Tricyclic pyrazoles. Part 6. Benzofuro[3,2-c]pyrazole: A versatile architecture for CB2 selective ligands

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 281-292

  Pinna, Giovanni ^a   Loriga, Giovanni ^b   Lazzari, Paolo ^a,c,d   Ruiu, Stefania ^b   Falzoi, Matteo ^e,f   Frau, Simona ^a   Pau, Amedeo ^a   Murineddu, Gabriele ^a   Asproni, Battistina ^a   Pinna, Gerard A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b INSTITUTE OF TRANSLATIONAL PHARMACOLOGY   (Italy)

^c KemoTech Srl   (Italy)

^d Neuroscienze PharmaNess Scarl   (Italy)

^e Consorzio ELPRO Edificio 5 ^*  (Italy)

^f UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

benzofuro 3,2 c pyrazole derivatives; Cannabinoid receptors; Monoterpenes

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; HYDRAZONE DERIVATIVE; N (MORPHOLIN 1 YL) 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOHYDRAZIDE; N (PIPERIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOHYDRAZIDE; N (PYRROLIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOHYDRAZIDE; N ADAMANT 1 YL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOXAMIDE; N ADAMANT 2 YL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOXAMIDE; N BORNYL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO [3,2 C]PYRAZOLE 3 CARBOXAMIDE; N CYCLOHEXYL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOXAMIDE; N FENCHYL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO [3,2 C]PYRAZOLE 3 CARBOXAMIDE; N ISOPINOCAMPHEYL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO[3,2 C]PYRAZOLE 3 CARBOXAMIDE; N MENTHYL 1 (2,4 DICHLOROPHENYL) 6 METHYL 1H BENZOFURO [3,2 C]PYRAZOLE 3 CARBOXAMIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; BENZOFURAN DERIVATIVE; LIGAND;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CONTROLLED STUDY; CYCLIZATION; DRUG SYNTHESIS; IN VITRO STUDY; LIGAND BINDING; MALE; MOUSE; NONHUMAN; OPTICAL DENSITY; UPREGULATION; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HL 60 CELL LINE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

BENZOFURANS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; HL-60 CELLS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PYRAZOLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902212755     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.05.055     Document Type: Article

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