Retinoic acid prevents experimental Cushing syndrome

Journal of Clinical Investigation

Volumn 108, Issue 8, 2001, Pages 1123-1131

  Paez Pereda M ^a   Kovalovsky, D ^a   Hopfner, U ^a   Theodoropoulou, M ^a   Pagotto, U ^a   Uhl, E ^a   Losa, M ^a   Stalla, J ^a   Grubler Y ^a   Missale, C ^a   Arzt, E ^a   Stalla, G K ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; DEXAMETHASONE; FORSKOLIN; RETINOIC ACID; TRANSCRIPTION FACTOR AP 1;

ADRENAL CORTEX; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORTICOSTERONE RELEASE; CORTICOTROPIN RELEASE; CUSHING SYNDROME; HUMAN; HUMAN CELL; NEUROENDOCRINE TUMOR; NUDE MOUSE; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH;

EID: 0034776771     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11098     Document Type: Article

References (43)

1. Cushing's syndrome
2. The molecular pathogenesis of corticotroph tumors
3. Ectopic adrenocorticotropic hormone syndrome
4. The corticotropin-release inhibitory factor hypothesis: A review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenoorticotropin secretion and biosynthesis
5. Pituitary pro-opiomelanocortin gene expression requires synergistic interactions of several regulatory elements
6. Corticotropin-releasing hormone stimulates proopiomelanocortin transcription by cFos-dependent and -independent pathways: Characterization of an AP-1 site in exon 1
7. Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing
8. Regulation of adrenocorticotropic hormone secretion: Lessons from mice deficient in corticotropin-releasing hormone
9. CRF stimulates expression of multiple for and jun related genes in the AtT-20 corticotroph cell
10. Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
11. Antagonism between Nur77 and glucocorticoid receptor for control of transcription
12. Heterodimerization between members of the Nur subfamily of orphan nuclear recepors as a novel mechanism for gene activation
13. Retinoic acid is a negative regulator of AP-1-responsive genes
14. Nuclear receptor/AP-1 interaction
15. Separation of transactivation and AP1 antagonism functions of retinoic acid receptor alpha
16. Ligand activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/c-For dimerization
17. Retinoic acid and its receptors repress the expression and transactivation functions of Nur77: A possible mechanism for the inhibition of apoptosis by retinoic acid
18. Retinoids in cancer chemoprevention
19. Recent advances in chemoprevention of cancer
20. The biologic basis for the use of retinoids in cancer prevention and treatment
21. Perspectives on cancer chemoprevention research and drug development
22. Inhibition of neoplastic transformation in vitro by retinoids
23. The effect of butyric acid and retinoic acid on invasion and experimental metastasis of murine melanoma cells
24. Retinoic acid stimulates meningioma cell adhesion to the extracellular matrix and inhibits invasion
25. Nerve growth factor and retinoic acid inhibt proliferation and invasion in thyroid tumor cells
26. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation
27. Modulation of retinoic acid sensitivity in lung cancer cells through dynamic balance of orphan receptors nur77 and COUP-TF and their heterodimerization
28. COUP orphan receptors are negative regulators of retinoic acid response pathways
29. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling
30. Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyoid hormone, and retinoic acid receptors
31. Transplantation of ACTH-secreting pituitary tumor cells in athymic nude mice
32. Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures
33. Interleukin involvement in anterior pituitary cell growth regulation: Effects of IL-2 and IL-6
34. High levels of matrix metalloproteinase activity regulate proliferation and hormone secretion in pituitary cells
35. Identification of DNA elements cooperatively activating proopiomelanocortin gene expression in the pituitary glands of transgenic mice
36. Molecular and functional evidence for in vitro cytokine enhancement of human and murine target cell sensitivity to glucocorticoids. TNF-alpha priming increases glucocorticoid inhibition of TNF-alpha-induced cytotoxicity/apoptosis
37. COUP-TF upregulates NGFI-gene expression through an Sp1 binding site
38. Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines
39. Apopain/CPP32 cleaves proteins that are essential for cellular repair: A fundamental principle of apoptotic death
40. Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growth factor expression in prolactinoma pathogenesis
41. In vivo prevention of corticosteroid-induced skin atrophy by tretinoin in the hairless mouse is accompanied by modulation of collagen, glycosaminoglycans, and fibronectin
42. Retinoic acid selectively stimulates growth hormone secretion and messenger ribonuleic acid levels in rat pituitary cells
43. Immunostimulation by retinoic acid