Functional characterization of histamine H4 receptor on human mast cells

Molecular Immunology

Volumn 62, Issue 1, 2014, Pages 19-28

  Jemima, E Angel ^a   Prema, A ^a   Thangam, E Berla ^a  

^a SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

4 methylhistamine; Cytokine; Histamine; Histamine H4 receptor; Inflammatory mediators; Mast cells

Indexed keywords

CALCIUM; COLONY STIMULATING FACTOR 1; CYCLIC AMP; EOTAXIN 2; GALPHAI PROTEIN; GALPHAQ PROTEIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HISTAMINE H4 RECEPTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 16; INTERLEUKIN 1ALPHA; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 8; LEUKOTRIENE B4; LYMPHOTOXIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEPTIDOLEUKOTRIENE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN; RANTES; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 4-METHYLHISTAMINE; AUTACOID; CYTOKINE; G PROTEIN COUPLED RECEPTOR; HISTAMINE DERIVATIVE; HISTAMINE H1 RECEPTOR; HISTAMINE RECEPTOR; HRH4 PROTEIN, HUMAN; LEUKOTRIENE;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CD34 SELECTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INFLAMMATION; MAST CELL; MAST CELL DEGRANULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TH2 CELL; TIME; UMBILICAL CORD BLOOD; CELL CULTURE; GENE EXPRESSION; GENETICS; IMMUNE SYSTEM; IMMUNOLOGY; METABOLISM; NEWBORN; PHYSIOLOGY; TH1 CELL;

CELLS, CULTURED; CYTOKINES; GENE EXPRESSION; HUMANS; IMMUNE SYSTEM; INFANT, NEWBORN; INFLAMMATION MEDIATORS; LEUKOTRIENES; MAST CELLS; METHYLHISTAMINES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RECEPTORS, HISTAMINE H1; TH1 CELLS; TH2 CELLS;

EID: 84902255859     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2014.05.007     Document Type: Article

References (42)

