Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats

European Journal of Endocrinology

Volumn 153, Issue 3, 2005, Pages

  Silva, A P ^a   Schoeffter, P ^a   Weckbecker, G ^a   Bruns, C ^a   Schmid, Herbert A ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; OCTREOTIDE; PASIREOTIDE; SOMATOSTATIN RECEPTOR 1; SOMATOSTATIN RECEPTOR 3; SOMATOSTATIN RECEPTOR 5;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOSTERONE RELEASE; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; DOSE RESPONSE; HORMONE INHIBITION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; RAT STRAIN; RECEPTOR AFFINITY;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; MALE; OCTREOTIDE; RATS; RATS, SPRAGUE-DAWLEY; SOMATOSTATIN;

EID: 26244435250     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.01998     Document Type: Article

References (15)

1. Miyachi Y. Pathophysiology and diagnosis of Cushing's syndrome. Biomedicine and Pharmacotherapy 2000 54 113s-117s.
2. Engler D, Redei E & Kola I. The corticotropin-release inhibitory factor hypothesis: a review of the evidence for the existence of inhibitory as well as stimulatory hypophysiotropic regulation of adrenocorticotropin secretion and biosynthesis. Endocrine Reviews 1999 20 460-500.
3. Gillies G. Somatostatin: the neuroendocrine story. Trends in Pharmacological Sciences 1997 18 87-95.
4. Bruns C, Lewis I, Briner U, Meno-Tetang G & Weckbecker G. SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile. European Journal of Endocrinology 2002 146 707-716.
5. Strowski MZ, Dashkevicz MP, Parmar RM, Wilkinson H, Kohler M, Schaeffer JM & Blake AD. Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells. Neuroendocrinology 2002 75 339-346.
6. Uwaifo GI, Koch CA, Hirshberg B, Chen CC, Hartzband P, Nieman LK & Pacak K. Is there a therapeutic role for octreotide in patients with ectopic Cushing's syndrome? Journal of Endocrinological Investigation 2003 26 710-717.
7. de Herder WW & Lamberts SW. Is there a role for somatostatin and its analogs in Cushing's syndrome? Metabolism 1996 45 83-85.
8. Hofland LJ, van der Hoek J, Feeklers R, van Aken MO, van Koetsveld PM, Waaijers M, Sprij-Mooij D, Bruns C, Weckbecker G, de Herder WW, Beckers A & Lamberts SWJ. The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5. European Journal of Endocrinology 2005 152 643-652.
9. Day R, Dong W, Panetta R, Kraicer J, Greenwood MT & Patel YC. Expression of mRNA for somatostatin receptor (sstr) types 2 and 5 in individual rat pituitary cells. A double labeling in situ hybridization analysis. Endocrinology 1995 136 5232-5235.
10. Mezey E, Hunyady B, Mitra S, Hayes E, Liu Q, Schaeffer J & Schonbrunn A. Cell specific expression of the sst2A and sst5 somatostatin receptors in the rat anterior pituitary. Endocrinology 1998 139 414-419.
11. Schmid HA & Schoeffter P. Functional activity of the multiligand analog SOM230 at human recombinant somatostatin receptor subtypes supports its usefulness in neuroendocrine tumors. Neuroendocrinology 2004 80 47-50.
12. de Herder WW & Lamberts SW. Octapeptide somatostatin-analogue therapy of Cushing's syndrome. Postgraduate Medicine Journal 1999 75 65-66.
13. van der Hoek J, Waaijers M, van Koetsveld PM, Sprij-Mooij D, Feelders RA, Schmid HA, Schoeffter P, Hoyer D, Cervia D, Taylor JE, Culler MD, Lamberts SW & Holland LJ. Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumour cells. American Journal of Physiology-Endocrinology and Metabolism 2005 289 278-287.
14. Unger N, Serdiuk I, Shen SY, Walz MK, Schulz S, Schmid KW, Mann K & Petersenn S. Immunohistochemical determination of somatostatin receptor subtypes 1, 2A, 3, 4, and 5 in various adrenal tumors. Endocrine Research 2004 30 931-934.
15. O'Carroll AM. Localization of messenger ribonucleic acids for somatostatin receptor subtypes (sstr1-5) in the rat adrenal gland. Journal of Histochemistry and Cytochemistry 2003 51 55-60.