TGF-ß and FGF-trigger intercellular induction of apoptosis: Analogous activity on non-transformed but differential activity on transformed cells

International Journal of Oncology

Volumn 13, Issue 6, 1998, Pages 1247-1252

  Dormann, Sabine ^a   Bauer, Georg ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Autocrine loop; Fibroblast growth factor; Intercellular induction of apoptosis; Transforming growth factor

Indexed keywords

ACETYLCYSTEINE; DNA; FIBROBLAST GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ANIMALS; APOPTOSIS; CELL LINE, TRANSFORMED; CELLS, CULTURED; FIBROBLAST GROWTH FACTORS; RATS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031774257     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Jürgensmeier JM, Viesel E, Höfler P and Bauer G: TGF-ß-treated normal fibroblasts eliminate transformed fibroblasts by induction of apoptosis. Cancer Res 54: 393-398, 1994.
2. Langer C, Jürgensmeier JM and Bauer G: Reactive oxygen species act both at TGF-ß-dependent and -independent steps during induction of apoptosis of transformed cells by normal cells. Exp Cell Res 222:117-124, 1996.
3. Bauer G: Elimination of transformed cells by normal cells: a novel concept for the control of carcinogenesis. Histol Histopathol 11: 237-255, 1996.
4. Jürgensmeier JM, Höfler P and Bauer G: TGF-ß-induced elimination of transformed fibroblasts by normal cells: independence of cell-to-cell contact and dependence on reactive oxygen species. Int J Oncol 5: 525-531, 1994.
5. Panse J, Hipp ML and Bauer G: Fibroblasts transformed by chemical carcinogens are sensitive for intercellular induction of apoptosis: implications for the control of oncogenesis. Carcinogenesis 18:259-264, 1997.
6. Beck E, Schäfer R and Bauer G: Sensitivity of transformed fibroblasts for intercellular induction of apoptosis is determined by their transformed phenotype. Exp Cell Res 234: 47-56, 1997.
7. Bauer G: Resistance to TGF-ß-induced elimination of transformed cells is required during tumor progression. Int J Oncol 6: 1227-1229, 1995.
8. Jürgensmeier JM and Bauer G: Interference of Bcl-2 with intercellular control of carcinogenesis. Int J Cancer 71: 698-704, 1997.
9. Melchinger W, Strauss S, Zucker B and Bauer G: Antiapoptotic activity of bovine papilloma virus: implications for the control of carcinogenesis. Int J Oncol 9: 927-933, 1996.
10. Hackenjos K, Langer C, Zabel S and Bauer G: Transformed cells trigger induction of their own apoptosis in coculture with normal cells. Oncol Rep 3: 27-31, 1996.
11. Eckert S and Bauer G: TGF-ß isoforms and fibroblast growth factor exhibit analogous indirect antioncogenic activity through triggering of intercellular induction of apoptosis. Anticancer Res 18: 45-52, 1998.
12. Iten E, Ziemiecki A and Schäfer R: The transformation-suppressive function is lost in tumorigenic cells and is restored upon transfer of a suppressor gene. Recent Results Cancer Res 113: 78-89, 1989.
13. Gorcyca W, Gong J and Darzynkiewicz Z: Detection of DNA strand breaks in individual apoptotic cells by the in-situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res 53: 1945-1951, 1993.
14. Vossbeck H, Strahm B, Höfler P and Bauer G: Direct transforming activity of TGF-ß on rat fibroblasts. Int J Cancer 61: 92-97, 1995.
15. Fürstenberger G, Rogers M, Schnapke R, Bauer G, Höfler P and Marks F: Stimulatory role of transforming growth factors in multistage skin carcinogenesis: possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin. Int J Cancer 43: 915-921, 1989.
16. Bauer G, Götschl M and Höfler P: Tumor-promoting activity of Epstein-Barr-virus-inducing factor/transforming growth factor type beta (EIF/TGF-ß) is due to the induction of irreversible transformation. Int J Cancer 47: 881-888, 1991.
