Differential effect of glucocorticoid receptor antagonists on glucocorticoid receptor nuclear translocation and DNA binding

Journal of Psychopharmacology

Volumn 25, Issue 2, 2011, Pages 211-221

  Spiga, Francesca ^a   Knight, David M ^a   Droste, Susanne K ^a   Conway Campbell, Becky ^a   Kershaw, Yvonne ^a   MacSweeney, Cliona P ^b   Thomson, Fiona J ^b   Craighead, Mark ^b   Peeters, Bernard Wmm ^b   Lightman, Stafford L ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

corticosterone; depression; DNA binding; glucocorticoid receptor; glucocorticoid receptor antagonist; HPA axis; nuclear translocation; RU486

Indexed keywords

1,3 BENZODIOXOLE DERIVATIVE; CORTICOSTERONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ANTAGONIST; MIFEPRISTONE;

ADRENALECTOMY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; HIPPOCAMPUS; HYPOPHYSIS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CORTICOSTERONE; DNA; DRUG SYNERGISM; HIPPOCAMPUS; HORMONE ANTAGONISTS; MALE; MICE; MIFEPRISTONE; PITUITARY GLAND; PREFRONTAL CORTEX; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID;

EID: 79551657367     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881109348175     Document Type: Article

References (43)

1. Bachmann CG, Linthorst AC, Holsboer F., Reul JM (2003) Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis. Neuropsychopharmacology 28: 1056-1067.
2. Beck CA, Estes PA, Bona BJ, Muro-Cacho CA, Nordeen SK, Edwards DP (1993) The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors. Endocrinology 133: 728-740.
3. Conway-Campbell BL, McKenna MA, Wiles CC, Atkinson HC, De Kloet ER, Lightman SL (2007) Proteasome-dependent down-regulation of activated nuclear hippocampal glucocorticoid receptors determines dynamic responses to corticosterone. Endocrinology 148: 5470-5477.
4. De Kloet ER, Joels M., Holsboer F. (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6: 463-475.
5. Fitzsimons CP, van Hooijdonk LW, Morrow JA, et al. (2009) Antiglucocorticoids, neurogenesis and depression. Mini Rev Med Chem 9: 249-264.
6. Gagne D., Pons M., Philibert D. (1985) RU 38486: a potent antiglucocorticoid in vitro and in vivo. J Steroid Biochem 23: 247-251.
7. Gold PW, Goodwin FK, Chrousos GP (1988) Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress. N Engl J Med 319: 413-420.
8. Gruol DJ, Altschmied J. (1993) Synergistic induction of apoptosis with glucocorticoids and 3',5'-cyclic adenosine monophosphate reveals agonist activity by RU 486. Mol Endocrinol 7: 104-113.
9. Havel PJ, Busch BL, Curry DL, Johnson PR, Dallman MF, Stern JS (1996) Predominately glucocorticoid agonist actions of RU-486 in young specific-pathogen-free Zucker rats. Am J Physiol 271: R710 - R717.
10. Heitzer MD, Wolf IM, Sanchez ER, Witchel SF, DeFranco DB (2007) Glucocorticoid receptor physiology. Rev Endocr Metab Disord 8: 321-330.
11. Holsboer F. (2000) The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477-501.
12. Jewell CM, Webster JC, Burnstein KL, Sar M., Bodwell JE, Cidlowski JA (1995) Immunocytochemical analysis of hormone mediated nuclear translocation of wild type and mutant glucocorticoid receptors. J Steroid Biochem Mol Biol 55: 135-146.
13. Kitchener P., Di BF, Borrelli E., Piazza PV (2004) Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle. Eur J Neurosci 19: 1837-1846.
14. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
15. Lin W., Celik A., Paczynski RP, Hsu CY, Powers WJ (1999) Quantitative magnetic resonance imaging in experimental hypercapnia: improvement in the relation between changes in brain R2 and the oxygen saturation of venous blood after correction for changes in cerebral blood volume. J Cereb Blood Flow Metab 19: 853-862.
16. Mangelsdorf DJ, Thummel C., Beato M., et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839.
17. Mayer JL, Klumpers L., Maslam S., De Kloet ER, Joels M., Lucassen PJ (2006) Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis. J Neuroendocrinol 18: 629-631.
18. Mikuni S., Pack C., Tamura M., Kinjo M. (2007) Diffusion analysis of glucocorticoid receptor and antagonist effect in living cell nucleus. Exp Mol Pathol 82: 163-168.
19. Nemeroff CB (1996) The corticotropin-releasing factor (CRF) hypothesis of depression: new findings and new directions. Mol Psychiatry 1: 336-342.
