Attenuation of Aβ25-35-induced parallel autophagic and apoptotic cell death by gypenoside XVII through the estrogen receptor-dependent activation of Nrf2/ARE pathways

Toxicology and Applied Pharmacology

Volumn 279, Issue 1, 2014, Pages 63-75

  Meng, Xiangbao ^a   Wang, Min ^a   Sun, Guibo ^a   Ye, Jingxue ^b   Zhou, Yanhui ^c   Dong, Xi ^d   Wang, Tingting ^a   Lu, Shan ^a   Sun, Xiaobo ^a  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b JILIN AGRICULTURAL UNIVERSITY   (China)

^c People's Hospital of Jilin Province   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Apoptosis; Autophagy; Nuclear factor erythroid 2 related factor 2; Oxidative stress; Phytoestrogen

Indexed keywords

AMYLOID BETA PROTEIN[25-35]; CARBONYL DERIVATIVE; CASPASE 3; CYTOCHROME C; DNA; ESTROGEN RECEPTOR; GYPENOSIDE; GYPENOSIDE 17; HEME OXYGENASE 1; LACTATE DEHYDROGENASE; MALONALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; PHYTOESTROGEN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; ATTENUATION; AUTOPHAGY; CELL VIABILITY; CONTROLLED STUDY; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; ESTROGEN RESPONSIVE ELEMENT; GYNOSTEMMA PENTAPHYLLUM; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PANAX NOTOGINSENG; PC12 CELL LINE; PROTEIN EXPRESSION; RAT;

ALZHEIMER'S DISEASE; APOPTOSIS; AUTOPHAGY; NUCLEAR FACTOR-ERYTHROID 2-RELATED FACTOR 2; OXIDATIVE STRESS; PHYTOESTROGEN;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; CASPASE 3; CELL DIFFERENTIATION; CELL SURVIVAL; FLUORESCENT ANTIBODY TECHNIQUE; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GYNOSTEMMA; HEME OXYGENASE-1; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PC12 CELLS; PEPTIDE FRAGMENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PLANT EXTRACTS; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84902258259     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.03.026     Document Type: Article

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