag. 6, 505-516 (2010)
    • (2010) Ther. Clin. Risk Manag. , vol.6 , pp. 505-516
    • Mancini, T.1    Porcelli, T.2    Giustina, A.3
  • 124
    • 0036933584 scopus 로고    scopus 로고
    • Medical therapy of Cushing's disease
    • L.K. Nieman, Medical therapy of Cushing's disease. Pituitary 5, 77-82 (2002)
    • (2002) Pituitary , vol.5 , pp. 77-82
    • Nieman, L.K.1
  • 130
    • 69249206536 scopus 로고    scopus 로고
    • Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors
    • D. LaSala, Y. Shibanaka, A.Y. Jeng, Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. Anal. Biochem. 394, 56-61 (2009)
    • (2009) Anal. Biochem. , vol.394 , pp. 56-61
    • LaSala, D.1    Shibanaka, Y.2    Jeng, A.Y.3
  • 131
    • 78149238346 scopus 로고    scopus 로고
    • Aldosterone synthase inhibition with LCI699: A proof-of-concept study in patients with primary aldosteronism
    • L. Amar, M. Azizi, J. Menard, S. Peyrard, C. Watson, P.F. Plouin, Aldosterone synthase inhibition with LCI699: a proof-of-concept study in patients with primary aldosteronism. Hypertension 56, 831-838 (2010)
    • (2010) Hypertension , vol.56 , pp. 831-838
    • Amar, L.1    Azizi, M.2    Menard, J.3    Peyrard, S.4    Watson, C.5    Plouin, P.F.6
  • 132
    • 80255141746 scopus 로고    scopus 로고
    • Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: Results of a randomized, double-blind, placebo- and active-controlled phase 2 trial
    • D.A. Calhoun, W.B. White, H. Krum, W. Guo, G. Bermann, A. Trapani, M.P. Lefkowitz, J. Menard, Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial. Circulation 124, 1945-1955 (2011)
    • (2011) Circulation , vol.124 , pp. 1945-1955
    • Calhoun, D.A.1    White, W.B.2    Krum, H.3    Guo, W.4    Bermann, G.5    Trapani, A.6    Lefkowitz, M.P.7    Menard, J.8
  • 133
    • 84862265357 scopus 로고    scopus 로고
    • Advances in medical therapies for Cushing's syndrome
    • N.A. Tritos, B.M. Biller, Advances in medical therapies for Cushing's syndrome. Discov. Med. 13, 171-179 (2011)
    • (2011) Discov. Med. , vol.13 , pp. 171-179
    • Tritos, N.A.1    Biller, B.M.2
  • 136
    • 0018167425 scopus 로고
    • Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis
    • P. Komanicky, R.F. Spark, J.C. Melby, Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J. Clin. Endocrinol. Metab. 47, 1042-1051 (1978)
    • (1978) J. Clin. Endocrinol. Metab. , vol.47 , pp. 1042-1051
    • Komanicky, P.1    Spark, R.F.2    Melby, J.C.3
  • 138
    • 68849101237 scopus 로고    scopus 로고
    • A novel use of etomidate for intentional adrenal suppression to control severe hypercortisolemia in childhood
    • N. Mettauer, J. Brierley, A novel use of etomidate for intentional adrenal suppression to control severe hypercortisolemia in childhood. Pediatr. Crit. Care Med. 10, e37-e40 (2009)
    • (2009) Pediatr. Crit. Care Med. , vol.10
    • Mettauer, N.1    Brierley, J.2
  • 140
    • 36549032804 scopus 로고    scopus 로고
    • Mifepristone (RU 486) in Cushing's syndrome
    • S. Johanssen, B. Allolio, Mifepristone (RU 486) in Cushing's syndrome. Eur. J. Endocrinol. 157, 561-569 (2007)
    • (2007) Eur. J. Endocrinol. , vol.157 , pp. 561-569
    • Johanssen, S.1    Allolio, B.2
  • 141
    • 0028023218 scopus 로고
    • Steroid antagonists and receptor-associated proteins
    • M.C. Lebeau, E.E. Baulieu, Steroid antagonists and receptor-associated proteins. Hum. Reprod. 9, 437-444 (1994)
    • (1994) Hum. Reprod. , vol.9 , pp. 437-444
    • Lebeau, M.C.1    Baulieu, E.E.2
  • 142
    • 0029112776 scopus 로고