20. Nihalani ND, Schwartz TL (2007) Mifepristone, a glucocorticoid antagonist for the potential treatment of psychotic major depression. Curr Opin Investig Drugs 8: 563-569.
21. Oitzl MS, Fluttert M., De Kloet ER (1998) Acute blockade of hippocampal glucocorticoid receptors facilitates spatial learning in rats. Brain Res 797: 159-162. (Pubitemid 28331501)
22. Pandit S., Geissler W., Harris G., Sitlani A. (2002) Allosteric effects of dexamethasone and RU486 on glucocorticoid receptor-DNA interactions. J Biol Chem 277: 1538-1543.
23. Pariante CM (2004) Glucocorticoid receptor function in vitro in patients with major depression. Stress 7: 209-219.
24. Pariante CM, Lightman SL (2008) The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31: 464-468.
25. Pariante CM, Miller AH (2001) Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49: 391-404.
26. Pariante CM, Pearce BD, Pisell TL, Su C., Miller AH (2001) The steroid receptor antagonists RU40555 and RU486 activate glucocorticoid receptor translocation and are not excreted by the steroid hormones transporter in L929 cells. J Endocrinol 169: 309-320.
27. Peeters BW, Ruigt GS, Craighead M., Kitchener P. (2008) Differential effects of the new glucocorticoid receptor antagonist ORG 34517 and RU486 (mifepristone) on glucocorticoid receptor nuclear translocation in the AtT20 cell line. Ann N Y Acad Sci 1148: 536-541.
28. Peeters BW, Tonnaer JA, Groen MB, et al. (2004) Glucocorticoid receptor antagonists: new tools to investigate disorders characterized by cortisol hypersecretion. Stress 7: 233-241.
29. Picard D., Yamamoto KR (1987) Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor. EMBO J 6: 3333-3340.
30. Pratt WB, Toft DO (2003) Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp Biol Med (Maywood) 228: 111-133.
31. Qi M., Stasenko LJ, DeFranco DB (1990) Recycling and desensitization of glucocorticoid receptors in v-mos transformed cells depend on the ability of nuclear receptors to modulate gene expression. Mol Endocrinol 4: 455-464.
32. Revest JM, Di BF, Kitchener P., et al. (2005) The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci 8: 664-672.
33. Schmidt TJ (1986) In vitro activation and DNA binding affinity of human lymphoid (CEM-C7) cytoplasmic receptors labeled with the antiglucocorticoid RU 38486. J Steroid Biochem 24: 853-863.
34. Segnitz B., Gehring U. (1990) Mechanism of action of a steroidal antiglucocorticoid in lymphoid cells. J Biol Chem 265: 2789-2796.
35. Spiga F., Lightman SL (2009) Dose-dependent effects of corticosterone on nuclear glucocorticoid receptors and their binding to DNA in the brain and pituitary of the rat. Brain Res 1293: 101-107.
36. Spiga F., Conway-Campbell BL, Droste SK, et al. (2008) Differential effects of the glucocorticoid receptor antagonists RU486 and a Schering-Plough GR antagonist on glucocorticoid receptor nuclear translocation and DNA binding in vivo in brain and pituitary of rat. Abstract of the 38th Annual Meeting of the Society for Neuroscience, 15-19 November 2008, Washington, DC, USA.
37. Spiga F., Harrison LR, Wood SA, et al. (2007) Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion. J Neuroendocrinol 19: 891-900.
38. Sposito NM, Gross PM (1987) Morphometry of individual capillary beds in the hypothalamo-neurohypophysial system of rats. Brain Res 403: 375-379.
39. Thomson FBC, Craighead M., Eason S., et al. (2004) In vivo and in vitro characterization of the glucocorticoid receptor antagonist Org 34517. J Affect Dis 78: S99 - S142.
40. Vallone D., Battista S., Pierantoni GM, et al. (1997) Neoplastic transformation of rat thyroid cells requires the junB and fra-1 gene induction which is dependent on the HMGI-C gene product. EMBO J 16: 5310-5321.
41. van Eekelen JA, Kiss JZ, Westphal HM, De Kloet ER (1987) Immunocytochemical study on the intracellular localization of the type 2 glucocorticoid receptor in the rat brain. Brain Res 436: 120-128.
42. van Haarst AD, Oitzl MS, De Kloet ER (1997) Facilitation of feedback inhibition through blockade of glucocorticoid receptors in the hippocampus. Neurochem Res 22: 1323-1328.
43. Young AH, Gallagher P., Watson S., Del-Estal D., Owen BM, Ferrier IN (2004) Improvements in neurocognitive function and mood following adjunctive treatment with mifepristone (RU-486) in bipolar disorder. Neuropsychopharmacology 29: 1538-1545.