An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval

American Journal of Human Genetics

Volumn 94, Issue 6, 2014, Pages 854-869

  Kapoor, Ashish ^a   Sekar, Rajesh B ^a   Hansen, Nancy F ^b   Fox Talbot, Karen ^a   Morley, Michael ^c   Pihur, Vasyl ^a   Chatterjee, Sumantra ^a   Brandimarto, Jeffrey ^c   Moravec, Christine S ^d   Pulit, Sara L ^e   Pfeufer, Arne ^f,g   Mullikin, Jim ^b   Ross, Mark ^h   Green, Eric D ^b   Bentley, David ^h   Newton Cheh, Christopher ⁱ   Boerwinkle, Eric ^j   Tomaselli, Gordon F ^a   Cappola, Thomas P ^c   Arking, Dan E ^a   Halushka, Marc K ^a   Chakravarti, Aravinda ^a   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f INSTITUTE OF EPIDEMIOLOGY   (Germany)

^g Isar Medizin Zentrum   (Germany)

^h Illumina   (United Kingdom)

ⁱ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^j UNIVERSITY OF TEXAS   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ASSAY; DNA POLYMORPHISM; EMBRYO; ENHANCER REGION; GENE; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENE OVEREXPRESSION; GENE SEQUENCE; GENE TARGETING; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HUMAN; HUMAN GENETICS; HUMAN TISSUE; MOLECULAR GENETICS; MOUSE; NONHUMAN; NOS1AP GENE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; QT INTERVAL; QUANTITATIVE TRAIT LOCUS; RAT; CONTROLLED STUDY; ELECTRIC CONDUCTIVITY; HEART FUNCTION; HUMAN CELL; PROTEIN EXPRESSION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; COHORT STUDIES; ELECTROCARDIOGRAPHY; GENE EXPRESSION REGULATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HEK293 CELLS; HUMANS; LENTIVIRUS; LONG QT SYNDROME; MICE; MYOCYTES, CARDIAC; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; ZEBRAFISH;

NOS1AP PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84902245734     PISSN: 00029297     EISSN: 15376605     Source Type: Journal    
DOI: 10.1016/j.ajhg.2014.05.001     Document Type: Article

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