Induction of autophagic cell death in the rat brain caused by iron

American Journal of the Medical Sciences

Volumn 345, Issue 5, 2013, Pages 369-374

  Chen, Gao ^a   Jing, Chao Hui ^a   Liu, Pan Pan ^a   Ruan, Di ^a   Wang, Lin ^a  

^a THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

ATG5; Autophagic cell death; Beclin 1; Iron; Microtubuleassociated protein light chain 3

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; FERROUS CHLORIDE; FERROUS ION;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASTROCYTE; AUTOPHAGY; CELL DEATH; CELL VACUOLE; CONFOCAL MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MALE; NERVE CELL; NONHUMAN; PARIETAL CORTEX; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

EID: 84876842614     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e318271c031     Document Type: Article

References (36)

1. Gerlach M, Benshachar D, Riederer P, et al. Altered brain metabolism of iron as a cause of neurodegenerative diseases. J Neurochem 1994;63:793-807.
2. Rite I, Machado A, Cano J, et al. Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons. J Neurochem 2007;101:1567-82.
3. Popescu BO, Toescu EC, Popescu LM, et al. Blood-brain barrier alterations in ageing and dementia. J Neurol Sci 2009;283:99-106.
4. Perez de la Ossa N, Sobrino T, Silva Y, et al. Iron-related brain damage in patients with intracerebral hemorrhage. Stroke 2010;41: 810-3.
5. Chen Z, Gao C, Hua Y, et al. Role of iron in brain injury after intraventricular hemorrhage. Stroke 2011;42:465-70.
6. Oakley AE, Collingwood JF, Dobson J, et al. Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 2007;68:1820-5.
7. Zecca L, Youdim MB, Riederer P, et al. Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 2004;5:863-73.
8. Codogno P, Meijer AJ. Autophagy and signaling: Their role in cell survival and cell death. Cell Death Differ 2005;12(suppl 2):1509-18.
9. Bursch W, Hochegger K, Torok L, et al. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000;113(pt 7):1189-98.
10. Gutteridge JM. Hydroxyl radicals, iron, oxidative stress, and neurodegeneration. Ann N Y Acad Sci 1994;738:201-13.
11. Carbonell T, Rama R. Iron, oxidative stress and early neurological deterioration in ischemic stroke. Curr Med Chem 2007;14:857-74.
12. Kim YM, Chung HT, Simmons RL, et al. Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J Biol Chem 2000;275:10954-61.
13. Kabeya Y, Mizushima N, Ueno T, et al. Lc3, a mammalian homologue of yeast apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8.
14. Kabeya Y, Mizushima N, Yamamoto A, et al. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J Cell Sci 2004;117:2805-12.
15. Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev Cell 2004;6: 463-77.
16. Kroemer G, Galluzzi L, Vandenabeele P, et al. Classification of cell death: Recommendations of the nomenclature committee on cell death 2009. Cell Death Differ 2009;16:3-11.
17. Shimizu S, Kanaseki T, Mizushima N, et al. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 2004;6:1221-8.
18. Yu L, Alva A, Su H, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004;304:1500-2.
19. Pyo JO, Jang MH, Kwon YK, et al. Essential roles of ATG5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005;280:20722-9.
20. Banks WA, Kastin AJ, Fasold MB, et al. Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier. Brain Res Bull 1988;21:881-5.
21. Cozzi A, Santambrogio P, Levi S, et al. Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro. FEBS Lett 1990;277:119-22.
22. Hua Y, Xi G, Keep RF, et al. Complement activation in the brain after experimental intracerebral hemorrhage. J Neurosurg 2000;92:1016-22.
23. Wu J, Hua Y, Keep RF, et al. Iron and iron-handling proteins in the brain after intracerebral hemorrhage. Stroke 2003;34:2964-9.
24. Suzuki H, Muramatsu M, Kojima T, et al. Intracranial heme metabolism and cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2003;34:2796-800.
25. Zheng W, Monnot AD. Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases. Pharmacol Ther 2012;133:177-88.
26. Crichton RR, Dexter DT, Ward RJ. Brain iron metabolism and its perturbation in neurological diseases. J Neural Transm 2011;118:301-14.
27. Gutteridge JM. Iron and oxygen radicals in brain. Ann Neurol 1992;32 (suppl):S16-21.
28. He Y, Wan S, Hua Y, et al. Autophagy after experimental intracerebral hemorrhage. J Cereb Blood Flow Metab 2008;28:897-905.
29. Lee JY, He Y, Sagher O, et al. Activated autophagy pathway in experimental subarachnoid hemorrhage. Brain Res 2009;1287:126-35.
30. Gorman AM. Neuronal cell death in neurodegenerative diseases: Recurring themes around protein handling. J Cell Mol Med 2008;12:2263-80.
31. Chen Y, McMillan-Ward E, Kong J, et al. Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. Cell Death Differ 2008;15:171-82.
32. Lee JY, Keep RF, He Y, et al. Hemoglobin and iron handling in brain after subarachnoid hemorrhage and the effect of deferoxamine on early brain injury. J Cereb Blood Flow Metab 2010;30:1793-803.
33. Wang J, Dore S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage. Brain 2007;130:1643-52.
34. Schipper HM, Liberman A, Stopa EG. Neural heme oxygenase-1 expression in idiopathic Parkinson's disease. Exp Neurol 1998;150:60-8.
35. Schipper HM, Cisse S, Stopa EG. Expression of heme oxygenase-1 in the senescent and Alzheimer-diseased brain. Ann Neurol 1995;37:758-68.
36. Zukor H, Song W, Liberman A, et al. Ho-1-mediated macroautophagy: A mechanism for unregulated iron deposition in aging and degenerating neural tissues. J Neurochem 2009;109:776-91.