Rational design of organophosphorus hydrolase with high catalytic efficiency for detoxifying a V-type nerve agent

Biochemical and Biophysical Research Communications

Volumn 449, Issue 3, 2014, Pages 263-267

  Jeong, Young Su ^a   Choi, Jung Min ^a   Kyeong, Hyun Ho ^a   Choi, Jae Youl ^b   Kim, Eui Joong ^b   Kim, Hak Sung ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b GenoFocus Inc   (South Korea)

Author keywords

Organophosphates; Organophosporus hydrolase; Rational design; V type agent

Indexed keywords

ARYLDIALKYLPHOSPHATASE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER;

ARTICLE; CATALYSIS; CHEMICAL BOND; DETOXIFICATION; ENZYME ACTIVE SITE; FLAVOBACTERIUM; GENE EXPRESSION SYSTEM; HYDROLYSIS; KINETICS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; SIMULATION; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY;

ANIMALIA; BACTERIA (MICROORGANISMS);

ORGANOPHOSPHATES; ORGANOPHOSPORUS HYDROLASE; RATIONAL DESIGN; V-TYPE AGENT;

ANIMALS; ARYLDIALKYLPHOSPHATASE; BACTERIAL PROTEINS; CATALYSIS; CATALYTIC DOMAIN; CHEMICAL WARFARE AGENTS; DRUG DESIGN; FLAVOBACTERIUM; HUMANS; MODELS, CHEMICAL; MOLECULAR DOCKING SIMULATION; MUTATION; ORGANOTHIOPHOSPHORUS COMPOUNDS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

EID: 84902212077     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.04.155     Document Type: Article

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