17. Nugent MA, Lane EA, Keski-Oja J, Moses HL and Newman MJ: Growth stimulation, altered regulation of epidermal growth factor receptors, and autocrine transformation of spontaneously transformed normal rat kidney cells by transforming growth factor B. Cancer Res 49: 3884-3890, 1989.
18. 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int J Cancer 49: 129-139, 1991.
19. Wehrle I, Jakob A, Höfler P and Bauer G: Transformation of murine fibroblasts by UV light and TGF-ß: establishment of an autocrine TGF-ß loop. Int J Oncol 5: 1341-1346, 1994.
20. Iida S, Yoshida T, Naito K, Sakamoto H, Katoh O, Hirohashi S, Sato T, Onda M, Sugimura T and Terada M: Human hst-2 (FGF-6) oncogene: cDNA cloning and characterization. Oncogene 7: 303-309, 1992.
21. Dickson C and Peters G: Potential oncogene product related to growth factors. Nature 326: 833, 1987.
22. Damen JC, Greenberg AH and Wright JA: Transformation and amplification of the K-fgf protooncogene in NIH-3T3 cells, and induction of metastatic potential. Biochem Biophys Acta 1097: 103-110, 1991.
23. Goldfarb M, Deed R, MacAllan D, Walker W, Dickson C and Peters G: Cell transformation by int-2, a member of the fibroblast growth factor family. Oncogene 6: 61-71, 1991.
24. Talarico D and Basilico C: The K-fgf/hst oncogene induces transformation through an autocrine mechanism that requires extracellular stimulation of the mitogenic pathway. Mol Cell Biol 11: 1138-1145, 1991.
25. Taira M, Yoshida T, Miyagawa K, Sakomoto H, Terada M and Sugimura T: cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci USA 84: 2980-2984, 1987.
26. Delli-Bovi P, Curatola AM, Newman KM, Sato Y, Moscatelli D, Hewick RM, Rifkin DB and Basilico C: Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential. Mol Cell Biol 8: 2933-2941, 1988.
27. Yayon A and Klagsbrun M: Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin. Proc Natl Acad Sci USA 87: 5346-5350, 1990.
28. Rogelj S, Weinberg RA, Fanning P and Klagsbrun M: Basic fibroblast growth factor fused to a signal peptide transforms cells. Nature 331: 173-175, 1988.
29. Sasada R, Kurokawa T, Iwane M and Igarashi K: Transformation of mouse Balb/c 3T3 cells with human basic fibroblast growth factor cDNA. Mol Cell Biol 8: 588-594, 1988.
30. Quarto N, Talarico D, Sommer A, Florkiewicz R, Basilico C and Rifkin DB: Transformation by basic fibroblast growth factor requires high levels of expression: comparison with transformation by hst/k-fgf. Oncogene Res 5: 101-110, 1989.
31. Blam SB, Mitchell R, Tischer E, Rubin JS, Silva M, Silver S, Fiddes JC, Abraham JA and Aaronson SA: Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein. Oncogene 3: 129-136, 1988.
32. Jaye M, Lyall RM, Mudd R, Schlessinger J and Sarver N: Expression of acidic growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells. EMBO J 7: 963-969, 1988.
33. Li JJ, Huang YQ, Moscatelli D, Nicolaides A, Zwang WC and Friedman-Kien AE: Expression of fibroblast growth factors and their receptors in acquired immunodeficiency syndrome-associated Kaposi sarcoma tissue and derived cells. Cancer 72: 2253-2259, 1993.
34. Neufeld G, Mitchell R, Ponte P and Gospodarowicz D: Expression of human FGF cDNA in baby hamster kidney-derived cells results in autonomous cell growth. J Cell Biol 106: 1385-1393, 1988.
35. Moscatelli D and Quarto N: Transformation of NIH 3T3 cells with basic fibroblast growth factor of the hst/fgf oncogens causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin. J Cell Biol 109: 2519-2527, 1989.
36. Maret A, Galy B, Arnaud E, Bayard F and Prats H: Inhibition of fibroblast growth factor 2 expression by antisense RNA induced a loss of the transformed phenotype in a human hepatoma cell line. Cancer Res 55: 5075-5079, 1995.