    • The glucocorticoid receptor and RU 486 in man
    • C.M. Bamberger, G.P. Chrousos, The glucocorticoid receptor and RU 486 in man. Ann. N. Y. Acad. Sci. 761, 296-310 (1995)
    • (1995) Ann. N. Y. Acad. Sci. , vol.761 , pp. 296-310
    • Bamberger, C.M.1    Chrousos, G.P.2
  • 144
    • 0025188132 scopus 로고
    • Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction
    • H.F. Yang-Yen, J.C. Chambard, Y.L. Sun, T. Smeal, T.J. Schmidt, J. Drouin, M. Karin, Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62, 1205-1215 (1990)
    • (1990) Cell , vol.62 , pp. 1205-1215
    • Yang-Yen, H.F.1    Chambard, J.C.2    Sun, Y.L.3    Smeal, T.4    Schmidt, T.J.5    Drouin, J.6    Karin, M.7
  • 146
    • 57649210173 scopus 로고    scopus 로고
    • Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line
    • B.W. Peeters, G.S. Ruigt, M. Craighead, P. Kitchener, Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line. Ann. N. Y. Acad. Sci. 1148, 536-541 (2008)
    • (2008) Ann. N. Y. Acad. Sci. , vol.1148 , pp. 536-541
    • Peeters, B.W.1    Ruigt, G.S.2    Craighead, M.3    Kitchener, P.4
  • 148
    • 1642498185 scopus 로고    scopus 로고
    • Pharmacological properties of mifepristone: Toxicology and safety in animal and human studies
    • R. Sitruk-Ware, I.M. Spitz, Pharmacological properties of mifepristone: toxicology and safety in animal and human studies. Contraception 68, 409-420 (2003)
    • (2003) Contraception , vol.68 , pp. 409-420
    • Sitruk-Ware, R.1    Spitz, I.M.2
  • 153
    • 77956554285 scopus 로고    scopus 로고
    • Medical treatment of Cushing's syndrome: Glucocorticoid receptor antagonists and mifepristone
    • F. Castinetti, B. Conte-Devolx, T. Brue, Medical treatment of Cushing's syndrome: glucocorticoid receptor antagonists and mifepristone. Neuroendocrinology 92(Suppl 1), 125-130 (2010)
    • (2010) Neuroendocrinology , vol.92 , Issue.SUPPL. 1 , pp. 125-130
    • Castinetti, F.1    Conte-Devolx, B.2    Brue, T.3
  • 154
    • 84861967547 scopus 로고    scopus 로고
    • Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome
    • M. Fleseriu, B.M. Biller, J.W. Findling, M.E. Molitch, D.E. Schteingart, C. Gross, Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome. J. Clin. Endocrinol. Metab. 97, 2039-2049 (2012)
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 2039-2049
    • Fleseriu, M.1    Biller, B.M.2    Findling, J.W.3    Molitch, M.E.4    Schteingart, D.E.5    Gross, C.6
  • 155
    • 0028973101 scopus 로고
    • 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: Explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome
    • P.M. Stewart, B.R. Walker, G. Holder, D. O'Halloran, C.H. Shackleton, 11 beta-Hydroxysteroid dehydrogenase activity in Cushing's syndrome: explaining the mineralocorticoid excess state of the ectopic adrenocorticotropin syndrome. J. Clin. Endocrinol. Metab. 80, 3617-3620 (1995)
    • (1995) J. Clin. Endocrinol. Metab. , vol.80 , pp. 3617-3620
    • Stewart, P.M.1    Walker, B.R.2    Holder, G.3    O'Halloran, D.4    Shackleton, C.H.5
  • 156
    • 7244247137 scopus 로고    scopus 로고
    • Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension
    • S.H. van Uum, J.W. Lenders, A.R. Hermus, Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension. Semin. Vasc. Med. 4, 121-128 (2004)
    • (2004) Semin. Vasc. Med. , vol.4 , pp. 121-128
    • Van Uum, S.H.1    Lenders, J.W.2    Hermus, A.R.3
  • 157
    • 84881136007 scopus 로고    scopus 로고
    • Mifepristone: Is there a place in the treatment of Cushing's disease?