1. Ali H., Richardson R.M., Tomhave E.D., DuBose R.A., Haribabu B., Snyderman R. Regulation of stably transfected platelet activating factor receptor in RBL-2H3 cells. Role of multiple G proteins and receptor phosphorylation. J. Biol. Chem. 1944, 269:24557-24563.
2. Beermann S., Glage S., Jonigk D., Seifert R., Neumann D. Opposite Effects of Mepyramine on JNJ7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. PloS one 2012, 7:e30285.
3. Buckland K.F., Williams T.J., Conroy D.M. Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Brit. J. Pharmacol. 2003, 140:1117-1127.
4. Damaj B.B., Becerra C.B., Esber H.J., Azzam Y.W., Maghazachi A. Functional expression of H4 histamine receptor in human natural killer cells, monocytes, and dendritic cells. J. Immunol. 2009, 179:7907-7915.
5. Damaj B.B., Becerra C.B., Esber H.J., Wen Y., Maghazachi A. Functional expression of H4 Histamine receptor in human natural killer cells, monocytes and dendritic cells. J. Immunol. 2007, 179:7907-7915.
6. De Esch I.J., Thurmond R.L., Jongejan A., Leurs R. The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol. Sci. 2005, 26:462-469.
7. Desai P., Thurmond R.L. Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. Eur. J. Immunol. 2011, 41:1764-1773.
8. Dijkstra D., Leurs R., Chazot P., Shenton F.C., Stark H., Werfel T., Gutzmer R. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J. Allergy Clin. Immunol. 2007, 120:300-307.
9. Dy M., Schneider E. Histamine-cytokine connection in immunity and hematopoiesis. Cytokine Growth Factor. Rev. 2004, 15:393-410.
10. Gantner F., Sakai K., Tusche M.W., Cruikshank W.W., Center D.M., Bacon K.B. Histamine H4 and H2 receptors control histamine induced interleukin-16 release from human CD8+ T cells. J. Pharmacol. Exp. Therapeut. 2002, 303:300-307.
11. Gilfillan A.M., Beaven M.A. Regulation of mast cell responses in health and disease. Crit. Rev. Immunol. 2011, 31:475-529.
12. Gschwandtner M., Schakel K., Werfel T., Gutzmer R. Histamine H4 receptor activation on human slan-dendritic cells down-regulates their pro- inflammatory capacity. Immunology 2010, 132:49-56.
13. Gutzmer R., Mommert S., Gschwandtner M., Zwingmann K., Stark H., Werfel T. The histamine H4 receptor is functionally expressed on Th2 cells. J. Allergy Clin. Immunol. 2009, 123:619-625.
14. p70 production and mediates chemotaxis in human Monocyte- derived dendritic cells. J. Immnol. 2005, 174:5224-5232.
15. 4 receptor expression in human leukocytes. Ann. Allergy Asthma Immunol. 2013, 111:38-44.
16. Hofstra C.L., Pragnya L., Desai J., Thurmond R.L., Fung-Leung W.P. Histamine H4Receptor mediates chemotaxis and calcium mobilization of mast cells. Pharmacol. Exp. Therapeut. 2003, 305:1212-1221.
17. Kinet J.P. The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu. Rev. Immunol. 1999, 17:931-972.
18. Kirshenbaum A.S., Akin C., Wu Y., Rottem M., Goff J.P., Beaven M.A., Rao V.K., Metacafe D.D. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of Fce{open}R1 or FcγR1. Leuk. Res. 2003, 27:677-682.
19. Leurs R., Smit M.J., Timmerman H. Molecular pharmacological aspects of histamine receptors. Pharmacol. Therapeut. 1995, 66:413-463.
20. Lim H.D., van Rijn R.M., Ling P., Bakker R.A., Thurmond R.L., Leurs R. Evaluation of histamine H1-H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exp. Therapeut. 2005, 314:1310-1321.
21. Lippert U., Artuc M., Grützkau A., Babina M., Guhl S., Haase I., Blaschke V., Zachmann K., Knosalla M., Middel P., Kruger-Krasagakis S., Henz B.M. Human skin mast cells express H2 and H4, but not H3 receptors. J. Invest. Dermatol. 2004, 123:116-123.
22. MacGlashan D.W., Schleimer R.P., Peters S.P., Schulman E.S., Adams G.K., Newball H.H., Lichtenstein L.M. Generation of leukotrienes by purified human lung mast cells. J. Clin. Invest. 1982, 70:747-751.
23. Matsubara M., Tamura T., Ohmori K., Hasegawa K. Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+ dependent protein kinase C Raf/MEK/ERK and IKK/I κB/NF-κB signal cascades. Biochem. Pharmacol. 2005, 69:433-449.
24. Michel D.Y., Schneider E. Histamine- cytokine connection in immunity and hematopoiesis. Cytokine Growth Factor Rev. 2004, 15:393-410.
25. Mommert S., Gschwandter M., Gutzmer R., Werfe T. The role of the histamine H4 receptor in atopic dermatitis. Curr. Allergy Asthma Rep. 2011, 11:21-28.
26. Morse K.L., Behen J., Laz T.M., West R.E., Greenfeder S.A., Anthes J.C., et al. Cloning and characterization of a novel human histamine receptor. J. Pharmacol. Exp. Therapeut. 2001, 296:1058-1066.
27. Radinger M., Jensen B.M., Kuehn H.S., Kirshenbaum A., Gilfillan A.M. Generation, isolation, and maintenance of human mast cells and mast cell lines. Curr. Proto. Immunol. 2010, 7:37.
28. Reher T.M., Neumann D., Buschauer A., Seifert R. Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations. Biochem. Pharmacol. 2012, 84:192-203.
29. Reuter S., Stassen M., Taube C. Mast cells in allergic asthma and beyond. Yonsei Med. J. 2010, 51:797-807.
30. Rivera J. Molecular adapters in Fce{open}RI signaling and the allergic response. Curr. Opin. Immunol. 2002, 14:688-693.
31. Salcedo C., Pontes C., Merlos M. Is the H4 receptor a new drug target for allergies and asthma?. Front. Biosci. 2013, 5:178-187.
32. Schwartz L.B. Mast cells: function and contents. Curr. Opin. Immunol. 1994, 6:91.
33. Seifert R., Strasser A., Schneider E.H., Neumann D., Dove S., Buschauer A. Molecular and cellular analysis of human histamine receptor subtypes. Trends Pharmacol. Sci. 2013, 34:33-58.
34. Shahid M., Tripathi T., Sobia F., Moin S., Siddiqui M., Khan R.A. Histamine receptors, and their role in immunomodulation: an updated systematic review. Th. Open. Immunol. J. 2009, 2:9-41.
35. Simon T., Laszlo V., Lang O., Buzas E., Falus A. Histamine regulates relevant murine dentritic cell functions via H4 receptor. Front. Biosci. 2011, 3:1414-1424.
36. Takeshita K., Sakai K., Bacon K.B., Gantner F. Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo. J. Pharmacol. Exp. Therapeut. 2003, 307:1072-1078.
37. Thurmond R.L., Desai P.J., Dunford P.J., Fung- Leung W.P., Hofstra C.L., Jiang W., Nguyen S., Riley J.P., Sun S., Williams K.N., Edwards J.P., Karlsson L. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J. Pharmacol. Exp. Therapeut. 2004, 309:404-413.
38. Thurmond R.L., Gelfand E.W., Dunford P.J. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nature 2008, 7:41-53.
39. Umetsu D., McIntire J., Akbari O., Macaubas C., DeKruyf R. Asthma. An epidemic of dysregulated immunity. Nat. Immunol. 2002, 715-720.
40. Venkatesha R.T., Thangam E.B., Zaidi A.K., Ali H. Distinct regulation of C3a-induced MCP-1/CCL2 and RANTES/CCL5 production in human mast cells by extracellular signal regulated kinase and PI3 kinase. Mol. Immunol. 2005, 42:581-587.
41. Zampeli E., Tiligada E. The role of histamine H4 receptor in immune and inflammatory disorders. Brit. J. Pharmacol. 2009, 157:24-33.
42. Zhang M., Thurmond R.L., Dunford P.J. The histamine H4 receptor: a novel modulator of inflammatory and immune disorders. Pharmacol. Therapeut. 2007, 113:594-606.