    • J.D. Carmichael, M. Fleseriu, Mifepristone: is there a place in the treatment of Cushing's disease? Endocrine 44, 20-32 (2013)
    • (2013) Endocrine , vol.44 , pp. 20-32
    • Carmichael, J.D.1    Fleseriu, M.2
  • 159
    • 4644336258 scopus 로고    scopus 로고
    • Pituitary carcinoma: A review of the literature
    • B.T. Ragel, W.T. Couldwell, Pituitary carcinoma: a review of the literature. Neurosurg. Focus 16, 1-9 (2004)
    • (2004) Neurosurg. Focus , vol.16 , pp. 1-9
    • Ragel, B.T.1    Couldwell, W.T.2
  • 160
    • 0036312567 scopus 로고    scopus 로고
    • Long-term survival with ACTH-secreting carcinoma of the pituitary: A case report and review of the literature
    • R.E. Landman, M. Horwith, R.E. Peterson, A.G. Khandji, S.L. Wardlaw, Long-term survival with ACTH-secreting carcinoma of the pituitary: a case report and review of the literature. J. Clin. Endocrinol. Metab. 87, 3084-3089 (2002)
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 3084-3089
    • Landman, R.E.1    Horwith, M.2    Peterson, R.E.3    Khandji, A.G.4    Wardlaw, S.L.5
  • 161
    • 0032452430 scopus 로고    scopus 로고
    • The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors
    • G.A. Kaltsas, J.J. Mukherjee, The role of cytotoxic chemotherapy in the management of aggressive and malignant pituitary tumors. J. Clin. Endocrinol. Metab. 83, 4233-4238 (1998)
    • (1998) J. Clin. Endocrinol. Metab. , vol.83 , pp. 4233-4238
    • Kaltsas, G.A.1    Mukherjee, J.J.2
  • 162
    • 59149096718 scopus 로고    scopus 로고
    • Malignant pituitary corticotroph adenomas: Report of two cases and a comprehensive review of the literature
    • A.A. van der Klaauw, T. Kienitz, C.J. Strasburger, J.W. Smit, J.A. Romijn, Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature. Pituitary 12, 57-69 (2009)
    • (2009) Pituitary , vol.12 , pp. 57-69
    • Van Der Klaauw, A.A.1    Kienitz, T.2    Strasburger, C.J.3    Smit, J.W.4    Romijn, J.A.5
  • 163
    • 67650330274 scopus 로고    scopus 로고
    • Significant response to pasireotide (SOM230) in the treatment of a patient with persistent, refractory Cushing's disease
    • Oxf
    • K. Cukier, R. Tewari, F. Kurth, H.A. Schmid, C. Lai, D.J. Torpy, Significant response to pasireotide (SOM230) in the treatment of a patient with persistent, refractory Cushing's disease. Clin. Endocrinol. (Oxf). 71, 305-307 (2009)
    • (2009) Clin. Endocrinol. , vol.71 , pp. 305-307
    • Cukier, K.1    Tewari, R.2    Kurth, F.3    Schmid, H.A.4    Lai, C.5    Torpy, D.J.6
  • 164
    • 78349239330 scopus 로고    scopus 로고
    • SOM230 (pasireotide) and temozolomide achieve sustained control of tumour progression and ACTH secretion in pituitary carcinoma with widespread metastases
    • H. Bode, M. Seiz, A. Lammert, M.A. Brockmann, W. Back, H.P. Hammes, C. Thomé, SOM230 (pasireotide) and temozolomide achieve sustained control of tumour progression and ACTH secretion in pituitary carcinoma with widespread metastases. Exp. Clin. Endocrinol. Diabetes 118, 760-763 (2010)
    • (2010) Exp. Clin. Endocrinol. Diabetes , vol.118 , pp. 760-763
    • Bode, H.1    Seiz, M.2    Lammert, A.3    Brockmann, M.A.4    Back, W.5    Hammes, H.P.6    Thomé, C.7
  • 167
    • 70349771361 scopus 로고    scopus 로고
    • Temozolamide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy
    • C. Hagen, H.D. Schroder, S. Hansen, C. Hagen, M. Andersen, Temozolamide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. Eur. J. Endocrinol. 161, 631-637 (2009)
    • (2009) Eur. J. Endocrinol. , vol.161 , pp. 631-637
    • Hagen, C.1    Schroder, H.D.2    Hansen, S.3    Hagen, C.4    Andersen, M.5
  • 169
    • 79955089003 scopus 로고    scopus 로고
    • Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor
    • M. Thearle, P. Freda, J. Bruce, S. Isaacson, Y. Lee, R. Fine, Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor. Pituitary 14, 418-424 (2011)
    • (2011) Pituitary , vol.14 , pp. 418-424
    • Thearle, M.1    Freda, P.2    Bruce, J.3    Isaacson, S.4    Lee, Y.5    Fine, R.6
  • 170
    • 84867361736 scopus 로고    scopus 로고
    • Successful long-term treatment of Cushing disease with mifepristone (RU486)
    • M. Basina, H. Liu, A.R. Hoffman, D. Feldman, Successful long-term treatment of Cushing disease with mifepristone (RU486). Endocr. Pract. 18, e114-e120 (2012)
    • (2012) Endocr. Pract. , vol.18
    • Basina, M.1    Liu, H.2    Hoffman, A.R.3    Feldman, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.